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GlycoproteinsMembrane GlycoproteinsLysosome-Associated Membrane GlycoproteinsPlatelet Membrane GlycoproteinsCell MembraneIntracellular MembranesMembranesFucoseMembrane LipidsOligosaccharidesGlucosamineMembrane ProteinsElectrophoresis, Polyacrylamide GelLectinsMolecular WeightCell LineGlycosylationErythrocyte MembraneMembrane PotentialsGlycopeptidesMannoseCarbohydrate SequenceMembranes, ArtificialGalactose OxidaseViral Envelope ProteinsMolecular Sequence DataBlood PlateletsPolysaccharidesSialic AcidsGolgi ApparatusMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseNeuraminidaseCarbohydratesAmino Acid SequenceReceptors, Concanavalin ALysosomesImmunoelectrophoresis, Two-DimensionalChromatography, AffinityMembrane FluidityGalactoseBlood Platelet DisordersAmino SugarsMicroscopy, ElectronWheat Germ AgglutininsViral ProteinsCricetinaeAntibodies, MonoclonalCarbohydrate ConformationAcetylgalactosamineCell Membrane PermeabilityEndoplasmic ReticulumN-Acetylneuraminic AcidBasement MembraneGlycoside HydrolasesSialoglycoproteinsProtein Processing, Post-TranslationalFluorescent Antibody TechniqueBunyaviridaeCells, CulturedTunicamycinViral Fusion ProteinsPeriodic AcidProtein BindingSindbis VirusCell FractionationPeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine AmidaseKineticsVesicular stomatitis Indiana virusBase SequenceAntigens, CDBoratesPlatelet AggregationAntigens, SurfaceAsparagineGlycolipidsUukuniemi virusMutationSubcellular FractionsHemagglutinins, ViralMonensinMembrane Transport ProteinsHexosaminidasesGalactosyltransferasesHydrogen-Ion ConcentrationConcanavalin ARabbitsMicrosomesCattleSolubilityChromatography, GelDipeptidyl-Peptidases and Tripeptidyl-PeptidasesBiological TransportErythrocytesSialyltransferasesCloning, MolecularEpitopesLipid BilayersCHO CellsTemperatureProtein Transport
ProteinsGene encodes P-glycoproteinIntegralProtein encodedReceptorsReceptorBindsCellular membranePlateletSuperfamilyPivotal roleABCB1GenesDrug transporterDifferent isoformsTransporterMDR1CD107aTypeTransmembraneLYVE1EpithelialViralChromosomeEnvelope proteinExtracellularExpressionAntibodiesRegulatorChainsPlasmaPromotesHumansHomologyMutationAntibodyYieldsDrugsFunctionalSurfaceAlphaMemberDomainsStructureHostMouseFormVirusImpact
Proteins11
  • These ORFs code for the envelope protein, glycoproteins (2b-5), membrane, and nucleocapsid proteins. (cdc.gov)
  • Seven virus-encoded proteins have been identified that are components of IEV, and five of them are present in CEV or EEV. (microbiologyresearch.org)
  • These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. (nih.gov)
  • Kidney Injury Molecule-1 (KIM-1, HAVCR1) is a class I integral membrane glycoprotein that belongs to the TIM family of proteins. (transcriptionfactor.org)
  • The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (transcriptionfactor.org)
  • The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. (transcriptionfactor.org)
  • For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
  • In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
  • The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
  • They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)
  • Three of these RNP segments encode the virus' surface proteins, i.e., the HA, NA and M proteins. (cdc.gov)
Gene encodes P-glycoprotein2
  • OBJECTIVE: The ABCB1 gene encodes P-glycoprotein (P-gp), a cellular membrane pump. (edu.au)
  • The MDR-1 gene encodes P-glycoprotein, a vital membrane protein found in various normal cells throughout the body. (umsida.ac.id)
Integral4
  • LYVE1 is a type I integral membrane glycoprotein. (wikipedia.org)
  • Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)
  • Description: This gene encodes a type I integral membrane glycoprotein. (microbiologystudents.com)
  • Classed as a type I integral membrane glycoprotein, in its capacity as a receptor, LYVE1 can bind to soluble and immobilised HA. (prospecbio.com)
Protein encoded6
  • the human version of the protein encoded by the MDR1 gene), a drug-transporter glycoprotein associated with the cell or plasma membrane (which encloses the cell's cytoplasm) with a wide variety of drug substrates. (thefutureofthings.com)
  • P-glycoprotein (Pgp) is a plasma membrane protein encoded by mammalian multidrug resistance gene (MDRI). (wikidoc.org)
  • The protein encoded by this gene acts as a membrane receptor for both the human hepatitis A virus (HHAV) and TIMD4. (transcriptionfactor.org)
  • The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. (transcriptionfactor.org)
  • The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. (transcriptionfactor.org)
  • The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. (transcriptionfactor.org)
Receptors3
  • This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
  • Analysis of this HA gene shows that it is closely related to avian A(H5) viruses in HA clade 2.3.4.4b and lacked amino acid changes that improve recognition of mammalian receptors or fusion of the viral membrane with the host endosomal membranes. (cdc.gov)
  • A(H5) viruses in HA clade 2.3.4.4b and lacked amino acid changes that improve recognition of mammalian receptors or fusion of the viral membrane with the host endosomal membranes. (cdc.gov)
Receptor6
Binds3
  • The H4A3 monoclonal antibody specifically binds to CD107a which is also known as Lysosomal-associated membrane protein 1 (LAMP-1). (bdbiosciences.com)
  • IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. (utsouthwestern.edu)
  • The encoded protein is secreted and binds hydroxyapatite with high affinity. (transcriptionfactor.org)
Cellular membrane1
  • Specifically, by using lipid nanodiscs as cellular membrane mimics, we obtained yields of up to 440 µg/mL for the single-subunit OST enzyme, 'Protein glycosylation B' (PglB) from Campylobacter jejuni , as well as for three additional PglB homologs from Campylobacter coli, Campylobacter lari , and Desulfovibrio gigas . (biorxiv.org)
Platelet1
  • Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein. (bdbiosciences.com)
Superfamily2
  • The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. (sigmaaldrich.com)
  • This gene encodes a member of the cadherin superfamily. (anticorps-enligne.fr)
Pivotal role1
  • The results unveiled the pivotal role of P-glycoprotein in modulating drug permeability and highlighted its significance in determining pharmacotherapy outcomes. (umsida.ac.id)
ABCB11
  • It is unclear whether the pharmacokinetic diversity of P-gp substrates is highly dependent on ABCB1 polymorphisms encoding P-gp. (bvsalud.org)
Genes5
  • This gene encodes one of three related filamin genes, specifically gamma filamin. (nih.gov)
  • Another cluster included genes encoding enzymes in the mitochondrial beta-oxidation pathway. (biomedcentral.com)
  • The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle. (transcriptionfactor.org)
  • The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. (transcriptionfactor.org)
  • In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. (edu.au)
Drug transporter3
  • The researchers concluded that treatment of the drug-resistant tumor cells with low frequency, low intensity AC stimulation in vitro drastically enhances chemotherapeutic efficacy of doxorubicin, a substrate for the MDR1 glycoprotein drug transporter. (thefutureofthings.com)
  • Ochilova G. S. Characterization of glycoprotein-P as a drug transporter protein // New day in medicine. (umsida.ac.id)
  • P-glycoprotein (P-gp) is a widely membrane-expressed multi-drug transporter. (bvsalud.org)
Different isoforms2
  • Two transcript variants encoding different isoforms have been found for this gene. (nih.gov)
  • Alternative splicing results in multiple transcript variants encoding different isoforms. (utsouthwestern.edu)
Transporter2
  • Further investigation demonstrated that electrical stimulation not only decreases levels of the MDR1 glycoprotein transporter, but also changes the localization of the MDR1 glycoprotein from close to the plasma membrane to the cytosol (the fluid portion of the cytoplasm). (thefutureofthings.com)
  • In the brain, the efflux transporter P-glycoprotein (Pgp) is predominantly located on the luminal membrane of microvascular endothelial cells (BMECs) that form the blood-brain barrier. (bvsalud.org)
MDR12
  • This altered expression of the MDR1 glycoprotein is believed to have caused the loss of the cell's drug extrusion ability, which it mediates. (thefutureofthings.com)
  • A primary role of plasma membrane P-glycoprotein (P-gp), encoded by multidrug resistance type I (MDR1), is to protect against naturally occurring xenotoxics. (elsevierpure.com)
CD107a1
  • We hypothesized lysosome-associated membrane glycoprotein 1 (LAMP1, CD107a) to be a marker for fratricide in TCR transgenic CD8 + T cells. (oncotarget.com)
Type3
  • This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. (nih.gov)
  • The herpes simplex virus type 1 (HSV-1) glycoprotein N (gN/UL49.5) is a type I transmembrane protein conserved throughout the herpesvirus family. (mdpi.com)
  • The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. (anticorps-enligne.fr)
Transmembrane1
LYVE11
Epithelial1
  • The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. (modellab.cn)
Viral1
Chromosome1
  • We selected 17 patients clinically and his- is encoded by a single gene located on the tologically proven to be suffering from PV short arm of chromosome 11 [ 6 ]. (who.int)
Envelope protein1
  • Extracellular vaccinia virus formation and cell-to-cell virus transmission are prevented by deletion of the gene encoding the 37,000-Dalton outer envelope protein. (microbiologyresearch.org)
Extracellular1
  • The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation. (transcriptionfactor.org)
Expression7
  • Sawada R, Lowe JB, Fukuda M. E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels. (bdbiosciences.com)
  • Sequence analysis, expression, and deletion of a vaccinia virus gene encoding a homolog of profilin, a eukaryotic actin-binding protein. (microbiologyresearch.org)
  • Understanding the expression of P-glycoprotein is essential for comprehending drug pharmacokinetics and optimizing pharmacotherapy outcomes. (umsida.ac.id)
  • In this study, our goal was to investigate the influence of P-glycoprotein expression on drug permeability and its implications for therapeutic effectiveness. (umsida.ac.id)
  • This research emphasizes the necessity of considering P-glycoprotein expression when designing drug delivery strategies, enabling targeted therapies, and maximizing therapeutic efficacy. (umsida.ac.id)
  • Influence of P-glycoprotein expression on pharmacotherapy outcomes. (umsida.ac.id)
  • We anticipate that this broadly applicable production method will advance glycoengineering efforts by enabling preparative expression of membrane-embedded OSTs from all kingdoms of life. (biorxiv.org)
Antibodies2
  • Rational Laboratory Diagnostics of Antiphospholipid Antibodies: Anti-Cardiolipin, Anti-β2-Glycoprotein I, Anti-Prothrombin and Anti-Annexin V Antibodies. (ncbcs.org)
  • A attainable co-appearance of anticardiolipin (aCL), anti-β2-glycoprotein I (anti-β2-GPI), anti-prothrombin (aPT) and anti-annexin V (aANXV) antibodies of IgG, IgM and IgA class have been studied in 58 sufferers with SLE alone and 32 sufferers APS within the view of rational laboratory diagnostics. (ncbcs.org)
Regulator1
  • P-glycoprotein: Key regulator of drug permeability and cellular absorption. (umsida.ac.id)
Chains1
  • Information by which neurons established only certain connection with certain neurons is encoded in the structure of the polysaccharide chains of membrane glycoproteins. (doclecture.net)
Plasma2
  • This protein is one of the plasma membrane components of adherens junctions. (nih.gov)
  • Most of the lipids of nerve tissue are composed of plasma and subcellular membranes of neurons and myelin sheaths. (doclecture.net)
Promotes1
  • The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. (utsouthwestern.edu)
Humans1
  • Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
Homology2
  • The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. (sigmaaldrich.com)
  • Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)
Mutation1
  • The primary defect in Dubin-Johnson syndrome is a mutation in an apical canalicular membrane protein responsible for the excretion of bilirubin and other nonbile salt organic anions. (medscape.com)
Antibody1
  • mRNA-1345 is a vaccine against RSV encoding for a prefusion F glycoprotein, which elicits a superior neutralizing antibody response compared to the postfusion state. (pharmiweb.com)
Yields1
  • The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
Drugs2
  • This protein plays a crucial role in actively facilitating the absorption of drugs across cell membranes. (umsida.ac.id)
  • Kim R. Drugs as P-glycoprotein substrates, inhibitors, and inducers. (umsida.ac.id)
Functional1
  • Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. (nih.gov)
Surface4
  • IEV is formed by wrapping of IMV with intracellular membranes, and is an intermediate between IMV and CEV/EEV that enables efficient virus dissemination to the cell surface on microtubules. (microbiologyresearch.org)
  • The hemagglutinin (HA) gene codes for one of the two surface glycoproteins and is central to species specificity because it is responsible for virus attachment and fusion with host cells. (cdc.gov)
  • The neuraminidase (NA) gene encodes the other surface protein of the virus. (cdc.gov)
  • This illustration depicted a 3D computer-generated rendering of a half-sliced influenza (flu) virus with a grey surface membrane, set against a white background. (cdc.gov)
Alpha1
  • Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. (edu.au)
Member3
Domains1
  • This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. (transcriptionfactor.org)
Structure2
  • 1. Structure: lipids are part of the cell membranes of neurons. (doclecture.net)
  • HN - 2008 BX - Lateral Sinus MH - Atrial Septum UI - D054087 MN - A07.541.459.249 MS - The thin membrane-like muscular structure separating the right and the left upper chambers (HEART ATRIA) of a heart. (bvsalud.org)
Host1
  • The hallmark of these diseases is the accumulation of a disease-associated partially Protease-resistant isoform (PrP Sc ) resulting from the conversion of the host-encoded membrane-bound glycoprotein, cellular prion protein (PrP c ). (biomedcentral.com)
Mouse1
  • Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. (bdbiosciences.com)
Form2
  • This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. (utsouthwestern.edu)
  • This indicates that changes in the nervous system, reflecting the individual experience of the organism, are encoded in the form of synthesized macromolecules. (doclecture.net)
Virus3
  • Lassa fe- Lassa virus in many more districts and states in en- ver is endemic in West Africa and has been reported demic countries of the West African sub-region and from Sierra Leone, Guinea, Liberia, and Nigeria4-7. (folkhalsomyndigheten.se)
  • Nous avons déterminé la fréquence des différents sérotypes du virus de la dengue pour mettre en évidence son hyperendémicité à Rawalpindi (Pakistan). (who.int)
  • Les échantillons de sérum de 140 patients susceptibles d'avoir contracté le virus de la dengue ont été analysés entre mai et octobre 2015 à l'aide du test ELISA et de l'amplification en chaîne par polymérase multiplexe. (who.int)
Impact1
  • Through a comprehensive analysis of existing literature, we explored the methods employed to assess P-glycoprotein activity and its impact on drug absorption. (umsida.ac.id)