Determination of enalapril and its active metabolite enalaprilat in plasma and urine by gas chromatography/mass spectrometry. (nih.gov)
ENALAPRIL is quickly metabolized in a liver with formation of an active metabolite of enalaprilat which is more APF active inhibitor, than enalapril. (rxeli.com)
Injection1
Hikma Pharmaceuticals currently has one solution of enalaprilat injection available, while another is on back order until August or September. (medssafety.com)
Intravenously2
The hypertension was treated with labetalol and enalaprilat intravenously. (springeropen.com)
Before the second bout of exercise at ~25% of V̇O(2max) later that day, enalaprilat (n = 8) or nitroprusside (n = 5) was administered intravenously to lower blood pressure to a comparable level and saline was infused as a time control (n = 4). (psu.edu)
Pronunciation1
These figures support aid experimentationation enalaprilat pronunciation exercises for beginners on the advance of AGF-cloadsd therapies on AD. (upb.ro)
Enzyme1
Enalaprilat prevents conversion of angiotensin I to angiotensin II (a potent vasoconstrictor) through competitive inhibition of angiotensin-converting enzyme (ACE), resulting in decreased plasma angiotensin II concentrations. (medscape.com)
Prodrug2
As a prodrug, enalapril is hydrolyzed in vivo to the active form enalaprilat by various esterases. (wikipedia.org)
Enalapril is a prodrug hydrolyzed in vivo to enalaprilat. (medscape.com)
Breast milk1
Enalaprilat easily passes through gisto-gematichesky barriers, excepting a blood-brain barrier, a small amount gets through a placenta and into breast milk. (rxeli.com)
Hypertension1
Effect of enalaprilat on postoperative hypertension after surgical repair of coarctation of the aorta. (ucsfbenioffchildrens.org)
Liver1
Combined recirculation of the rat liver and kidney: studies with enalapril and enalaprilat. (nih.gov)
Form1
ENALAPRIL mainly by kidneys of 60% (20% - in the form of enalapril and 40% - in the form of enalaprilat), through intestines of 33% is removed (6% in the form of enalapril and 27% - in the form of enalaprilat). (rxeli.com)
Drug2
A physiological model for renal drug metabolism: enalapril esterolysis to enalaprilat in the isolated perfused rat kidney. (nih.gov)
Anesthesia Central , anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/51258/all/enalapril_enalaprilat. (unboundmedicine.com)
Plasma3
Peak plasma enalaprilat concentrations occur 2 to 4 hours after oral enalapril administration. (wikipedia.org)
At rest and during exercise, the decrease in blood pressure and the increase in plasma NE and NE spillover were similar with enalaprilat and nitroprusside. (psu.edu)
The maximum concentration of enalapril in blood plasma is reached in 1 hour, enalaprilat 3-4 hours. (rxeli.com)
Studies1
11. Pharmacokinetic studies of enalaprilat in the in vitro perfused human placental lobule system. (nih.gov)
Hours1
Elimination half-life of enalaprilat about 11 hours. (rxeli.com)
Results1
This results an additional intracellular pool of protein-bound enalaprilat. (nih.gov)