• Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
  • Most cases of early-onset AD are linked to autosomal dominant inherited mutations in the genes encoding amyloid precursor protein ( APP ), presenilin 1 ( PSEN1 ), and presenilin 2 ( PSEN2 ). (biomedcentral.com)
  • Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. (wikipedia.org)
  • Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)
  • Alzheimer's possesses complex pathologies of heterogeneous nature counting proteins as one major factor along with enzymes and mutated genes. (benthamscience.com)
  • BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. (novusbio.com)
  • A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains. (lookformedical.com)
  • 100% sequence homology with Mouse, Rat, Canine, Equine and all other mammalian proteins examined. (novusbio.com)
  • A polypeptide substance comprising about one third of the total protein in mammalian organisms. (lookformedical.com)
  • Agrin-like glycoproteins and proteins with sugar-binding domains are also predominant. (biomedcentral.com)
  • The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)
  • The N-domain also includes weak binding sites for recombinant domain 3 (ED3, residues 296-400) from the envelope proteins of two Flaviviruses, West-Nile virus and serotype 2 of DENV. (wikipedia.org)
  • Comparison of the mechanisms that govern the production of calcium carbonate (CaCO 3 ) biominerals in hexacorallians (scleractinians) and octocorallians is thus expected to shed light on the conservation of the protein toolkit used by these organisms for making their biocalcification. (biomedcentral.com)
  • It also acts as a cell surface receptor, in particular for laminin, and is involved in several pathogenic processes. (wikipedia.org)
  • Many of the effects of laminin are mediated through interactions with cell surface receptors. (wikipedia.org)
  • Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)
  • The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)
  • We identified a total of 102 OM proteins, 52 are found in the two red coral biominerals with scleritin being the most abundant protein in each fraction. (biomedcentral.com)
  • A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
  • RPSA is a ribosomal protein which has acquired the function of laminin receptor during evolution. (wikipedia.org)
  • The inferred regulatory function of these OM proteins suggests that the difference between the two biominerals is due to the modeling of the matrix network, rather than the presence of specific structural components. (biomedcentral.com)
  • These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. (wikipedia.org)
  • Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI. (lookformedical.com)
  • In order to gain insight into the red coral biomineralization process and cnidarian biomineralization evolution, we studied the protein repertoire forming the organic matrix (OM) of its two biominerals. (biomedcentral.com)
  • Both recombinant N-domain and C-domain of RPSA bind laminin in vitro, and they bind with similar dissociation constants (300 nM). (wikipedia.org)
  • In addition, the comparison with stony coral skeletomes highlighted the low proportion of similar proteins between the biomineral OMs of hexacorallian and octocorallian corals, suggesting an independent acquisition of calcification in anthozoans. (biomedcentral.com)
  • Two alternatively spliced transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
  • The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. (novusbio.com)
  • Contrary to reef building corals, the red coral organic matrix possesses a large number of collagen-like proteins. (biomedcentral.com)
  • HSPs, which ameliorate oxidative stress, calpains, which help in regulating synaptic plasticity, and calmodulin-like skin protein (CLSP) with its neuroprotective role are few promising future targets for developing anti-AD therapies. (benthamscience.com)
  • The high-affinity cellular receptor for the basement membrane component laminin is differentially expressed during tumor invasion and metastasis. (nih.gov)
  • Both recombinant N-domain and C-domain of RPSA bind laminin in vitro, and they bind with similar dissociation constants (300 nM). (wikipedia.org)
  • The N-domain also includes weak binding sites for recombinant domain 3 (ED3, residues 296-400) from the envelope proteins of two Flaviviruses, West-Nile virus and serotype 2 of DENV. (wikipedia.org)
  • In addition, the recombinant laminin receptor bound Gal-3 and its CRD to comparable level. (nottingham.ac.uk)
  • 40S ribosomal protein SA is a ribosomal protein that in humans is encoded by the RPSA gene. (wikipedia.org)
  • The RPSA gene encodes a multifunctional protein, which is both a ribosomal protein and a high-affinity, non-integrin laminin receptor. (wikipedia.org)
  • Ribosomal protein SA and RPSA are the approved name and symbol. (wikipedia.org)
  • The N-domain of RPSA is homologous to the ribosomal protein S2 (RPS2) of prokaryotes. (wikipedia.org)
  • RPSA is a ribosomal protein which has acquired the function of laminin receptor during evolution. (wikipedia.org)
  • i) Yeast two-hybrid screens have shown that RPSA binds to Ribosomal protein S21 of the 40S small ribosomal subunit. (wikipedia.org)
  • UN induced dramatic alterations in expression levels of more than 200 genes, mainly up-regulated, including oxidative-response-related genes, genes encoding for cellular metabolism, ribosomal proteins, signal transduction, and solute transporters. (nih.gov)
  • Antisera to three different domains of the cDNA-predicted receptor were used to study the relationship between the 37- and 67-kilodalton polypeptides. (nih.gov)
  • Cytokines Cytokines represent a family of pleiotropic polypeptides (8-26 kDa) that regulate cell activation, proliferation and Differentiation. (medscape.com)
  • Primer extension experiments demonstrated that the clone contained the complete 5' sequence of the murine laminin receptor mRNA. (nih.gov)
  • RNA blot data demonstrated a single-sized laminin receptor mRNA, approximately 1400 bases long, in human, mouse, and rat. (nih.gov)
  • The apparent molecular weight on SDS-polyacrylamide gels of the rabbit reticulocyte cell-free translation product of selectively hybridized laminin receptor mRNA is 37,000. (nih.gov)
  • Alterations in the mRNA expression, protein levels and proteolytic activity of matrix metalloproteinases (MMPs) have been detected in VVs and VLU. (oaepublish.com)
  • MMP mRNA expression, protein levels and proteolytic activity can be modulated by numerous factors including venous hydrostatic pressure, hypoxia, tissue metabolites and the inflammatory response. (oaepublish.com)
  • RPSA is a potential cellular receptor for several pathogenic Flaviviruses, including the dengue virus (DENV), and Alphaviruses, including the Sindbis virus (SINV). (wikipedia.org)
  • AB - Using computer-aided molecular modeling techniques to analyze models recently proposed for the receptor binding sites of dopaminergic agonists, we superimposed the chemical structures of various compounds that mimic the pharmacological behavior of dopamine, as well as inactive enantiomers, on a postulated three dimensional frame of reference. (nih.gov)
  • AB - A series of apomorphine congeners has been studied with respect to their ability to mimic the structural requirements of the dopamine pharmacophore in the potent and stereoselective dopamine receptor agonist (R)-apomorphine. (nih.gov)
  • Neurotransmission through dopamine D1 receptors is required for aversive memory formation and Arc activation in the cerebral cortex. (niigata-u.ac.jp)
  • Here, we investigated the role of dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) in aversive memory formation in a passive avoidance test using D1R knockdown (KD) mice, in which the expression of D1Rs can conditionally and reversibly be controlled by doxycycline (Dox) treatment. (niigata-u.ac.jp)
  • Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages. (niigata-u.ac.jp)
  • Dopamine signal is transduced through the dopamine receptor gene family. (niigata-u.ac.jp)
  • The dopamine D1 receptor (D1R) is highly expressed in the striatum, and is responsible for regulating the motor function. (niigata-u.ac.jp)
  • Cell-adhesive protein LAMR1 plays an important role in the processes of cancer proliferation, invasion and metastasis. (nih.gov)
  • RPSA binds to proteins that are involved in the translation of the genetic code. (wikipedia.org)
  • RPSA was initially identified as a laminin binding protein. (wikipedia.org)
  • Both RPSA and laminin belong to the heparin/heparan sulfate interactome. (wikipedia.org)
  • Moreover, the C-domain of RPSA and heparin compete for binding to laminin, which shows that the highly acidic C-domain of RPSA mimicks heparin (and potentially heparan sulfates) for the binding to laminin. (wikipedia.org)
  • RPSA is also a receptor for small molecules. (wikipedia.org)
  • The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)
  • It also acts as a cell surface receptor, in particular for laminin, and is involved in several pathogenic processes. (wikipedia.org)
  • The relationship between the 67 LR and its precursor 37 LRP is not completely understood, but previous observations have suggested that 37 LRP can undergo homo- and/or hetero- dimerization with Galectin-3 (Gal-3) to form mature 67 LR. (nottingham.ac.uk)
  • Given the binding of meningococcal PilQ to 37 LRP/67 LR and Gal-3, this study sought to investigate possible dimerization between 37 LRP and Gal-3 to form 67 LR. (nottingham.ac.uk)
  • This work also attempts to study whether the 37 LRP/67 LR meningococcal ligands (rPorA, loop 4 of PorA and rPilQ) have any influence on the surface level of 67 LR and Gal-3. (nottingham.ac.uk)
  • The regression analysis of log KD with respect to the distances of the vectors of the acidic hydrogen support the hypothesis that these compounds bind to the receptor as donors in hydrogen bond formation. (nih.gov)
  • We also performed whole-brain imaging after aversive footshock stimulation in activity-regulated cytoskeleton protein (Arc)-dVenus D1RKD mice, which were crossbred from Arc-dVenus transgenic mice and D1RKD mice, to examine the distribution of Arc-controlled dVenus expression in the hippocampus and cerebral cortex during aversive memory formation. (niigata-u.ac.jp)
  • Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
  • A cDNA clone encoding the murine laminin receptor was isolated and identified on the basis of sequence homology to the human laminin receptor [Wewer et al. (nih.gov)
  • It has been recently demonstrated that Neisseria meningitidis targets the laminin receptor (37 LRP/67 LR) on the surface of human brain microvascular endothelial cells, and two meningococcal outer membrane proteins, PorA and PilQ, have been identified as bacterial ligands. (nottingham.ac.uk)
  • Their receptors are constitutively expressed, albeit at very low levels. (medscape.com)
  • the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)
  • Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
  • Protein glycosylation is an important posttranslational modification that confers both structural and functional properties to the molecules [ 1 ]. (intechopen.com)