CatalysisCatalytic Enantioselective SynthesisTransformationsAsymmetricTotal SynthesisCyclizationDiels-AlderAldehydesKetoneReactionsDerivativesAlkenesHighlyCatalystsDevelopmentsAdvancesSignificantlyChemistryApproachTitleReportsLeadJournalProtocolSynthesisCatalytic enantioselectiveConjugateAllylicAliphaticHydrogenationAlcoholsCycloadditionSynthesesCatalystComplexesIntramolecularDesymmetrizationCopper catalyzed
Catalysis5
- Enantioselective catalysis (known traditionally as "asymmetric catalysis") is performed using chiral catalysts, which are typically chiral coordination complexes. (wikipedia.org)
- Catalysis is effective for a broader range of transformations than any other method of enantioselective synthesis. (wikipedia.org)
- Scott Denmark reports on the enantioselective sulfenocyclization of polyenes under Lewis base catalysis. (thieme.de)
- A novel family of urea-derived chiral iodoarenes was designed and synthesized for use in enantioselective iodine(I/III) catalysis. (hud.ac.uk)
- Finally, and perhaps most interestingly, studies aimed at enantioselective catalysis are presented, resulting in the first example of enantioselective Lewis-acid catalysis of an organic transformation in water. (chempedia.info)
Catalytic Enantioselective Synthesis1
- The first catalytic enantioselective synthesis of benzodiazepinones employing an efficient hydrogenation protocol has been developed. (edu.sa)
Transformations4
- In the past three decades, metal-catalysed enantioselective transformations have attained a significant level of expertise and refinement as it was recognised that these are among the most efficient ways to produce enantioenriched materials. (europa.eu)
- However, protocols for enantioselective synthesis are rather limited and these stereospecific transformations require stoichiometric amounts of optically pure reagents and do not create new stereogenic centers. (duke.edu)
- Impressive progress on enantioselective titanium-catalysed transformations has been achieved in the past seven years, with exciting new discoveries ranging from basic reactions to novel methodologies. (feelbooks.in)
- This book contains up to date research and covers all types of enantioselective transformations using chiral titanium catalysts. (feelbooks.in)
Asymmetric3
- Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis. (wikipedia.org)
- A versatile example of enantioselective synthesis is asymmetric hydrogenation, which is used to reduce a wide variety of functional groups. (wikipedia.org)
- Swindell CS, Tao M (1993) Chiral Auxiliary-Mediated Asymmetric Induction in a Thermal Inverse Electron Demand Hetero - Diels-Alder Reaction - Enantioselective Synthesis of the Taxol A-Ring Side Chain . (chempedia.info)
Total Synthesis1
- Tadashi Katoh and co-workers, Tohoku Pharmaceutical University, Japan, have reported the enantioselective total synthesis of (+)-stachyflin. (chemistryviews.org)
Cyclization2
- Tariq, M & Moran, WJ 2020, ' Design and synthesis of chiral urea-derived iodoarenes and their assessment in the enantioselective dearomatizing cyclization of a naphthyl amide ', Tetrahedron , vol. 76, no. 45, 131634. (hud.ac.uk)
- A concise enantioselective synthesis of the fungal metabolite ent-malbrancheamide B was accomplished through the union of a C-prenylated proline derivative and a substituted indole pyruvic acid SEM enol ether, followed by a cationic double cyclization as the key step. (birmingham.ac.uk)
Diels-Alder4
- The first highly enantioselective catalytic hetero Diels-Alder reaction of ketones. (dtu.dk)
- Among these approaches, the dipole/HOMO-controlled reactions of electron-deficient alkenes are especially promising because a variety of combinations between chiral Lewis acids and electron-deficient alkenes have been well investigated in the study of catalyzed enantioselective Diels-Alder reactions. (chempedia.info)
- As for the aza- Diels-Alder reaction , enantioselective reactions between imino dienophiles 60 and diene 61, using a chiral binaphtholzirco-nium catalyst 23, are known (Eq. 26) [27]. (chempedia.info)
- Chiral substituents in dienophiles can be used to make Diels-Alder reactions enantioselective. (chempedia.info)
Aldehydes2
- Sterically encumbered chiral pyrrolidine derivatives are highly efficient organocatalysts for the direct enantioselective α sulfenylation of aldehydes using an electrophilic sulfur source. (organic-chemistry.org)
- The enantioselective catalytic alkynylation of aromatic aldehydes is reported using a sterically highly hindered bis-cyclometalated rhodium-based Lewis acid catalyst featuring the octahedral metal as the only stereogenic center. (researcher-app.com)
Ketone1
- Previous studies on enantioselective synthesis of α-heterocyclic amine derivatives include diastereoselective addition of organometallics to enantiopure pyridyl imines derived from Ellman auxiliary, and enantioselective reduction of a pyridyl ketone, conversion to a leaving group, and azide displacement followed by the reduction to obtain the amine. (duke.edu)
Reactions3
- New directing-group-free enantioselective [2 + 2] photocycloaddition reactions that give chiral cyclobutanes would be useful. (chemistryviews.org)
- It illustrates the economic, health, and environmental benefits of chiral titanium catalysts, showing the types of highly enantioselective reactions that they are able to induce are unlimited. (feelbooks.in)
- Nitrones are important 1,3-dipoles that have been the target of catalyzed enantioselective reactions [66]. (chempedia.info)
Derivatives1
- The regio- and enantioselective synthesis of cyclobutane derivatives can be challenging. (chemistryviews.org)
Alkenes1
Highly3
- Their reinvestigation of this protocol led the authors to achieve a catalytic, highly enantioselective procedure using furyl ( 6 ) or cumyl hydroperoxides ( 7 ). (organic-chemistry.org)
- Koenigs, René M. / First highly enantioselective synthesis of benzodiazepinones by catalytic hydrogenation . (edu.sa)
- A highly regioselective and enantioselective C7-Friedel-Crafts alkylation of 4-aminoindoles with trifluoromethyl ketones promoted by a spirocyclic phosphoric acid was developed. (bvsalud.org)
Catalysts1
- Most enantioselective catalysts are effective at low substrate/catalyst ratios. (wikipedia.org)
Developments1
- This is mainly due to new developments in the enantioselective sulfoxidation of sulfides that is the most straightforward method for their synthesis, where overoxidation is the major problem. (organic-chemistry.org)
Advances2
- Despite the many advances that have been made in this area, catalytic, enantioselective polyene cyclizations are significantly less well developed. (thieme.de)
- Although enantioselective synthesis remains an ongoing challenge, exciting recent advances in this area feature spirooxindoles with greater complexity, up to eight stereogenic centers, more practical synthetic methods, and new catalytic activation strategies. (rsc.org)
Significantly1
- Via analysis of the urines of two patients, the metabolism of MDMA is demonstrated to be enantioselective, with significantly higher urinary amounts of R-(-)-MDMA being excreted compared to S-(+)-MDMA. (erowid.org)
Chemistry1
- Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of pharmaceuticals, as the different enantiomers or diastereomers of a molecule often have different biological activity. (wikipedia.org)
Approach2
- A novel hybrid online enantioselective four-dimensionaldynamic GC (e4D-DGC) approach to study reversible molecular interconversion through specific isolation of a diastereo and enantiopure oxime, 2-phenylpropanaldehyde oxime, from prior multidimensional separation, is described. (monash.edu)
- Ganesh, Krishna N. (2002) Enantioselective enzymatic approach to (+)-and (-)-2-acetoxy/hydroxycyclopentanones Tetrahedron: Asymmetry, 13 (13). (ias.ac.in)
Title1
- Su folleto {{ title }} generado en {{ timestamp }} está listo para descargar. (europa.eu)
Reports1
- This review features efficient strategies for the enantioselective synthesis of spirocyclic oxindoles, focusing on reports in 2010 and 2011. (rsc.org)
Lead1
- A new strategy for the enantioselective synthesis of tetrahydrofuran imidazole based human histamine H3 and H4 receptor potential agonists was designed based on the lead structures imifuramine and OUP-16. (uni-regensburg.de)
Journal2
- Concise Enantioselective Synthesis of ent-Malbrancheamide B . Journal of the American Chemical Society , 131 (12), 4214-4215. (birmingham.ac.uk)
- Frebault F, Simpkins N, Fenwick A. Concise Enantioselective Synthesis of ent-Malbrancheamide B . Journal of the American Chemical Society . (birmingham.ac.uk)
Protocol1
- A new modification of the Modena protocol [Ti(O i -Pr) 4 /( R,R )-DET 1:4 and t -butyl hydroperoxide] for the enantioselective oxidation of alkyl (73% yield, 91% ee) and alkyl aryl (63-99% yield, 70-97% ee) sulfides is now reported by Scettri and co-workers. (organic-chemistry.org)
Synthesis14
- Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis. (wikipedia.org)
- Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of pharmaceuticals, as the different enantiomers or diastereomers of a molecule often have different biological activity. (wikipedia.org)
- As such enantioselective synthesis is of great importance but it can also be difficult to achieve. (wikipedia.org)
- Enantioselective synthesis can be achieved by using a chiral feature that favors the formation of one enantiomer over another through interactions at the transition state. (wikipedia.org)
- Catalysis is effective for a broader range of transformations than any other method of enantioselective synthesis. (wikipedia.org)
- A versatile example of enantioselective synthesis is asymmetric hydrogenation, which is used to reduce a wide variety of functional groups. (wikipedia.org)
- An efficient, enantioselective synthesis of hexahydro-4H-furopyranol (Tp-THF), a high-affinity P2 ligand for HIV-1 Protease inhibitors has been achieved from commercially available, inexpensive starting materials. (purdue.edu)
- Here, we present the enantioselective synthesis of small-molecule compounds based on the tetrahydro-beta-carboline core system with improved solubility, and the influence of the stereochemistry on the biological activity. (uni-regensburg.de)
- Dive into the research topics of 'Enantioselective synthesis of the medium ring ethers, tetrahydrooxepin, oxocane and hexahydrooxonin, of ciguatoxin. (elsevierpure.com)
- 10. Enantioselective synthesis of (+)-cephalostatin 1. (nih.gov)
- We are a synthetic chemistry research group with a focus on enantioselective catalysis, the synthesis of complex molecules and the investigation and exploitation of non-covalent interactions. (ox.ac.uk)
- A focus of our current work is the development of catalytic enantioselective methods for the synthesis of complex molecules. (ox.ac.uk)
- Our initial work on an approach to enantioselective electrocyclization led to a method for the synthesis of indolines, that provided insight into the mechanism of phase transfer catalysis. (ox.ac.uk)
- We have extended this approach to the synthesis of pyrroloindolines and indolenines, and demonstrated that enantioselective 5- endo - trig Michael addition reactions are not always precluded by geometric constraints (as embodied by the Baldwin rules). (ox.ac.uk)
Catalytic enantioselective2
- The very first catalytic enantioselective aminolysis of epoxides while kinetic resolution of 2 3 alcohols continues to be elusive. (sciencepop.org)
- Reynolds, TE & Scheidt, KA 2007, ' Catalytic enantioselective α-acylvinyl anion reactions of silyloxyallenes ', Angewandte Chemie - International Edition , vol. 46, no. 41, pp. 7806-7809. (northwestern.edu)
Conjugate1
- The ligands have been used in the enantioselective Rh-catalyzed conjugate addition of aryl boronic acids to cyclohexenone. (bath.ac.uk)
Allylic4
- The highly enantioselective asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with anthrones is presented. (nature.com)
- Yi-Yong Huang of the Wuhan University of Technology used a chiral phosphoric acid to mediate the enantioselective addition of the allylic boronate 36 to the aldehyde 35 . (organic-chemistry.org)
- 90/10) and enantioselective (ee 91-96%) copper catalyzed allylic substitution on cinnamyl-type chlorides. (unige.ch)
- 15] Recently our group created a W-catalyzed enantioselective epoxidation of allylic alcohols utilizing the same BHA as ligand. (sciencepop.org)
Aliphatic3
- We report a PdII -catalyzed enantioselective β-C(sp3)-H arylation reaction of aliphatic ketones using a chiral TDG. (unboundmedicine.com)
- Herein, we describe an operationally straightforward radiosynthesis of a chiral transition metal fluoride catalyst, [ 18 F](salen)CoF, and its use for late-stage enantioselective aliphatic radiofluorination. (princeton.edu)
- abstract = "Herein, we describe an operationally straightforward radiosynthesis of a chiral transition metal fluoride catalyst, [18F](salen)CoF, and its use for late-stage enantioselective aliphatic radiofluorination. (princeton.edu)
Hydrogenation1
- Enantioselective hydrogenation of polar substrates in inverted supercritical CO2 aqueous biphasi. (rwth-aachen.de)
Alcohols1
- After cautious testing of ligands solvents and temp we been successful in creating the optimum response circumstances LY 2183240 for the kinetic quality of 2 3 alcohols through enantioselective aminolysis (Structure 1). (sciencepop.org)
Cycloaddition1
- A Rh-BINAP complex catalyzed an intermolecular and enantioselective [4 + 2] cycloaddition of 1-monosubstituted, 1,1- or 1,2-disubstituted buta-1,3-dienes with dimethyl acetylenedicarboxylate to give chiral cyclohexa-1,4-dienes. (elsevierpure.com)
Syntheses1
- Enantioselective syntheses of (-)-alloyohimbane and (-)-yohimbane were achieved in a convergent fashion. (purdue.edu)
Catalyst3
- Most enantioselective catalysts are effective at low substrate/catalyst ratios. (wikipedia.org)
- The team used a chiral, C 2 -symmetric iodoresorcinol-based catalyst, Selectfluor ® as an oxidant, and amine/HF mixtures as reactants to create a variety of fluorinated chromanes in an enantioselective fashion. (chemistryviews.org)
- Catalytic Asymmetyric Desymmetrization of meso-Diamide derivatives through Enantioselective N-Allylation Using Chiral -Allyl Pd Catalyst: Improvement and Reversal of the Enantioselectivity. (elsevierpure.com)
Complexes1
- Chiral octahedral cobalt complexes, K[Co(edta)]·2H 2 O and K[Co(trdta)]·2H 2 O, induce enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde , affording the pyrimidyl alkanol with high (85-94%) enantiomeric excesses. (rsc.org)
Intramolecular1
- The key steps were a highly enantioselective enzymatic desymmetrization of meso-diacetate, an intramolecular transacetalization, and a highly diastereoselective reduction of a ketone. (purdue.edu)
Desymmetrization1
- The key step involved a modified mild procedure for the enantioselective enzymatic desymmetrization of a meso-diacetate, providing expedient access to an optically pure monoacetate in multi-gram amounts. (purdue.edu)
Copper catalyzed1
- Copper catalyzed enantioselective. (unige.ch)