AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Encephalomyocarditis virusCardiovirus InfectionsEnterovirus InfectionsMengovirusCarcinoma, Krebs 2RNA, ViralCardiovirusL Cells (Cell Line)Protein BiosynthesisInterferonsPicornaviridaeViral ProteinsVirus ReplicationEncephalomyelitis, Enzootic PorcineVirus CultivationVesicular stomatitis Indiana virusMyocarditisRibosomesPoly CRNA VirusesMaus Elberfeld virusCell-Free SystemHeLa CellsVaccinia virusViral Plaque AssaySulfur IsotopesPoliovirusVirus DiseasesCell LineReticulocytes2',5'-Oligoadenylate SynthetaseCytopathogenic Effect, ViralPeptide Chain Initiation, TranslationalReceptors, VirusAntiviral AgentsMolecular Sequence DataDefective VirusesPolypyrimidine Tract-Binding ProteinSemliki forest virusBase SequencePoly I-COligoribonucleotidesCulture TechniquesMice, Inbred DBAInterferon Type IPolyproteinsRNA CapsCapsidRNA, MessengerGenes, ViralEukaryotic Initiation Factor-4GHepatovirusInterferon InducersPeptide BiosynthesisGene Expression Regulation, ViralAntigens, ViralVirusesAntibodies, ViralCricetinaeRibonucleasesNeutralization TestsRNA, Double-StrandedPeptide Initiation FactorsEndoribonucleasesVirus Shedding5' Untranslated RegionsCercopithecus aethiops
EMCVHepatitis C virInfectionIRESReplicationPicornaviridaeInterferonMurine1999Pathogens1987Electron microscopyAntibodiesExperimentallyHerpes simplDiseasesOrbivirusParasiticAssayAcuteSequencesIsolationSIMIANAntibodyAntiviral activityMengoPigsGenomeZikaSpeciesImmuneCellsHumansOrganismsVertebrateMutationRodentsInfectiousCHIKVHumanGeneticInflammationAntigenNucleicProteinHostsIFNs
EMCV13
  • Virus isolated in Vero E6 cells was identified as encephalomyocarditis virus (EMCV) by electron microscopy and by subsequent molecular diagnostic testing of samples from 2 febrile patients with nausea, headache, and dyspnea. (cdc.gov)
  • Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness. (cdc.gov)
  • Virus isolation and serologic studies indicate EMCV is distributed worldwide, but clinical disease in humans or domestic animals is relatively infrequent. (cdc.gov)
  • Human EMCV infection and disease have been documented by virus isolation from several specimen types, including serum, stool samples, cerebral spinal fluid, and throat washings ( 10 - 12 ). (cdc.gov)
  • Serologic studies also indicate that humans have been infected by EMCV or immunologically related viruses ( 17 - 22 ). (cdc.gov)
  • Fatal encephalomyocarditis virus (EMCV) infections in a ring-tailed lemur (Lemur catta), a squirrel monkey (Saimiri sciureus), three mandrills (Mandrillus sphinx), a chimpanzee (Pan troglodytes), a pygmy hippopotamus (Choeropsis liberiensis), and two Goodfellows tree kangaroos (Dendrolagus goodfellowi) occurred at Taronga Zoo. (nih.gov)
  • Transmission of encephalomyocarditis virus (EMCV) among pigs experimentally quantified. (sciensano.be)
  • Two types of transmission experiments were performed to estimate the basic reproduction ratio R(0), indicating the level of encephalomyocarditis virus ( EMCV ) transmission among pigs. (sciensano.be)
  • Mengovirus, also known as Columbia SK virus, mouse Elberfield virus, and Encephalomyocarditisvirus (EMCV), belongs to the genus Cardiovirus which is a member of the Picornaviridae. (wikipedia.org)
  • Recombinant Mouse IL-28B/ IFN-lambda 3 (Catalog # 1789-ML ) reduces the Encephalo-myocarditis Virus (EMCV)-induced cytopathy in the HepG2 human hepatocellular carcinoma cell line in a dose-dependent manner (orange line). (rndsystems.com)
  • This study examines these properties using two RNA viruses, Sendai virus (SeV) and encephalomyocarditis virus (EMCV) and two human cell lines. (nih.gov)
  • Encephalomyocarditis virus (EMCV) can cause acute myocarditis in various animals including mice. (fujita-hu.ac.jp)
  • A murine stem cell virus (MSCV)-based retroviral vector (MSCV-hIL12.B7) utilized distinct IRES sequences from the encephalomyocarditis virus (EMCV) and the foot-and-mouth disease virus (FMCV), whereas Ad5-based adenovirus vectors contained transcriptional units with two EMCV IRES sequences under the control of murine (AdMh12.B7) or human (AdHh12.B7) cytomegalovirus promoters. (mcmaster.ca)
Hepatitis C vir2
  • Studies of influenza virus, hepatitis C virus, herpes simplex virus and vaccinia virus highlight the importance of IFNs for the control of virus replication and pathogenesis. (nature.com)
  • Intriguingly, the knockdown of HSPA6 also caused the reduction of luciferase activity driven by the IRES from coxsackievirus A16, echovirus 9, encephalomyocarditis virus, or hepatitis C virus, supporting that HSPA6 may assist the function of a cellular protein generally required for viral IRES activities. (nycu.edu.tw)
Infection15
  • Carcases had frequently become decomposed or had been scavenged by the time they were found, but seven of eight elephants examined early in 1994 had lesions of cardiac failure suggestive of encephalomyocarditis (EMC)-virus infection, and the virus was isolated from the heart muscles of three fresh carcases. (elephant.se)
  • 1995. The evaluation of a vaccine against encephalomyocarditis infection in elephants (Loxodonta africana) under controlled conditions. (elephant.se)
  • Encephalomyocarditis virus infection in an Italian zoo. (nih.gov)
  • Epidemiological studies in humans and experimental studies in animal have shown that viral infections can induce or protect from autoimmunopathologies depending on several factors including genetic background, host-elicited immune responses, type of virus strain, viral load, and the onset time of infection. (mdpi.com)
  • 17. SUMOylation promotes PML degradation during encephalomyocarditis virus infection. (nih.gov)
  • Studies of immunologic function in lymphoma patients and cardiac transplant patients treated with immunosuppressive drugs have shown specific defects in cell mediated immunity to herpes viruses which may relate to their increased susceptibility to infection by these agents. (nih.gov)
  • A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection. (umassmed.edu)
  • The expression of IL-28A, B, and IL-29 is induced by virus infection or double‑stranded RNA. (rndsystems.com)
  • Interferons (IFNs) - the body's first line of antiviral defence - are cytokines that are secreted by host cells in response to virus infection. (nature.com)
  • Understanding the complex network of cellular antiviral processes and virus-host interactions should aid in identifying new and common targets for the therapeutic intervention of virus infection. (nature.com)
  • It is now clear that although IFN levels markedly increase in response to virus infection, the sequence of events, types of IFN that are produced and ISGs that are targeted have an important effect on the outcome. (nature.com)
  • Five human interferon- α (leukocyte) subtypes derived from genes cloned in Escherichia coli have been compared for their ability to induce antiviral activity against vesicular stomatitis virus infection of various mammalian cell cultures. (microbiologyresearch.org)
  • The variable regions of the murine monoclonal antibody A1, which effectively neutralizes the infection of susceptible cells by the murine hepatitis virus strain JHM, were cloned, sequenced, and expressed in mammalian cells as a functional recombinant antibody, To accomplish the concurrent synthesis of both antibody chains, the light-and heavy-chain-coding regions were inserted into a bicistronic expression cassette based on the encephalomyocarditis virus internal ribosomal entry site. (elsevierpure.com)
  • Human immunodeficiency virus type 2 infection associated with AIDS in West Africa. (academicinfluence.com)
  • The innate immune system recognizes virus infection as the first line of defense and induces antiviral responses by producing type I interferons with antiviral, antiproliferative, and immunomodulatory functions. (biomedcentral.com)
IRES3
  • Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation. (ox.ac.uk)
  • To answer this question, 16 derivatives of PTB1, each with a single cysteine flanking the RNA-binding surface in an RBD, were constructed and used in directed hydroxyl radical probing with the encephalomyocarditis virus IRES. (ox.ac.uk)
  • IRES elements have been found in numerous transcripts from viruses that infect vertebrate, invertebrate, or plant cells, as well as in transcripts from vertebrate and invertebrate genes. (allindianpatents.com)
Replication7
  • P1 encodes the virus capsid proteins, P2 and P3 encode genes required for genome replication to occur. (wikipedia.org)
  • By inducing the expression of hundreds of IFN-stimulated genes, several of which have antiviral functions, IFNs block virus replication at many levels. (nature.com)
  • In turn, viruses encode mechanisms to counteract the host response and support efficient viral replication, thereby minimizing the therapeutic antiviral power of IFNs. (nature.com)
  • Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis virus replication in mouse cells. (microbiologyresearch.org)
  • Virus Oncolitici 0 domande Tumor-selective, replication competent VIRUSES that have antineoplastic effects. (lookformedical.com)
  • Adaptation of lymphadenopathy associated virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines. (academicinfluence.com)
  • Site-specific cleavage of the host poly(A) binding protein by the encephalomyocarditis virus 3C proteinase stimulates viral replication. (ucsb.edu)
Picornaviridae2
  • family Picornaviridae , genus Cardiovirus ) is a group of closely related virus strains belonging to 1 serotype with a wide host range ( 1 ). (cdc.gov)
  • Duck hepatitis A virus (DHAV), which belongs to genus Avihepatovirus in the Picornaviridae family, mainly infects 1-to 4-week-old ducklings, causing neurological symptoms such as corn, spasms, and convulsions. (biomedcentral.com)
Interferon2
  • Response of cloned progeny of clinical isolates of herpes simplex virus to human leukocyte interferon. (microbiologyresearch.org)
  • Zusman I, Engelhard D, Yaffe P, Ron A, Panet A, Ornoy A. Effects of interferon and encephalomyocarditis virus on in vitro development of preimplantation mouse embryos with and without the zona pellucida. (libguides.com)
Murine1
  • 1996. Protection of non-murine mammals against encephalomyocarditis virus using a genetically engineered Mengo virus. (elephant.se)
19991
  • 1999. Genetically engineered Mengo virus vaccination of multiple captive wildlife species. (elephant.se)
Pathogens1
  • Rats as indicators of the presence and dispersal of pathogens in Cyprus: ectoparasites, parasitic helminths, enteric bacteria, and encephalomyocarditis virus. (cabi.org)
19872
  • The results of tests for neutralizing antibody on 362 elephant sera collected for unrelated purposes from 1984 onwards and kept frozen, indicated that the virus had been present in the KNP since at least 1987. (elephant.se)
  • 1987. Encephalomyocarditis in zoo animals: Recent experiences with the disease and vaccination. (elephant.se)
Electron microscopy1
  • General evaluation of samples for virus particles using transmission electron microscopy (TEM). (tamu.edu)
Antibodies1
  • Detection of antibodies to encephalomyocarditis virus (EMC) by virus neutralization. (tamu.edu)
Experimentally1
  • Eight-year observation and comparative study of specific pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV) subtypes A and B: terminal acquired immunodeficiency syndrome in a cat infected with FIV petaluma strain. (uchicago.edu)
Herpes simpl2
  • Resistance of mRNA translation to acute endoplasmic reticulum stress-inducing agents in herpes simplex virus type 1-infected cells requires multiple virus-encoded functions. (ucsb.edu)
  • Maintenance of endoplasmic reticulum (ER) homeostasis in herpes simplex virus type 1-infected cells through the association of a viral glycoprotein with PERK, a cellular ER stress sensor. (ucsb.edu)
Diseases1
  • Animal Models of Infectious Diseases Core supports classical and modern methods for detection of viruses in animal models such as TCID50, EID50, plaque assay and ELISA. (nih.gov)
Orbivirus1
  • Viruses of the Orbivirus genus, probably from the Eubenangee serogroup, were isolated from samples of the cerebral cortex of nine tammar wallabies, and myocardium of two tammar wallabies, and the liver and intestine of another tammar wallaby that originated from a research facility in Sydney. (vin.com)
Parasitic1
Assay1
  • Measured in an anti-viral assay using L‑929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. (bio-techne.com)
Acute3
  • Patients' clinical signs and symptoms were recorded, and acute- and convalescent-phase serum samples were obtained for serologic examination and virus isolation in Vero E6 and C6/36 cells. (cdc.gov)
  • The virus was recovered from acute-phase serum samples from both case-patients and identified with cardiovirus-specific reverse transcription-PCR and sequencing. (cdc.gov)
  • Duck hepatitis A virus type 1 (DHAV-1) is an acute, highly lethal infectious agent that infects ducklings and causes up to 95% mortality in ducklings up to 1 week of age, posing a significant economic threat to the duck farming industry. (biomedcentral.com)
Sequences6
  • A RefSeq record is created from one of the complete genome sequences for each virus species, and the others are tagged as neighbors to the RefSeq. (nih.gov)
  • Databases specific to viruses that have a large number of genome sequences generated from sequencing projects are created for easy data retrieval and analyses. (nih.gov)
  • Like other organisms, the number of sequences for viruses increased dramatically in recent years thanks to the advances of sequencing technologies. (nih.gov)
  • There are over 500,000 sequences in the INSDC databases for human immunodeficiency virus 1 alone. (nih.gov)
  • From all complete viral genome sequences (including Viroids), one RefSeq record (or a set of RefSeq records for segmented viruses) is created for each species. (nih.gov)
  • Provirus 0 domande Duplex DNA sequences in eukaryotic chromosomes, corresponding to the genome of a virus, that are transmitted from one cell generation to the next without causing lysis of the host. (lookformedical.com)
Isolation3
  • researchers could not unequivocally establish that the virus did not originate from the mice used for isolation and passage rather than from human clinical specimens ( 12 ). (cdc.gov)
  • After death or euthanasia, the piglets were checked for heart lesions and virus isolation was done on various tissues. (sciensano.be)
  • Isolation of Infectious Ribonucleic Acid from Encephalomyocarditis and Mengo Encephalitis Viruses. (wikidata.org)
SIMIAN1
  • The human and simian immunodeficiency viruses HIV-1, HIV-2 and SIV interact with similar epitopes on their cellular receptor, the CD4 molecule. (academicinfluence.com)
Antibody1
  • There was a striking temporal correlation between the occurrence of a population explosion (as evidenced by markedly increased catch rates per trap-night) and a surge in prevalence of antibody to EM virus in rodents, and the occurrence of the outbreak of disease in elephants. (elephant.se)
Antiviral activity2
  • The action of interferons (IFNs) on virus-infected cells and surrounding tissues elicits an antiviral state that is characterized by the expression and antiviral activity of IFN-stimulated genes. (nature.com)
  • Individual IFN-alpha subtypes are known to display unique efficacies to viral protection, and IFN alpha-13 displays antiviral activity protective against Theiler's virus, Mengo virus, VSV (4). (bio-techne.com)
Mengo1
Pigs2
  • 1998. The efficacy of an experimental oil-adjuvenated encephalomyocarditis vaccine in elephants, mice and pigs. (elephant.se)
  • Conclusions: This study demonstrates that nucleic acids from a number of targeted viruses were present in pig oral secretions and pig fecal samples, and that several viruses were detected in bioaerosol samples or in the nasal passages of humans with occupational exposure to pigs. (cdc.gov)
Genome6
  • Its genome is a single stranded positive-sense RNA molecule, making the Mengoviruses a class IV virus under the Baltimore classification system. (wikipedia.org)
  • The genome is approximately 8400nt in length, and has 5' VG protein (Virus genome protein) and a 3' polyadenine tail. (wikipedia.org)
  • The National Center for Biotechnology Information ( NCBI ) Viral Genome Resource hosts all virus-related data and tools. (nih.gov)
  • The genome organization and expression strategy can vary dramatically from virus to virus. (nih.gov)
  • Virus Incompleti 0 domande Viruses which lack a complete genome so that they cannot completely replicate or cannot form a protein coat. (lookformedical.com)
  • Virus Riassortanti 0 domande Viruses containing two or more pieces of nucleic acid (segmented genome) from different parents. (lookformedical.com)
Zika1
  • 2016. Zika virus cell tropism in the developing human brain and inhibition by azithromycin. . (ucsb.edu)
Species1
  • Occasionally, more than one RefSeq record is created in a species to represent different subgroups of the virus (e.g. (nih.gov)
Immune1
  • When I first began, my research career in was in the area of virology and that rapidly moved me into the interaction between viruses and the immune system. (nih.gov)
Cells5
  • Batteriofagi 0 domande Viruses whose hosts are bacterial cells. (lookformedical.com)
  • Such viruses are produced in cells coinfected with different strains of a given virus. (lookformedical.com)
  • Recombinant Mouse IFN-alpha 13 Protein ( 10481-IF ) suppresses viral activity on L-929 mouse fibroblast cells infected with encephalomyocarditis (EMC) virus. (bio-techne.com)
  • Measure by its ability to protect HepG2 cells infected with encephalomyocarditis (EMC) virus. (leadgenebio.com)
  • The ED50 as measured in anti-viral assays using human HeLa cells infected with encephalomyocarditis (EMC) virus is 0.15-0.80 ng/ml. (watson-int.cn)
Humans1
Organisms1
  • Viruses are unique compared to other organisms in that there is significant variability in the forms of their genomes-linear or circular, single-stranded or double-stranded, DNA or RNA. (nih.gov)
Vertebrate1
  • A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. (lookformedical.com)
Mutation1
  • 3.2.3 Virus with high recombination rates or mutation rates. (who.int)
Rodents1
  • First investigation of pathogenic bacteria, Protozoa and viruses in rodents and shrews in context of forest-savannah-urban areas interface in the city of Franceville (Gabon). (cabi.org)
Infectious2
  • Virus 1 quesito Minute infectious agents whose genomes are composed of DNA or RNA, but not both. (lookformedical.com)
  • Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI. (academicinfluence.com)
CHIKV1
  • Novel animal models of myositis have been recently developed using Leishmania infantum or Chikungunya virus (CHIKV). (medscape.com)
Human2
Genetic2
Inflammation1
Antigen1
  • Virus preparation and viral antigen preparation available. (nih.gov)
Nucleic1
Protein1
Hosts1
IFNs1
  • Viruses counteract the antiviral response by encoding mechanisms to control IFN signalling, block the actions of IFN-stimulated gene products and disrupt the various levels of cross-talk between IFNs and other cellular pathways. (nature.com)