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Acinetobacter InfectionsAcinetobacter baumanniiAcinetobacter calcoaceticusCarbapenemsDrug Resistance, Multiple, BacterialAnti-Bacterial AgentsColistinMicrobial Sensitivity TestsCross Infectionbeta-LactamasesImipenemDrug Resistance, BacterialDNA, Bacterialbeta-Lactam ResistanceBacterial ProteinsMinocyclineMolecular Sequence DataSequence Analysis, DNAElectrophoresis, Gel, Pulsed-FieldGram-Negative BacteriaThienamycinsGenes, BacterialBacterial Typing TechniquesSulbactamAlkanesProtocatechuate-3,4-DioxygenaseGram-Negative Bacterial InfectionsAlcaligenesMolecular EpidemiologyDNA FingerprintingDrug Resistance, MicrobialBacteremiaPhylogenyMolecular TypingAdipatesIntensive Care UnitsDisease OutbreaksIntegronsPolymerase Chain ReactionCommunicable Diseases, EmergingMoraxellaBacteriaAmikacinHospitals, MilitaryMultilocus Sequence TypingHospitalsTransformation, Bacterialbeta-LactamsPseudomonas aeruginosaGenome, BacterialHydroxybenzoatesBase SequenceDisk Diffusion Antimicrobial TestsPlasmidsCluster AnalysisRNA, Ribosomal, 16SEnterobacteriaceaeGenotypePneumonia, BacterialCatechol 1,2-DioxygenaseParabensBiodegradation, EnvironmentalMonobactamsPolymyxinsCatecholsAminoglycosidesAmino Acid SequenceMutationCulture MediaVanillic AcidGlucose DehydrogenasesPneumonia, Ventilator-AssociatedSpecies SpecificityGram-Positive BacteriaDNA Transposable ElementsDrug Resistance, MultipleEscherichia coliChromosomes, BacterialEnvironmental MicrobiologySewageDNA, RibosomalPQQ CofactorPolymyxin BPseudomonasBiofilmsWound InfectionWaxesPseudomonas InfectionsQuinic AcidAmplified Fragment Length Polymorphism AnalysisMicrobial ViabilityMeningitis, BacterialFuel OilsAnti-Infective AgentsKanamycin ResistanceBacteriological TechniquesHospitals, UniversityKlebsiella pneumoniaeOxygenasesGene Expression Regulation, Bacterial
IsolatesStrainsInfectionsPseudomonas aeruginosa and AcinetobacterBacteriaCarbapenem resistanceInfectionPathogensMultidrug resistanceResistantAbstractAntibioticGenomicSpecies are Gram-negativeAntimicrobialCarbapenemases amongAerobicGenusCharacterizationDrug-resistanceClin Microbiol RevPrevent the emergenceAntibacterial activityIncreasinglyMechanismEffluxClinical impactCommunity-acquiredHospitalToxicityMotilitySpreadOccurTherapeutic
Isolates13
  • The highest rate of resistance in Gram-negative isolates was seen in the intensive care unit, with Acinetobacter spp. (who.int)
  • Two sequential outbreaks caused by multidrug-resistant Acinetobacter baumannii isolates producing OXA-58 or OXA-72 oxacillinase in an intensive care unit in France. (microbiologyresearch.org)
  • Molecular detection of OXA carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolates from Iraq and Georgia. (microbiologyresearch.org)
  • Twenty-four invasive Acinetobacter isolates were collected from 2009-2013. (biomedcentral.com)
  • 1] T. Tada, T. Miyoshi-Akiyama, and Y. Kato, "Emergence of 16S rRNA methylase-producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in hospitals in Vietnam," BMC Infect. (fujipress.jp)
  • ISCR2 in minocycline-resistant Acinetobacter baumannii isolates. (bvsalud.org)
  • Acinetobacter baumannii isolates in Al-Hussein Hospital at King Hussein Medical Centre in Amman, Jordan. (who.int)
  • The significance of Acinetobacter isolates from clinical specimens, such as respiratory secretions from intubated patients or specimens from open wounds, is difficult to determine because they often represent colonization. (msdmanuals.com)
  • Emergence of Oxacillinases in Environmental Carbapenem-Resistant Acinetobacter baumannii Associated with Clinical Isolates. (cdc.gov)
  • This article reports on severe clinical cases of nosocomial infections that were caused by multidrug-resistant (MDR) isolates of Acinetobacter baumannii and Pseudomonas aeruginosa in an intensive care unit (ICU). (bvsalud.org)
  • To identify risk factors associated with the emergence of imipenem heteroresistance, a retrospective case-control study was undertaken involving cases with subsequent clinical isolates of the same genotype showing loss of imipenem susceptibility and matched controls with isolates belonging to imipenem-susceptible MDR-AB. (shengsci.com)
  • The emergence of multidrug resistant A. baumannii isolates is a significant unsolved public health problem. (edu.au)
  • To analyze the antibiotic resistance patterns among Acinetobacter isolates and to detect Carbapenemase and MBL among MDR Acinetobacter isolates. (microbiologyjournal.org)
Strains10
  • citation needed] Most strains of Acinetobacter, except some of the A. lwoffii strain, grow well on MacConkey agar (without salt). (wikipedia.org)
  • Therefore we aimed to determine risk factors for invasive Acinetobacter infections within an academic, pediatric setting as well as defining microbiologic characteristics of predominant strains. (biomedcentral.com)
  • Additionally, in recent years, some Acinetobacter strains have demonstrated a propensity to acquire resistance to multiple classes of antibiotics, rendering treatment of such hospitalized patients extremely difficult [ 4 ]. (biomedcentral.com)
  • Furthermore Acinetobacter strains were sequenced typed and preliminary characterized for motility and biofilm formation/maintenance. (biomedcentral.com)
  • The traditional approach was to treat nosocomial infections for 14-21 days at the cost of increased toxicity, added expense and the emergence of multidrug-resistant bacterial strains. (ersjournals.com)
  • Furthermore, their individual effects and synergistic potential in combination with antibiotics were examined against clinical strains of both S. aureus and Acinetobacter baumannii . (biomedcentral.com)
  • The slow-pace of discovery of novel antimicrobial agents, the dearth of new antibiotics already in the drug development pipeline, and the emergence and rapid diffusion of strains resistant to last resort antibiotics, make novel therapeutic approaches an urgent need to reduce the burden of infectious diseases. (le.ac.uk)
  • The descriptive study of all phenotypically identified strains and multidrug-resistant strains of Acinetobacter species was conducted. (microbiologyjournal.org)
  • Of 6355 samples processed, 303 were found to be Acinetobacter species, among those 50 were multidrug-resistant strains. (microbiologyjournal.org)
  • Method: Thirty-three strains of acinetobacter baumannii were isolated from clinical specimen of January, 2009 to March, 2010 in Gansu Province Hospital of Traditional Chinese Medicine and the results of allergic reaction were retrospectively investigated and analyzed. (paperopen.com)
Infections12
  • Pediatric Acinetobacter infections are largely undefined in developed countries and clinical laboratory identification methods do not reliably differentiate between members of the Acinetobacter calcoaceticus-baumannii complex, leading to improper identification. (biomedcentral.com)
  • However, certain Acinetobacter species are frequently isolated increasingly from healthcare facilities and are concomitantly the source of many nosocomial infections [ 1 ]. (biomedcentral.com)
  • Patients with impaired host defenses in intensive care unit (ICU) settings appear to be an at risk group of acquiring Acinetobacter infections [ 2 ]. (biomedcentral.com)
  • However, invasive Acinetobacter infections associated with large pediatric, academic institutes in developed countries are still poorly defined due to unclear risk factors. (biomedcentral.com)
  • Therefore, the purpose of this study was to retrospectively review cases of invasive Acinetobacter infections occurring within an academic, pediatric setting in a developed country from a clinical perspective to define additional risk factors. (biomedcentral.com)
  • This resulted in the clinical candidate F365 (QPX9003) with superior safety and efficacy against lung infections caused by top-priority MDR pathogens Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae. (monash.edu)
  • Acinetobacter baumannii is the most common species to cause infections, followed by Acinetobacter nosocomialis and Acinetobacter pittii [ 4 , 5 ]. (pfmjournal.org)
  • Clinical and pathophysiological overview of Acinetobacter infections: A century of challenges. (msdmanuals.com)
  • Acinetobacter baumannii has emerged as a major pathogen causing nosocomial infections, particularly in critical patients admitted to the Intensive Care Unit. (shengsci.com)
  • Specifically, the majority of nosocomial (hospital-related) infections are caused by so-called ESKAPE pathogens ( Enterococcus faecium , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and Enterobacter species ). (patentdocs.org)
  • Acinetobacter species cause infections that are difficult to control due to multi-drug resistance and are noted for their intrinsic resistance to antibiotics and for their ability to acquire genes encoding resistance for the production of beta-lactamases and Aminoglycoside-modifying enzymes. (microbiologyjournal.org)
  • Modeling Acinetobacter baumannii wound infections: The critical role of iron. (uchicago.edu)
Pseudomonas aeruginosa and Acinetobacter3
Bacteria13
  • Acinetobacter is a genus of Gram-negative bacteria belonging to the wider class of Gammaproteobacteria. (wikipedia.org)
  • citation needed] Bacteria of the genus Acinetobacter are known to form intracellular inclusions of polyhydroxyalkanoates under certain environmental conditions (e.g. lack of elements such as phosphorus, nitrogen, or oxygen combined with an excessive supply of carbon sources). (wikipedia.org)
  • My lab performs research investigating novel treatment approaches for multidrug-resistant gram-negative bacteria including E. coli, Klebsiella, Burkholderia, Pseudomonas, and Acinetobacter. (harvard.edu)
  • ICUs face the emergence and rapid dissemination of multidrug-resistant bacteria, especially P. aeruginosa and Acinetobacter spp. (ersjournals.com)
  • Colistin is an old drug, and its use has recently resurged because of increasing antibiotic resistance in gram-negative bacteria such as Acinetobacter baumannii . (pfmjournal.org)
  • In 1954, Brisou and Prévot proposed the genus Acinetobacter to indicate that the bacteria were non-motile because they lacked flagella: the Greek "akineto" means "immobile" [ 1 ]. (pfmjournal.org)
  • Similarly, the emergence and spreading of carbapenemases among Gram-negative bacteria can be verified, especially with Enterobacteriaceae species. (scirp.org)
  • One of the biggest threats we face globally is the emergence of antimicrobial resistant (AMR) bacteria, which runs in parallel with a lack in the development of new antimicrobials. (preprints.org)
  • Among these AMR bacteria, pathogens belonging to the ESKAPE group can be highlighted (Enterococcus spp, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp) due to their profile of drug resistance and virulence. (preprints.org)
  • Conclusion: We should choose antibacterials according to allergic result of bacteria in hospital to effectively control plant and spread of acinetobacter baumannii. (paperopen.com)
  • Following the initial remarkable success of antibiotics, the emergence and spread of human pathogenic bacteria resistant to antibiotics has become a major phenomenon in the past fifty years. (europa.eu)
  • The emergence and spread of human pathogenic bacteria resistant to antibiotics has become a major problem in the past fifty years. (europa.eu)
  • We also hear a lot about this newest bacteria, multi-drug resistant Acinetobacter, and we're very concerned about the problems with it. (cdc.gov)
Carbapenem resistance2
Infection7
  • Acinetobacter species are a key source of infection in debilitated patients in the hospital, in particular the species Acinetobacter baumannii. (wikipedia.org)
  • citation needed] The morphology of Acinetobacter species can be quite variable in Gram-stained human clinical specimens, and cannot be used to differentiate Acinetobacter from other common causes of infection. (wikipedia.org)
  • Carbapenem-resistant Acinetobacter baumannii (CRAB) presents a serious therapeutic and infection control challenge. (frontiersin.org)
  • and Acinetobacter , see the Healthcare-Associated Infection (HAI) website . (cdc.gov)
  • Objective: To provide scientific evidence for guide of rational use of antibacterials by knowing distribution characters of acinetobacter baumannii in hospital infection and drug resistance of antibacterials. (paperopen.com)
  • MA Xin,ZHENG Jingjing,ZHANG Jie,et al.The Effects of Xuebijing Injection and Tigecycline on Carbapenem Resistant Acinetobacter Baumannii Infection[J].Western Journal of Traditional Chinese Medicine,2020,33(10):110. (paperopen.com)
  • Prevention of AMR emergence and transmission in healthcare facilities, food production and the community, through infection prevention and control (IPC) measures. (who.int)
Pathogens5
  • The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global medical challenge. (monash.edu)
  • The emergence of multidrug resistance in many hospital-associated pathogens has resulted in "superbugs" that are effectively untreatable. (edu.au)
  • patients in ICUs have encountered an increasing emergence and spread of MDR pathogens. (bvsalud.org)
  • Thereafter, antibiotic discovery and development of new molecules gradually declined with the parallel emergence of drug resistance of many human bacterial pathogens. (le.ac.uk)
  • Acinetobacter species are increasingly important nosocomial pathogens and are capable of rapid adaptation to the hospital environment. (microbiologyjournal.org)
Multidrug resistance1
Resistant10
  • Clonal spread of carbapenem-resistant OXA-72-positive Acinetobacter baumannii in a Croatian university hospital. (microbiologyresearch.org)
  • Acinetobacter baumannii resistant records at Al-Hussein Hospital, King adopted in this study. (who.int)
  • Imipenem heteroresistance induced by imipenem in multidrug-resistant Acinetobacter baumannii: mechanism and clinical implications. (shengsci.com)
  • This study aimed to test the effect of photodynamic therapy (PDT) on the inhibition and removal of biofilms containing multidrug-resistant Acinetobacter baumannii . (ophrp.org)
  • Ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii in patients with COVID-19: Two problems, one solution? (environmed.pl)
  • 3 Lenie D Alexandr N Harald S.An increasing threa in hospitals multidrug-resistant acinetobacter baumannii J .Nat Rev Microbiol 2007 5(12) 939-951. (paperopen.com)
  • 5 Kuo LC Yu CJ Lee LN et al.Clincal features of pandrug-resistant acinetobacter baumannii bactermia at a university hospital in Taiwan J .J formos Med Assoc 2003 102(9) 601-606. (paperopen.com)
  • Antibiotic resistance in community-acquired pneumonia caused by Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus, and Acinetobacter baumannii. (wustl.edu)
  • The worldwide emergence of community-acquired methicillin-resistant Staphylococcus aureus has also led to discussion of this pathogen in recent revisions of the international CAP guidelines. (wustl.edu)
  • Dynamic Interplay of MexAB-OprM, PDC-5 and OprD in Pseudomonas aeruginosa Facilitates Emergence of Meropenem Resistant Phenotype in Rabbit Pneumonia Model. (asm.org)
Abstract1
  • ABSTRACT The emergence of antimicrobial resistance is a global problem in the community and in hospitals. (who.int)
Antibiotic5
  • We are particularly focused on the identification of combinations of existing antibiotic and non-antibiotic drugs that prevent the emergence of resistance during treatment and on understanding how resistance to these drugs and drug combinations develops using genomic and transcriptomic approaches. (harvard.edu)
  • Optimised antibiotic therapy holds great promise for improving patient outcomes and decreasing the emergence of resistance. (ersjournals.com)
  • To gain a handle on the factors that are propelling the problem of AMR, molecular and patient-level investigations are necessary to better elucidate the time-varying and heterogeneous role of antibiotic selection pressure on emergence and selection of AMR. (europa.eu)
  • Many results drawn from previous studies of the effect of antibiotic use on emergence, selection and spread of AMR have lacked a holistic view combining all aspects into one study. (europa.eu)
  • The pharmacodynamic study modelled the relationships between antibiotic exposure and AMR emergence over time for various classes of agents. (europa.eu)
Genomic1
  • This method allowed identification of A. calcoaceticus-A. baumannii complex by the formation of smooth, rounded, mucoid colonies at 37 °C. Closely related species could not be differentiated and individual species such as A. baumannii and Acinetobacter genomic species 3 could not be positively identified phenotypically. (wikipedia.org)
Species are Gram-negative2
  • Acinetobacter species are Gram-negative coccobacilli many of which are found in soil and fresh water throughout our natural habitats [ 1 ]. (biomedcentral.com)
  • Acinetobacter baumannii and Brucella species are Gram-negative organisms that are vulnerable to misinterpretation as Gram-positive or Gram-variable in blood cultures. (openmicrobiologyjournal.com)
Antimicrobial1
  • Antimicrobial resistance represents a major global public health concern, characterized by the emergence of new traits that lead to the loss of effectiveness of a drug, whether they arise naturally or are acquired [ 1 ]. (biomedcentral.com)
Carbapenemases among1
  • Emergence and widespread dissemination of OXA-23, -24/40 and -58 carbapenemases among Acinetobacter spp. (microbiologyresearch.org)
Aerobic3
  • Species of the genus Acinetobacter are strictly aerobic, nonfermentative, Gram-negative bacilli. (wikipedia.org)
  • Acinetobacter are gram-negative aerobic bacilli or coccobacilli that belong to the family Moraxellaceae. (msdmanuals.com)
  • The genus Acinetobacter contains strictly aerobic, non-motile, Gram-negative, coccobacillary rods that are oxidase negative, nitrate negative and do not ferment sugars 1 . (microbiologyjournal.org)
Genus3
  • The genus Acinetobacter comprises 38 validly named species. (wikipedia.org)
  • Growth on the AMA indicates a positive transformation assay and confirms the isolate as a member of the genus Acinetobacter. (wikipedia.org)
  • Specifically, A. baumannii , A. pittii , and A. nosocomialis of the Acinetobacter calcoaceticus-baumannii ( Acb ) complex have become the most medically relevant members of the genus as they are most frequently isolated from health care facilities as well as human tissues. (biomedcentral.com)
Characterization1
Drug-resistance2
  • Acinetobacter species are associated with increasing mortality due to emerging drug-resistance. (biomedcentral.com)
  • QUAN Jin-lin,LI Yan-ping,QIAO Deng-yan.Analysis on Drug Resistance and Epidemiological Investigation of Acinetobacter Baumannii[J].Western Journal of Traditional Chinese Medicine,2012,25(10):73-74. (paperopen.com)
Clin Microbiol Rev1
  • 2 Peleg AY Seifert H Paterson DL.Acinetobacter bau-mannii emergence of a successful pathogen J .Clin Microbiol Rev 2008 21(3) 538-582. (paperopen.com)
Prevent the emergence1
  • Decisive and comprehensive action to prevent the emergence and reduce the spread of AMR. (who.int)
Antibacterial activity1
Increasingly1
Mechanism1
  • Global emergence of Acinetobacter baumannii (A. baumannii) displays a mechanism of resistance to all existing antimicrobials. (omicsonline.org)
Efflux1
  • In one example we recently identified the Acinetobacter chlorhexidine efflux protein (AceI) efflux pump in Acinetobacter. (edu.au)
Clinical impact1
Community-acquired1
  • Acinetobacter can cause community-acquired bronchiolitis and tracheobronchitis in healthy children and tracheobronchitis in immunocompromised adults. (msdmanuals.com)
Hospital1
  • Hospital-acquired Acinetobacter pneumonias are frequently multilobar and complicated. (msdmanuals.com)
Toxicity1
  • By extending the infusion period, a lower dose can achieve almost the same efficacy as a higher dose infused over a shorter period of time, in addition to reducing cost, toxicity and the likelihood for the emergence of resistance. (ersjournals.com)
Motility1
  • Acinetobacter species are oxidase-negative, exhibit twitching motility, and occur in pairs under magnification. (wikipedia.org)
Spread1
  • Regular surveillance of AMR can provide timely information on its emergence and spread in a given setting. (who.int)
Occur1
  • Acinetobacter species are widely distributed in nature, and commonly occur in soil and water. (wikipedia.org)
Therapeutic1
  • The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2. (environmed.pl)