Encode mouse homeobox gene. Medical search. Frequent questions

Homeobox protein NOBOX, also known as newborn ovary homeobox protein, is a protein that in humans is encoded by the NOBOX gene. (wikipedia.org)
The human NOBOX is a 14 kb protein and encoded by 8 exons. (wikipedia.org)
The 14/SATB1 monoclonal antibody specifically binds to the special AT-rich sequence binding protein 1 that is encoded by the SATB1 (SATB homeobox 1) gene. (bdbiosciences.com)
Alvarez JD, Yasui DH, Niida H, Joh T, Loh DY, Kohwi-Shigematsu T. The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. (bdbiosciences.com)
The encoded protein acts as a transcription factor and may be autoregulatory. (thermofisher.com)
A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. (thermofisher.com)
Studies of the mouse and chick homolog suggest the encoded protein may play a role in developing teeth and craniofacial mesenchyme of neural crest origin. (nih.gov)
Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
TP53 encodes the protein p53, which is known as the "guardian of the genome. (medscape.com)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. (origene.com)
The encoded protein is a transcription factor important for the development of the renal and urogenital systems. (origene.com)
Several new homebox genes seem to mediate the ventralising activity of bone morphogenetic protein. (xenbase.org)
It is a genome that encodes a homeodomain-containing protein accompanying to a subfamily of paired-like homeodomain proteins. (keratoconusa.net)
Human VSX1 protein structure is 55% identical to a similar protein zebrafish and 35% protein Chx10 in mice. (keratoconusa.net)
NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
These sequences represent the protein coding region of the PBX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)
Later on, with Kurt Wüthrich, he determined the three-dimensional structure of the protein domain (called Homeodomain) encoded by the Homeobox at atomic resolution. (balzan.org)
CDX2 Mouse Monoclonal Antibody detects endogenous levels of CDX2 protein. (ebiocell.com)
The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. (ebiocell.com)
Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ribosome biogenesis, translation and protein folding), cellular remodelling and autophagy. (biomedcentral.com)
OTX2 is a 289 amino acid containing protein encoding a member of the bicoid sub-family of homeodomain-containing transcription factors. (thermofisher.com)
I found that pollywog encodes the zebrafish mitogen activated protein kinase kinase kinase 4 ( map3k4 ) gene and that it acts upstream of p38a MAPK in the YSL. (rice.edu)
This gene encodes a homeobox-containing protein that belongs to the NK-2 homeobox family. (utsouthwestern.edu)
It encodes a 47-kDa protein with a double homeodomain identical to DUX4 but divergent in the carboxyl-terminal region. (fshfriends.org)
How many mobile elements, simple sequence repeats, or protein kinases are encoded in the genome? (cshlpress.com)
How Many Protein-coding Genes Are Present in the Genome? (cshlpress.com)
Does Exon Number Correlate with Gene Size or Protein Size? (cshlpress.com)
How Many Protein Kinases Are Encoded in the Genome? (cshlpress.com)
Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
[ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
This locus, however, also encodes a protein from an alternative reading frame, designated p19ARF. (medscape.com)

The full English name of this gene is Visual system homeobox 1 homolog, CHX10 - like (zebrafish), abbreviated as VSX1. (keratoconusa.net)
By contrast, targeted deletion of genes such as Math1 (a mouse homolog of Drosophila proneural gene atonal ) or sequences encoding BRN 3.1 and BDNF produces congenital sensorineural anomalies of the inner ear. (nih.gov)

We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. (ntnu.edu.tw)
We have previously identified a double homeobox gene ( DUX4 ) within each D4Z4 unit that encodes a transcription factor expressed in FSHD but not control myoblasts. (fshfriends.org)

The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. (nih.gov)
Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. (lookformedical.com)

Molecular characterization of a novel gene family (PHTF) conserved from Drosophila to mammals. (nih.gov)
Mutants with a loss of the function of Pax6 (or its homologues Eyeless in Drosophila, Small eye in mouse, Aniridia in human) prevent eye development at early stages. (balzan.org)
The generation of mutant and transgenic animal models, involving such species as the mouse, Drosophila, zebrafish and Caenorhabditis elegans (C. elegans), provides powerful tools for elucidation of these functions. (nih.gov)
By analyzing lethal mutations in the fruit fly Drosophila Hadorn accumulated evidence that genes control development to a large extent and that they determine the body plan in great detail. (balzan.org)
Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)

This gene encodes a member of the Bar subclass of homeobox transcription factors. (nih.gov)
Such regulation derives, in part, from the function of transcription factors - specialized proteins that bind to specific DNA sequences in our genes and either encourage or shut down the expression of a given gene. (scientificinquirer.com)
Tbx20 physically interacted with cardiac transcription factors Nkx2-5, GATA4, and GATA5, collaborating to synergistically activate cardiac gene expression. (nih.gov)
This allows to conclude that Homeobox-containing genes are coding for transcription factors which regulate the activity of other genes. (balzan.org)

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. (thermofisher.com)

In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. (wikipedia.org)
Regulation of these oocyte-specific genes is thru direct binding of NOBOX to its promoter regions via the specific consensus sequences, the NOBOX DNA binding elements (NBEs). (wikipedia.org)
In contrast, radial nerve showed an unexpected level of complexity with the expression of 3,370 genes significantly altered more than two-fold with age, including genes involved in nerve function, signaling, metabolism, transcriptional regulation and chromatin modification. (nature.com)
The reduced expression of genes involved in mitochondrial oxidative respiration occurs in early adulthood, before the onset of functional decline, and more abruptly than a damage-response model would predict, which supports the possibility of programmed age-related transcriptional regulation 3 . (nature.com)
Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)

Those studies used mice lacking serotonergic neurons resulting from the loss of function mutations in the gene encoding the LIM homeobox transcription factor 1 ( Lmx1b ). (aspetjournals.org)
[ 3 ] Loss of function mutations in this gene are implicated in pediatric retinoblastoma. (medscape.com)
Some studies suggest an association of the VSX1 gene mutations with the development of the rear polymorphous dystrophy of the cornea. (keratoconusa.net)
Mutations in this gene are associated with persistent truncus arteriosus. (utsouthwestern.edu)
Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)

On this basis, Homeobox-containing genes are called developmental control genes. (balzan.org)

CDX2 is a homeobox gene that encodes an intestine-specific transcription factor. (micro-shop.pl)

Furthermore, external acid environment triggered expression of the GFP reporter gene fused downstream of the cdx 2 intestinal homeogene regulatory sequences in P3E6 transfected cells. (silverchair.com)
The following PBX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
He showed that the Homeodomain binds to specific DNA sequences of the promoter region of certain genes. (balzan.org)
For example, the identification of regulatory sequences of genes expressed specifically in the vestibular system will allow the targeted introduction of foreign genes into the vestibular system of transgenic mice. (nih.gov)
What Is the Size Distribution of snRNA Genes and Related Sequences in the Genome? (cshlpress.com)

Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)

Search for RefSeq genes (e.g. (vectorbuilder.kr)

This C terminus is believed to be critical in its transcriptional activities when bound to oocyte-specific genes. (wikipedia.org)
Recently it has been reported that repression of SATB1 was essential for the phenotype and function of mouse regulatory T cells but inhibitory for the establishment of transcriptional programs expressed by effector T cells. (bdbiosciences.com)
Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. (nih.gov)
Early life stress encodes lifelong susceptibility to stress through long-lasting transcriptional programming in a brain reward region implicated in mood and depression, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published June 15 in the journal Science. (scientificinquirer.com)
Genome-wide transcriptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and esophagus tissue. (nature.com)

Western blot analysis of extracts on different cells, using CDX2 Mouse Monoclonal Antibody (EAB13069) at 1:1000 dilution. (ebiocell.com)
Immunohistochemical analysis of paraffin-embedded Human rectal cancer tissue, using CDX2 Mouse Monoclonal Antibody (EAB13069) at 1:1000 dilution. (ebiocell.com)

And like an episode of Law and Order in which a suspect showing up in the first 15 minutes can't possibly be the perp, those researchers implicated a gene on chromosome 17. (rickilewis.com)

The homeobox transcription factor HOXC13 upregulates human papillomavirus E1 gene expression and contributes to viral genome maintenance. (nih.gov)
How do numerous non-coding variations in the human genome affect gene expression in the retina? (nih.gov)
How many genes are in the human genome? (cshlpress.com)
Which Genes Are Present in the Mitochondrial Genome? (cshlpress.com)
How Are Genes Organized in the Mitochondrial Genome? (cshlpress.com)
How Are microRNA Genes Distributed in the Genome? (cshlpress.com)
Gene expression is a key determinant of cellular phenotype, and genome-wide expression analysis can provide insight into the molecular events underlying complex processes such as aging. (nature.com)

searched for novel genes involved in early mammalian folliculogenesis in 2002. (wikipedia.org)
In the last four decades, transgenic and knockout mouse models have helped to understand the mechanisms of mammalian sex determination, germ cell development, and adult gonad functions. (lidsen.com)
Moreover, the conservation of this genetic control of eye development throughout evolution was demonstrated by the fact that insect and mammalian genes are interchangeable. (balzan.org)

These findings demonstrate that chronic exposure of esophageal keratinocytes to acid pH induces transcription of cdx 2, an intestinal specific homeobox gene known to play a critical role in the differentiation and maintenance of intestinal epithelial functions. (silverchair.com)
Thus, LMX1B regulates the expression of multiple podocyte genes critical for podocyte differentiation and function. (nih.gov)
Second, networks of genes and hormones regulate the advancement of sex determination and gonad differentiation, known as the gonadal sex phase. (lidsen.com)
To understand the development of adiposity, it is crucial to identify the genes which expression is associated with adipogenic differentiation. (biomedcentral.com)
Proliferation cluster comprised 1028 genes up-regulated from days 3 to 8 of culture meanwhile the differentiation cluster was characterized by 2140 induced genes from days 15 to 21. (biomedcentral.com)
On the other hand, the terminal differentiation phase was enriched with genes involved in energy production, lipid and carbohydrate metabolism. (biomedcentral.com)
Overall, our study demonstrates the coordinated expression of functionally related genes during proliferation and differentiation of rainbow trout adipocyte cells. (biomedcentral.com)
In keeping with the known role of Myf5 in myoblast accumulation during mouse muscle regeneration DUX4c over-expression activated proliferation of human primary myoblasts and inhibited their differentiation. (fshfriends.org)

A mutation in the NOBOX gene is associated with premature ovarian failure (POF), also known as premature ovarian insufficiency (POI). (wikipedia.org)
In rare cases, the development of keratoconus was also associated with a mutation of this gene, but this was not confirmed by studies. (keratoconusa.net)
Other genes whose mutation produces homeotic transformations were discovered and analysed by Edward Lewis in the United States using classical genetic techniques. (balzan.org)
Germline mutation of one TP53 allele is found in patients with Li-Fraumeni syndrome who generally inherit a mutated TP53 gene from an affected parent. (medscape.com)

The homeobox gene Pax6, which participates in eyes primordium perseverance and handles the pluripotency of retinal progenitor cells, regulates Atoh7 transcription [17]C[19] positively. (baxkyardgardener.com)
Walter Gehring made a second discovery of fundamental importance in developmental biology as he identified the Pax6 gene (which contains a Homeobox as well), a "master control gene" for eye development in all animals, including humans. (balzan.org)
The transcription factor of the Pax6 gene is critical for the development of the eye in all organisms endowed with a visual system. (balzan.org)
In 1995, Walter Gehring demonstrated the importance of Pax6 in an elegant experiment in which targeted ectopic expression of this gene in the fly generated eyes on legs, wings or antennae. (balzan.org)

SATB1 can recruit chromatin-remodeling factors and thereby regulate chromatin structure and gene expression. (bdbiosciences.com)
The Mount Sinai study focuses on epigenetics, the study of changes in the action of genes caused not by changes in DNA code we inherit from our parents, but instead by molecules that regulate when, where, and to what degree our genetic material is activated. (scientificinquirer.com)

I describe the temporal and spatial expression patterns of these genes through embryonic development. (rice.edu)

There are 175 organisms that have orthologs with human gene NOBOX. (wikipedia.org)
The human NOBOX is located in chromosome 7q35 while the mouse NOBOX is in proximal chromosome 6. (wikipedia.org)
This mouse paradigm will be useful for understanding the molecular correlates of increased risk of depression resulting from early life stress and could pave the way to look for such sensitive windows in human studies," says Eric J. Nestler, MD, PhD, Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute at Mount Sinai and senior investigator of the study. (scientificinquirer.com)
Our investigations utilize in vivo mouse retina and human retinal organoids derived from pluripotent stem cells as study systems. (nih.gov)
Immunohistochemical staining of paraffin-embedded human embryonic brain cortex tissue within the normal limits using anti-OTX2 mouse monoclonal antibody. (thermofisher.com)
How similar are human proteins to those of mouse, yeast, or bacteria? (cshlpress.com)
How Does Codon Usage Vary Among Human Genes? (cshlpress.com)
Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)

It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. (genscript.com)

LMX1B encodes a LIM-homeodomain transcription factor. (nih.gov)

Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)

In teleosts, the Yolk Syncytial Layer (YSL) is functionally similar to the anterior visceral endoderm found in mice and is required for morphogenesis of the overlying blastoderm. (rice.edu)

Specifically, Mount Sinai investigators identified a role for the developmental transcription factor orthodenticle homeobox 2 (Otx2) as a master regulator of these enduring gene changes. (scientificinquirer.com)

Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target. (nih.gov)

Its deficiency can cause rapid loss of postnatal oocytes and during its absence in female mice, follicles are replaced by fibrous tissue. (wikipedia.org)
The research team showed that baby mice that were stressed in a sensitive period (from postnatal day 10-20) had suppressed Otx2 in the VTA. (scientificinquirer.com)

The official symbol (NOBOX) and the official full name (NOBOX oogenesis homeobox) are maintained by the HGNC. (wikipedia.org)

It is capable of regulating other genes that are important in the development of follicles. (wikipedia.org)
Homeobox (HOX) genes encode proteins that are important in normal foetal development. (endocrine-abstracts.org)
To explore mechanisms whereby Malpighian keratinocytes can transdifferentiate into an intestinal-like epithelium, as observed in the early steps of Barrett's esophagus (BE) development, long-standing cultures of esophageal keratinocytes derived from normal mouse esophageal explants were developed. (silverchair.com)
[ 5 ] Targeted disruption of TP53 in the mouse leads to the development of various tumors. (medscape.com)
Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development. (bepress.com)
We performed lineage-tracing experiments to examine the contribution of the notochord to spinal development from E12.5 through to skeletally mature mice (9 months). (bepress.com)
This suggests that notochordal cells might serve as tissue-specific progenitor cells within the disc and establishes the Noto-cre mouse as a unique tool to interrogate the contribution of notochordal cells to both intervertebral disc development and disc degeneration. (bepress.com)
The development of the gonadal and reproductive tract (uterus and vagina in females, and seminal vesicles, prostate glands, and penis in males) starts around E10.5 in mice, and they are almost completely developed at birth. (lidsen.com)
The product of this gene may play a role in the development of hair, nail, and filiform papilla. (nih.gov)
The scientific presentations emphasized developmental processes, encompassing such areas as: 1) the role of homeobox genes and growth factors in inner ear development and plasticity, 2) effects of altered gravitational loading on the development of the inner ear gravity receptor, 3) effects of altered gravitational loading on developing and mature neuromuscular systems and 4) molecular mechanisms that determine muscle fiber diversity and hypertrophic responses. (nih.gov)
The large majority of the early embryologists thought that the genes played only a minor role in development, for example by determining eye color, and that development is rather controlled by tissue interactions. (balzan.org)
In conjunction with related gene, NKX2-5, this gene may play a role in both pharyngeal and cardiac embryonic development. (utsouthwestern.edu)

HOXC-AS2 mediates the proliferation, apoptosis, and migration of non-small cell lung cancer by combining with HOXC13 gene. (nih.gov)
The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)

Expression of this gene is restricted to the node and the posterior notochord during gastrulation [embryonic day 7.5 (E7.5)-E12.5]. (bepress.com)
Cellular localization of β-galactosidase (encoded by lacZ) and cytokeratin-8 demonstrated that both notochordal cells and chondrocyte-like nucleus pulposus cells are derived from the embryonic notochord. (bepress.com)

By illustration, a large number of zebrafish and mouse mutants with vestibular system involvement have been developed. (nih.gov)
Incuded in this thesis is work highlighting the alpha-actinin gene family in zebrafish. (rice.edu)
All zebrafish actinin genes have unique expression profiles, indicating specialization of each gene. (rice.edu)

This gene belongs to the homeobox family of genes. (nih.gov)

Which Genes Have the Most Exons? (cshlpress.com)

Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. (ebiocell.com)

Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. (nih.gov)
Few genes show differential expression with age in tissues (brain, liver and kidney) of naked mole rats and, contrary to other mammals and short-lived model animals, mitochondrial gene expression does not change with age 13 . (nature.com)

Expression of glomerular basement membrane (GBM) collagens is reduced in Lmx1b(-/-) mice, suggesting one basis for NPS nephropathy. (nih.gov)

Essentially, this brain region encodes a lifelong, latent susceptibility to depression that is revealed only after encountering additional stress. (scientificinquirer.com)
Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects. (genscript.com)
The findings from the present study that a SNP of the PBX2 gene in the MHC region (at 6p21.3) was associated with allergic rhinitis (AR) in allele and genotypic analysis suggests a new susceptibility gene for AR in the MHC region and another gene associated with both asthma and AR in Chinese subjects. (genscript.com)

In addition, knockout mouse studies have suggested a role for HOXA10 in implantation but its precise mechanism of action remains unclear. (endocrine-abstracts.org)
2016). Increased fronto-hippocampal connectivity in the Prrxl1 knockout mouse model of congenital hypoalgesia . (up.pt)

PHENOTYPE: Mice homozygous for a targeted null allele are viable and fertile and develop normally, with no anomalies detected in the caudal pharyngeal pouch derivatives, heart or gut. (utsouthwestern.edu)

When the methods of gene technology became available, Gehring cloned the Antennapedia gene. (balzan.org)

Direct evidence linking the INK4A locus to tumorigenesis was provided by the targeted disruption of exon 2 of INK4A in mice. (medscape.com)

With Eddy De Robertis, he was the first to demonstrate the evolutionary conservation of Homeobox-containing genes present in all metazoan Bilateria, where they play a key role in patterning the body plan. (balzan.org)

Duxbl gene, a tandem triplicate produces two major transcripts, Duxbl and Duxbl-s. (ntnu.edu.tw)
We discovered that disrupting maternal care of mice produces changes in levels of hundreds of genes in the VTA that primes this brain region to be in a depression-like state, even before we detect behavioral changes. (scientificinquirer.com)

Gene expression profiles in animals that exhibit slow aging or negligible senescence may reveal distinct insight into potential mechanisms involved in long-term maintenance of tissues and healthy aging. (nature.com)

This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. (genscript.com)
This gene is a member of the caudal-related homeobox transcription factor gene family. (ebiocell.com)
I show that this pathway acts in the YSL along with a mixer gene family member, mix-type homeobox gene 1 ( mxtx1 ), to non-autonomously coordinate extracellular matrix deposition and morphogenetic movements in the overlying blastoderm. (rice.edu)

Moreover, during this phase an enrichment in genes involved in the formation of the lipid droplets was evidenced as well as the activation of the thyroid-receptor/retinoic X receptor (TR/RXR) and the peroxisome proliferator activated receptors (PPARs) signalling pathways. (biomedcentral.com)

More importantly, we used mice deficient in the gene encoding tryptophan hydroxylase 2 ( Tph2 ), which could not synthesize 5-HT in the brain. (aspetjournals.org)
Electroencephalographic (EEG) recording also showed decreased sleep in Tph2 -deficient mice. (aspetjournals.org)
Tumors that developed in mice deficient in INK4A were enhanced by the topical application of carcinogens and ultraviolet light. (medscape.com)

Diseases3

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Information Science2

Protein37

Homolog2

Double homeobox gene2

Highly conserved2

Drosophila5

Transcription factors4

Member of the bicoid1

Regulation6

Mutations5

Developmental control genes1

Intestine-specific1

Sequences5

Proteins encoded2

RefSeq1

Transcriptional5

Cdx22

Chromosome 171

Genome7

Mammalian3

Differentiation8

Mutation4

Pax64

Regulate2

Temporal and spatial expression1

Human9

Similarity1

Homeodomain1

Humans1

Morphogenesis1

Orthodenticle1

PMID1

Postnatal2

HGNC1

Development12

Apoptosis2

Organism1

Embryonic2

Zebrafish3

Belongs1

Exons1

Intestinal1

Mammals2

Lmx1b1

Susceptibility3

Knockout mouse2

Phenotype1

Antennapedia1

Locus1

Evolutionary1

Produces2

Exhibit1

Family3

Enrichment1

Deficient3