Encodes a putative receptor kinase gene encodes. Medical search. Frequent questions

Mutations in the INS R gene have been linked to insulin-resistant diabetes mellitus, noninsulin-dependent diabetes mellitus and leprechaunism, an extremely rare disorder characterized by abnormal resistance to insulin that results in a variety of distinguishing characteristics, including growth delays and abnormalities affecting the endocrine system. (rndsystems.com)
Genetic testing of OWRD patients and their family members can confirm the presence of mutations within implicated genes, most commonly the endoglin gene ( ENG ) in chromosome 9 or the activin receptorlike kinase type I (ALK-1) gene ( ALK1 ) in chromosome 12 (involved in HHT type 1 and type 2, respectively). (medscape.com)
Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. (embl.de)
The LCR for breast cancer in women harboring germline mutations in this gene is similar to the risk of carriers of germline mutations in BRCA1 (44 to 68 % until 70 years of age), whereas the risk of ovarian cancer ranges from 11 to 40 % [ 5 - 8 ]. (biomedcentral.com)
Considering the relevance of receptor tyrosine kinases and Eph in NSCLC, these seven mutations were assessed for change in the folding pattern using molecular dynamic simulation. (genominfo.org)
Mutations reported in different functional domains of RTKs are linked to the kinase constitutive expression, ligand-independent signaling, and drug sensitivity [ 1 ]. (genominfo.org)
In MEN 2A patients, 50% of those with RET gene mutations develop the disease by age 50 years, and 70% develop the disease by age 70 years. (medscape.com)
As a scientist she has been involved in mapping the human genome and identifying genes and mutations, which give rise to heritable disorders. (bepress.com)
Mutations in the tumor suppressor genes encoding TSC1 (Hamartin) and TSC2 (Tuberin) cause a multisystemic tumor syndrome termed tuberous sclerosis complex (TSC). (springer.com)
This possibility is supported by the fact that Pit1 mutations cause compound pituitary hormone deficiency (CPHD) [11] in which expressions of the TSHβ gene as well as the prolactin (PRL) and growth LM22A-4 hormone (GH) genes are decreased or abolished. (bioerc-iend.org)
Proto-oncogene changes to oncogene mainly by somatic point mutations, gene amplifications, or chromosomal translocations that bring proto-oncogene under control of differentially expressed protein. (wikilectures.eu)
Interestingly, there are common sites of KRAS gene somatic mutations (mainly changing guanine to other nucleotides) which make the oncoprotein to provide excessive growth promoting signal. (wikilectures.eu)
Mutations in GPR56 , an orphan G-protein-coupled receptor (GPCR), cause bilateral frontoparietal polymicrogyria (BFPP), a disorder characterized by mental retardation, seizures, motor developmental delay, and ataxia. (jneurosci.org)
However, these problems in mutants could be complemented by adding exogenous cAMP or by spontaneous mutations in the regulatory subunit of PKA gene [44]. (bio2009.org)
Deletion or mutations of their encoding genes usually severely impair either oogenesis or spermatogenesis or both. (ijbs.com)
In human, an array of four DAZ genes ( DAZ 1-4) is located in two clusters on the Y chromosome and mutations of these genes cause severe oligospermia or azospermia [ 1 ]. (ijbs.com)

Li, J. & Chory, J. A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. (nature.com)
Encodes GASSHO1 (GSO1), a putative leucine-rich repeat transmembrane-type receptor kinase. (or.jp)
Encodes GASSHO2 (GSO2), a putative leucine-rich repeat transmembrane-type receptor kinase. (or.jp)

In Drosophila, localized Jeb activates Alk and the downstream Ras/mitogen-activated protein kinase cascade to specify a select group of visceral muscle precursors as muscle-patterning pioneers. (nsjbio.com)
Studies using GH3 cells showed that TRH-induced activity of the TSHβ promoter depends on protein kinase C but not the mitogen-activated protein kinase suggesting that the signaling pathway is different from that in the prolactin gene. (bioerc-iend.org)
Mitogen-activated protein kinase phosphatases (MKPs) belongs to the dual-specificity phosphatase (DUSP) family. (cancer-research-network.com)

The CLAVATA (CLV)signaling pathway, including the CLV1 receptor-kinase, promotes the differentiation of stem cells by limiting the WUS expression domain,yet the mechanism of CLV signaling is largely unknown. (biologists.com)
The pathway appears to be generally well conserved as genes found in other invertebrates are present. (mun.ca)
The cyclic AMP-dependent protein kinase A signaling pathway plays a major role in regulating plant infection from the rice blast fungus and or are both necessary for development of spores and appressoria by and play roles in cell wall differentiation, regulating melanin pigmentation and cell surface hydrophobicity during spore formation. (bio2009.org)

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. (wikipedia.org)
Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. (wikipedia.org)
The Insulin Receptor (INS R) and insulin-like growth factor-1 receptor (IGF-1 R) constitute a subfamily of receptor tyrosine kinases (1‑4). (rndsystems.com)
Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
Expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. (nsjbio.com)

INS R is highly conserved between species, rat INS R shares 94% and 97% aa sequence homology with the human and mouse receptor, respectively. (rndsystems.com)
The proteins encoded by these genes contain large cytoplasmic domains characterized by a distinctive highly conserved sequence (SEX domain). (cnr.it)
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. (lookformedical.com)
Ephs belong to the largest family of receptor tyrosine kinase and are highly conserved both sequentially and structurally. (genominfo.org)
The juxtamembrane domain has two highly conserved tyrosine that regulate activation of catalytic core of the receptor. (genominfo.org)
These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)
DAZ family genes are highly conserved. (ijbs.com)

Unlike the receptors of the HGF family, p220SEX, a MET-SEX chimera or a constitutively dimerized TPR-SEX does not show tyrosine kinase activity. (cnr.it)
C-met is a protein encoded by a met gene in humans, which has tyrosine kinase activity. (cancer-research-network.com)

MicroRNA-34a gene (MIR-34A) that is located on chromosome 1p36 belongs to one of evolutionary-conserved miRNA families (MIR-34 family) that consists of three members: MIR-34A, MIR-34B, and MIR-34C [ 10 ]. (hindawi.com)
In hunting for unknown genes on the human X chromosome, we identified a cDNA in Xq28 encoding a transmembrane protein (SEX) of 1871 amino acids. (cnr.it)
The mouse Tzfp gene, mapped to chromosome 7 B2-B3, encodes a 465-amino acid transcription factor containing a conserved N-terminal BTB/POZ domain and three C-terminal PLZF-like C(2)H(2) zinc fingers. (lookformedical.com)
Aurora kinases are found in all organisms in which their function has been conserved throughout evolution, namely the control of chromosome segregation. (lookformedical.com)
Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. (atlasgeneticsoncology.org)
Although leaf angle quantitative trait loci (QTL) have been previously reported, only the Dwarf3 ( Dw3 ) auxin transporter gene, colocalizing with a major-effect QTL on chromosome 7, has been validated. (biomedcentral.com)
5 ] detected significant associations between leaf angle variation and markers in the region but not with Dw3 itself, and thus, authors proposed other genes on the chromosome 7 interval could be controlling the trait as well. (biomedcentral.com)
In all species, Boule and Dazl are located in single copy on autosomes, while multiple DAZ genes are located on the Y chromosome. (ijbs.com)
Researchers have identified a gene on the X chromosome, GPR101 , which was overexpressed 1000-fold more than normal in a genetic study of 43 patients affected by sporadic or inherited gigantism that manifested during childhood or adolescence. (medscape.com)
and 10% had X-linked acro-gigantism (X-LAG) due to chromosome Xq26.3 microduplications on the GPR101 gene. (medscape.com)

The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. (wikipedia.org)
Unified nomenclature for Eph family receptors and their ligands, the ephrins. (wikipedia.org)
AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. (senescence.info)
GDNF family ligands (GFLs) activate the Ret receptor tyrosine kinase through binding of glycosylphosphatidylinositol-anchored GDNF family receptor α coreceptors (GFRα1-4) ( Sariola and Saarma, 2003 ). (jneurosci.org)
In addition we have recently started to explore the structure and molecular function of pain receptors from animals, i.e. transient receptor potential (TRP) ion channels, and their activation by temperature and various ligands. (lu.se)

Those transformed cells form tumours when implanted in immunodeficient mice, indicating that the kinase is an oncogene. (lookformedical.com)
The RET proto-oncogene is 80 kilobases (kb) long and encodes a putative tyrosine kinase receptor. (medscape.com)
This gene is a member of the protein-tyrosine kinase oncogene family. (cancerindex.org)

In metazoans, intracellular receptors recognize these molecules. (nature.com)
The two receptors share structural similarity as well as overlapping intracellular signaling events, and are believed to have evolved through gene duplication from a common ancestral gene. (rndsystems.com)
The intracellular region contains the kinase domain sandwiched between the juxtamembrane domain used for docking insulin-receptor substrates (IRS), and the carboxy-terminal tail that contains two phosphotyrosine-binding sites. (rndsystems.com)
The alpha subunit is localized extracellularly and mediates ligand binding while the transmembrane beta subunit contains the cytoplasmic kinase domain and mediates intracellular signaling. (rndsystems.com)
constituting the extracellular ligand binding domain, a fibronectin domain followed by intracellular juxtamembrane kinase, and SAM domain. (genominfo.org)
Structurally Eph receptors are similar to RTKs, comprises extracellular region, a ligand binding and fibronectin repeat domain, whereas intracellular has a juxtamembrane, kinase, and SAM domain. (genominfo.org)
Conversely, during starvation mTORC1 is inhibited and autophagy is induced by AMP-activated protein kinase (AMPK), leading to generation of intracellular nutrients and energy during degradation of non-functional or non-essential organelles or protein aggregates [ 4 , 6 ], in turn contributing to cell survival. (springer.com)
Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl-heidelberg.de)
In this review, we summarized the current knowledge of hemocyte-mediated phagocytosis, in particular focusing on the related receptors for recognition and internalization of pathogens as well as the downstream signal pathways and intracellular regulators involved in the process of hemocyte phagocytosis. (frontiersin.org)

As a broad host range pathogen, M. phaseolina possesses a large number of pathogen-host interaction genes including those for adhesion, signal transduction, cell wall breakdown, purine biosynthesis, and potent mycotoxin patulin. (biomedcentral.com)
Genes encoding regulators of apoptosis, signal transduction and metabolism were altered by the interaction between FGL-treatment and TBI. (phoenixpeptide.com)

These data define a gene family (SEX family) involved in the development of neural and epithelial tissues, which encodes putative receptors with unexpected enzymatic or binding properties. (cnr.it)

INS R cDNA encodes a type I transmembrane single chain preproprotein with a putative 27 amino acid residues (aa) signal peptide. (rndsystems.com)
The recessive wild-type spl26 allele (Oryza sativa spotted-leaf 26, Osspl26) is highly conservative in grass species and encodes a putative G-type lectin S-receptor-like serine/threonine protein kinase with 444 amino acid residuals. (bvsalud.org)
The deduced amino acid sequences reveal that ALK is a novel receptor tyrosine kinase having a putative transmembrane domain and an extracellular domain. (nsjbio.com)

Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. (lookformedical.com)
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
Taken together, our results indicate that Tzfp recognizes a sequence-specific motif (tbs) and may play a role in the regulation of the genes carrying the tbs. (lookformedical.com)
Transcriptome studies of wild type Haloferax cells and the deletion mutant revealed up-regulation of six genes in the deletion strain, showing that the sRNA has a clearly defined function. (uni-stuttgart.de)
Three of the six up-regulated genes encode potential zinc transporter proteins (ZnuA1, ZnuB1, ZnuC1) suggesting involvement of s479 in regulation of zinc transport. (uni-stuttgart.de)
A pituitary-specific transcription factor Pit1 has been postulated to be a candidate mediator of TRH signaling in TSHβ gene regulation. (bioerc-iend.org)
However, the mechanisms underlying receptor-dependent regulation of Rho family members remain incompletely understood. (embl-heidelberg.de)
The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and thus is believed to be involved in receptor-mediated regulation of the proteins. (embl-heidelberg.de)
negative regulation of the vacuole-mediated resistance to k(+) stress by a novel c2h2 zinc finger transcription factor encoded by asla in aspergillus nidulans. (liverpool.ac.uk)

The remaining 1284 genes were differentially expressed genes (DEGs) between RILs. (biomedcentral.com)

The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. (cancerindex.org)
Thyrotropin-releasing hormone (TRH) activates not merely the secretion of thyrotropin (TSH) but also the transcription of TSHβ and α-glycoprotein (αGSU) subunit genes. (bioerc-iend.org)
A family of genes, including (also referred as is controlled by Tpk2 (a catalytic subunit of PKA) in [23]. (bio2009.org)

Mutated ALK proteins were overexpressed, hyperphosphorylated, and showed constitutive kinase activity. (nsjbio.com)

RIViT-seq technology could speed up associating transcription factors with their target genes. (doe.gov)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
These findings indicate miR-34a along with its putative target genes could play a role in RCC tumorigenesis and progression. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
It interacts directly with specific DNA sequences to regulate expression of target genes. (wikilectures.eu)

Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)

These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. (senescence.info)
A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. (cnr.it)
SEX shares significant homology with the extracellular domain of the receptors encoded by the oncogenes MET, RON, and SEA [hepatocyte growth factor (HGF) receptor family]. (cnr.it)
The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. (embl-heidelberg.de)
ROCK1 and ROCK2 exhibit 60% sequence homology and 90% kinase domain homology. (cancer-research-network.com)

Oncogenes are product of interaction between organisms and environment and cannot be inherited as syndromes known in tumor suppressor genes defects. (wikilectures.eu)

Shiu, S. H. & Bleecker, A. B. Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. (nature.com)
Phylogenetic analysis clearly distinguished three V. vinifera LysM‐RKs (VvLYKs) located in the same clade as the Arabidopsis CHITIN ELICITOR RECEPTOR KINASE1 (AtCERK1), which mediates chitin‐induced immune responses. (uzh.ch)
The Arabidopsis mutant Atcerk1, impaired in chitin perception, was transformed with these three putative orthologous genes encoding VvLYK1‐1, ‐2, or ‐3 to determine if they would complement the loss of AtCERK1 function. (uzh.ch)

Northern blot analysis revealed different expression of the SEX family of genes in fetal tissues, with SEX, OCT, and NOV predominantly expressed in brain, and SEP expressed at highest levels in kidney. (cnr.it)
Considering the predicted functions of candidate genes, their potential undesirable pleiotropic effects should be further investigated across tissues and developmental stages. (biomedcentral.com)

However, alterations in other genes may contribute to this overrepresentation of RET or may influence MEN 2-related tumor development through completely different mechanisms and pathways. (medscape.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
TRH-bound TRH-R1 (TRH/TRH-R1) induces protein kinase C (PKC)- phosphophatidyl-inoshitol- and Ca2+-mediated pathways [8] [9]. (bioerc-iend.org)

Fourteen different tyrosine kinase sequences were identified. (silverchair.com)
Major distinctions in the gene sequences between SARS‑CoV and SARS‑CoV‑2 include the spike gene, open reading frame (ORF) 3b and ORF 8. (spandidos-publications.com)
17] confirmed that Pit1 recognizes the DNA sequences in the mouse TSHβ gene corresponding to those sites in the rat and human genomes using DNA foot printing overexpression of Pit1 had a minimal effect on the activity of the TSHβ promoter in TtT97 TSHoma or thyrotroph-derived αTSH cells. (bioerc-iend.org)

They do not, however, express trkA, the gene encoding the tyrosine kinase receptor TrkA, the high-affinity receptor for nerve growth factor (NGF), the prototypic NT. (lsu.edu)
Expression of the GFRα3 receptor is primarily restricted to the peripheral nervous system and is found in a subpopulation of nociceptive sensory neurons of the dorsal root ganglia (DRGs) that coexpress the Ret and TrkA receptor tyrosine kinases and the thermosensitive channel TRPV1. (jneurosci.org)
Expression of artemin caused a 20.5% increase in DRG neuron number and increased the level of mRNA encoding GFRα3, TrkA, TRPV1, and the putative noxious cold-detecting channel TRPA1. (jneurosci.org)

This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)
A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
Projects focused on gene expression profiling of ageing and of dietary manipulations of ageing, such as caloric restriction. (senescence.info)
Among them, 7526 genes displayed a similar expression trend in both RILs, and some of them were likely involved in non-host resistance. (biomedcentral.com)
After comparing DEGs to genes identified in previously described quantitative trait loci (QTLs) for resistance to SB, nine genes were common and three of them showed differential gene expression between a resistant and a susceptible bulk consisting of five RILs each. (biomedcentral.com)
Real-time q-PCR confirmed the expression of all four receptors. (mun.ca)
These results indicate that the level of artemin in the skin modulates gene expression and response properties of afferents that project to the skin and that these changes lead to behavioral sensitivity to both hot and cold stimuli. (jneurosci.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Here, we show that two chitooligosaccharides, chitin and chitosan, act as PAMPs in grapevine (Vitis vinifera) as they elicit immune signalling events, defense gene expression and resistance against fungal diseases. (uzh.ch)
To identify their cognate receptors, the grapevine family of LysM receptor kinases (LysM‐RKs) was annotated and their gene expression profiles were characterized. (uzh.ch)
Our results provide evidence that VvLYK1‐1 and VvLYK1‐2, but not VvLYK1‐3, functionally complement the Atcerk1 mutant by restoring chitooligosaccharide‐induced MAPK activation and immune gene expression. (uzh.ch)
In CV1 cells transfected with TRH receptor expression plasmid GATA2-dependent transactivation of αGSU and endothelin-1 promoters was enhanced by TRH. (bioerc-iend.org)
The present study analyzed the global gene expression profile in response to cryo-induced TBI by means of microarray analysis. (phoenixpeptide.com)
Mechanistically, EPB41L4A-AS2, acting at least in part as a tumor suppressor, upregulated tumor suppressor gene expression. (cancerindex.org)
Increasing gene dosage greatly enhances recombinant expression of aquaporins in Pichia pastoris. (lu.se)

Smooth muscle cells express Kv7.4 and Kv7.5 voltage-dependent potassium channels, which have each been implicated as regulators of smooth muscle contractility, though they display different sensitivities to signaling via cAMP/protein kinase A (PKA) and protein kinase C (PKC). (aspetjournals.org)

SARS‑CoV‑2 infection is initiated when the virus interacts with angiotensin‑converting enzyme 2 (ACE2) receptors on host cells. (spandidos-publications.com)

Encodes a protein with similarity to mammalian RACKs. (or.jp)

Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)

We have used RT-PCR to screen pluripotent murine embryonic stem cells to identify receptor tyrosine kinases (RTKs) potentially involved in the determination or differentiation of cell lineages during early mouse development. (silverchair.com)

Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (lookformedical.com)
In this report, we describe a testis zinc finger protein (Tzfp) that binds to the upstream flanking sequence of the Aie1 gene. (lookformedical.com)
The zinc finger domain of Tzfp binds to the TGTACAGTGT motif (Tzfp binding site, termed tbs) located at the upstream flanking sequence of the Aie1 gene by gel mobility shift, DNase I footprinting, and competition analyses. (lookformedical.com)
Eph binds to respective ephrin ligand, through the ligand binding domain and forms a tetrameric complex to activate the kinase domain. (genominfo.org)
Artemin, a neuronal survival factor in the glial cell line-derived neurotrophic factor family, binds the glycosylphosphatidylinositol-anchored protein GFRα3 and the receptor tyrosine kinase Ret. (jneurosci.org)

Alternatively spliced transcript variants encoding distinct isoforms exist. (cancerindex.org)

however the mechanism that mediates TRH signaling for transcription of the TSHβ gene has been elusive. (bioerc-iend.org)

We propose that steroid binding to BRI1 generates a docking platform for a co-receptor that is required for receptor activation. (nature.com)
Our findings provide insight into the activation mechanism of this highly expanded family of plant receptors that have essential roles in hormone, developmental and innate immunity signalling. (nature.com)
Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. (senescence.info)
While inhibition by T3 is dominant over TRH-induced activation unliganded TR or the putative negative T3-responsive element are not required for TRH-induced stimulation. (bioerc-iend.org)
Predicated on this hypothesis the putative adverse T3 responsive component (nTRE) continues to be reported as the series necessary for activation by unliganded TR and inhibition by T3 [22] [25]. (bioerc-iend.org)
The mechanism of fibroblast growth factor receptor (FGFR) activation by the neural cell adhesion molecule (NCAM) is not well understood. (phoenixpeptide.com)
The activation of FMS like receptor tyrosine kinase 3 (FLT3) is a cytokine receptor that belongs to the receptor tyrosine kinase class III. (cancer-research-network.com)

Typical products of proto-oncogenes are signaling molecules, growth factors or growth factor receptors. (wikilectures.eu)
Many oncogenes derived from cellular proto-oncogenes have been found in different retroviruses, implying that the normal vertebrate genome contains many potential cancer-causing genes. (wikilectures.eu)

Ligand binding induces a conformational change of the receptor, resulting in ATP binding, autophosphorylation, and subsequent downstream signaling. (rndsystems.com)
The single base substitution from T to A at position 293 leads to phenylalanine/tyrosine replacement at position 98 in the encoded protein in the mutant and induces excessive accumulation of H2O2, leading to oxidative damage to cells, and finally, formation of the spotted-leaf phenotype in Spl26. (bvsalud.org)

Ectopic kinase overexpression in any culture cell line leads to polyploidy and centrosome amplification. (lookformedical.com)
About 25% of breast cancer patients show overexpression of HER2 receptor caused mainly by HER2 gene amplification. (wikilectures.eu)

Anaplastic lymphoma kinase also known as CD246 (cluster of differentiation 246), is an enzyme that in humans is encoded by the ALK gene. (nsjbio.com)
A group of genes (but also miRNAs) whose products are mainly stimulants of cell division, inhibitors of cell differentiation, or signals for prolonged cell life. (wikilectures.eu)
natural variation in bcvel1 encoding the ortholog of aspergillus nidulans vea, a member of the velvet complex, was previously shown to affect light-dependent differentiation, the formation of oxalic acid (oa), and virulence. (liverpool.ac.uk)

Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)

Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
Eph receptor belongs to the largest family of RTK. (genominfo.org)

EST analyses of cDNA libraries revealed that the four receptors were differently expressed under various conditions. (mun.ca)

Adolescent rats were subjected to TBI and treated with either placebo or a neural cell adhesion molecule (NCAM)-derived fibroblast growth factor receptor (FGFR) agonist, FGL peptide, which has been demonstrated to have neuroprotective effects. (phoenixpeptide.com)
A peptide motif from the second fibronectin module of the neural cell adhesion molecule, NCAM, NLIKQDDGGSPIRHY, is a binding site for the FGF receptor. (phoenixpeptide.com)
Jacobsen J, Kiselyov V, Bock E, Berezin V. A peptide motif from the second fibronectin module of the neural cell adhesion molecule, NCAM, NLIKQDDGGSPIRHY, is a binding site for the FGF receptor. (phoenixpeptide.com)

In contrast, the same chimera did not activate the reporter gene when an essential nucleotide fifth C was mutated to A at the tbs. (lookformedical.com)

The sRNA gene is encoded between a CRISPR RNA locus and the Cas protein gene cluster, the s479 deletion strain is viable and was characterized in detail. (uni-stuttgart.de)

Results: The Daphnia pulex draft genome sequence assembly was scanned for major components of the ISP with a special attention to the insulin-like receptor. (mun.ca)

Phagocytosis currently is described as an endocytic process that endogenous foreign particles or pathogens larger than 0.5 μm were first recognized by phagocyte surface receptor and then uptaken and engulfed into a plasma-membrane device, known as phagosome, following initiation of a signaling cascade to generate phagolysosome by fusion of phagosome with lysosomes. (frontiersin.org)

Thus, the hypothesis of a putative neuroprotective role of FGL was supported by our findings. (phoenixpeptide.com)

The most relevant eleven candidate genes for layer-specific angle modification include those homologous to genes controlling leaf angle in rice and maize or genes associated with cell size/expansion, shape, and cell number. (biomedcentral.com)

After synthesis, the single chain INS R precursor is glycosylated, dimerized and transported to the Golgi apparatus where it is processed at a furin-cleavage site within the middle fibronectin type III domain to generate the mature disulfide-linked alpha 2 beta 2 tetrameric receptor. (rndsystems.com)

Click gene/probe ID to show a list of genes that are homologous to the gene. (or.jp)

Insulin Receptor Substrate 1 (IRS-1). (embl.de)
Major findings include a lower number of insulin-like peptides in Daphnia as compared to other invertebrates and the presence of multiple insulin-like receptors (InR), with four genes as opposed to a single one in other invertebrates. (mun.ca)
Conclusions: Duplications of the insulin receptor genes might represent an important evolutionary innovation in Daphnia as they are known to exhibit extensive phenotypic plasticity in body size and in the size of defensive structures in response to predation. (mun.ca)

Transcriptome analysis shows that several floral development-related genes are affected by STM3 mutation. (nature.com)
Women harboring a germline mutation in the BRCA1 gene show a lifetime cumulative risk (LCR) between 44 and 68 % of developing breast cancer until 70 years of age. (biomedcentral.com)
substitution in the GATA2-Zn finger domain or mutation of GATA-responsive element in the TSHβ gene. (bioerc-iend.org)
In a separate analysis of 248 patients with sporadic acromegaly, a mutation in the GPR101 gene was found in about 4% of cases. (medscape.com)

Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
A trans-interaction of Eph-ephrin followed by heterotetramer formation activates the signaling cascade and transforms the kinase domain from closed to open conformation which in-turn, expose the ATP binding pocket [ 5 ]. (genominfo.org)
Dappu_InR-4 has undergone extensive evolutionary divergence and lacks the conserved site of the catalytic domain of the receptor tyrosine kinase. (mun.ca)
Trio and its homologue UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. (embl-heidelberg.de)

Anatomy15

Organisms16

Diseases1

Chemicals and Drugs156

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes47

Technology, Industry, Agriculture1

Information Science4

Mutations16

Leucine-rich r3

Mitogen-activa3

Pathway3

Subfamily5

Highly conserved7

Tyrosine kinase activity2

Chromosome10

Ligands5

Oncogene3

Intracellular9

Signal transduction2

Epithelial1

Amino3

Regulation10

Differentially expressed genes1

Subunit3

Constitutive1

Target genes5

Beta-adrenerg1

Homology5

Tumor suppr1

Arabidopsis3

Tissues2

Pathways3

Sequences3

TrkA3

Expression15

Regulators1

Interacts1

Similarity1

Characterization1

Embryonic1

Binds6

Isoforms exist1

Mediates1

Activation7

Oncogenes2

Induces2

Overexpression2

Differentiation3

Group of genes1

Belongs2

CDNA libraries1

Neural3

Activate1

Locus1

Sequence1

Plasma-membrane1

Hypothesis1

Candidate genes1

Fibronectin type1

Homologous1

Insulin3

Mutation4

Domain4