• Taken together, these data indicate the autoreactive T cells can be genetically designed to produce therapeutic factors in an antigen-inducible manner resulting in a decreased severity of clinical and histological autoimmune demyelinating disease. (rupress.org)
  • The objective of this study is to evaluate the activity of a novel peptide, i.e., bifunctional peptide inhibitor (BPI), which targets the immunological synapse and inhibits autoimmune responses in an antigen-specific manner. (aspetjournals.org)
  • We here study the adjuvant properties of immunostimulatory DNA sequences (ISS) and coinjected cytokine-coding cDNA in suppressive vaccination with DNA encoding an autoantigenic peptide, myelin basic protein peptide 68-85, against Lewis rat experimental autoimmune encephalomyelitis (EAE). (diva-portal.org)
  • DESCRIPTION (provided by applicant): There are over 80 different autoimmune diseases that are debilitating against which currently there is no cure. (labome.org)
  • These results suggest that BPI-type molecules can be used to treat different autoimmune diseases in which antigenic epitopes have been identified. (aspetjournals.org)
  • Their findings upon a transfer of inflamed patient tissue to primates was published in the Journal of Experimental Medicine. (wikipedia.org)
  • In a previous study, we demonstrated that mouse adult F 1 offspring, exposed to a vitamin D deficiency during pregnancy, developed a less severe and delayed Experimental Autoimmune Encephalomyelitis (EAE), when compared with control offspring. (mdpi.com)