Encodes a mads mads domain proteins. Medical search. Frequent questions

MEF2B is a member of the myocyte enhancer-binding factor 2 (MEF2) family of transcription factors (including MEF2A -B -C -D) which are characterized by high homology in the MADS (MCM1 Agamous Deficiens SRF) box and an adjacent MEF2 domain17. (researchassistantresume.com)

MADS-domain proteins are generally transcription factors. (wikipedia.org)
Furthermore, gene-gene and gene-metabolite network analyses discovered that the light-responsive expression of genes encoding bHLH, MYB, WRKY, NAC, and MADS-box transcription factors, and proteins involved in genetic information processing and epigenetic regulation such as nucleosome assembly and histone acetylation, showed a high positive correlation with grape berry phenolic accumulation in response to different light regimes. (biomedcentral.com)
As a kind of transcription factors gene family, MADS-box genes play an important role in plant development processes. (notulaebotanicae.ro)
The highly divergent C-terminal half of MEF2 proteins has been suggested to modulate their transcriptional activity17 18 The spectrum of targets activated by MEF2 transcription factors in different cell types is dependent on association with specific co-repressors and co-activators in response to multiple signaling pathways17. (researchassistantresume.com)
2014). AGAMOUS (AG) gene encodes MADS family of transcription factors which plays a role in specifying reproductive organ identity and acts in a negative feedback loop to limit floral stem cell proliferation. (grassius.org)
In all these organisms, cardiac induction in the lateral mesoderm involves the concerted action of signals mediated by Bmp, Wnt and Fgf family members, which act upon cardiogenic genes encoding NK homeodomain, Gata and T-box transcription factors (reviewed by Zaffran and Frasch, 2002 ). (biologists.com)

The genes which contain this motif are called the MADS-box gene family. (wikipedia.org)
MADS-box genes were detected in nearly all eukaryotes studied. (wikipedia.org)
While the genomes of animals and fungi generally possess only around one to five MADS-box genes, genomes of flowering plants have around 100 MADS-box genes. (wikipedia.org)
The structure of the tetramerisation domain of the MADS-domain protein SEPALLATA3 was solved illustrating the structural basis for tetramer formation A geneticist intensely investigating MADS-box genes is Günter Theißen at the University of Jena. (wikipedia.org)
MADS-box genes have a variety of functions. (wikipedia.org)
In animals, MADS-box genes are involved in muscle development and cell proliferation and differentiation. (wikipedia.org)
In plants, MADS-box genes are involved in controlling all major aspects of development, including male and female gametophyte development, embryo and seed development, as well as root, flower and fruit development. (wikipedia.org)
Some MADS-box genes of flowering plants have homeotic functions like the HOX genes of animals. (wikipedia.org)
The floral homeotic MADS-box genes (such as AGAMOUS and DEFICIENS) participate in the determination of floral organ identity according to the ABC model of flower development. (wikipedia.org)
Another function of MADS-box genes is flowering time determination. (wikipedia.org)
In Arabidopsis thaliana the MADS box genes SOC1 and Flowering Locus C (FLC) have been shown to have an important role in the integration of molecular flowering time pathways. (wikipedia.org)
LFY encodes a novel plant-specific DNA-binding protein that can bind in vitro to the promoters of several floral organ-identity genes. (oboolo.com)
To find genes involved in the floral transition of Ginkgo biloba , a MADS-box gene, designated as GbMADS2, was cloned from G. biloba based on EST sequences by RT-PCR. (notulaebotanicae.ro)
2015). Altered distribution of sucrose away from pith toward developing grain was associated with altered expression of genes encoding Sucrose Will Eventually Be Exported Transporters (SWEETs) and prevented abortion of grain under drought (Oszvald et al. (grassroots.tools)
In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier , a cardiogenic gene encoding a Gata factor. (biologists.com)
Polycomb Group protein complexes stably shut down genes by compacting the packaging material of DNA. (mpg.de)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). (bvsalud.org)

The carboxyl terminal (C) domain is highly variable and is involved in transcriptional activation and assemblage of heterodimers and multimeric protein complexes. (wikipedia.org)
The protein encoded by this gene is a transcriptional regulatory protein. (antikoerper-online.de)
Thus LFY may need to interact with additional proteins to function in transcriptional regulation. (oboolo.com)
This protein behaves similarly to fulllength SMAD3 in Fshb transcriptional assays. (elsevierpure.com)
The gene encodes a transcriptional activator and is found mutated in ～11% of diffuse large B cell lymphomas (DLBCLs) and ～12% of follicular lymphomas. (researchassistantresume.com)
Together these two conserved domains in the N-terminal half of MEF2B direct DNA binding homodimerization of MEF2 polypeptides and interaction with specific transcriptional co-factors. (researchassistantresume.com)
The canonical TGFβ signalling pathway involves ligand-dependent assembly of a heteromeric receptor complex, receptor-kinase activation and subsequent phosphorylation and activation of SMAD proteins, which are transcriptional regulators that consequently accumulate in the nucleus. (nature.com)

The MADS-box gene family got its name later as an acronym referring to the four founding members, ignoring ARG80: MCM1 from the budding yeast, Saccharomyces cerevisiae, AGAMOUS from the thale cress Arabidopsis thaliana, DEFICIENS from the snapdragon Antirrhinum majus, SRF from the human Homo sapiens. (wikipedia.org)
The sequence of GbMADS2 protein was highly homologous to those of MADS-box proteins from other plant species with the highest homologous to AGAMOUS (CyAG) from Cycas revoluta . (notulaebotanicae.ro)

EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)
Thus far among the lamins, these have been described only for LMNA , which maps to chromosome 1q21.2 and encodes lamin A and lamin C through alternative splicing. (bmj.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)

GL7 encodes a protein homologous to LONGIFOLIA in Arabidopsis thaliana and increase grain length and improvement of grain appearance quality [12]. (researchsquare.com)

Notably, however, we discovered that the recombined Smad3 allele produces a transcript that encodes the entirety of the SMAD3 C-terminal Mad homology 2 (MH2) domain. (elsevierpure.com)
As the truncated protein lacks the N-terminal Mad homology 1 (MH1) domain, these results show that SMAD3 DNAbinding activity as well as SMAD2 are dispensable for normal FSH synthesis in vivo. (elsevierpure.com)
CDK8 can directly interact with Mad in vitro through the linker region between the DNA-binding MH1 (Mad homology 1) domain and the carboxy terminal MH2 (Mad homology 2) transactivation domain. (sdbonline.org)

These findings suggest a critical role of p97/Cdc48 in mitochondria homeostasis regulation, but how substrates are recruited to p97/Cdc48 in MAD is unclear. (rupress.org)

Floral homeotic gene encoding a MADS domain transcription factor. (or.jp)

MADS proteins regulate the accumulation of storage substances in plant seeds by binding specifically to cis-acting elements of downstream gene promoters. (paperonce.org)
Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. (bvsalud.org)

Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)
Lamins are intermediate filament proteins comprising a major structural component of the nuclear lamina, which underlies the inner membrane of the nuclear envelope in most somatic cells. (bmj.com)
Recently, MAD has been shown to be caused by a specific mutation (R527H) in LMNA , which encodes lamins A and C. (bmj.com)

FUSCA3, encodes a protein with a conserved VP1/ABI3_like B3 domain which is of functional importance for the regulation of seed maturation in Arabidopsis thaliana J . The Plant Journal, 1998, 15(6): 10. (paperonce.org)
A Conserved KIN17 Curved DNA-Binding Domain Protein Assembles with SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE7 to Adapt Arabidopsis Growth and Development to Limiting Copper Availability. (mpg.de)
Functional characterisation of Arabidopsis SPL7 conserved protein domains suggests novel regulatory mechanisms in the Cu deficiency response. (mpg.de)
The Arabidopsis COPT6 Transport Protein Functions in Copper Distribution Under Copper-Deficient Conditions. (mpg.de)

The MADS box is a conserved sequence motif. (wikipedia.org)
There is evidence that the MADS domain evolved from a sequence stretch of a type II topoisomerase in a common ancestor of all extant eukaryotes. (wikipedia.org)
The protein sequence is most similar to that of AGL15, which is expressed in developing embryos. (or.jp)
Sequence analysis results showed that the cDNA sequence of GbMADS2 contained a 663 bp length ORF encoding 221 amino acids protein, which displayed typical structure of plant MADS-box protein including MADS, I, and K domains and C terminus. (notulaebotanicae.ro)
Sites of interaction with other molecules have been mapped to short stretch of amino acids such as the Arg-Gly-Asp (RGD) sequence found in various FN3 domains. (embl.de)
A gene encoding L-serine dehydrogenase (L-SerDH) that exhibits extremely low sequence identity to the Agrobacterium tumefaciens L-SerDH was identified in the hyperthermophilic archaeon Pyrobaculum calidifontis. (rcsb.org)
WebReverse Translate accepts a protein sequence as input and uses a codon usage table to generate a DNA sequence representing the most likely non-degenerate coding sequence. (lebendigefluesse.at)
Based on DNA binding studies, OsULT1 exhibited sequence specific binding through its SAND domain at GAGAG motif on OsDREB1b promoter whereas the B-box motif mediates protein multimerization function (Roy et al. (grassius.org)

8 Messenguy F, Dubois E. Role of MADS box proteins and their cofactors in combinatorial control of gene expression and cell development J . Gene, 2003, 316(1): 1-21. (paperonce.org)
These results suggest that CDK8 and CycC, together with a few other subunits of the MED complex, may coordinate with other transcription cofactors in regulating Mad-dependent transcription during wing development in Drosophila. (sdbonline.org)

The key integrator of the vernalization pathway is a MADS-box transcription factor, FLOWERING LOCUS C ( FLC ), which functions as a repressor of flowering and whose expression decreases during vernalization [ 24 ]. (biomedcentral.com)
Signalling through the GA pathway involves inactivation of a family of DELLA proteins that act as negative regulators of GA responses. (oboolo.com)
It was observed that CDK8-CycC positively regulates transcription activated by Mad (Mothers against dpp) , the primary transcription factor downstream of the Dpp/TGFβ signaling pathway . (sdbonline.org)

AGL15, a MADS domain protein expressed in developing embryos J . The Plant Cell, 1995, 7(8): 1271-1282. (paperonce.org)

The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. (wikipedia.org)
Lastly, mutations in the transmembrane protein 43 (TMEM43), also termed LUMA, which binds to emerin and SUN2, has also been reported to cause an EDMD phenotype in a few families. (medscape.com)

The PcG repressive function of CURLY LEAF (CLF) which is a component of PRC2 (Polycomb Repressive Complex 2) is counteracted by SAND domain of ULT1, thus ULT1 regulates cell fate in plants (Carles et al. (grassius.org)
The recently reported GL6 encodes a plant-specific PLATZ transcription factor and positively regulates grain length to increase TGW [10]. (researchsquare.com)
LMI1 homeodomain protein regulates organ proportions by spatial modulation of endoreduplication. (mpg.de)

FLOWERING LOCUS T ( FT ) encodes a mobile signal long described as "florigen", which functions as a central floral integrator in the control of flowering [ 11 ]. (biomedcentral.com)
Moreover, we dissected the complex inverted haplotype of the MAPT (encoding tau) Parkinson's disease risk locus, identifying putative ectopic regulatory interactions in neurons that may mediate this disease association. (stanford.edu)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

the SRF-like or Type I MADS-domain proteins and the MEF2-like (after MYOCYTE-ENHANCER-FACTOR2) or Type II MADS-domain proteins. (wikipedia.org)
MEF2-like MADS-domain proteins in animals and fungi have the MEF2 domain as a second conserved domain. (wikipedia.org)
In plants, the MEF2-like MADS-domain proteins are also termed MIKC-type proteins referring to their conserved domain structure, where the MADS (M) domain is followed by an Intervening (I), a Keratin-like (K) and a C-terminal domain. (wikipedia.org)

Ectopic expression of a TPP enzyme in maize reproductive tissue using the MADS-box transcription factor 6 (MADS6) gene promoter increased grain numbers in the field, especially under drought (Nuccio et al. (grassroots.tools)

In vitro cell line data suggest that activins stimulate FSH β-subunit (Fshb) transcription via complexes containing the receptor- regulated SMAD proteins SMAD2 and SMAD3. (elsevierpure.com)

In 5 of 6 gene mutations that have been shown to cause EDMD, the affected protein is present in the LINC (linker of nucleoskeleton and cytoskeleton) complex. (medscape.com)
New mutations have been found in the synaptic nuclear envelope protein 1 (SYNE1) gene and in the synaptic nuclear envelope protein 2 (SYNE2) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)
Whatever the true mechanism, the discovery of mutations in several different nuclear membrane proteins that cause similar diseases will likely eventually lead to a better understanding of nuclear membrane physiology and the pathophysiology of diseases caused by mutations in these proteins. (medscape.com)
Novelli et al analysed lamin A/C for mutations in five consanguineous Italian families with MAD. (bmj.com)

The length of the MADS-box reported by various researchers varies somewhat, but typical lengths are in the range of 168 to 180 base pairs, i.e. the encoded MADS domain has a length of 56 to 60 amino acids. (wikipedia.org)
nitrogenous bases there, so there's four possible, so And mRNA is actually the translated form of DNA that the machinery can recognize and use to assemble amino acids into proteins. (lebendigefluesse.at)

A member of ARF GAP domain (AGD), A thaliana has 15 members, grouped into four classes. (or.jp)

The first MADS-box gene to be identified was ARG80 from budding yeast, Saccharomyces cerevisiae, but was at that time not recognized as a member of a large gene family. (wikipedia.org)

They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)

The multifunctional nuclear protein large T-antigen was detectable by immunohistochemical analyses in a subset of neoplastic cells. (cdc.gov)

Based on phenotypic analysis, ULT gene plays a role in regulating floral organ and whorl number, shoot and floral meristem size partly by controlling the CLV1 (CLAVATA 1) domain expression and organ patterning, since ult mutant flowers exhibit extra sepals and petals indicating floral meristem and inflorescence size increase thus functioning as a negative regulator of meristem cell accumulation in inflorescence and floral meristems. (grassius.org)

Thus far, all families with MAD in whom a mutation was discovered harbour the identical base alteration. (bmj.com)
There is a highly specific genotype-phenotype correlation between the LMNA R527H mutation and MAD. (bmj.com)
The researchers found that the man had a mutation in a gene coding for a protein called reelin, which is associated with brain disorders including schizophrenia and autism. (cdc.gov)

2003). At least some of the indispensability of T6P and its profound and widespread effects on plant growth and development can be explained through T6P inhibition of the SNF1-related protein kinase SnRK1 (Zhang et al. (grassroots.tools)

The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)

1] Even though these proteins are ubiquitously expressed, disease manifestations are tissue specific for as yet unclear reasons. (medscape.com)

Constam, D. B. & Robertson, E. J. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. (nature.com)

2001) and B-box like motif near C-terminus that might play role in protein-protein or protein-DNA interaction and share similar expression pattern in embryonic shoot apical meristem, inflorescence and floral meristem and in developing stamens, carpels and ovules except in vegetative meristem and leaf primordia where only ULT1 mRNA accumulates (Carles et al. (grassius.org)

Next to the MADS domain is the moderately conserved Intervening (I) and Keratin-like (K) domains, which are involved in specific protein-protein interactions. (wikipedia.org)
It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. (antikoerper-online.de)

Furthermore, transgenic mice harboring the viral-encoded large T-antigen (LT-Ag) alone develop tumors of neuroectodermal origin, including malignant peripheral nerve sheath tumors (MPNSTs) and glioblastomas. (cdc.gov)

Large proteins are typically not suited for oral administration, as such drugs would be degraded in the digestive tract and poorly absorbed. (pharmtech.com)

Encodes a pollen-specific Rop GTPase, member of the Rho family of small GTP binding proteins that interacts with RIC3 and RIC4 to control tip growth in pollen tubes. (or.jp)
Genome-wide analysis of the MADS-box gene family in polyploid cotton (Gossypium hirsutum) and in its diploid parental species (Gossypium arboreum, and Gossypium raimondii) J . Plant Physiology & Biochemistry, 2018, 127: 169-184. (paperonce.org)

ROP1 activity is regulated by the REN1 GTPase activator protein. (or.jp)

first measured the half-life of endogenously tagged MOM proteins to identify substrates suitable for mechanistic characterization of this process. (rupress.org)
Another important line of research in our group are infectious diseases, which we approach by unveiling the mechanistic basis of the activity of proteins essential for organismal viability. (csic.es)

The fold of the catalytic domain showed similarity with that of Ps. (rcsb.org)

What converts mRNA into a protein? (lebendigefluesse.at)

The laboratory is interested in the determination of the structure of proteins important for pathogen viability and virulence. (csic.es)

In plants, MADS-domain protein form tetramers and this is thought to be central for their function. (wikipedia.org)
Maintenance of class B gene expression The maintenance of AP3 and PI expression in flowers requires the activity of both AP3 and PI indicating that these two proteins function in a positive autoregulatory loop. (oboolo.com)

2017). This protein also bears two HMG-boxes but the mechanism of binding is from one side of the DNA, as a staple. (csic.es)

2018). In sorghum, it was found through genetic crosses of sweet and grain sorghum that a Basic Leucine Zipper Domain (bZIP) transcription factor elevated TPP expression, which underpinned the large differences in height of stems and accumulation of carbohydrates within stems of sweet and grain sorghum (Paul et al. (grassroots.tools)

The preferred route of administration for an injected therapeutic agent is subcutaneous (SC), but SC injections are generally limited to no more than 1-2 mL in volume, representing a major challenge, especially for large protein biologics. (pharmtech.com)

The MADS box protein structure is characterized by four domains. (wikipedia.org)
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. (embl.de)
The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. (embl.de)
Crystal structure of tandem type III fibronectin domains from Drosophila neuroglian at 2.0 A. (embl.de)
beta bulges and left-handed polyproline II helices disrupt the regular beta sheet structure of both neuroglian domains. (embl.de)
Two different crystal structures of P. calidifontis L-SerDH were determined using the Se-MAD and MR method: the structure in complex with NADP + /sulfate ion at 1.18 Å and the structure in complex with NADP + /L-tartrate (substrate analog) at 1.57 Å. (rcsb.org)
Other proteins studied in the laboratory and whose structure we solved include single-strand binding protein mtSSB (or SSBP1, Piro-Mégy et al. (csic.es)

[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)

Furthermore, this analyses confirmed the positive roles of CDK9 and Yorkie in regulating Mad-dependent gene expression in vivo. (sdbonline.org)

In this way, AP2 protein (and thus activity) could be restricted to the outer two floral whorls. (oboolo.com)
Translational repression of AP2 The only floral organ-identity gene that does not encode a MADS-domain protein is the class A gene AP2. (oboolo.com)

129- Agaoua A, Rittener V, Troadec C, Desbiez C, Bendahmane A, Moquet F, Dogimont C. A single substitution in Vacuolar protein sorting 4 is responsible for resistance to watermelon mosaic virus in melon. (u-psud.fr)

This fold is topologically very similar to that of Ig-like domains, with a notable difference being the lack of a conserved disulfide bond in FN3 domains. (embl.de)

Besides CDK8 and CycC, further analyses of other subunits of the MED complex have revealed six additional subunits that are required for Mad-dependent transcription in the wing discs: Med12, Med13, Med15, Med23, Med24, and Med31. (sdbonline.org)

The results obtained here may be very informative for the creation of L- or D-serine-specific SerDH by protein engineering. (rcsb.org)
encodes a glycine-rich protein that is expressed only in flowers during a specific developmental stage (flower stages 11 and 12). (or.jp)
encodes a glycine-rich protein that is expressed only in flowers during a specific developmental stage (flower stage 12). (or.jp)

This model is supported by the higher levels of miRNA172 in the inner two whorls of the flower, however, the spatial pattern of expression of AP2 protein in inflorescences has not yet been determined. (oboolo.com)

Anatomy23

Organisms15

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Phenomena and Processes80

Information Science4

Health Care1

MCM1 Agamous Deficiens SRF1

Transcription factors6

Genes18

Transcriptional7

AGAMOUS2

Chromosome3

Homologous1

Homology3

Mitochondria1

Homeotic1

Regulate2

Lamins3

Arabidopsis4

Sequence8

Cofactors2

Pathway3

AGL151

Binds2

Regulates3

Locus4

MEF23

Reproductive1

SMAD1

Mutations4

Amino2

Thaliana1

Saccharomyces1

Regulatory1

Nuclear protein1

Regulator1

Mutation3

Kinase1

Complexes1

Tissue1

Regulation1

Meristem1

Interactions2

Tumors1

Poorly1

Family2

Activator1

Mechanistic2

Similarity1

MRNA1

Determination1

Function2

20171

Genetic1

Therapeutic1

Structure7

Functional1

Gene expression1

Floral2

Substitution1

Similar1

Analyses1

Specific3

Spatial1