• To try to overcome some of these limitations in this study, we have used Caenorhabditis elegans (nematode) and Danio rerio embryos (zebrafish) as alternative assays for DART hazard assessment of some candidate chemicals being considered for a new commercial application. (nih.gov)
  • The question of how the embryo perceives nodal flow remains unresolved, although various models exist. (biomedcentral.com)
  • We also find that reduction of Med or End activity results in aberrant numbers of intestinal cells in embryos that make endoderm. (ucsb.edu)
  • Shortly after this the embryo begins to undergo embryonic turning, the process that results in the embryo taking up the classic foetal position. (biomedcentral.com)
  • 2014 . A high-content assay for identifying small molecules that reprogram C. elegans germ cell fate. (nih.gov)
  • The C. elegans adult hermaphrodite contains a renewable pool of mitotically dividing germ cells that are contained within the progenitor zone (PZ), at the distal region of the germline. (nih.gov)
  • In the past decade, mutational analyses in the non-vertebrate genetic models of the worm (Caenorhabditis elegans) and the fruitfly (Drosophila melanogaster) have contributed significantly to our understanding of early developmental pathways. (nih.gov)
  • 2007 . Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay. (nih.gov)