• Nanoparticles range in size from 10 - 1000 nm (or 1 µm) and they can be made from natural or artificial polymers, lipids, dendrimers, and micelles. (wikipedia.org)
  • Herein, a redox and pH dual-responsive poly(ethylene glycol)-SS-b-polypeptide micelles encapsulated with disulfide bridged paclitaxel-pentadecanoic acid prodrug was developed for cancer chemotherapy. (bvsalud.org)
  • Many methods were successfully evaluated to prepare chitosan nanoparticles for loading various compounds including ionotropic gelation, micelles and emulsification methods. (sysrevpharm.org)
  • In this sense, biomaterials can be categorized into polymers, liposomes, micelles, dendrimers, and calcium phosphate (CaP) nanoparticles, where each will show a different type of bioactivity. (encyclopedia.pub)
  • Various nanocarriers are being introduced and assessed, such as polymer nanoparticles, liposomes, and micelles. (hindawi.com)
  • Targeted drug delivery systems (DDS) for cancer therapy, including nanoparticles, lipids, micelles and liposomes, have been studied for decades. (eurekaselect.com)
  • We have prepared stable PLGA nanoparticles (NPs) and evaluated their capacity to transport an active molecule into the human monocyte/macrophage cell line THP-1 using bovine serum albumin (BSA) as a proof-of-concept compound. (canada.ca)
  • Solution blowing of such plant-derived biomaterials as soy protein, zein, lignin, oats, sodium alginate and cellulose acetate, and such animal-derived biomaterials as silk protein (sericin), chitosan and bovine serum albumin, was demonstrated as a versatile, robust and industrially scalable approach to form monolithic and core-shell nanofibers from bio-waste. (sbpmat.org.br)
  • One type of nanoparticle involves use of liposomes as drug molecule carriers. (wikipedia.org)
  • In this study sterically stabilized liposomes was prepared from DPPC/Cholesterol/PEG-PE encapsulated doxorubicin. (biomedcentral.com)
  • The results indicated that lyophilization of the prepared liposomes encapsulating doxorubicin led to marked stability when stored at 5 °C and it is possible to use the re-hydrated lyophilized liposomes within 12 days post reconstitution. (biomedcentral.com)
  • We can conclude that lyophilization of the liposomes encapsulating doxorubicin lead to marked stability for the liposomes when stored at 5°C. Moreover, the use of low energy diode laser for targeting anticancer drug to the tumor cells through the use of photosensitive sterically stabilized liposomes loaded with doxorubicin is a promising method. (biomedcentral.com)
  • There are four main strategies to target drugs encapsulated liposomes. (biomedcentral.com)
  • Some of the nanotheranostic platforms highlighted include photoactivatable multi-inhibitor nanoliposomes, plasmonic nanobubbles, reduced graphene oxide-iron oxide nanoparticles, photoswitching nanoparticles, multispectral optoacoustic tomography using indocyanine green, low temperature sensitive liposomes, and receptor-targeted iron oxide nanoparticles loaded with gemcitabine. (ntno.org)
  • Nanoparticles based drug delivery systems have the potential for realizing water soluble formulation of highly hydrophobic anticancer drugs like niclosamide, thus evading the drawbacks of poor solubility. (rsc.org)
  • were used to encapsulate the hydrophobic drug, tamoxifen, in albumin nanoparticles. (ewha.ac.kr)
  • Iron oxide nanoparticles functionalized with novel hydrophobic and hydrophilic porphyrins as potential agents for photodynamic therapy. (docksci.com)
  • Please cite this article as: O. Penon, M.J. Marín, D.B. Amabilino, D.A. Russell, L. Pérez-García, Iron oxide nanoparticles functionalized with novel hydrophobic and hydrophilic porphyrins as potential agents for photodynamic therapy, Journal of Colloid and Interface Science (2015), doi: http://dx.doi.org/10.1016/j.jcis. (docksci.com)
  • Abstract The preparation of novel porphyrin derivatives and their immobilization onto iron oxide nanoparticles to build up suitable nanotools for potential use in photodynamic therapy (PDT) has been explored. (docksci.com)
  • To achieve this purpose, a zinc porphyrin derivative, ZnPR-COOH, has been synthesized, characterized at the molecular level and immobilized onto previously synthesized iron oxide nanoparticles covered with oleylamine. (docksci.com)
  • In the past few years, the mentioned lipid-based nanoparticles (LNP) can improve both the water solubility and the bioavailability of drugs. (9dok.org)
  • Most polymers used for nanoparticle drug delivery systems are natural, biocompatible, and biodegradable, which helps prevent contamination in the CNS. (wikipedia.org)
  • Polymers with distinct characteristics are widely used but nature origin polymer has its own important properties that make it a choice as polymer for nanoparticles. (sysrevpharm.org)
  • 2004). Chitosan is considered one of the most valuable polymers for biomedical and pharmaceutical applications and can be used in the development of nanoparticles, microspheres, hydrogels, films, and fibers (Kumar MN, 2000). (sysrevpharm.org)
  • Under suitable gentle conditions, the proteinoid polymers may self-assemble to form nano-sized hollow proteinoid nanoparticles (NPs) of a relatively narrow size distribution. (nature.com)
  • The use of encapsulated nanosized antiretrovirals in various polymers has shown potential for enhanced permeation into the CNS and other latent viral reservoirs thus providing hope for prevention and treatment of neurocognitive disorders in HIV positive patients. (rroij.com)
  • Nanoparticles for drug delivery to the brain is a method for transporting drug molecules across the blood-brain barrier (BBB) using nanoparticles. (wikipedia.org)
  • Intracellular localization of fluorescent BSA molecules encapsulated into PLGA NPs was monitored in live cells using confocal microscopy, and cellular uptake was quantified by flow cytometry. (canada.ca)
  • Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmaco-dynamic properties of various types of drug molecules. (ijpsr.com)
  • Regarding the porosity and pore structure effect on nanoparticles' ability to adsorb and retain the cargo, it is known that mesoporous inorganic materials with high pore volume and adequate pore size are able to adsorb higher amounts of therapeutic molecules and ensure a sustained release [ 2 ] [ 4 ] . (encyclopedia.pub)
  • Agrochemical molecules may be encapsulated within these hollow proteinoid NPs, integrated in the crude proteinoid shell, or bound covalently/physically to the NP surface. (nature.com)
  • Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. (mdpi.com)
  • Thus, the current study was carried out using sophorolipid (ASL) encapsulated curcumin as fluorescence tagging system in bacterial cells. (campaignfornonviolentschools.org)
  • The current studies reveal that at the optimum concentration Chalcone 4 hydrate of 5?w/v%, acidic sophorolipid can encapsulate curcumin. (campaignfornonviolentschools.org)
  • Physico-chemical characterization confirms that the prepared nanoparticles are spherical, highly monodispersed, and stable in aqueous systems. (rsc.org)
  • This article reviews the introduction of nanoparticles with especial focus on protein nanoparticles with preparation, characterization and applications of Protein Nanoparticles. (ijpsr.com)
  • Nanoparticles are a type of colloidal system comprising particles with a size range from 10 to 1000 nm in diameter ( Figure 1 ). (sysrevpharm.org)
  • One of the colloidal carrier systems is the human serum albumin based nanoparticles. (9dok.org)
  • Another type of colloidal carrier systems is the solid lipid nanoparticles (SLN). (9dok.org)
  • The ephedrine alkaloid-containing colloidal nanoparticles discovered in another licorice containing Chinese medicinal decoction [ 12 ] imply that licorice root proteins would hypothetically interact with aconitine to form aggregates thereafter affecting the toxicity. (springer.com)
  • In this article we have reviewed the current aspects made-up from chitosan nanoparticles. (sysrevpharm.org)
  • Chitosan nanoparticles having application to improve bioavailability, controlled released of loaded drug also increases cellular uptake and targeting to cancer cells, stabilization of proteins and enhanced the affectivity of anti-microbial agents. (sysrevpharm.org)
  • In agriculture chitosan nanoparticles are used for herbicides, insecticide and pesticide loading to improve the cultivation of crops and used in foods packaging. (sysrevpharm.org)
  • Chitosan nanoparticles are also having wide application as an implant and therapeutics agent. (sysrevpharm.org)
  • In this work niclosamide was encapsulated into albumin nanoparticles through a desolvation method to improve its scope of application in cancer therapy. (rsc.org)
  • Gallic acid (GA) has been encapsulated under optimal desolvation conditions using the FEA/GA acid ratios of 1:1, 2:1, 4:1, and 8:1. (jrespharm.com)
  • Further research in the field proved that the use of preparations containing albumin nanoparticles does not only improve the solubility of the drug, but can also exhibit other beneficial effects, such as targeted therapy. (9dok.org)
  • Voriconazole, the model active pharmaceutical ingredient, exhibits low water solubility, making the drug difficult to administer in liquid preparation, so nanoparticles can be good candidates to encapsulate VCZ, potentially increase its water solubility and its therapeutic efficacy in the treatment of fungal infection. (9dok.org)
  • These drug encapsulated albumin nanoparticles, unlike the free drug demonstrate better in vitro therapeutic efficacy against human lung and breast cancer cell lines, as assessed by cell viability assay and morphological analyses. (rsc.org)
  • Methods: We constructed nanoparticles to fully encapsulate the therapeutic drug (ginsenoside Rg1), which can be transferred into brain tissue via the receptor-mediated transfer of drug-encapsulated nanoparticles. (cbinsights.com)
  • Among the various existing nanosystems, nanoparticles have the ability to transform conventional medicine by reducing the adverse effects and providing a controlled release of therapeutic agents. (oaepublish.com)
  • With the aid of nanoparticle delivery systems, however, studies have shown that some drugs can now cross the BBB, and even exhibit lower toxicity and decrease adverse effects throughout the body. (wikipedia.org)
  • In this study, a boiling-stable 31-kDa protein (namely GP) was purified from licorice and self-assembled into nanoparticles (206.2 ± 2.0 nm) at pH 5.0, 25 °C. The aconitine-encapsulated GP nanoparticles (238.2 ± 1.2 nm) were prepared following the same procedure and tested for its toxicity by intraperitoneal injection on ICR mouse ( n = 8). (springer.com)
  • Encapsulation of poisonous alkaloids into self-assembled herbal protein nanoparticles contributes to toxicity attenuation of combined use of herbs, implying a prototype nanostructure and a universal principle for the safer clinical applications of herbal medicines. (springer.com)
  • The aim of this study was to develop mechanical homogenization processes to fabricate protein-based nanoparticles. (ewha.ac.kr)
  • Considering this, the current study aims to fabricate stable egg albumin nanoparticles by using chloroacetic acid to modify their surfaces. (jrespharm.com)
  • To date, various nanomedicines have been approved by the FDA for cancer therapy, such as paclitaxel albumin-bound nanoparticles (Abraxane) and liposomal irinotecan (Onivyde) ( Ventola, 2017 ). (frontiersin.org)
  • Fluorescent nanodiamonds encapsulated by Cowpea Chlorotic Mottle Virus (CCMV) proteins for intracellular 3D-trajectory analysis. (mpg.de)
  • In this study, we utilized the negatively charged and FDA approved polymer poly(lactic-co-glycolic acid) to encapsulate Notch Intracellular Domain-containing plasmid in nanoparticles. (frontiersin.org)
  • Here the methods of the synthesis of alginate beads, micro- and nanoparticles are reviewed with special attention to the calcium alginate ones. (blogspot.com)
  • Facile synthesis of ultrasmall polydopamine-polyethylene glycol nanoparticles for cellular delivery. (mpg.de)
  • The potentials to overcome the problem of burst release of the encapsulated substances by means of cyclodextrin inclusion complexes and employing additional crosslinking agents are also discussed. (blogspot.com)
  • These means include dissolving or absorbing a drug throughout the nanoparticle, encapsulating a drug inside the particle, or attaching a drug on the surface of the particle. (wikipedia.org)
  • SEM monochrome image of functionalized EA nanoparticles also supported the particle size of around 130 nm. (jrespharm.com)
  • Out of the investigated systems, solid lipid nanoparticles (SLN) offer unique properties, such as the few hundred nanometers particle size and high drug loading capacity due to their large surface area. (9dok.org)
  • Injection of GP-AC nanoparticles and the mixed licorice-aconite decoction, respectively, caused mild recoverable toxic effects and no death, while the aconitine, particle-free GP-AC mixture and aconite decoction induced sever toxic effects and 100 % death. (springer.com)
  • In order to achieve the set goals, the aims was to study the effect of the applied organic solvent, concentration of VCZ, the concentration of the HSA solution and the ratio of the organic and aqueous solutions on the prepared nanoparticles. (9dok.org)
  • Fluorescent dye Rhodamine B was used as a model hydrophilic drug in controlled release experiments after it had been encapsulated in solution-blown soy protein-containing hydrophilic nanofibers and the release kinetics associated with dye desorption was studied in detail. (sbpmat.org.br)
  • Next, using genetically modified plants, which express fluorescent protein and are responsive to the level of auxin, we demonstrated the possibility to deliver encapsulated agrochemicals into cells. (nature.com)
  • Zhao, Y. TPGS-stabilized NaYbF4: Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance. (eurekaselect.com)
  • To obtain stable nanoparticles of suitable size, various reaction parameters viz concentration of FEA, pH, agitation speed, glutaraldehyde concentration, and rate of ethanol addition were examined. (jrespharm.com)
  • We demonstrated that our nanoparticles are non-toxic, stable over time, and compatible with blood. (frontiersin.org)
  • This was a huge breakthrough in the nanoparticle drug delivery field, and it helped advance research and development toward clinical trials of nanoparticle delivery systems. (wikipedia.org)
  • The clinical application of alginate nanoparticles is still limited because of the burst release of encapsulated drugs and the poor size control of the particles formed. (blogspot.com)
  • The translation of nanoparticles (NPs) from laboratory to clinical settings is limited, which is not ideal. (hokudai.ac.jp)
  • The surface morphology of the nanoparticles determined by transmission electron microscopy showed semi-spherical nanoparticle shapes. (ewha.ac.kr)
  • The obtained GA entrapped FEA spherical nanoparticles (GA-FEA) had a -30.9mV zeta potential and were negatively charged. (jrespharm.com)
  • In contrast to BSA alone, BSA encapsulated into PLGA NPs increased leukocyte infiltration in vivo, suggesting the in vivo enhanced delivery and protection of the protein by the polymer nanocarrier. (canada.ca)
  • Albumin-basednanoparticles (NP-HSA, diameter 100 Å ) is the newest frontier in thisfield since they retain most of the parent protein features, showing yet muchhigher stability and exhibiting the capability to encapsulate small moleculedrugs that are released over time. (cnr.it)
  • Nowadays active research is focused on the preparation ofnanoparticles using proteins like albumin, gelatin, gliadin and legumin.Protein nanoparticles hold promise as drug delivery systems for parentral as well as oral. (ijpsr.com)
  • Nanomaterials derived from proteins, especially protein nanoparticles are biodegradable, non-antigenic, metabolizable and can also be easily amenable for surface modification and covalent attachment of drugs and ligands. (ijpsr.com)
  • Because of the defined primary structure of proteins the protein-based nanoparticles may suggest various possibilities for surface alteration and covalent drug attachment 2 . (ijpsr.com)
  • When exposed to biological medium or multiple composition dispersions like herbal decoction, protein corona formed on the nanoparticles (NPs) diversely alters the biological fate and pharmaceutical efficacy of particles [ 10 ]. (springer.com)
  • In this paper, we review the use of remotely triggered theranostic nanoparticles for cancer applications, focusing heavily on advances in the past five years. (ntno.org)
  • He, H. Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells. (eurekaselect.com)
  • Conclusion: The ginsenoside Rg1 nanoparticles may be an available blood-brain barrier penetrating agent for ischemic stroke. (cbinsights.com)
  • Further, the proficient induction of apoptosis by these nanoparticles was confirmed by semi-quantitative RT-PCR. (rsc.org)
  • First, three RBD mRNAs of SARS-CoV-2, Delta, and Omicron were coencapsulated into lipid nanoparticles (LNPs) by using microfluidic technology. (bvsalud.org)
  • Nanoparticles with Proteins are especially worthy of notice because they can be used for site specific targeting. (ijpsr.com)
  • HAP nanoparticles have been used as vehicles for delivery due to their affinity to DNA, proteins, several drugs, and proper release activity. (encyclopedia.pub)
  • Cholesterol, a type of lipid, is also often incorporated in the lipid-nanoparticle formulation. (wikipedia.org)
  • Nanoparticles have been widely used as nanocarriers in recent years. (hindawi.com)
  • The characteristics of the optimized nanoparticles were within the desired range to meet the requirements of intravenous injection. (ewha.ac.kr)
  • We show that primary human umbilical vein endothelial cells (HUVECs) readily uptake the nanoparticles with and without specific antibody targets. (frontiersin.org)
  • Compared with general treatments, nanomedicines greatly increase the efficiency of therapy (e.g., the increased loading compacity, prolonged circulation of drug and combined therapies, etc.) and limit side effects (e.g., encapsulated anti-cancer drugs and specific tumor targeting, etc. (frontiersin.org)
  • 1) The aim of the study was to prepare and investigate the critical parameters of producing voriconazole-loaded nanoparticles (VCZ-NPs). (9dok.org)
  • 2) The other objective of the study was to formulate and evaluate solidlipid nanoparticles of VCZ (VCZ-SLN) and to determine the critical parameters of preparation. (9dok.org)
  • One of the reasons for this is that we currently have limited ability to precisely regulate various physicochemical parameters of nanoparticles. (hokudai.ac.jp)
  • Another type of lipid-nanoparticle that can be used for drug delivery to the brain is a cationic liposome. (wikipedia.org)
  • Further, the secondary structure of albumin in nanoparticles was determined via circular dichroism, which showed only slight structural changes versus native albumin, making it a promising, self-targeted drug delivery system. (ewha.ac.kr)
  • Guerrero-Beltrán, C.E. Hydroxyapatite Nanoparticles in Drug Delivery. (encyclopedia.pub)
  • Hydroxyapatite Nanoparticles in Drug Delivery" Encyclopedia , https://encyclopedia.pub/entry/15487 (accessed December 05, 2023). (encyclopedia.pub)
  • Nanoparticles can come in contact with the human body through inhalation but also through ingestion, dermal deposition, or by medical applications through injection. (ijpsr.com)
  • The present invention provides systems, methods, and compositions for targeted delivery of nanoparticles and/or agents to tissues, cells, and/or subcellular locales. (patsnap.com)
  • Human serum albumin (HSA), is the natural ligand carrier most abundant(40 mg/mL) and with the longest half-life in the blood (19 days). (cnr.it)
  • Evaluation of the HET-CAM model for biodistribution studies of nanoparticles using PET and MR imaging. (mpg.de)
  • Along with delivery and transport methods, there are several means of functionalizing, or activating, the nanoparticle carriers. (wikipedia.org)
  • Though there exist many obstacles that make developing a robust delivery system difficult, nanoparticles provide a promising mechanism for drug transport to the CNS. (wikipedia.org)
  • For nanoparticles, most studies have shown increasing progression with intravenous delivery. (wikipedia.org)
  • Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
  • High-Contrast Magnetic Resonance Imaging and Efficient Delivery of an Albumin Nanotheranostic in Triple-Negative Breast Cancer Xenografts. (mpg.de)
  • Lastly, we elucidated that these nanoparticles could upregulate the downstream genes of Notch signaling, indicating that the payload was viable and successfully altered the genetic downstream effects. (frontiersin.org)
  • Nanoparticles have advantages, such as small size, high surface area, and modification using functional groups for high capacity or selectivity. (ijpsr.com)
  • One of the main advantages of working with nanoparticles is the manipulation of their properties by controlling the material, size and shape of the nanocore, and the chemical functionalization with specific ligands, which provides multifunctionality to the nanosystem [6]. (docksci.com)
  • Lipid nanoparticles can be manufactured by high pressure homogenization, a current method used to produce parenteral emulsions. (wikipedia.org)
  • Finally, BT474 viability assays and western blot analysis showed the effectiveness of the tamoxifen-loaded albumin nanoparticles prepared via homogenization. (ewha.ac.kr)
  • High-Contrast Imaging of Nanodiamonds in Cells by Energy Filtered and Correlative Light-Electron Microscopy: Toward a Quantitative Nanoparticle-Cell Analysis. (mpg.de)