Emergence of carbapenem resistant enterobacteriaceae. Medical search. Frequent questions

ABSTRACT The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the blaKPC gene that encodes for carbapenemase production have complicated the management of patient infections. (who.int)
The aim of this study was to characterise the molecular mechanism of resistance in the clinical isolates of Enterobacteriaceae causing bacteremia and showing resistance to β-lactams, including carbapenems. (omicsonline.org)
Isolates of E.coli (n=42) and K. pneumoniae (n=134) from blood culture collected during 2013-2015 were screened for carbapenemase production by using carba NP test and the presence of carbapenem resistant genes (KPC, IMP, VIM, NDM and OXA- 48 like). (omicsonline.org)
The organism is difficult to identify using traditional biochemical methods, some isolates have been found to be resistant to all three major classes of antifungal medications, and C. auris has caused health care-associated outbreaks. (cdc.gov)
First, many isolates are multidrug-resistant, with some strains having elevated minimum inhibitory concentrations to drugs in all three major classes of antifungal medications ( 9 ), a feature not found in other clinically relevant Candida species. (cdc.gov)
Carbapenem-resistant Escherichia coli clinical isolates from a tertiary hospital in Wenzhou, east China, were investigated for NDM-1 production. (biomedcentral.com)
All CPE isolates carrying either bla OXA-232 or bla NDM-1 were resistant to meropenem, but only 40 from 45 were susceptible to colistin. (biomedcentral.com)
Of the 96 Enterobacter isolates, 35 (36.5%) and 28 (29.2%) were phenotypically ESBL-positive and non-susceptible carbapenem, respectively. (ac.ir)
According to the BMD method, 62 (48.4%) of the isolates were susceptible and 66 (51.6%) were colistin resistant. (ijmedicine.com)
As of June 2010[update], there were three reported cases of Enterobacteriaceae isolates bearing this newly described resistance mechanism in the US, the Centers for Disease Control and Prevention (CDC) stated that "All three U.S. isolates were from patients having received recent medical care in India. (wikipedia.org)
Many of the isolates also proved resistant to other drugs as well as colistin, although there was little evidence of extensive carbapenem coresistance. (medscape.com)
In the cross-sectional analysis, the 76 MCRPEC isolates were significantly more resistant to several other drugs compared with isolates that were mcr-1 negative, including ciprofloxacin ( P = .0005), cefotaxime ( P = .0005), and cefepime ( P = .001). (medscape.com)
More than 91% Enterobacteriaceae isolates, belonging to Escherichia coli , Klebsiella pneumoniae , Enterobacter cloacae and Serratia marcescens , were susceptible to amikacin, meropenem, and tigecycline. (biomedcentral.com)
Vancomycin-resistant (VR) isolates represented 1.4% of Enterococcus faecalis (VR. (biomedcentral.com)
13] on pathogenic and and on isolates of components on the even more novel multiple medication resistant (MDR) bacterial strains determined from the Infectious Disease Culture of America (IDSA) as specifically difficult to take care of, and that your present study specifically addressed. (technuc.com)
Out of the 80 meropenem-resistant isolates, bla VIM (66/80, 82.5%), followed by the bla OXA- 48 gene (60/80, 75%), were the most prevalent gene, whether as a single gene or coexpressed with other genes. (ekb.eg)
Carbapenem-resistant Enterobacter-iaceae (CRE) isolates mediated by carbapenemase production are broadly disseminated [1] . (ekb.eg)
Extended-spectrum beta-lactamase produc- ing Enterobacteriaceae was found in 37.5% (54) isolates and carbapenem resistant bacteria were identified in 27.8% of patients. (who.int)
Multidrug-resistant (MDR) phenotypes were present in 22% of the isolates, while 53% of the isolates were ESBL-producing with the bla CTX-M gene as the most frequent β-lactamase gene. (biomedcentral.com)
In this work, we studied the antimicrobial resistance and performed a comparative genomics analysis of ten CR- Kp isolates from the Chilean surveillance of carbapenem-resistant Enterobacteriaceae . (biorxiv.org)

Carbapenem-resistant Enterobacteriaceae (CRE) have been defined as carbapenem-nonsusceptible and extended-spectrum cephalosporin-resistant Escherichia coli, Enterobacter aerogenes, Enterobacter cloacae complex, Klebsiella pneumoniae, or Klebsiella oxytoca. (wikipedia.org)
Infections with carbapenem-resistant Klebsiella pneumoniae were associated with organ/stem cell transplantation, mechanical ventilation, exposure to antimicrobials, and overall longer length of stay in hospitals. (wikipedia.org)
RÉSUMÉ L'émergence et la propagation rapide des souches de Klebsiella pneumoniae résistantes aux antibiotiques et porteuses du gène blaKPC codant la production de carbapénèmases ont compliqué la prise en charge des infections des patients. (who.int)
Enterobacteriaceae , particularly Escherichia coli and Klebsiella pneumioniae , are common pathogens causing nosocomial infections. (biomedcentral.com)
Infections that develop with resistant Klebsiella pneumoniae have been associated with high morbidity and mortality. (ijmedicine.com)
Emergence of a novel mobile colistin resistance gene, mcr-8, in NDM-producing Klebsiella pneumoniae. (ijmedicine.com)
long considered not to be a classical nosocomial pathogen, in contrast to Klebsiella pneumoniae and Escherichia coli, is fast gaining importance as a clinical multidrug-resistant pathogen. (helmholtz-hzi.de)
Molecular epidemiology of carbapenem resistant Enterobacteriaceae in Valle d'Aosta region, Italy, shows the emergence of KPC-2 producing Klebsiella pneumoniae clonal complex 101 (ST101 and ST1789). (helmholtz-hzi.de)
The high level of concern for this evolving threat of mcr-1 mediated resistance recapitulates the alarm evoked by the emergence and transmission of bacteria producing Klebsiella pneumoniae carbapenemase and of highly-resistant bacteria containing the New Delhi metallo-β-lactamase (NDM-1) gene, both of which spread globally through travel and transmission within healthcare settings ( 5, 6) . (resistancecontrol.info)
The infection was identified as a carbapenem-resistant Klebsiella pneumoniae strain bearing the novel gene blaNDM-1. (wikipedia.org)
The genus Klebsiella belongs to the tribe Klebsiellae, a member of the family Enterobacteriaceae.The organisms are named after Edwin Klebs, a 19th century German microbiologist. (medscape.com)
Among the Gram-negative bacteria the Enterobacteriaceae (Escherichia coli, Klebsiella spp. (scirp.org)
The "urgent threat" pathogens included many drug-resistant GNB such as Carbapenem-resistant Enterobacteriaceae (CRE), which include E. coli and Klebsiella pneumoniae. (juniperpublishers.com)
In Klebsiella pneumoniae (KP), modifications in the porin OmpK36 are implicated in increasing resistance to carbapenems. (imperial.ac.uk)
Multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae , particularly carbapenem-resistant strains (CR- Kp ) causing high mortality and morbidity, are critical concerns[ 1 ]. (biorxiv.org)

Carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae (CPE) are Gram-negative bacteria that are resistant to the carbapenem class of antibiotics, considered the drugs of last resort for such infections. (wikipedia.org)
revealed that exposure to antibiotics, especially fluoroquinolones and previous hospitalization dramatically increased the risk of acquisition carbapenem-resistant bacteria. (wikipedia.org)
Carbapenemases are a versatile group of Ã�-lactamases that are characterised by their resistance to virtually all Ã�-lactam antibiotics including cephalosporins and carbapenems, complicating therapy and limiting treatment options. (omicsonline.org)
Researchers are going so far as to send antibiotic resistant bacteria into space in order to determine how the bacteria mutate, with the thought being that in space, bacteria will mutate at an accelerated rate, making it easier to study bacterial resistance patterns and, therefore, develop better antibiotics that are active against resistant bacterial forms. (patentdocs.org)
Following the initial remarkable success of antibiotics, the emergence and spread of human pathogenic bacteria resistant to antibiotics has become a major phenomenon in the past fifty years. (europa.eu)
The emergence and spread of human pathogenic bacteria resistant to antibiotics has become a major problem in the past fifty years. (europa.eu)
Thienamycin, the first representative of carbapenem antibiotics was discovered in the mid-1970s from soil microorganism, Streptomyces cattleya, during the race to discover inhibitors of bacterial peptidoglycan synthesis. (bvsalud.org)
Carbapenemase-producing Enterobacteriaceae (CPE) confer resistance to antibiotics which can be of vital significance to human medication. (bioconstructor.com)
The basic idea behind the plan is to limit our overuse of antibiotics, better track and understand superbug infections, and create new antibiotics, all with the aim of staving off the threat posed by drug-resistant bacteria. (vox.com)
Introduction: The emergence and spread of carbapenem-resistant Enterobacteriaceae (CRE) is in dramatic increase, resulting in failure of almost all the available antibiotics and hence limit the effective therapeutic options. (ac.lk)
NDM-1 is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotics. (wikipedia.org)
These include the antibiotics of the carbapenem family, which are a mainstay for the treatment of antibiotic-resistant bacterial infections. (wikipedia.org)
Carbapenems are a class of beta-lactam antibiotics that are capable of killing most bacteria by inhibiting the synthesis of one of their cell wall layers. (wikipedia.org)
However, the blaNDM-1 gene produces NDM-1, which is a carbapenemase beta-lactamase - an enzyme that hydrolyzes and inactivates these carbapenem antibiotics. (wikipedia.org)
In initial assays the bacterium was fully resistant to all antibiotics tested, while later tests found that it was susceptible to tigecycline and colistin. (wikipedia.org)
As previously, the bacteria were fully resistant to all the aminoglycoside, β-lactam, and quinolone antibiotics, but were susceptible to tigecycline and colistin. (wikipedia.org)
A CHP spokesman said that proper use of antibiotics and personal hygiene, especially hand hygiene, are important for the prevention of emergence and cross-transmission of NDM strains. (gov.hk)
Some of the most clinically relevant resistance genes, such those encoding carbapenemases (ß-lactamase enzymes able to degrade carbapenem antibiotics), are carried on conjugative plasmids that spread across high-risk bacterial clones 5 , 6 . (nature.com)
MRSA strains are resistant to all -lactam antibiotics, likewise making treatment a public health problem. (technuc.com)
The future is going to be difficult and challenging.Infections caused by drug-resistant gram-negative bacteria (GNB) are a major health problem and have the potential to cause a global health crisis if new antibiotics are not developed. (juniperpublishers.com)
Antibiotics are losing efficacy at an alarming rate, due to the rapid spread of drug-resistant bacteria and the slow rate at which new antibiotics are being developed. (juniperpublishers.com)
Rampant use of antibiotics in infections has led to the emergence of multiresistant bacteria worldwide. (apibpj.com)
Additionally, antibiotics in animal feed, used to stimulate growth in cows and chicken, may contribute to spreading resistant bacteria to humans. (superpages.com)
Carbapenems are last-resort antibiotics for treating severe infections caused by MDR Enterobacteriaceae [ 3 ]. (biorxiv.org)
Ciprofloxacin, clindamycin, and amoxicillin were the most sensitive antibiotics, while vancomycin and chloramphenicol were the most resistant. (bvsalud.org)

This may further predispose patients to infections from MRSA (Methicillin-resistant Staphylococcus aureus ), CRE (carbapenem-resistant Enterobacteriaceae ), or Clostridium difficile . (patentdocs.org)
All these efforts would help reduce the incidence of superbugs, the administration said, including Clostridium difficile, hospital-acquired Carbapenem-resistant Enterobacteriaceae infections, and methicillin-resistant Staphylococcus aureus infections. (vox.com)
However, US experts stated that it is unclear as to whether this strain is any more dangerous than existing antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus, which are already common in the USA. (wikipedia.org)
Currently in Paraguay, the emergence of methicillin-resistant Staphylococcus aureus is among the most worrying resistances. (una.py)

We analyzed population-based surveillance data from the Toronto Invasive Bacterial Diseases Network to describe carbapenemase-producing Enterobacteriaceae (CPE) infections during 2007-2015 in south-central Ontario, Canada. (cdc.gov)
The global emergence of carbapenemase-producing Enterobacteriaceae (CPE) poses a threat to the achievements of modern medicine. (cdc.gov)
They are resistant because they produce an enzyme called a carbapenemase that disables the drug molecule. (wikipedia.org)
Emergence and global spread of carbapenemase producing Enterobacteriaceae (CPE) are of great concern in healthcare settings. (omicsonline.org)
Carbapenemase producing Enterobacteriaceae (CPE) causing bacteremia is of great clinical concern. (omicsonline.org)
The most common carbapenemase in Enterobacteriaceae belongs to class A carbapenemase (KPC), class B metallo Ã�-lactamases (IMP, VIM, NDM) and class D oxacillinase (OXA-48 like) [ 2 , 3 ]. (omicsonline.org)
Infections caused by carbapenemase-producing Enterobacteriaceae (CPE) have continually grown as a global public health threat, with significant mortality rates observed across the world. (biomedcentral.com)
Infections caused by carbapenemase-producing Enterobacteriaceae (CPE), which have increased worldwide in number to become a significant clinical problem over the last decade, are associated with high morbidity and mortality [ 1 ]. (biomedcentral.com)
Prompt detection of extended-spectrum β-lactamases (ESBL) and carbapenemase-producing enterobacteriaceae is crucial for infection prevention and control strategies. (ac.ir)
Enterobacteriaceae show a wide variety of carbapenemase genes. (aid-diagnostika.com)
The Public Health Laboratory Services Branch (PHLSB) of the Centre for Health Protection (CHP) of the Department of Health confirmed a case of New Delhi metallo- ]-lactamase-1 (NDM-1) Carbapenemase-producing Enterobacteriaceae in a 26-year-old woman. (gov.hk)
The patient's rectal swab grew NDM-1 Carbapenemase-producing Enterobacteriaceae, as confirmed by the PHLSB. (gov.hk)
This is the 19th detected case of NDM Carbapenemase-producing Enterobacteriaceae in Hong Kong. (gov.hk)
The increase of resistant-bacteria to carbapenem (imipenem, meropenem), both enterobacteria by KPC carbapenemase production and non-fermenting glucose gram-negative bacilli by metallobetalactamese type carbapenemase production, impermeability, efflux, among others, especially in high complexity hospitals of our country, leave us only toxic and / or very costly therapeutic alternatives like colystin. (una.py)
The most concerning carbapenem resistance mechanism corresponds to carbapenem-inactivating beta-lactamases, especially the K. pneumoniae carbapenemase (KPC) distributed worldwide, showing the highest prevalence. (biorxiv.org)
Worsening epidemiological situation of carbapenemase-producing Enterobacteriaceae in Europe, assessment by national experts from 37 countries, July 2018. (eurosurveillance.org)

The Enterobacteriaceae are a class of germs like Escherichia coli (E. coli) that normally live in the gut but can cause serious infections elsewhere in the body. (superpages.com)

Carbapenemases, particularly the Ambler class A K. pneumoniae carbapenemases (KPCs) and the Ambler class B metallo-β-lactamases (MBLs), were mainly associated with carbapenem resistance among Enterobacteriaceae [ 2 ]. (biomedcentral.com)
IMP- and VIM-type MBLs were another frequently described carbapenemases in Enterobacteriaceae worldwide [ 3 ]. (biomedcentral.com)
These results underline the increasing importance of the Citrobacter species as emerging carriers of carbapenemases and therefore as potential disseminators of Carbapenem- and multidrug-resistance in the hospital setting. (helmholtz-hzi.de)
Similarly, the emergence and spreading of carbapenemases among Gram-negative bacteria can be verified, especially with Enterobacteriaceae species. (scirp.org)
Although the first report of carbapenemases was registered with Enterobacteriaceae, the others Gram-nega- tive bacteria, such as A. baumannii and P. aeruginosa, can also produce this enzyme. (scirp.org)

The work package focusing on molecular studies generated new evidence about the changes effected by antibiotic therapy on commensal organisms or opportunistic pathogens in the oropharyngeal, nasal and gastro-intestinal flora and study AMR mechanisms and the dissemination of successful clones of fluoroquinolone-resistant, carbapenem-resistant or extended-spectrum beta-lactamase harboring Gram-negative bacteria, MRSA and fluoroquinolone-resistant viridans streptococci. (europa.eu)
There was a high percentage of extended-spectrum beta-lactamase among the Enterobacteriacae, methicillin-resistant S. aureus , and borderline oxacillin-resistant S. aureus among S. aureus and metallo-β-lactamase among the Acinetobacter and Pseudomonas . (apibpj.com)

Age 65 years, presence of septic shock, and presence of carbapenem-resistant bacteria were independently associated with in- creased in-hospital mortality. (who.int)

Multidrug resistance (MDR) for Enterobacteriaceae has been increasing rapidly and limits the selection of antimicrobials for empiric treatment of infections caused by these organisms, which is becoming a threat to public health [ 1 ]. (biomedcentral.com)
Carbapenems are the choice for the treatment of infections caused by MDR Enterobacteriaceae, especially extended-spectrum β lactamase (ESBL)- and/or plasmid-mediated AmpC (pAmpC)-producing organisms. (biomedcentral.com)
Infections caused by carbapenem-resistant Enterobacteriaceae (CRE), were recognized as an urgent threat among patients. (uams.edu)
The carbapenem-resistant Enterobactericeae (CRE) are resistant Tetrodotoxin manufacture to all third generation cephalosporins and to at least one carbapenem, the antibiotic that has been used as a final recourse to treat lethal infections caused by MDR Enterobacteriaceae species [20]. (technuc.com)
Conclusion High number of resistant microorganisms was isolated, and increased mortality was documented from infections caused by carbapenem-resistant bacteria. (who.int)

Carbapenem resistance for E. coli WZ51 and WZ33 could not be transferred to E. coli recipients through conjugation, but could be transferred to E. coli recipients by chemical transformation. (biomedcentral.com)
Systemic surveillance should focus on the dissemination of bla NDM-1 among Enterobacteriaceae, especially E. coli ST167 clone associated with animal infection. (biomedcentral.com)
First detection of a plasmid located carbapenem resistant blaVIM-1 gene in E. coli isolated from meat products at retail in Belgium in 2015. (bioconstructor.com)
Our goal was to characterize the origin of the carbapenem resistance within the E. coli. (bioconstructor.com)
Whole genomes of carbapenem-resistant E. coli were investigated using a hybrid assembly of Illumina and Oxford Nanopore Technologies sequencing reads. (microbiologyresearch.org)
Three carbapenem-resistant E. coli were detected, two from neonates and one from an HIV infected adult. (microbiologyresearch.org)
Our results demonstrate that highly diverse, resistant and pathogenic E. coli clones are circulating among leukemia patients in Iranian hospitals. (biomedcentral.com)

The ecology of environmental antibiotic resistance has recently become an important area of research as antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are recognized as emerging biological contaminants. (marquette.edu)
The current emergence of mobile-colistin-resistance (mcr) genes has threatened the effectiveness of colistin. (bioconstructor.com)
Our results suggest gut of young Bangladeshi children to be an important reservoir for multi-drug resistant pathogenic bacteria carrying ESBL related genes. (biomedcentral.com)
Basic research of drug-resistant bacteria, such as identifying responsible genes and enzymes, is crucial to understanding the mechanism of antimicrobial resistance and transmission. (who.int)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
Multidrug and carbapenem-resistant K. pneumoniae (CR- Kp ) are considered critical threats to global health and key traffickers of resistance genes to other pathogens. (biorxiv.org)

These indicate resistance to most beta-lactams, cephalosporins, and at times to carbapenems. (apibpj.com)

The current study highlights that Carba NP strip test can be a reliable and excellent alternative to other tedious and expensive standard techniques, making carbapenem resistance diagnosis reachable to routine laboratories. (ekb.eg)

Emergence of multidrug resistance in Enterobacteriaceae limits the selection of antimicrobials for treatment of infectious diseases. (biomedcentral.com)
Identification of NDM-1 makes more difficulty in treating multidrug-resistant Enterobacteriaceae infections. (biomedcentral.com)
In Bangladesh, infectious diseases due to multidrug resistant (MDR) bacteria are at rise, although the reservoir for such MDR bacteria is not well defined. (biomedcentral.com)
We confirmed the gut of children under 5 years of age as an important reservoir for MDR bacterial genera belonging to the family Enterobacteriaceae, which included surface water bacteria, including important human pathogens carrying major virulence plasmids and related genetic elements responsible for multidrug resistance. (biomedcentral.com)
Currently, he is using large genomic datasets to understand the emergence of multidrug-resistant Enterobacteriaceae in vulnerable human populations, with the goal of informing health professionals of mitigation strategies. (broadinstitute.org)
The multidrug-resistance among species of Enterobacteriaceae has become a global challenge, with high levels of resistance against carbapenems worldwide. (scirp.org)

The carbapenems were developed to overcome antibiotic resistance mediated by bacterial beta-lactamase enzymes. (wikipedia.org)
in December 2009 in a Swedish national who fell ill with an antibiotic-resistant bacterial infection that he acquired in India. (wikipedia.org)
In the United States alone, at least 2 million people per year become infected with drug-resistant bacterial pathogens[1], and this number is much higher in developing nations such as China, Russia, Brazil, and India[2-4]. (juniperpublishers.com)

Future prevalence of colonization with extended-spectrum betalactamase (ESBL-) producing K. pneumoniae in humans and the potential of public health interventions against the spread of these resistant bacteria remain uncertain. (biomedcentral.com)

Should mcr-1 be transferred to organisms that are already resistant to carbapenem, it would "seriously compromise treatment options not only in China but also globally," write Yang Wang, PhD, from the Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, and colleagues in one of two studies published online January 27 in the Lancet Infectious Diseases . (medscape.com)
Multi-center studies should be done to determine the extent of resistant organisms in health facilities throughout the country.epidemiology, and the findings should be factored into clinical decision making and program design for disease prevention, screening, and treatment. (who.int)

Also, SATURN had as mission to improve methodological standards and conduct research to better understand the impact of antibiotic use on acquisition, selection and transmission of antibiotic-resistant bacteria (ARB) in different environments, by combining state-of-the-art analyses of molecular, ecologic and individual patient-level data. (europa.eu)
The continuing emergence and rapid dissemination of antibiotic-resistant pathogens are becoming a major threat to public health. (uams.edu)
The White House has released its first-ever plan to combat antibiotic-resistant bacteria. (vox.com)

Epidemiological situation, laboratory capacity and preparedness for carbapenem-resistant Acinetobacter baumannii in Europe, 2019. (eurosurveillance.org)

Dr. Huang's lab discovered a novel antibiotic, paenipeptin, that showed potent activity against drug-resistant pathogens and biofilms. (uams.edu)
The most important of these are theextended spectrum β-lactamase producing Enterobacteriaceae as well as the glucose non-fermenting healthcare-associated pathogens P. aeruginosa and A. baumannii [1]. (juniperpublishers.com)
The objective of the current ering new classes of antimicrobials and the increasing study was, therefore, to assess the bacteriologic pro- emergence and reemergence of resistant pathogens, file, resistance pattern, and patient's outcome in Lan- mortality from infectious disease is increasing [1]. (who.int)

High prevalence of extended-spectrum beta-lactamases and plasmid-mediated AmpC beta-lactamases in Enterobacteriaceae isolated from long-term care facilities in Korea. (ac.ir)
Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. (ijmedicine.com)

The public health community is faced with the global challenge posed by antimicrobial-resistant bacteria, including meticillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum β-lactamases (ESBLs)-producing enterobacteriaceae. (who.int)
however, this antibiotic has no activity on meticillin-resistant Staphylococcus aureus . (una.py)

Low Prevalence of carbapenem-resistant bacteria in river water: resistance is mostly related to intrinsic mechanisms. (ac.ir)
Amid growing concerns about the global emergence of extensively drug-resistant "superbugs," two new studies provide a snapshot of the prevalence and risk factors for colistin -resistant Enterobacteriaceae among hospital patients in China. (medscape.com)

Multicenter clinical and molecular epidemiological analysis of bacteremia due to carbapenem-resistant Enterobacteriaceae (CRE) in the CRE epicenter of the United States. (ijmedicine.com)

La présente étude menée dans un hôpital de soins tertiaires en Égypte a utilisé la méthode de PCR en temps réel pour évaluer la présence du gène blaKPC dans les isolats de K. pneumoniae non sensibles à l'ertapénème, puis a comparé les résultats à l'aide du test de Hodge modifié. (who.int)
KPC prévalence de la non sensibilité à l'ertapénème dans un hôpital de soins tertiaires en Égypte était principalement imputable aux mécanismes de résistance médiés par les carbapénèmases dans les isolats de K. pneumoniae . (who.int)
OBJECTIVES: This study investigated a ceftazidime/avibactam (CZA)-resistant K. pneumoniae (NE368), isolated from a patient exposed to CZA, expressing a novel KPC-3 variant, named KPC-109. (imperial.ac.uk)
However, in the presence of porin alterations commonly encountered in high-risk clonal lineages of K. pneumoniae, KPC-109 was able to confer clinical-level resistance to carbapenems as well. (imperial.ac.uk)

In this study, we examined the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of BIPM for 14 IMP-1-producing Enterobacteriaceae strains isolated from the Okayama region in Japan. (bvsalud.org)
Colistin MIC values were determined by BMD, broth microdilution based commercial kit (Sensititre, ThermoFisher, USA), Vitek2 (bioMerieux, France) and gradient test (Bioanalyse, Turkey) in 128 carbapenem resistant K. pneumonaie strains isolated from various clinical samples sent from July 2018 to July 2019 to the microbiology laboratory. (ijmedicine.com)

In today's world of international travel, the globalization of drug-resistant bacteria is a pressing issue for public health professionals. (who.int)
The federal Centers for Disease Control and Prevention (CDC) has identified 18 top threats to the U.S. from drug resistant bacteria. (superpages.com)

Among the MDR strains, IDSA has identified diseases due Tetrodotoxin manufacture to the following bacteria as especially difficult to treat: the Gram positive vancomycin-resistant (VRE) and methicillin-resistant (MRSA), the Gram negative extended spectrum -lactamase (ESL)-producing Enterobacteriaaceae, carbapenem-resistant Enterobacteriaceae (CRE), metallo-lactamase (ML)-producing and [16]. (technuc.com)

This study found that carbapenem-resistant acquisition has a significantly higher mortality rate and poorer clinical response compared to that of the ertapenem-resistance acquisition. (wikipedia.org)
Carbapenem-resistant members of the family Enterobacteriaceae are emerging as a global public-health threat and cause substantial challenges in clinical practice. (microbiologyresearch.org)
Bacteria harbouring this NDM gene are commonly resistant to multiple antimicrobials, limiting therapeutic options and rendering severe clinical infections difficult to treat. (gov.hk)

To gain a handle on the factors that are propelling the problem of AMR, molecular and patient-level investigations are necessary to better elucidate the time-varying and heterogeneous role of antibiotic selection pressure on emergence and selection of AMR. (europa.eu)
The resistance mechanism for CPE is attributed to the following Ambler molecular classes of carbapenem-hydrolysing beta-lactamases: class A (KPC), class B (IMP, NDM, VIM), and class D (OXA-48) [ 5 ]. (biomedcentral.com)
Molecular and microbiological report of a hospital outbreak of NDM-1-carrying Enterobacteriaceae in Mexico. (ac.ir)

Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of AMR have lacked a holistic view combining all aspects into one study. (europa.eu)
The emergence and spread of carbapenem-hydrolysing ß-lactamases amongst gram-negative bacteria over the past decade represents a serious issue in the hospital environment. (aid-diagnostika.com)
Josh is a microbiologist interested in the ecological and evolutionary processes that drive the development and spread of antimicrobial-resistant superbugs. (broadinstitute.org)
Our findings highlight the urgent need for a robust antimicrobial resistance (AMR) surveillance system to monitor and rapidly report on the incidence and spread of emerging resistant bacteria in Tanzania. (microbiologyresearch.org)
Antimicrobial resistant microorganisms are found in people, animals and the environment and can spread globally. (who.int)
Regular surveillance of AMR can provide timely information on its emergence and spread in a given setting. (who.int)
The Centers for Disease Control and Prevention (CDC) has expanded its guidelines for preventing the spread of carbapenem-resistant Enterobacteriaceae (CRE). (medscape.com)
What accelerates the emergence and spread of antimicrobial resistance? (paho.org)
Decisive and comprehensive action to prevent the emergence and reduce the spread of AMR. (who.int)

It can be implemented in low-resource healthcare settings for early detection of carbapenem resistance, hence initiating proper therapy. (ekb.eg)

Similarly, in 2016, the CDC passed the Antibiotic Resistance Solutions Initiative, allocating roughly $160 Million in order to 'detect, respond, and contain resistant infections across healthcare setting and communities. (patentdocs.org)
The rise of Carbapenem-resistant Enterobacterales (CRE) represents an increasing threat to patient safety and healthcare systems worldwide. (helmholtz-hzi.de)
Prevention of AMR emergence and transmission in healthcare facilities, food production and the community, through infection prevention and control (IPC) measures. (who.int)

In March 2010, a study in a hospital in Mumbai found that most carbapenem-resistant bacteria isolated from patients carried the blaNDM-1 gene. (wikipedia.org)

Carbapenem-resistant Enterobacteriaceae (CRE) poses an increasing public health threat and has limited treatment options with high associated mortality. (kjcls.org)

While the emergence of antibiotic resistance is a natural phenomenon that occurs in microorganisms, this fact is mainly exacerbated by the inappropriate use of antimicrobials, poor quality of medicine, lack or deficient programs for the prevention and control of infections, weak capacity of laboratories to detect resistance, inadequate surveillance and regulation of antimicrobial use. (una.py)

Candida auris , an emerging fungus that can cause invasive infections, is associated with high mortality and is often resistant to multiple antifungal drugs. (cdc.gov)

It focuses on slowing the emergence of resistant bacteria and strengthening surveillance efforts of resistant infections. (vox.com)
Constructing a standardized surveillance system in the Region would provide useful data to monitor and assess the pattern and frequency of resistant bacteria. (who.int)
The WHO South-East Asia and the Western Pacific Regional Offices are collaborating to build up standard laboratory methods and surveillance systems to monitor resistant bacteria in both regions. (who.int)

One such infection is carbapenem-resistant Enterobacteriaceae (CRE), which has a mortality rate of about 50 percent in hospitalized patients who become infected. (acsh.org)

The patterns of resistant microorganisms were compared by rep-PCR (Diversilab). (scirp.org)

Organisms21

Diseases8

Chemicals and Drugs18

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes6

Information Science1

Health Care1

Isolates20

Klebsiella15

Antibiotics25

Methicillin-resist4

Carbapenemase16

Escherichia1

Carbapenemases5

Extended-spectrum2

Presence of carbapenem resistant1

Infections caused5

Coli7

Genes6

Cephalosporins1

Making carbapenem resistance1

Multidrug6

Bacterial3

ESBL1

Organisms2

Antibiotic-resistant3

Acinetobacter1

Pathogens3

Plasmid-mediated2

Staphylococcus2

Prevalence2

Bacteremia1

Pneumoniae4

Strains isolated2

Drug-resistant bacteria2

MRSA1

Clinical3

Molecular3

Spread9

Detection1

Healthcare3

Bacteria Isolated1

Public health threat1

Antimicrobials1

High mortality1

Surveillance3

Mortality rate1

Microorganisms1