Stationary phasesHPLCPhasesEnantiomersCarbon dioxideSelectorsEnantioseparationMultidimensionalInternational SymposiumChiralityStereoisomersEnantioselectiveMatricesElucidationChiral DrugsPurityPreciseDemonstrateMethodsMassLiquidCompoundsColumnHigh-performanceApplicationsDrugJournalColumnsPhaseDevelopment
Stationary phases5
- A Review on Chiral Stationary Phases for Separation of Chiral Drugs" (PDF). (wikipedia.org)
- Here we demonstrate the benefits of supercritical fluid chromatography (SFC) with three chiral stationary phases exemplified by high frequency resolution of 41 out of 50 chiral derivatives of eight commonly used drug discovery scaffolds including 1,3-thiazoles, 1,3-benzothiazoles, pyranoquinolones, indoles, and leucolines. (chromatographyonline.com)
- Chiral stationary phases (CSPs) The most convenient and most popular analytical methodology to assess chiral purity is the direct separation of enantiomers on so-called chiral stationary phases (CSPs). (chiralpedia.com)
- On the other hand, enantioselective chromatography is improved by the synthesis of new chiral stationary phases. (uni-tuebingen.de)
- Among the most common methods of enantioseparation is high-performance liquid chromatography (HPLC) on chiral stationary phases. (sciendo.com)
HPLC2
- The principle can be also applied to the fabrication of Monolithic HPLC columns or Gas Chromatography columns. (wikipedia.org)
- Various other analytical methods have been reported for simultaneous estimation of Azilsartan Medoxomil and Chlorthalidone in pure drug, pharmaceutical formulations and biological fluids by spectrophotometric [ 21 ] and HPLC [ 22 - 26 ]. (biomedres.info)
Phases1
- Reflect coated phases are available in a range of particle sizes, allowing analytical scale separations up through large scale preparative separations. (cubecounty.com)
Enantiomers5
- Chiral column chromatography is a variant of column chromatography that is employed for the separation of chiral compounds, i.e. enantiomers, in mixtures such as racemates or related compounds. (wikipedia.org)
- Lead A wide range of chiral compounds have been examined as chiral selectors with regard to their ability to separate enantiomers using chromatography as part of the development of CSPs. (chiralpedia.com)
- Kinetic data of interconverting enantiomers (enantiomerization) are determined by dynamic chromatography and by stopped-flow multidimensional chromatography. (uni-tuebingen.de)
- Individual pure enantiomers were then selectively heart-cut from within the 2D separation space, cryofocused, then eluted on a 3D reactor column for E ⇌ Z isomerization under controlled oven temperature and flow. (monash.edu)
- Chiral Stationary-Phase Optimized Selectivity Liquid Chromatography: a Novel Approach for the Separation of Mixtures of Enantiomers. (ilmexhibitions.com)
Carbon dioxide2
- A low-viscosity mobile phase consisting of compressed trial organic matter in geosciences because the composition carbon dioxide is used in SFC to achieve fast and efficient of its phenols is an important indicator of the type of original separation. (lu.se)
- Energy conversion and storage, including solar cells, heat/cold storage, magnetocaloric and thermoelectric conversion, capacitors, fuel cells and related oxygen and carbon dioxide gas separation for oxy-fuel and CO2-lean processes. (ua.pt)
Selectors1
- Chiral selectors derived from metal complexes (complexation chromatography) and modified cyclodextrins (inclusion chromatography) were established more than two decades ago. (uni-tuebingen.de)
Enantioseparation1
- It incorporates a pre-enantioseparation step that applies comprehensive two-dimensional GC (GC × GC), prior to multiple microfluidic (Deans) switching for selection of components of a diastereomeric (E,Z) and enantiomeric (R,S) oxime into a third reactor column where isomerization occurs. (monash.edu)
Multidimensional1
- A novel hybrid online enantioselective four-dimensionaldynamic GC (e4D-DGC) approach to study reversible molecular interconversion through specific isolation of a diastereo and enantiopure oxime, 2-phenylpropanaldehyde oxime, from prior multidimensional separation, is described. (monash.edu)
International Symposium1
- In 2014, Wolfgang was co-chair of the International Symposium of Chromatography and he is active on several editorial advisory boards, including the Journal of Chromatography B and Chirality. (theanalyticalscientist.com)
Chirality1
- The precise and correct determination of enantiomeric ratios is the prerequisite for the screening of enantioselective reactions (chirality pool synthesis, catalysis, kinetic resolution, enzymatic transformations) being investigated in parallel. (uni-tuebingen.de)
Stereoisomers3
- On the one hand, our research group is concerned with the separation of stereoisomers by chromatography and by electromigration techniques. (uni-tuebingen.de)
- Selected separation regions were then modulated and separated using a second dimension ( 2 D) column via GC × GC, resolving the interfering stereoisomers. (monash.edu)
- Selected separation regions were then modulated and separated using a second dimension (2D) column via GC × GC, resolving the interfering stereoisomers. (monash.edu)
Enantioselective1
- A unified approach toward an enantioselective separation system was developed. (uni-tuebingen.de)
Matrices2
- In the field of chiral environmental organochlorines, enantiomeric ratios in biogenic matrices are determined. (uni-tuebingen.de)
- Alkaline cupric oxide (CuO) oxidation is one of the mostly performance supercritical fluid chromatography (UHPSFC) adopted methods for analyzing lignin in various complex using columns with sub-2 m packing can further improve environmental matrices such as soils and sediments [9]. (lu.se)
Elucidation1
- Pirkle Type", Chiral Separations and Stereochemical Elucidation (1 ed. (wikipedia.org)
Chiral Drugs1
- Synopsis The development of chromatographic methods for the separation of chiral drugs presents a significant challenge, necessitating a comprehensive understanding of the compounds' chemical properties and the factors influencing their separation. (chiralpedia.com)
Purity1
- High resolution greatly improves preparative loading, leading to greater productivity and higher purity separations. (cubecounty.com)
Precise1
- Heart-cuts taken over the resulting interconversion distribution were cryotrapped at the inlet of a 4 D column, on which achiral separation allows precise quantification of each E and Z isomer of the enantiomer. (monash.edu)
Demonstrate1
- The high separation power and short analysis time obtained demonstrate for the first time that supercritical fluid chromatography is a fast and reliable technique for the analysis of lignin-derived phenols in complex environmental samples. (lu.se)
Methods2
- Different methods, involving gas chromatography, supercritical fluid chromatography, micro liquid chromatography and capillary electrochromatography are employed. (uni-tuebingen.de)
- stomach protection End-user of final method stomach protection Will the separation techniques with specialised detection methods. (sprecherschuh.net)
Mass5
- Separation of isomeric metabolites of carbamazepine by liquid chromatography and high resolution accurate mass. (ilmexhibitions.com)
- Analysis of hexafluoropropylene oxide-dimer acid (HFPO-DA) by Liquid Chromatography-Mass Spectrometry (LC-MS): Review of Current Approaches and Environmental Levels. (well-labs.com)
- Coupling supercritical fluid chromatography to positive ion atmospheric pressure ionization mass spectrometry: Ionization optimization of halogenated environmental contaminants. (well-labs.com)
- A fast analytical method on supercritical fluid chromatography-tandem mass spectrometry was established in 4â ¯min, and the environmental hazards of chiral cyproconazole were studied in earthworm-soil microcosm, including stereoselective bioaccumulation and dissipation. (bvsalud.org)
- Screening for and validated quantification of amphetamines and of amphetamine- and piperazine-derived designer drugs in human blood plasma by gas chromatography/mass spectrometry. (ncats.io)
Liquid1
- The relevant oligomers for liquid chromatographic enantiomer separation are composed of 6(α-CD), 7(β-CD), and 8(γ-CD) monosaccharide units, in that order. (chiralpedia.com)
Compounds1
- The new ultra-high performance super- critical fluid chromatography method was also applied for the qualitative and quantitative analysis of lignin-derived phenolic compounds obtained upon alkaline cupric oxide oxida- tion of a commercial humic acid. (lu.se)
Column1
- This is followed by E/Z separation in a fourth analytical column. (monash.edu)
High-performance1
- UHPSFC , ultra- pacted by other parameters, such as the addition of the mod- high performance supercritical fluid chromatography ifier and the change of the mobile phase density [20]. (lu.se)
Applications1
- The mechanism of transport through porins is of utmost and direct interest for drug discovery, extending toward nanotechnology applications for blue energy, separations, and sequencing. (ibecbarcelona.eu)
Drug2
- They are known to bind /interact stereoselectively with small molecules reversibly, making them extremely versatile CSPs for chiral separation of drug molecules. (chiralpedia.com)
- The dispersions were fully characterized by means of differential scanning calorimetry and broadband dielectric spectroscopy, and the drug release profile was measured in a simulated body fluid. (ibecbarcelona.eu)
Journal2
- Journal of Chromatography A. Chiral Separations. (wikipedia.org)
- Journal of Chromatography A. Enantioseparations - 2014. (wikipedia.org)
Columns2
- or Supercritical Fluid Chromatography columns. (wikipedia.org)
- Preparation of immunoaffinity columns for direct enantiomeric separation of amphetamine and/or methamphetamine. (ncats.io)
Phase1
- Lead Surprisingly, chiral chromatography could not be performed in 1980 because there was no single chiral stationary phase on the market. (chiralpedia.com)
Development1
- Development and Validation of Retention Models in Supercritical Fluid Chromatography for Impregnation Process Design. (tuhh.de)