• We have previously shown that administration of tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 T cell (Th2) cytokine transcription factor GATA-3. (listlabs.com)
  • Accelerated course of experimental autoimmune encephalomyelitis in PD-1-deficient central nervous system myelin mutants. (mcw.edu)
  • Some key differences between EAE in mice, and MS in humans include: B-cells: Some research points to anti-CD20 B-cells being the basis of the autoimmune attacks. (wikipedia.org)
  • Anti-MOG associated encephalomyelitis can be passed from humans to mice, inducing MS type II demyelination (pattern II) Deficiency of TBX21 or STAT4 provides resistance against EAE, while interferon-γ-, interferon-γ-receptor-, interleukin-12 subunit α-, interleukin 12 receptor, β 2 subunit-, and interleukin 18-deficiency exacerbated disease. (wikipedia.org)
  • Recent evidence suggests that clozapine, quetiapine, tamoxifen and pioglitazone may improve functional recovery in multiple sclerosis (MS). We have compared the effectiveness of oral administration of these drugs, beginning at peak disease, at reducing disease severity and demyelination in mice subjected to experimental autoimmune encephalomyelitis (EAE). (dal.ca)
  • This is supported by in vivo results obtained by inducing experimental autoimmune encephalomyelitis (EAE) mimicking multiple sclerosis (MS) in MRlysMcre and MRflox/flox mice. (uni-goettingen.de)
  • Following intravenous administration of these cells to mice with experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), GFP+ cells were observed to migrate specifically into spinal cord lesions. (uni-goettingen.de)
  • Experimental autoimmune encephalomyelitis (EAE) is an animal model of demyelinating disease that exhibits cellular infiltration and a breakdown in the blood-spinal cord barrier (BSB) in mice. (ismrm.org)
  • Experimental autoimmune encephalomyelitis (EAE) mimics key features of MS in humans and is a well-established rodent model for human MS. We have found that xenografts of EBV-immortalized B lymphocytes, which partially resemble the hyperproliferation of EBV-infected cells in IM, exacerbate autoimmune responses in myelin oligodendrocyte glycoprotein-induced EAE in C57BL/6 mice. (nebraska.edu)
  • We tested whether a-LA is capable to prevent MOG35-55-induced experimental autoimmune encephalomyelitis (EAE), an established model of multiple sclerosis (MS). Daily oral administration of a-LA, starting at the time of immunization, significantly prevented EAE progression as compared to control mice. (drcalapai.com)
  • Autoantibody response to MOG (35-55) has been observed in multiple sclerosis (MS) patients and MOG (35-55)-induced experimental autoimmune encephalomyelitis (EAE) C57/BL6 mice and Lewis rats. (anaspec.com)
  • Multiple sclerosis (MS) is a neuroinflammatory disease with an autoimmune component that is characterised by activation of self-reactive lymphocytes, which enter the central nervous system (CNS) and cause destruction of myelin producing cells and neurons leading to the formation of inflammatory lesions. (nature.com)
  • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. (aai.org)
  • We report that experimental autoimmune encephalomyelitis, a T cell-mediated autoimmune disease studied as a model for multiple sclerosis, can be suppressed in Lewis rats by the oral administration of myelin basic protein (MBP). (aai.org)
  • The myelin-oligodendrocyte-glycoprotein (MOG) induced experimental autoimmune encephalomyelitis (EAE) model was used to investigate the retinas of Brown Norway rats with (i) visual evoked potentials (VEP) confirmed ON, (ii) VEP confirmed absence of ON and (iii) control animals. (lu.se)
  • EAE is also the prototype for T-cell-mediated autoimmune disease in general. (wikipedia.org)
  • Depending on the relapse-remission intervals, rats can have up to three bouts of disease within an experimental period. (wikipedia.org)
  • microglia behaviour: In contrast to experimental models of inflammatory demyelination, lesion formation in multiple sclerosis occurs on a background of pro-inflammatory microglia activation, which is seen already in the normal white matter of age-matched controls, and this may contribute to neurodegeneration in the disease. (wikipedia.org)
  • The reactions have been diverse according to the sources of the disease The researchers in the last report have termed the condition "human autoimmune encephalitis" (HAE). (wikipedia.org)
  • Multiple sclerosis (MS) is a demyelinating autoimmune disease mediated by infiltration of T cells into the central nervous system after compromise of the blood-brain barrier. (listlabs.com)
  • Our results indicate that JQ1 and I-BET726 possess therapeutic benefits for autoimmune diseases by adjusting innate and adaptive immune response, indicating that BET bromodomain might be potential molecular targets for autoimmune disease therapy. (authorea.com)
  • The oral administration of a non-disease-inducing portion of an autoantigen represents an antigen-specific method by which an experimental autoimmune disease can be immunoregulated. (aai.org)
  • Measurement of the length of time between introduction of a disease-producing stimulus to the observation of symptoms of experimental autoimmune encephalomyelitis (EAE), an animal model of brain inflammation in which inflammation is induced through immunization of the animal with central nervous system antigens or by the passive transfer of autoreactive T cells. (mcw.edu)
  • Our data show that the interplay between immune dysregulation and myelinopathy results in a stable exacerbation of actively induced autoimmune CNS inflammation, suggesting that the combination of several pathological issues contributes significantly to disease susceptibility or relapses in human disease. (mcw.edu)
  • The factors that contribute to disease progression in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are not known. (aai.org)
  • These therapies inhibit the proinflammatory action of TNF-α in common autoimmune diseases such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease. (frontiersin.org)
  • TNF-α blockade quickly became the "standard of care" for these autoimmune diseases due to their effectiveness in controlling disease and decreasing patient's adverse risk profiles compared to broad-spectrum immunosuppressive agents. (frontiersin.org)
  • An experimental animal model for central nervous system demyelinating disease. (nih.gov)
  • In conclusion, vitamin D has properties that could ameliorate immune-mediated disease, and vitamin D deficiency has been a common finding in immune-mediated liver and non-liver diseases, including autoimmune hepatitis. (springer.com)
  • Experimental encephalomyelitis at age 90, still relevant and elucidating how viruses trigger disease. (stanford.edu)
  • Weighing In On Autoimmune Disease: 'Hub-and-spoke' T cell traffic in autoimmunity. (stanford.edu)
  • JQ1 and I-BET726, new inhibitors of BET proteins, have potential therapeutic benefit for autoimmune diseases (AD). (authorea.com)
  • In this study, we explored the effects of JQ1 and I-BET726 on innate and adaptive immunity in experimental autoimmune encephalomyelitis (EAE) model to investigate the mechanism and therapeutic benefit for AD. (authorea.com)
  • Cell-based modulation of autoimmune responses in multiple sclerosis and experimental autoimmmune encephalomyelitis: therapeutic implications. (bvsalud.org)
  • The therapeutic effect of mesenchymal stem cells (MSCs) in multiple sclerosis (MS) and the experimental autoimmune encephalomyelitis (EAE) model has been well described. (uandes.cl)
  • However, anti-TNF-α therapies have limitations, including known adverse safety risk, loss of therapeutic efficacy due to drug resistance, and lack of efficacy in numerous autoimmune diseases, including multiple sclerosis. (frontiersin.org)
  • The results support the conclusion that development of autoimmune-directed inflammation in the CNS is associated with differences in hsp 60 expression that may act as an additional target and/or modulator of the immune response. (aai.org)
  • Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
  • Multiple sclerosis (MS) is a prototypic autoimmune inflammatory disorder of the central nervous system (CNS). (bvsalud.org)
  • It is assumed that the onset and course of autoimmune inflammatory central nervous system (CNS) disorders (eg, multiple sclerosis) are influenced by factors that afflict immune regulation as well as CNS vulnerability. (mcw.edu)
  • Activation of invariant NKT cells in early phase of experimental autoimmune encephalomyelitis results in differentiation of Ly6Chi inflammatory monocyte to M2 macrophages and improved outcome. (ox.ac.uk)
  • We show in this article that Ly6C(hi) inflammatory monocytes are the early and dominant infiltrating cells in the CNS during experimental autoimmune encephalomyelitis, a model for the acute phase of multiple sclerosis. (ox.ac.uk)
  • The standard treatment for autoimmune or autoinflammatory diseases had long been immunosuppressive agents until the advent of immunomodulatory biologic drugs, which aimed at blocking inflammatory mediators, including proinflammatory cytokines. (frontiersin.org)
  • Among these diverse features, it should be acknowledged that auto-antibodies toward glutamate receptors, GABA receptors, and K + channel-related proteins are preferentially found in autoimmune limbic encephalitis but not in IMCAs [ 10 ] (Table 1 ). (springer.com)
  • In autoimmune limbic encephalitis, it is assumed that these auto-antibodies diffusely interfere with basal synaptic transmission or neural excitability and weaken overall functions of the temporal lobe [ 18 ]. (springer.com)
  • Previous studies in our lab revealed that chemical zinc chelation or zinc transporter 3 ( ZnT3 ) gene deletion suppresses the clinical features and neuropathological changes associated with experimental autoimmune encephalomyelitis (EAE). (mdpi.com)
  • UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production. (second-opinions.co.uk)
  • Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis. (stanford.edu)
  • Along these lines, other cell subsets such as dendritic cells (DCs), myeloid-derived suppressor cells ( MDSCs ), γδ T cells and natural killer (NK) cells have been shown to regulate the autoimmune response in the CNS under certain circumstances. (bvsalud.org)
  • It is now well documented that experimental autoimmune encephalomyeltitis (EAE) can be effectively prevented by estrogen therapy. (elsevierpure.com)
  • Vitamin D deficiency has been commonly present in patients with immune-mediated liver and non-liver diseases, and it has been associated with histological severity, advanced hepatic fibrosis, and non-response to conventional glucocorticoid therapy in autoimmune hepatitis. (springer.com)
  • These observations have implications for therapy of autoimmune diseases. (nih.gov)
  • The goals of this review are to describe the nature of these expanded roles, examine the implications of vitamin D deficiency in autoimmune hepatitis, and identify opportunities for future investigation. (springer.com)
  • Blockade of the CD28-B7 or CD40L-CD40 T cell costimulatory signals prevents induction of experimental autoimmune encephalomyelitis (EAE). (nih.gov)
  • WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome. (cdc.gov)
  • Our data indicate that a-LA can effectively interfere with the autoimmune reaction associated with EAE through mechanisms other than its antioxidant activity and supports further studies on the use of a-LA as a potential for MS. (drcalapai.com)
  • Vitamin D analogues that are independent of hepatic hydroxylation constitute an investigational opportunity to supplement current management of autoimmune hepatitis. (springer.com)
  • Beyazit Y, Kocak E, Tanoglu A, Kekilli M. Oxidative stress might play a role in low serum vitamin D associated liver fibrosis among patients with autoimmune hepatitis. (springer.com)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • Their findings upon a transfer of inflamed patient tissue to primates was published in the Journal of Experimental Medicine. (wikipedia.org)
  • 1 Experimental Ultrahigh Field Magnetic Resonance, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany. (jci.org)
  • 5 Experimental and Clinical Research Center, a joint venture of the Max Delbrück Center for Molecular Medicine and the Charité - Universitätsmedizin Berlin, Berlin, Germany. (jci.org)
  • Or to: Friedemann Paul, Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Lindenberger Weg 80, D-13125 Berlin, Germany. (jci.org)
  • Journal of Experimental Medicine. (lu.se)
  • Clinical and experimental medicine 2023 0 0. (cdc.gov)
  • Advances in experimental medicine and biology 2023 0 0. (cdc.gov)
  • We report the autopsy findings for a 45-year-old man with polyradiculoneuropathy and fatal acute disseminated encephalomyelitis after having Mycoplasma pneumoniae pneumonia. (cdc.gov)
  • The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. (mcw.edu)