Embryos simplifying developmental early embryo morphogenesis. Medical search. Frequent questions

The group studies a population of coupled genetic oscillators in the vertebrate embryo termed the segmentation clock. (ens-lyon.fr)
Some examples include the specialized hair cells of the mammalian cochlea, that display a spectacularly polarized organization of kinocilia and stereocilia on their apical surfaces, the dynamic ciliated cells of the tracheal and reproductive tract epithelia, and cells in the gastrulating vertebrate embryo that display polarized migration and intercalation behaviors. (stanford.edu)

This paper addresses a fundamental question in developmental biology, that is, how morphogenetic movements driving tissue folding are patterned to occur with the correct spatiotemporal dynamics. (elifesciences.org)
For the end, vary Developmental Biology( growth). (cutechabeads.com)
Physica A 352 (2005) 113-130 A cell-centered approach to developmental biology Roeland M.H. Merks, James A. Glazier Department of Physics, Biocomplexity Institute, Indiana University, Swain Hall West 159, 727 East 3rd Street, Bloomington, IN 47405-7105, USA Available online 13 January 2005 Explaining embryonic development of multicellular organisms requires insight into complex interactions between genetic regulation and physical, generic mechanisms at multiple scales. (2medicalcare.com)
As more physicists move into developmental biology, we need to be aware of the ''cultural''differences between the two ﬁelds, whose concepts of ''explanations'' and ''models''traditionally differ: biologists aiming to identify genetic pathways and expression patterns,physicists tending to look for generic underlying principles. (2medicalcare.com)

Single mutant plants devoid of P5CS1 did not show any developmental defects. (biomedcentral.com)
In each case, PCP is critical to the function of these cells and tissues, and errors in the signaling system controlling PCP lead to human diseases and developmental defects, including congenital deafness, neural tube closure defects and cardiac outflow tract anomalies. (stanford.edu)
We also established that P. anserina developmental programs require H3K27me3-mediated silencing, since loss of the PaKmt6 EZH2-like enzyme caused severe defects in most aspects of the life cycle including growth, differentiation processes and sexual reproduction, whereas loss of the PaKmt1 SU(VAR)3-9-like enzyme resulted only in marginal defects, similar to loss of PaHP1. (biomedcentral.com)

The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. (elifesciences.org)
These early progenitor cells often travel long distances from their induction site to the site of terminal differentiation, making them vulnerable to environmental cues and movement of neighbouring tissues. (elifesciences.org)
Despite the importance of the developmental pathways followed by these small groups of progenitor cells and their impact on the physiology of the organism, we still know little about the set of developmental strategies that progenitor cells deploy in vivo to overcome the challenges imposed by the environment as they travel to the site of terminal differentiation. (elifesciences.org)
Ssbp2 is expressed in the Xenopus pronephros, and knockdown prevents normal morphogenesis and differentiation of the glomus and the convoluted renal tubules. (bvsalud.org)
In contrast, the 'facultative' heterochromatin corresponds to the deposition of H3K27me3 on gene-rich regions, whose silencing is transient and dynamic across developmental processes, allowing cell type-specific differentiation and rapid adaptation of gene expression [ 5 ]. (biomedcentral.com)

In many well-studied cases of tissue morphogenesis, such as mesoderm invagination or germband extension in the fly, many morphogenetic effectors are induced evenly across the tissue primordium. (elifesciences.org)
We show that expression of fos and rasl11b is blocked in the early mesoderm when Fgf and Erk signalling is inhibited. (bvsalud.org)

Early in development the expression of the first patterning genes broadly sets up embryonic regions. (elifesciences.org)
Here, we examine this question during the early stages of morphogenesis of the embryonic laterality organ, the first organ to form during vertebrate development, using the zebrafish as a model organism. (elifesciences.org)

The developmental investigation of sound transmitting apparatus is important in understanding the ontogenetic processes behind morphological diversity. (scielo.br)
During embryo development, naïve cell lineages undergo concurrent processes of fate specification and morphogenesis as critical steps towards the generation of differentiated tissues and organs. (elifesciences.org)
This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)

This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)

We report diverse spatiotemporal patterns of editing with deamination activity highest in early embryogenesis before zygotic genome activation and in the ovary. (bvsalud.org)

It is generally accepted that H3K27me3-enriched heterochromatin maintains transcriptional repression established during early development and regulates cell fate. (biomedcentral.com)

In the placodes of the forming tubes of the salivary glands in the Drosophila embryo, we previously identified spatially defined cell behaviors of cell wedging, tilting, and cell intercalation that are key to the initial stages of tube formation. (elifesciences.org)
RESULTS: Here, we identify millions of editing events in Xenopus with high accuracy and systematically map the editome across developmental stages, adult organs, and species. (bvsalud.org)

In keeping with our hypothesis, we show that Cic knockdown and Fgf overexpression have overlapping effects on embryo development and gene expression. (bvsalud.org)
Gamete and embryo development are crucial for successful reproduction and seed set in plants, which is often the determining factor for crop yield. (biomedcentral.com)
Both the level of free proline and proline metabolism were proposed to influence the transition to flowering, as well as pollen and embryo development. (biomedcentral.com)
Expression of P5C reductase (P5CR) was indispensable for embryo development but surprisingly not needed for pollen or egg cell fertility. (biomedcentral.com)
The overarching goal of the research in my lab is to understand how signal transduction pathways regulate morphogenesis - the emergence of spatial organization - during development. (stanford.edu)

Misplacement or enlargement of the initial invagination pit leads to early problems in cell behaviors that eventually result in a defective organ shape. (elifesciences.org)
By correlating dynamic patterns of transcription factor expression with rigorous, quantitative analyses of cell behaviors across the salivary gland primordium in Drosophila , their results suggest Hkb and Fkh transcription factor patterning induces switches in cell behaviors at fixed positions to promote continued morphogenesis of the tubular structure. (elifesciences.org)

We are using the regulation of shoot branching as a model system to investigate the mechanisms underlying this developmental plasticity. (ens-lyon.fr)

Hearing of the African lungfish (Protopterusannectens) suggests underwater pressure detection and rudimentary aerial hearing in early tetrapods. (scielo.br)

Peripheral endocrine glands (thyroid, pancreas, adrenals, gonads) form early in the second month from epithelial/mesenchye interactions and differentiate into the third month. (edu.au)

We find that early transcriptional patterning of key morphogenetic transcription factors drives the selective activation of downstream morphogenetic modules, such as GPCR signaling that activates apical-medial actomyosin activity to drive cell wedging at the future asymmetrically placed invagination point. (elifesciences.org)

Given the high evolutionary conservation of gene expression and segmentation patterning between mammalian and amphibian nephrons, the Xenopus laevis pronephric kidney offers a simplified model for studying nephrogenesis. (bvsalud.org)
Mansel knew( 1858) to surface Pascal's transportation on Kantian Students, reaching the early expression of' Kant's aerothermal w. very makes recovery after serving, all tricks are a ' human ' death, the industries expressing beneath the throughout the long payoffs, and a endochondral valuable conference flushing between the endochondral vascular education and the site. (need4speed.com)
Expression of P5CR-GFP under the control of the endogenous P5CR promoter was able to restore growth of homozygous p5cr mutant embryos. (biomedcentral.com)

Even sites that are detected in both X. laevis and X. tropicalis show largely divergent editing levels or developmental profiles. (bvsalud.org)
We characterise Xenopus Cic and show that it is widely expressed in the embryo. (bvsalud.org)

Notably, ADAR was first detected in frog oocytes and embryos as an activity that unwinds RNA duplexes. (bvsalud.org)

This study shows that the motor axons of intersegmental nerve b (ISNb) in the Drosophila embryo display targeting defects during axon development in the absence of foraging ( for ), a gene encoding PKG. (sdbonline.org)
The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)
Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action. (lookformedical.com)
TUNEL staining and flow cytometry were used to investigate the apoptosis level of Drosophila S2 embryos, and CCK-8 (Cell Counting Kit-8) was used to detect the cell viability of Drosophila S2 embryos. (bvsalud.org)
The exuberant phagocytosis of apoptotic cell corpses by macrophages in Drosophila embryos creates highly oxidative environments. (bvsalud.org)
Here we propose a neural network-based approach for dimensionality reduction and analysis of biological gene expression data, using, as a case study, a well-known genetic network in the early Drosophila embryo, the gap gene patterning system. (bvsalud.org)

The study of ontogeny is pivotal to understand which developmental processes underlie the incredible morphological disparity of arthropods and thus to eventually unravel evolutionary transformations leading to their success. (biomedcentral.com)
Yet, although the range of studied taxa has increased noticeably since the advent of comparative evolutionary developmental biology (evo-devo), several smaller groups remain understudied. (biomedcentral.com)
Further, we propose evolutionary developmental trajectories within crown-group Pycnogonida. (biomedcentral.com)
The transition of life from single cells to more complex multicellular forms has occurred at least two dozen times among eukaryotes and is one of the major evolutionary transitions, but the early steps that enabled multicellular life to evolve and thrive remain poorly understood. (biomedcentral.com)
The species Volvox carteri f. nagariensis (hereafter V. carteri or Volvox unless otherwise specified) is the best-studied species in the genus, and has become an established model for developmental and evolutionary biology [ 2 ]. (biomedcentral.com)

Cleavage is the sequence of cell divisions that turns a zygote into a multicellular embryo, and plays an essential role in the specification of cell fates before the onset of gastrulation. (biomedcentral.com)
The multicellular volvocine species Volvox carteri exhibits many hallmarks of complex multicellularity including complete germ-soma division of labor, asymmetric cell divisions, coordinated tissue-level morphogenesis, and dimorphic sexes-none of which have obvious analogs in its closest unicellular relative, the model alga Chlamydomonas reinhardtii . (biomedcentral.com)
While on its own Volvox is a highly tractable model organism, it has even greater utility when it is studied in the context of the volvocine algal clade which includes several additional multicellular genera with different sizes, cell numbers and degrees of developmental complexity (e.g. (biomedcentral.com)

The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. (lookformedical.com)

Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)

To overcome permeability issues and allow QD conjugate penetration, embryos were treated with proteinase K. The use of QDs dramatically increased sensitivity of whole-mount in situ hybridization (WISH) in comparison with organic fluorophores and enabled fluorescent detection of specific transcripts within cells without the use of enzymatic amplification. (hindawi.com)
From clade 2C onward all early blastomeres can be assigned one of the six basic fates, however the position in the sequence of cells varies between species. (biomedcentral.com)
This pattern arises during early development when cells within the inner layer of ectoderm are selected out by Notch to form ciliated cell precursors (CCPs) that then radially intercalate into the outer epithelial cell layer to form ciliated cells. (silverchair.com)
The skin of the amphibian embryo also produces a directed fluid flow generated by ciliated cells, thus serving as a model system for studying how such ciliated epithelia form during organogenesis. (silverchair.com)
Cells in the outer layer of the ectoderm, also called the superficial layer,differentiate into mucus-producing epidermal cells, thus forming an occluding epithelial barrier on the embryo surface. (silverchair.com)
These cultures can be crafted to replicate a simplified version of a complex organ, or to express specific characteristics to produce certain types of cells. (j-organoid.org)

With the advent of cell type specific molecular markers, description and analysis of developmental morphogenesis has become possible in a number of biological systems. (hindawi.com)
Using 3D-live imaging time-lapse microscopy (4D-microscopy), we characterize the cell lineage, MAPK signaling, and the expression of 16 developmental genes in the bryozoan Membranipora membranacea . (biomedcentral.com)
You will start your shop komplexität und dynamik genome when your cell includes deceived based via morphogenesis. (cutechabeads.com)
While in all studied representatives the same distinctive developmental steps need to be taken, cell behavior leading to these is not conserved. (biomedcentral.com)
VE-cadherin (cadherin 5) was discovered in the early 1990s [ 5 , 6 ] and is a major component of endothelial cell-cell contacts. (hindawi.com)

We found that the molecular identity and the fates of early bryozoan blastomeres are similar to the putative homologous blastomeres in spiral-cleaving embryos. (biomedcentral.com)
Alignment of early blastomeres (colored circles) along the a-p axis. (biomedcentral.com)

Different colors of lineage branches indicate distinct early cleavage patterns as indicated in Figure 1b. (biomedcentral.com)

Based on distinct developmental characters described in the text some clades are further subdivided (A, B, C). Data of species written in grey have been extracted from the literature. (biomedcentral.com)
Simplified cladogram of selected volvocine species from representative genera shown in cartoon form with successive cellular and developmental innovations indicated by bulleted descriptions above or below the node in which they arose. (biomedcentral.com)

was delivered to zebrafish through caudal vein microinjection during distinct periods in early neurodevelopment. (nih.gov)

We can discern six different early cleavage types and suggest that these variations are due to modifications in the activity of the POCs in conjunction with changes in the distribution of PAR proteins. (biomedcentral.com)
Comparison of early cleavage between the basal nematode Tobrilus stefanskii and the tardigrade Hypsibius dujardini revealed surprising similarities indicating that the presence of POCs is not restricted to nematode embryos. (biomedcentral.com)
Six early cleavage types. (biomedcentral.com)

The photostability and narrow emission spectra of nanometer-scale semiconductor crystallites (QDs) make them desirable candidates for whole-mount fluorescent in situ hybridization to detect mRNA transcripts in morphologically preserved intact embryos. (hindawi.com)

Morphogenesis provides form changes of a part, parts, or the whole organism. (lookformedical.com)

The study was conducted using 4-D microscopy and 3-D modeling of developing embryos. (biomedcentral.com)

PMID- 5097525 TI - Animalizing effects of Evans blue in embryos of Arbacia punctulata. (nih.gov)

. In situ hybridization (ISH) is a quite common technique among developmental research labs, yet its uses are quite diverse and include medical and prenatal diagnostics [ 9 - 16 ]. (hindawi.com)

Specifically, the use of QDs alleviates issues of photostability and limited brightness plaguing organic fluorophores and allows fluorescent imaging of cleared embryos. (hindawi.com)

Anatomy63

Organisms24

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Chemicals and Drugs58

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Vertebrate embryo2

Biology4

Defects3

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Mesoderm2

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Drosophila6

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