Embryonic stem scientists donor egg cell. Medical search. Frequent questions

Cloned human embryos express the genes required for pluripotency, but animal-human hybrids do not, according to a study published today (Feb. 2nd) in the journal__ linkurl:Cloning and Stem Cells. (the-scientist.com)
Interest in using stem cells from cloned human embryos has revived after success by scientists in the United States and Korea. (bioedge.org)
The researcher claimed he had created stem cell lines from cloned human embryos. (asianews.it)
But cloning research continued, and American scientists announced in 2013 that they had for the first time successfully obtained stem cells from cloned human embryos. (thenewatlantis.com)

In humans, a major roadblock in achieving successful SCNT leading to embryonic stem cells has been the fact that human SCNT embryos fail to progress beyond the eight-cell stage. (news-medical.net)
They derived several human embryonic stem cell lines from these cloned embryos whose DNA was an exact match to the adult cell that donated the DNA. (news-medical.net)
http://www.liebertonline.com/clo __The findings pave the way for isolating human embryonic stem cells from therapeutic cloning -- a landmark that has never been achieved after linkurl:Woo-suk Hwang's discredited cloning experiments;http://www.the-scientist.com/news/display/22933/ -- but call into question the utility of interspecies embryos. (the-scientist.com)
These eggs simply do not reprogram," lead author linkurl:Robert Lanza,;http://www.robertlanza.com/ chief scientific officer of Advanced Cell Technology in Worcester, Mass., said of the human-animal hybrid embryos. (the-scientist.com)
this approach has been championed as an answer to the many issues concerning embryonic stem cells (ESCs) and the destruction of viable embryos for medical use, though questions remain on how homologous the two cell types truly are. (wikipedia.org)
Controversy surrounds human ESC work due to the destruction of viable human embryos, leading scientists to seek alternative methods of obtaining pluripotent stem cells, SCNT is one such method. (wikipedia.org)
One aspect to this project will be to source oocytes, or immature egg cells to generate SCNT embryos from which embryonic stem cells are harvested. (medicalxpress.com)
Embryonic stem cells are derived from early embryos and have the ability to differentiate into any cell type. (spiked-online.com)
Then, in February 2004 he dropped a bombshell, claiming that his SNU research team had cloned the first human embryos and extracted stem cells from them. (koreatimes.co.kr)
The scientists of the BioRescue consortium have already produced northern white rhino embryos by in vitro fertilisation of oocytes with sperm. (izw-berlin.de)
Embryonic stem cells come from human embryos that are three to five days old. (healthline.com)
A year ago, we showed that you could do it with cells from embryos," says Wilmut. (newscientist.com)
Particularly valuable animals could be cloned from adult cells without the uncertainties of crossing them with other animals or tinkering with embryos. (newscientist.com)
More importantly, biotechnologists will for the first time be able to manipulate the genes of cells from farm animals directly before growing them into embryos. (newscientist.com)
But scientists have not managed to isolate such cells from farm animals, and must rely instead on injecting genes randomly into early embryos. (newscientist.com)
Nature adds that rogue scientists might implant cloned embryos into wombs to create cloned children, a possibility which is widely condemned. (bioedge.org)
These scientists destroyed the embryos and derived stem cell lines. (nationalrighttolifenews.org)
Most embryos…formed one or two pronuclei at the time of removal from TSA, whereas a slightly higher portion of embryos cleaved…suggesting that some SCNT embryos did not exhibit visible pronuclei at the time of examination… Most cleaved embryos developed to the eight-cell stage…but few progressed to compact morula…and blastocyst. (nationalrighttolifenews.org)
Activation of embryonic genes and transcription from the transplanted somatic cell nucleus are required for development of SCNT embryos beyond the eight-cell stage…Therefore, these results are consistent with the premise that our modified SCNT protocol supports reprogramming of human somatic cells to the embryonic state. (nationalrighttolifenews.org)
But it is an important step in research because it doesn't require the use of embryos in creating the type of stem cell capable of transforming into any other type of cell in the body. (nationalrighttolifenews.org)
Citizens disagree about whether we should destroy human embryos for their stem cells-and if so, which embryos, with whose money, under what regulatory guidelines. (eppc.org)
The holy grail of regenerative medicine-whatever one's ethical beliefs about destroying embryos-is to "reprogram" regular cells from one's own body so that individuals can be the source of their own rejection-proof therapies. (eppc.org)
That is to say, we risk turning developed cells into developing embryos, and thus risk engaging in the very activities of embryo destruction and human cloning that we seek to avoid. (eppc.org)
But we need to proceed carefully, recognizing that we are gaining new powers over human origins even when we do not use human embryos, and recognizing the danger of blurring the line between cellular parts and embryonic wholes. (eppc.org)
Far more controversial-and for good reason-are stem cells derived from destroyed human embryos. (eppc.org)
The eggs will then be used by scientists from Newcastle and Durham Universities to create embryos from which they will attempt to derive stem cells . (progress.org.uk)
The Australian government has issued its first license for cloning human embryos to obtain embryonic stem cells. (bioedge.org)
Chinese scientists have successfully created chimeric embryos containing a combination of human and pig cells. (bioedge.org)
It also produces mosaic embryos where some cells get fixed, others don't. (cosmosmagazine.com)
Mitalipov also carries the distinction of being the first to crack the long-standing problem of cloning human embryos and deriving embryonic stem cells. (cosmosmagazine.com)
Out of 58 embryos, 42 showed the normal gene in every cell. (cosmosmagazine.com)
This is where stem cells are reverse engineered from adult tissue cells rather than using live human or animal embryos. (scitechdaily.com)
In another article, which was recently published in Nature Cell Biology , researchers from UNSW Medicine & Health revealed the identity of cells in mice embryos responsible for blood stem cell creation. (scitechdaily.com)
More specifically, ISSCR explains it will support laboratory-based research focused on "gene editing of the nuclear genomes of human sperm, egg, or embryos, when performed under rigorous review, but hold that any attempt to apply this clinically would be premature and should be prohibited at this time. (biopharminternational.com)
A gene for a green fluorescent protein was inserted into the genomes of stem cells, which were then injected into macaque embryos grown for around four days in vitro. (planer.com)
Moreover, most early-stage embryos that are produced naturally (that is, through the union of egg and sperm resulting from sexual intercourse) fail to implant and are therefore wasted or destroyed. (wikiquote.org)
Researchers there are working on technology that induces human skin cells to change into the kind of stem cells that have been created by embryos. (cbc.ca)
Some argue that the possibility of mimicking stem cells without acquiring them from embryos, side-steps that moral dilemma. (cbc.ca)
Embryonic stem cells come from embryos, embryonic germ cells from testes, and adult stem cells can come from bone marrow. (cbc.ca)
This new method of generating stem cells does not require embryos as starting points and could be used to generate cells from many adult tissues, such as a patient's own skin cells,' said principal author Andras Nagy, senior investigator at Mount Sinai's Samuel Lunenfeld Research Institute. (cbc.ca)
Today, this technique continues to form the foundation for research on mammalian embryos, including technologies such as transgenic engineering, embryonic stem cell therapy, human in vitro fertilization, mammalian cloning, and knockout engineering. (avma.org)
Using this method of embryo manipulation, he next worked out many aspects of the metabolism and development of eggs and early embryos. (avma.org)
From there, Dr. Brinster became interested in modifying the development of animals and their germ lines, and he went on to become the first person to show that it was possible to colonize a mouse blastocyst with stem cells from older embryos. (avma.org)
Stem cells may be derived from adult tissues but the most potent are extracted from developing human embryos. (edu.au)
However, following the successful derivation of human embryonic stem cells in 1998, the debate over human cloning largely shifted to the question of whether it is acceptable for scientists to create human embryos only to destroy them. (thenewatlantis.com)
The subsequent discovery of promising alternative techniques for generating stem cells without creating or destroying embryos seemed to show that scientific progress would obviate the demand for cloning. (thenewatlantis.com)
This kind of cloning is today being performed at several scientific labs in the United States, despite the availability of alternative techniques that produce cells of nearly the same scientific and medical value but that require neither the creation nor destruction of human embryos. (thenewatlantis.com)
Such cells are derived from human embryos, and are undifferentiated, unlike other specialized cells in the human body. (nhsjs.com)
Proponents of stem cell research claim that the blastocyst is not human yet, and the embryos used for stem cell harvest are typically leftover from in vitro fertilization procedures with minimal chance that a human could ever develop from them. (nhsjs.com)
Adversaries of stem cell research argue that embryos are human and destroying one is equal to murdering a child. (nhsjs.com)
There are many types of stem cells, but most of the controversy surrounds embryonic stem cells, as they are derived from human embryos. (nhsjs.com)
The source of embryos is from those fertilized in vitro , and then donated for research with donor consent. (nhsjs.com)

In genetics and developmental biology, somatic cell nuclear transfer (SCNT) is a laboratory strategy for creating a viable embryo from a body cell and an egg cell. (wikipedia.org)
Development will ensue normally and after many mitotic divisions, the single cell forms a blastocyst (an early stage embryo with about 100 cells) with an identical genome to the original organism (i.e. a clone). (wikipedia.org)
Stem cells can then be obtained by the destruction of this clone embryo for use in therapeutic cloning or in the case of reproductive cloning the clone embryo is implanted into a host mother for further development and brought to term. (wikipedia.org)
The aim of carrying out this procedure is to obtain pluripotent cells from a cloned embryo. (wikipedia.org)
Embryonic stem cells are undifferentiated cells of an embryo. (wikipedia.org)
Hwang and colleagues report that the cells are chromosomally normal, self-renewing and "pluripotent" - meaning they have the ability to form the three major types of cells in the early embryo that give rise to all other cells in the body. (scienceblog.com)
Crucial to embryo production is the availability of oocytes (egg cells) and sperm. (izw-berlin.de)
The predominant bioethical concern arising from this technology is that the blastocyt-stage embryo must be destroyed in the process of isolating and separating the embryonic stem cells from the inner mass region of the pre-embryo. (jcpa.org)
The destruction of the pre-embryo has been the critical issue in the U.S. behind imposing limits on federal government-sponsored research in embryonic stem cells. (jcpa.org)
Many politicians, religious leaders, and bioethicists believe that any destruction of the pre-implanted embryo or fertilized egg is akin to murder. (jcpa.org)
During the process of harvesting embryotic stem cells, the embryo is destroyed. (healthline.com)
They produced idential lambs called Megan and Morag, which originated from different cells of the same embryo. (newscientist.com)
The latest experiments have also produced three lambs from the cells of a sheep fetus aborted after 26 days, and four from a nine-day-old embryo. (newscientist.com)
After growing and dividing for a week or so in a laboratory culture dish, the fused cell forms an early embryo called a blastocyst, which Wilmut's team implants into a surrogate mother. (newscientist.com)
However, the process is still ethically controversial, as researchers first create a human embryo and then destroy it to create stem cells. (bioedge.org)
It creates an embryo only for the purpose of harvesting its cells. (bioedge.org)
In a study published today in the journal Cell Stem Cell , researchers discovered it's possible to regenerate human eggs or oocytes-the cellular beginning of an embryo-by making use of genetic material that normally goes to waste. (salk.edu)
Research advocates attack President Bush for "banning stem cell research," while pro-life advocates lament a Republican administration and Congress that have banned nothing-not embryo destruction, not human cloning, not fetal farming, not genetic engineering. (eppc.org)
Before leaving office, President Clinton sought to get around the existing law without actually changing it, by funding research on embryonic stem cells so long as the actual embryo destruction was paid for with private dollars. (eppc.org)
UK scientists announced that they will ask the rarely-says-no UK Human Fertilisation and Embryology Authority (HFEA) for permission to implant an IVF embryo that is biologically related to three parents (two women and one man). (cbc-network.org)
The early mammalian embryo consists of the extra-embryonic cell layers-the trophoblast and a body of cells called the inner cell mass (ICM), which eventually become the embryo proper. (thefutureofthings.com)
The thing that just wows me about this is that blood stem cells, when they form in the embryo, form in the wall of the main vessel called the aorta. (scitechdaily.com)
It is also our view that there are no sound reasons for treating the early-stage human embryo or cloned human embryo as anything special, or as having moral status greater than human somatic cells in tissue culture. (wikiquote.org)
This mouse egg (top) is being injected with genetic material from an adult cell to ultimately create an embryo - and, eventually, embryonic stem cells. (usf.edu)
They look like the cells in a human embryo - in fact, they're called embryonic stem cells. (usf.edu)
Essential to embryo manufacturing is the provision of oocytes (egg cells) and sperm. (publicaawaz.com)
Keith Henry Stockman Campbell studied embryo growth and cell differentiation during the twentieth and twenty-first centuries in the UK. (asu.edu)
However, the removal of embryonic stem cells destroys the early embryo. (nhsjs.com)
The controversy over embryonic stem cell research is caused by the fact that the procurement of these stem cells involves the destruction of the embryo produced during in vitro fertilization. (nhsjs.com)
Last year, Hwang's team said it successfully cloned a human embryo from embryonic stem cells. (blogspot.com)
According to MBC, the scientist "maintains that Hwang's team fabricated data because in reality it failed to clone a somatic cell and instead used a frozen embryo from the hospital to make stem cells. (blogspot.com)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)

In the face of a shortfall of human egg donors, many researchers hope that by injecting human nuclei into animal eggs they will be able to obtain patient-specific human embryonic stem cells. (the-scientist.com)
Before patient-specific stem cells can potentially be used in the clinic, a variety of issues must be addressed, the researchers emphasized. (scienceblog.com)
In addition, researchers must develop methods to efficiently direct the differentiation of embryonic stem cells to specific stable cell types. (scienceblog.com)
The Korean researchers who performed this stem cell research improved upon their protocols that yielded the first embryonic stem cell line from a cloned human blastocyst. (scienceblog.com)
From the 185 donated oocytes, endowed with the genetic material from a different person (or in one case, the same person), the researchers report development of 31 hollow balls of cells called "human nuclear-transfer blastocysts. (scienceblog.com)
The researchers generated these stem cell lines ten times more efficiently than in their 2004 Science study, using improved laboratory methods. (scienceblog.com)
In attempt to combat this problem, researchers have essentially been-as one doctor described it-taking the "yellow part" of a mother's egg and inserting it into the "white" of a donor's egg. (scientificamerican.com)
Most researchers obtain embryonic stem cells from the inner mass of a blastocyst, an embryonic stage when a fertilized egg has divided into 128 cells. (jcpa.org)
The researchers wanted to see whether "mature" cells that have differentiated to fulfil a specialised role (such as that of an udder cell or a fetal cell) could be returned to a primitive state from which they could grow into entire organisms. (newscientist.com)
Next, the researchers take cells containing donor genetic material. (newscientist.com)
He points out that it is easy to get a "false positive" when attempting to transplant a nucleus, because researchers might inadvertently fail to remove all the original DNA from the egg. (newscientist.com)
US researchers have reported a breakthrough in stem cell research, describing how they have turned human skin cells into embryonic stem cells for the first time. (nationalrighttolifenews.org)
New discoveries about embryonic blood stem cell creation made independently by biomedical engineers and medical researchers at the University of New South Wales (UNSW) Sydney could one day eliminate the need for blood stem cell donors. (scitechdaily.com)
Although we have known about induced pluripotent stem cells since 2006 , researchers still have plenty to learn about how cell differentiation in the human body can be mimicked artificially and safely in the lab for the purposes of delivering targeted medical treatment. (scitechdaily.com)
UNSW researchers have recently completed two studies in this area that shine new light on not only how the precursors to blood stem cells occur in animals and humans, but how they may be induced artificially. (scitechdaily.com)
In the study detailed in Cell Reports , lead author Dr. Jingjing Li and fellow researchers described how a 3cm x 3cm (1.2″ x 1.2″) microfluidic system pumped blood stem cells produced from an embryonic stem cell line to mimic an embryo's beating heart and conditions of blood circulation. (scitechdaily.com)
In an article in Nature , researchers indicate that one option for improving oversight may be repurposing the Embryonic-Stem-Cell Research Oversight (ESCRO) committee, in order to take a more expansive role in research supervision. (biopharminternational.com)
Instead, researchers should "call on the existing human subjects review processes to oversee donor cell recruitment," ISSCR wrote in a press announcement . (biopharminternational.com)
Researchers used stem cells obtained from the embryonic tissue of cynomolgus monkeys, a type of macaque commonly used in genetics research because of their similarity to humans. (planer.com)
In the 18 years since researchers cloned a sheep, scientists have found another way to produce cloned human cell lines. (usf.edu)
However, researchers at the Harvard Stem Cell Institute say reprogrammed cells won't eliminate the need or value of studying embryonic stem cells. (cbc.ca)
A unique 3D model allows researchers to explore embryonic development. (bigthink.com)
Mouse cells and tissues created through nuclear transfer can be rejected by the body because of a previously unknown immune response to the cell's mitochondria, according to an international study in mice by researchers at the Stanford University, MIT and colleagues in Germany and England. (pharmaceuticalintelligence.com)
Although many stem cell researchers are focused on a different method of creating pluripotent stem cells, called induced pluripotent stem cells, there may be some applications for which SCNT-derived pluripotent cells are better suited. (pharmaceuticalintelligence.com)
This research informs the medical community of the margin of safety that would be required if, in the distant future, researchers need to use SCNT to create pluripotent cells to treat someone. (pharmaceuticalintelligence.com)
hero" is the right word for how Hwang Woo-suk is revered by the media -- and by a large section of the Korean public who have bought into the false promises of embryonic stem cell and cloning researchers. (blogspot.com)
Paul Root Wolpe of the Center for Bioethics at the University of Pennsylvania points out that Hwang did not resign because he used eggs from his researchers but because he lied about it and brought shame "in a country where public shame is so powerful. (blogspot.com)
A Korean television station whose investigative report was the nail in the coffin that prompted human cloning scientist Hwang Woo-suk to admit he lied about egg donations his researchers made says he may have lied about the results of his research as well. (blogspot.com)

The scientists castigated Kerry for making 'exaggerated claims' about the scientific potential of embryonic stem-cell research, and for dismissing 'the entire history of efforts to protect human subjects from research abuse. (davekopel.com)
Considering the great potential of embryonic stem cell research, it is argued here that their research be allowed to be legal, federally funded, and its development a national priority. (nhsjs.com)

The blastocyst stage is developed by the egg to help create embryonic stem cells from the inner cell mass of the blastocyst. (wikipedia.org)
Stem cells were then derived from the inner cell mass of the blastocyst. (scienceblog.com)
The stem cells derived from the inner mass of a blastocyst lack the ability to form a fetus when implanted into a woman, but are self-renewing and can be maintained for long periods of time in the laboratory as undifferentiated stem cells. (jcpa.org)
Moreover, Dr. Brinster first demonstrated that teratocarcinoma cells could combine with blastocyst cells to form adult chimeric mice, establishing the feasibility of this approach to change the genetic character of mice. (avma.org)
[ 2 ] This technique has evolved throughout the years and is now largely performed by biopsy of the blastocyst trophectoderm cells with analysis using techniques such as next-generation sequencing (NGS) and comparative genomic hybridization (CGH) to test for aneuploidy. (medscape.com)

Unlike SCNT, iPS cells are derived from adult cells, such as skin, which are reprogrammed to behave like embryonic stem cells. (medicalxpress.com)
To create iPSCs, scientists genetically reprogram the adult stem cells so they behave like embryonic stem cells. (healthline.com)

The therapeutic potential of cloned human cells has been demonstrated by another study using human oocytes to reprogram adult cells of a type 1 diabetic. (news-medical.net)
Although attempts have not yet been made to create a therapeutic transplant from embryonic stem cells, the methods have been developed to allow the creation of functional, mature cells using human cell cloning technology. (news-medical.net)
Yesterday, scientists in the United Kingdom announced that they'd been granted permission by the Human Fertilization and Embryology Authority to create stem cells by therapeutic cloning. (sentientdevelopments.com)
In therapeutic cloning, scientists take a human egg from a healthy donor, and remove its nucleus. (sentientdevelopments.com)
One of the next preclinical steps, according to the authors, is to evaluate, in the lab, differentiated patient-specific human embryonic stem cell lines for immune-system tolerance, therapeutic efficacy and safety. (scienceblog.com)
SCNT, or therapeutic cloning, is one method used to produce a source of individually-tailored stem cells. (medicalxpress.com)
A renewable, tissue culture source of human cells capable of differentiating into a wide variety of cell types would have broad applications in basic research and therapeutic techniques. (spiked-online.com)
But adult stem cells also raise some interesting ethical dilemmas alongside their great therapeutic promise. (eppc.org)
A number of large biotech companies and scientists are looking toward stem cells as the basis for a therapeutic solution to cure such illnesses as blindness, diabetes and spinal cord injuries. (thefutureofthings.com)
Novel culture and cryopreservation systems for human pluripotent stem cells and neural stem cells will be presented and their advantages and applicability in the production of high quality advanced therapeutic products or functional screening tools for preclinical research discussed. (selectbiosciences.com)
The opportunities and challenges of development of stem cell-based therapeutic interventions for joint surface repair for the treatment and prevention of osteoarthritis will be discussed. (selectbiosciences.com)
This presentation will describe the current status of strategies to generate induced pluripotent stem (iPS) cells from mouse and human somatic cells for patient-specific disease modeling and cell therapeutic applications. (selectbiosciences.com)
What are embryonic stem cells and what is their therapeutic potential? (myassignmentwriters.org)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

This was believed to be due to an inability to activate certain embryonic genes. (news-medical.net)
A potential use of stem cells genetically matched to a patient would be to create cell lines that have genes linked to a patient's particular disease. (wikipedia.org)
For example, if a person with Parkinson's disease donated their somatic cells, the stem cells resulting from SCNT would have genes that contribute to Parkinson's disease. (wikipedia.org)
Alternatively, transgenesis and gene targeting techniques can be used to introduce the patient's genes into the stem cell line. (spiked-online.com)
Scientists tweak genes and grow a dinosaur leg on a chicken. (arlingtoninstitute.org)
A chimeric monkey has been created using embryonic stem cells with two different sets of genes, a new study has demonstrated. (planer.com)
Ideally he would like to screen millions of adults and choose just a hundred or so whose genes would make them good DNA donors. (usf.edu)
He'd like to see a library of cells created with those carefully chosen genes. (usf.edu)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
But previous approaches required the use of viruses to deliver the four genes needed to activate the cell and accomplish that task. (cbc.ca)
Later, Dr. Brinster began to wonder whether he could inject genes instead of mRNA into the eggs. (avma.org)

This was the first successful reprogramming of human somatic cells into embryonic stem cells using a cloning technique, SCNT. (news-medical.net)

By transferring adult cell DNA into an embryonic stem cell, it is possible to create a line of immortal embryonic cells that are able to develop into any type of adult cell, genetically identical to the donor. (news-medical.net)
The resulting cells would be genetically identical to the somatic cell donor, thus avoiding any complications from immune system rejection. (wikipedia.org)
As the fertilized egg divides from one cell into two, physicians can separate these two cells and implant each one of them into a woman's uterus to generate two genetically identical children. (jcpa.org)
But they showed, for the first time, that it is possible to create cloned embryonic stem cells that are genetically identical to the person from whom they are derived. (nationalrighttolifenews.org)
Thus, the clone would be genetically identical to the nucleus donor only if the egg came from the same donor or from her maternal line. (who.int)

These achievements are part of a move in regenerative medicine towards the use of 'induced pluripotent stem cells' to treat disease. (scitechdaily.com)
Stem cell-based regenerative medicine shows much promise. (selectbiosciences.com)
There are other, less controversial alternatives to embryonic stem cells, such as adult, fetal, cord blood, and induced pluripotent stem cells, but they have other biological restrictions that make them less promising for use in regenerative medicine at this time. (nhsjs.com)

In 2013, scientists reported a successful SCNT procedure by modifying the protocol for specific human oocyte biology. (news-medical.net)
The technique consists of taking an denucleated oocyte (egg cell) and implanting a donor nucleus from a somatic (body) cell. (wikipedia.org)
The first being a female gamete, known as the ovum (egg/oocyte). (wikipedia.org)
Each of the 11 new human embryonic stem cell lines was created by transferring the nuclear genetic material from a non-reproductive cell of a patient into a donated egg, or "oocyte," whose nucleus had been removed. (scienceblog.com)
Oocyte donors and patients who donated non-reproductive cells were all unpaid volunteers. (scienceblog.com)
In a Science "Policy Forum" related to the team's latest findings, David Magnus and Mildred Cho from Stanford University in Palo Alto, CA discuss international oversight and ethical issues in oocyte donation, including the need to promote realistic expectations of the outcomes of stem cell research. (scienceblog.com)
The single cell line generated in the 2004 Science paper resulted from nuclear transfer in which the oocyte and non-reproductive ("somatic") cell came from the same healthy female. (scienceblog.com)
Wilmut and his colleagues fuse the empty oocyte with the donor cell by bringing them together and subjecting them to an electric current. (newscientist.com)
In the study, scientists successfully transplanted a polar body from a woman's developing oocyte into the cytoplasm of a donor oocyte stripped of its nucleus. (salk.edu)

The key is that the DNA, the genetic material in those embryonic stem cells, comes from the patient, whose immune system won't reject the stem cells. (sentientdevelopments.com)
The genetic material of the donor egg cell is removed and discarded, leaving it 'deprogrammed. (wikipedia.org)
This DNA comes from small cells called polar bodies that form off of eggs and contain the same genetic material as in a woman's egg nucleus. (salk.edu)
They repeated the process - this time starting with the genetic material extracted from the skin cells of a much older man. (usf.edu)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)

Now the U.K. is positioned to lead the world in translating the potential benefits of stem-cell research into patients. (sentientdevelopments.com)
Somatic cell nuclear transplantation has become a focus of study in stem cell research. (wikipedia.org)
This gives them the ability to create patient specific pluripotent cells, which could then be used in therapies or disease research. (wikipedia.org)
Another application of SCNT stem cell research is using the patient specific stem cell lines to generate tissues or even organs for transplant into the specific patient. (wikipedia.org)
Only a handful of the labs in the world are currently using SCNT techniques in human stem cell research. (wikipedia.org)
Victoria and New South Wales have put aside their competitive interstate rivalry to collaborate on a stem cell research project, as announced by Innovation Minister Gavin Jennings and NSW Minister for Science and Medical Research, Verity Firth, today. (medicalxpress.com)
Scientists from the Monash Institute of Medical Research (MIMR) and colleagues from New South Wales will compare two different methods of creating patient-specific stem cells: somatic cell nuclear transfer (SCNT) and induced pluripotent stem cells (iPS). (medicalxpress.com)
Mr Jennings said changes to the Victorian Infertility Treatment Act and the NSW Human Cloning and Other Prohibited Practices Act have opened up new opportunities for stem cell research in Australia. (medicalxpress.com)
Australia is already a global leader in overall stem cell research and this new and clear regulatory framework gives us an opportunity to extend our leadership into SCNT which could transform how we treat diabetes, heart diseases and Parkinson's," Mr Jennings said. (medicalxpress.com)
Citing a physics professor, Spencer wrote about 'stem-cell research debates that attack science in the name of fundamentalist objections to abortion and many forms of contraception. (davekopel.com)
Last October, 57 scientists sent John Kerry a public letter about stem-cell research. (davekopel.com)
Of course there are scientists on other side of the issue who deny that a fertilized egg is a human being, or that it deserves protection from research abuse. (davekopel.com)
There are also some scientists who share Spencer's extravagant hopes for the results of embryonic stem-cell research. (davekopel.com)
Alternatively, research using eggs may point the way to methods which mimic their properties using other human cells and chemical agents. (spiked-online.com)
Moreover, they can be used independently to research how, for example, diseases attack cells. (koreatimes.co.kr)
The neo-conservative administration of George W Bush ― an administration with a strongly Christian support base to appease ― banned stem cell research. (koreatimes.co.kr)
In order to better appreciate the role of stem cell research in reproductive medicine, there is a need to understand the critical biological principles of stem cell research and its potential applications to medicine. (jcpa.org)
While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
In 2009, in a major reversal of U.S. policy, President Obama signed an executive order pledging to "vigorously support" embryonic stem cell research. (jcpa.org)
However, more research is needed to help understand the potential uses of amniotic fluid stem cells. (healthline.com)
They don't think the fertilized eggs should be used for research. (healthline.com)
And this week, the New York Stem Cell Foundation Research Institute announced in Nature that it had created a line of cells from a woman with Type 1 diabetes. (bioedge.org)
There have been many false dawns in the field of embryonic stem cell research, but these results seem to confirm that it is possible to use adult cells to create genetically matched stem cell lines. (bioedge.org)
The method described on Wednesday by Oregon State University scientists in the journal Cell, would not likely be able to create human clones, said Shoukhrat Mitalipov, senior scientist at the Oregon National Primate Research Center. (nationalrighttolifenews.org)
But they are also less equipped to produce every cell type of the body and less able to reproduce themselves indefinitely, which makes them less appealing to scientists interested in basic research. (eppc.org)
These moral perils are surely not a reason to oppose adult stem cell research, which deserves vigorous and expanded public support. (eppc.org)
Sadly, longer-term risks remain a mystery, let alone properly understood, because of the lack of any long-term medical research or follow-ups on egg donors. (cbc-network.org)
This story is unique in that the woman was asked first to sell her eggs to help make a baby, then the agency asked her to consider selling her eggs for embryonic stem cell research. (cbc-network.org)
A controversial scheme to extend the practise of 'egg sharing' has been approved by the UK's Human Fertilisation and Embryology Authority (HFEA) to provide greater numbers of eggs for embryonic stem (ES) cell research. (progress.org.uk)
This is the first time the system has been approved in order to derive eggs for research. (progress.org.uk)
It is hoped that one donor per week will be recruited and that each new recruit will donate six to ten eggs for the research. (progress.org.uk)
The HFEA has also announced a public consultation, to run from September until November, to assess the opinion of the British public on the ethical status of egg donation for research. (progress.org.uk)
There are some risks involved in removing eggs, whether used in IVF or for research purposes, including ovarian hyper-stimulation syndrome. (progress.org.uk)
Dr Calum MacKellar, director of research at the SCHB, added, 'This kind of agreement by women to donate their eggs for research will generally exploit the poorest members of our society. (progress.org.uk)
Professor Alison Murdoch who leads the Newcastle team said, 'It is of paramount importance to ensure that all donors are not recruited to participate in this research against their best interest by coercion or excessive financial inducement. (progress.org.uk)
Peter Braude, Professor of Obstetrics and Gynaecology at Kings College London, who has also been granted HFEA licences for embryonic stem cell research in the past commented, 'This is a difficult situation because there is a strong need for eggs for research. (progress.org.uk)
However, this license surprises me as it is inconsistent with the stance of not paying for eggs for research. (progress.org.uk)
Discussing the planned public consultation Angela McNab, chief executive of the HFEA, said, 'We know there are a wide variety of views on the subject of donating eggs for research and we anticipate a strong response to the consultation from professional groups, scientists, clinicians and patients as well as the public. (progress.org.uk)
It reportedly has access to 7,200 human eggs for its research. (bioedge.org)
The director of the lobby group Australians for Ethical Stem Cell Research, David van Gend, criticised the issuing of the licence. (bioedge.org)
He said cloning research was no longer necessary because of recent advances in stem cell science. (bioedge.org)
Stem cells are at the forefront of medical research and incite some of the most controversial ethical and religious debates worldwide. (thefutureofthings.com)
While regarded by many top scientists as the Holy Grail of medicine, others consider embryonic stem-cell research sacrilegious. (thefutureofthings.com)
Recent advances in the field of stem-cell research are giving hope to millions. (thefutureofthings.com)
A particular field encouraged by the foundation is stem-cell research, with the great hope that it will result in the ability to get cells to differentiate into neurons and support cells to bridge the gap of a spinal cord injury. (thefutureofthings.com)
The updated guidelines detail best practices for conducting research with human embryonic stem cells. (biopharminternational.com)
On May 12, 2016, the International Society for Stem Cell Research (ISSCR) released its Guidelines for Stem Cell Science and Clinical Translation , an updated version of the organization's previous guidelines on stem cell research. (biopharminternational.com)
The ethical and policy practices related to embryonic stem cell research have been highly debated among scientists and regulatory bodies alike. (biopharminternational.com)
The guidelines detail best practices for conducting research with human embryonic stem cells, and attempt to navigate some of the complex scientific and ethical issues that have arisen related to stem cell research. (biopharminternational.com)
ISSCR also writes induced pluripotent stem cells (iPS cells) should be excluded from specific stem cell research oversight. (biopharminternational.com)
Whether or not stem cell research lives up to the media hype has been a popular discussion among experts, some of which believe communicators have neglected to emphasize the challenges associated with using stem cells. (biopharminternational.com)
An article published in the New England Journal of Medicine discusses how stem cell research may be "less advanced than the public has been led to believe. (biopharminternational.com)
ISSCR notes that while this guidance is not binding, it may provide an effective way for regulators and industry members to better understand stem cell research. (biopharminternational.com)
Lee Byeong-chun and Kang Seung-keun have been charged with faking, together with Wang Woo-suk, the results of embryonic stem cell research and of embezzling public funds for the studies. (asianews.it)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
In December 1999, the editors of Science, the journal devoted to scientific and medical matters, called stem cell research the 'Breakthrough of the Year. (cbc.ca)
Since then, there has been a flurry of announcements about developments in stem cell research and hints of promising treatments for diseases such as Alzheimer's, Parkinson's and cancer. (cbc.ca)
In May 2007, Ontario and California announced a $30-million stem cell research deal aimed at finding new therapies for those diseases. (cbc.ca)
Ontario and California together account for about 70 per cent of the stem cell research currently conducted in North America. (cbc.ca)
Some of that money would be aimed at turning the state into the second-largest stem cell research region in the United States. (cbc.ca)
Gurdon's research built on the work of Thomas King and Robert Briggs in the United States, who in 1952 published findings that indicated that scientists could take a nucleus from an early embryonic cell and successfully transfer it into an unfertilized and enucleated egg cell. (asu.edu)
From his research on immunology, Good was able to perform the first successful allogeneic (donor and recipient are unrelated) bone marrow transplant. (asu.edu)
It's given name is the "Human Cloning Ban and Stem Cell Research Protection Act of 2003," the stated purpose of which, supposedly, is to "prohibit human cloning and to protect important areas of medical research, including stem cell research. (lifeissues.net)
Egg harvesting and Embryonic Stem-cell Research Pose Serious Threat to Women's Health A congressional hearing last Thursday raised awareness on the risks to women's health and fertility by in vitro fertilization (IVF), human cloning, embryonic stem-cell. (physiciansforlife.org)
Adult Stem Cells Taken from Human Fat Tissue Used to Treat Heart Failure Sweden Company Wants To Start First Stem Cell Research Factory Leading Scientist Charges Colleagues With "Misleading" Public British Stem Cell Researcher: Benefits of. (physiciansforlife.org)
Embryonic stem cell technology is still at a preliminary research stage and announcements about its potential may be premature. (edu.au)
Experts from around the world are assessing the difficult issue of the extent to which embryonic stem cell research should be allowed to proceed, and to date there is little international consensus on this matter. (edu.au)
How, then, should embryonic stem cell research be regulated in Australia? (edu.au)
This issue was considered by the House of Representatives Standing Committee on Legal and Constitutional Affairs in its report entitled Human Cloning: Scientific, Ethical and Regulatory Aspects of Human Cloning and Stem Cell Research (hereafter the Andrews Report , after the Chair of the Committee, Mr Kevin Andrews, MP) released in September 2001. (edu.au)
In this article we examine embryonic stem cell research and explore the current regulatory framework associated with this research in Australia, with particular reference to the Andrews Report . (edu.au)
Overall, what is the potential and what are the risks of stem cell research?3. (myassignmentwriters.org)
Cloning-for-biomedical-research also endangers the health and safety of the women called on to undergo dangerous hormone treatments to serve as egg donors. (thenewatlantis.com)
Stem cell research represents one of the most polarized biomedical controversies of our time. (nhsjs.com)
Stem cell research is one of the most controversial issues in modern medicine. (nhsjs.com)
In the United States currently embryonic stem cell research is allowed but there has been a lot of public controversy and legal setbacks. (nhsjs.com)
Two bills were proposed: The first one was the Stem Cell Research Advancement Act, which passed in both the House of Representatives and the Senate but was vetoed by President George W. Bush. (nhsjs.com)
This newer bill calls for prioritizing federally assisted advancement of embryonic stem cell research ( 1). (nhsjs.com)
Additionally, there have been two executive orders focusing on embryonic stem cells, one released by President George W. Bush prohibiting embryonic stem cell research and related federal funding, the other by President Barack Obama reversing the previous order but still with restrictions in place ( 2). (nhsjs.com)
This showcases the ambivalence of public perception, policy and legislation about stem cell research. (nhsjs.com)
And the MSM (mainstream media), who remain desperately committed to push embryonic stem cell research despite its failures, dangers, and immoral foundations, may soon be reeling at the fall of one of their heroes. (blogspot.com)
embryonic stem cell research has not had a good year. (blogspot.com)
While ethical issues about (egg) donation should be debated and the process regulated, the scientific conclusions of Dr. Hwang's research remain intact," Schatten said in a statement. (blogspot.com)
However, Korean television station MBC has conducted interviews with an unnamed member of Hwang's research team who says the cells were never cloned successfully. (blogspot.com)

The cloning method is based on the fact that cytoplasmic factors in mature, metaphase II oocytes are able to reset the identity of a transplanted adult cell nucleus to an embryonic state. (news-medical.net)
The adult cell nuclei were transferred into metaphase-II stage human oocytes, producing a karyotypically normal diploid embryonic stem cell line from each of the adult male donor cells. (news-medical.net)
In their new paper, Science author Woo Suk Hwang from Seoul National University in Seoul, Korea and colleagues replaced the nuclei from donated oocytes with nuclei from skin cells from male and female patients, ranging in age from 2 to 56, who had spinal cord injuries, juvenile diabetes and the genetic disease "congenital hypogamma-globulinemia. (scienceblog.com)
The ten additional new lines resulted from nuclear transfer with skin cells of males or females and oocytes from biologically-unrelated females. (scienceblog.com)
Female Fatu is the only donor of natural oocytes left and frozen sperm is available to the program from only four males - and some of these males are closely related to Fatu. (izw-berlin.de)
First, they extract immature, unfertilised egg cells called oocytes from the ovaries of ewes. (newscientist.com)
Dolly was the only lamb born from 277 fusions of oocytes with udder cells. (newscientist.com)
Feminine Fatu is the one donor of pure oocytes left and frozen sperm is offered to this system from solely 4 males - and a few of these males are carefully associated to Fatu. (publicaawaz.com)
Reprogramming of differentiated cells can be efficiently induced in oocytes. (selectbiosciences.com)

These cells have been sought after as potential therapies for diseases ranging from heart disease to Parkinson's to cancer. (news-medical.net)
The work also moves scientists one step closer to the goal of transplanting healthy cells into humans to replace cells damaged by diseases such as Parkinson's and diabetes. (scienceblog.com)
Scientists anticipate that in the future stem cell lines will provide a virtually unending supply of pancreatic cells for diabetic patients, neuronal cells for patients with neural disorders such as Parkinson's or Alzheimer's disease, and a host of heart cells that may treat a variety of cardiac problems. (spiked-online.com)
Embryonic stem cells (ESC's) are said to hold the potential to treat and cure many disorders like diabetes and Parkinson's disease. (myassignmentwriters.org)

Religious groups believe that the raw material from which stem cells are sourced are themselves forms of human life, and by creating little chunks of humans in Petri dishes, scientists are, critics believe, playing God. (koreatimes.co.kr)
In sexually reproducing organisms such as humans, rhinos or mice, primordial germ cells (PGCs) are embryonic precursors of sperm and eggs that pass on genetic and epigenetic information from one generation to the next. (izw-berlin.de)
All humans start out as only one cell. (healthline.com)
In rodents, and even in some preliminary trials in humans, human embryonic stem cells have been shown to bridge gaps in spinal cord injuries , allowing restoration of motor functions. (thefutureofthings.com)
Techniques such as mitochondrial-replacement techniques (MRT) and CRISPR-Cas9 can allow scientists to modify nuclear DNA of sperm and eggs in humans. (biopharminternational.com)
It also means that finally getting the sheep technology to work with cells from adult humans may not turn out to be a turning point for this technology, after all. (usf.edu)
Indeed, if passed, Hatch/Feinstein/Kerry would explicitly legalize doing in humans the very cloning procedure -- somatic cell nuclear transfer (SCNT) -- that was used to make Dolly the sheep . (lifeissues.net)
Stem cell technology in humans derives from earlier and complementary work in animal studies. (edu.au)

The exact process of differentiation is not yet understood and although embryonic stem cells can, in principle, provide for all human tissue, scientists are some way from controlling the process. (spiked-online.com)
Cellular differentiation begins with the fertilized egg which serves as the identifying characteristic of an embryonic stem cell. (jcpa.org)
The term stem cell can be defined by two very important qualities: the cell has the ability to self-renew and, in a more general sense, the cell has not completed differentiation into its final state. (thefutureofthings.com)
This general definition includes a wide variety of cells with varying degrees of differentiation potential. (thefutureofthings.com)

Cloning of human cells is a technology that holds the potential to cure many diseases and provide a source of exactly matched transplant tissues and organs. (news-medical.net)
These cells are deemed to have a pluripotent potential because they have the ability to give rise to all of the tissues found in an adult organism. (wikipedia.org)
Blastocytes obtained through nuclear transfers would be used to generate the embryonic stem cells that could be differentiated to specific tissues or organs for transfer to the nuclear donor. (spiked-online.com)
These stem cells come from developed organs and tissues in the body. (healthline.com)
This long-sought technique may eventually let doctors create replacement cells for a wide variety of tissues from bits of a patient's own skin. (nationalrighttolifenews.org)
Today, we can derive stem cells from a range of adult and newborn tissues: liver cells, kidney cells, brain cells, fat cells, and umbilical cord blood. (eppc.org)
In addition to their ability to supply cells at the turnover rate of their respective tissues, they can be stimulated to repair injured tissue caused by liver damage, skin abrasions and blood loss. (thefutureofthings.com)
The ability of our body to regenerate some of its tissues is largely owed to the reserves of adult stem cells. (thefutureofthings.com)
In this study, we have provided strong evidence that naïve monkey pluripotent stem cells possess the capability of differentiating in vivo into all the various tissues composing a monkey body,' co-author Professor Miguel Esteban from the University of Chinese Academy of Sciences, Guangzhou, China told Nature. (planer.com)
This male macaque exhibited organs with a mixture of both sets of cells, including green eyes and fingertips, demonstrating tissues featuring a high proportion of cells derived from the injected stem cells. (planer.com)
Publishing their results in Cell, the authors analysed 26 different tissues, showing that donor cells accounted for 21 to 92 percent of the constituent cells, with an average incidence of 67 percent. (planer.com)
We have a very high level of contribution, with the donor cells forming a big part of the tissues (and) complex structures all over the monkey body. (planer.com)
But recent evidence suggests it may be possible to reprogram adult stems to repair tissues. (cbc.ca)
The hope has been that this would eliminate the problem of the patient's immune system attacking the pluripotent cells as foreign tissue, which is a problem with most organs and tissues when they are transplanted from one patient to another. (pharmaceuticalintelligence.com)

In its race to advance assisted reproduction and stem cell associated technologies to save the northern white rhinoceros from extinction, the BioRescue consortium announces a major breakthrough: the creation of primordial germ cell-like cells (PGCLSs) from induced pluripotent stem cells of the northern white rhino Nabire. (izw-berlin.de)
With stem cell associated techniques (SCAT) the BioRescue scientists aim to overcome this bottleneck: By using stored and preserved tissue of rhino skin it should be possible in principle to create induced pluripotent stem cells (iPCSs), primordial germ cells and finally artificial gametes. (izw-berlin.de)
According to their most recent paper published in the journal "Science Advances", the team has now successfully cultivated primordial germ cells (PGCs) - the precursors of eggs and sperm - from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). (izw-berlin.de)
The scientists relied on knowledge from the mouse model: In 2016, Katsuhiko Hayashi and his team managed to create primordial germ cell-like cells and finally germ cells from mice that were fertilised in the lab and resulted in healthy offspring being born. (izw-berlin.de)
The ICM continues to differentiate into three germ layers-ectoderm, mesoderm and endoderm, each of which follows a specific developmental destiny that takes them along an ever-specifying path at which end the daughter cells will make up the different organs of the human body. (thefutureofthings.com)
A somatic cell is any biological cell forming the body of a multicellular organism other than a gamete, germ cell, gametocyte, or undifferentiated stem cell. (scitechdaily.com)
Stem cells come in three forms: embryonic stem cells, embryonic germ cells and adult stem cells. (cbc.ca)
In its race to advance assisted replica and stem cell related applied sciences to avoid wasting the northern white rhinoceros from extinction, the BioRescue consortium declares a significant breakthrough: the creation of primordial germ cell-like cells (PGCLSs) from induced pluripotent stem cells of the northern white rhino Nabire. (publicaawaz.com)
With stem cell related methods (SCAT) the BioRescue scientists intention to beat this bottleneck: By utilizing saved and preserved tissue of rhino pores and skin it needs to be doable in precept to create induced pluripotent stem cells (iPCSs), primordial germ cells and eventually synthetic gametes. (publicaawaz.com)
The scientists relied on data from the mouse mannequin: In 2016, Katsuhiko Hayashi and his crew managed to create primordial germ cell-like cells and eventually germ cells from mice that have been fertilised within the lab and resulted in wholesome offspring being born. (publicaawaz.com)

One cloning technology that has been developed for mammalian and human cells is somatic cell nuclear transfer (SCNT). (news-medical.net)
SCNT is a method of cloning mammalian cells that can be used to create personalized embryonic stem cells from an adult animal or human. (news-medical.net)
But SCNT can also be used to clone human cells for transplant or other therapies. (news-medical.net)
Another successful attempt at human SCNT was made using cells from two adult males. (news-medical.net)
In human SCNT experiments, these eggs are obtained through consenting donors, utilizing ovarian stimulation. (wikipedia.org)
This method is called "somatic cell nuclear transfer" or SCNT. (scienceblog.com)
Once our team produces the iPS cells, we will compare the properties of iPS versus cells developed through SCNT. (medicalxpress.com)
Dolly was the first mammal cloned from specialized adult (somatic) cells with the technique of somatic cell nuclear transfer (SCNT). (asu.edu)
The promise of the SCNT method is that the nucleus of a patient's skin cell, for example, could be used to create pluripotent cells that might be able to repair a part of that patient's body. (pharmaceuticalintelligence.com)
One attraction of SCNT has always been that the genetic identity of the new pluripotent cell would be the same as the patient's, since the transplanted nucleus carries the patient's DNA. (pharmaceuticalintelligence.com)
Stanford University have raised the possibility in the past that the immune system of a patient who received SCNT-derived cells might still react against the cells' mitochondria, which act as the energy factories for the cell and have their own DNA. (pharmaceuticalintelligence.com)
This reaction could occur because cells created through SCNT contain mitochondria from the egg donor and not from the patient, and therefore could still look like foreign tissue to the recipient's immune system. (pharmaceuticalintelligence.com)
When transplanted back into the nucleus donor strain, the cells were rejected although there were only two single nucleotide substitutions in the mitochondrial DNA of these SCNT-derived cells compared to that of the nucleus donor. (pharmaceuticalintelligence.com)
When scientists at the Oregon Health and Science University announced success in performing SCNT with human cells last year, it reignited interest in eventually using the technique for human therapies. (pharmaceuticalintelligence.com)
The immunological reactions reported in the new paper will be a consideration if clinicians ever use SCNT-derived stem cells in human therapy, but such reactions should not prevent their use. (pharmaceuticalintelligence.com)

What we've shown is that we can generate a cell that can form all the different types of blood cells. (scitechdaily.com)
We are working to generate red blood cells in vitro from pluripotent stem cells, however the extremely large cell numbers involved pose unique challenges to culture technology and scale-up. (selectbiosciences.com)

For example, the stem cells can differentiate into cells that display characteristics of skin and retina cells, muscle cell bundles, bone matrix cells and cells of the gastrointestinal and respiratory lining. (scienceblog.com)
In his original report, Thompson demonstrated that human embryonic stem cells could be coaxed into developing gut-like structures, bone, cartilage and muscle (1). (spiked-online.com)
In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow. (healthline.com)
Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)
Long before the controversy emerged over human embryonic stem cells, scientists and doctors began using first-generation stem cells from adult bone marrow. (eppc.org)
Adult stem cells can be used to accelerate bone or tendon healing , and they can induce cartilage progenitor cells to produce a better matrix and repair cartilage damage . (thefutureofthings.com)

So ideally scientists would like to be able to extract DNA from the cells of older people - not just cells from infants - to create therapies for adult diseases. (usf.edu)
Stem cell therapies hold vast potential for repairing organs and treating disease. (pharmaceuticalintelligence.com)

They put the nucleus of the patient's cell into the egg whose nucleus has been removed. (sentientdevelopments.com)
Mitalipov previously developed a mitochondrial replacement therapy involving the implantation of patient's egg nucleus-or spindle-into a healthy donated egg stripped of its original nucleus. (salk.edu)

This is potentially a way to double the number of eggs we're able to get from one session of in vitro fertilization. (salk.edu)
We hope that by doing this, we can double the number of patient eggs available for in vitro fertilization. (salk.edu)

Current screening of potential new drugs is done using cell lines derived from animals or 'abnormal' human tissue such as tumor cells. (spiked-online.com)
Now there is one last step to master for the production of artificial rhino gametes (eggs and sperm) from preserved tissue. (izw-berlin.de)
They established culture systems for the southern white rhino, for which embryonic stem cells are available, and the northern white rhino, for which they used induced pluripotent stem cells derived from tissue samples. (izw-berlin.de)
This means they can potentially produce new cells for any organ or tissue. (healthline.com)
Mammary glands are rich in these cells, which are more adaptable than other tissue. (newscientist.com)
Study co-author Associate Professor Robert Nordon said he was amazed that not only did the device create blood stem cell precursors that went on to produce differentiated blood cells, but it also created the tissue cells of the embryonic heart environment that is crucial to this process. (scitechdaily.com)
If there are intact cells in this tissue they have been 'stored' frozen. (wikiquote.org)
In a study published in the online journal Nature on March 1, 2009, Canadian researches described a new method for generating stem cells from adult human tissue. (cbc.ca)
Now there's one final step to grasp for the manufacturing of synthetic rhino gametes (eggs and sperm) from preserved tissue. (publicaawaz.com)

Eventually, the cells begin to differentiate, taking on a certain function in a part of the body. (healthline.com)
Adult stem cells can't differentiate into as many other types of cells as embryonic stem cells can. (healthline.com)
They can differentiate into all types of specialized cells in the body. (healthline.com)
The breakthrough has created a way to "de-differentiate" the stem cells. (healthline.com)
At the top of the list comes the zygote-a fertilized egg, which of course has the ability to divide and differentiate into all cell types in the body and create a new organism. (thefutureofthings.com)
As the embryonic cells divide and the daughter cells differentiate, they become increasingly specific. (thefutureofthings.com)
These adult stem cells are considered multipotent, having the ability to differentiate into different cell types, albeit with a more limited repertoire than embryonic stem cells. (thefutureofthings.com)
These systems promoted the development of precursor blood stem cells which can differentiate into various blood components - white blood cells, red blood cells, platelets, and others. (scitechdaily.com)
When the stem cells divide, the new cell may remain a stem cell to divide again or may differentiate to become any of the 200 types of specialized cells in the human body. (nhsjs.com)

It is likely that human stem cells will have similar properties. (spiked-online.com)
Lee Byeong-chun and Kang Seung-keun were accused of faking the outcome of studies on cloning human stem cells while working with Hwang. (asianews.it)
The unique properties of human stem cells have aroused considerable optimism about their potential as new pathways for alleviating human suffering caused by disease and injury. (edu.au)

In January 2018, a team of scientists in Shanghai announced the successful cloning of two female crab-eating macaques (named Zhong Zhong and Hua Hua) from foetal nuclei. (wikipedia.org)
One group from CHA University in Seoul reported in Cell Stem Cell in April that it had managed to use cell nuclei from two men, aged 35 and 75, to create embryonic stem cell lines. (bioedge.org)
The team used cells that were created by transferring the nuclei of adult mouse cells into enucleated eggs cells from genetically different mice. (pharmaceuticalintelligence.com)

However, in recent years, there has been controversy surrounding the way human embryonic stem cells are obtained. (healthline.com)
Scientists have used cloning technology to transform human skin cells into embryonic stem cells, an experiment that may revive the controversy over human cloning. (nationalrighttolifenews.org)

It doesn't create stem cells. (nationalrighttolifenews.org)
Sir John Bertrand Gurdon further developed nuclear transplantation, the technique used to clone organisms and to create stem cells, while working in Britain in the second half of the twentieth century. (asu.edu)

After being inserted into the egg, the somatic cell nucleus is reprogrammed by its host egg cell. (wikipedia.org)

The egg is now viable and capable of producing an adult organism containing all necessary genetic information from just one parent. (wikipedia.org)
These cells genetically matched the donor organism from which they came. (wikipedia.org)
The first three divisions of the zygote give birth to eight totipotent cells, each of which also has the ability to become an entire organism. (thefutureofthings.com)
Chimerism is a phenomenon where an organism features two or more sets of cells with different genomes. (planer.com)
For decades scientists have been trying to reproduce cell culture environment for the closest mimicry of the natural cellular "embedding" within a living organism. (selectbiosciences.com)

These cells have been successfully used to treat children with blood cancers, such as leukemia, and certain genetic blood disorders. (healthline.com)

These cell lines will enable the study of human disease in cells in the laboratory. (scienceblog.com)
In laboratory culture, these cell lines displayed signs of immunological compatibility with the patients' cells, Science authors reported. (scienceblog.com)
Scientists must also find a way to remove the remaining animal components from the laboratory procedures. (scienceblog.com)
Other improvements over the last paper include the reduced use of animal products in laboratory procedures and better evidence that the cell lines matched the patients' cells and did not have a parthenogenetic origin, where unfertilized eggs can divide on their own. (scienceblog.com)
Dr Thomas Okarma, who heads up the Geron Corporation, claims to have heart cells that 'beat' in laboratory dishes developed from stem cells (2). (spiked-online.com)
Although it was only possible to examine a limited number of lines, from the point of view of epigenomic profiles, the quality of polar body-derived embryonic cells looks quite promising," says co-senior author Joseph Ecker , PhD, Salk professor and director of the Genomic Analysis Laboratory. (salk.edu)
She said that in the last few decades, biomedical engineers have been trying to make blood stem cells in laboratory dishes to solve the problem of donor blood stem cell shortages. (scitechdaily.com)
In 1995, Campbell and his scientific team used cells grown and differentiated in a laboratory to clone sheep for the first time. (asu.edu)

The fall from grace of stem cell scientist Hwang Woo-suk would be as spectacular as his meteoric ascent. (koreatimes.co.kr)
His father died when he was five but Hwang harbored the dream of being a scientist. (koreatimes.co.kr)
Hwang said his team had created a single cell line from 242 human eggs. (koreatimes.co.kr)
But what if Hwang Woo-Suk lied about more than the egg donations? (blogspot.com)

In the United States, scientists at the Harvard Stem Cell Institute, the University of California San Francisco, the Oregon Health & Science University, Stemagen (La Jolla, CA) and possibly Advanced Cell Technology are currently researching a technique to use somatic cell nuclear transfer to produce embryonic stem cells. (wikipedia.org)

Because the child ends up with DNA from its mother, father and a donor, this mitochondrial replacement therapy has been nicknamed the "three-parent baby" technique. (scientificamerican.com)

There are major obstacles to overcome before a stem cell line is liable to reach clinical trials. (spiked-online.com)
ISSCR advocates for robust safety precautions for clinical trials involving human embryonic stem cells. (biopharminternational.com)
The first clinical trials involving a patient receiving human embryonic stem cells began in October 2010 at the Shepard Center, a spinal cord injury hospital in Atlanta. (cbc.ca)
Details are provided about the quantitative market opportunity for various stem cell classes as well as the current state of the clinical trials space wherein stem cell-based therapeutics are being evaluated for therapy in various disease classes. (selectbiosciences.com)

Embryonic stem cells are immortal, and have the potential to develop into any type of adult cell, even after months growing in culture dishes. (news-medical.net)
One method of creating pluripotent stem cells is called somatic cell nuclear transfer, and involves taking the nucleus of an adult cell and injecting it into an egg cell from which the nucleus has been removed. (pharmaceuticalintelligence.com)

They demonstrated how a simulation of an embryo's beating heart using a microfluidic device in the lab led to the development of human blood stem cell 'precursors', which are stem cells on the verge of becoming blood stem cells. (scitechdaily.com)

Induced pluripotent stem cells are a type of pluripotent stem cell that can be generated directly from a somatic cell. (scitechdaily.com)

There was a thought that because the mitochondria were on the inside of the cell, they would not be exposed to the host's immune system. (pharmaceuticalintelligence.com)

The disease specific stem cell lines could then be studied in order to better understand the condition. (wikipedia.org)
Scientists have isolated the first human embryonic stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various ages, suffering from disease or spinal cord injury. (scienceblog.com)
The stem cell lines produced from patients with disease will likely display characteristics of the disease, so they will probably not be appropriate for direct use in treating patients. (scienceblog.com)
From the 31 nuclear-transfer blastocysts, the scientists derived 11 stem cell lines. (scienceblog.com)
Currently, iPS cell lines show variability in their potential to produce mature cells. (medicalxpress.com)
Both methods need to be investigated further so we can determine which will produce the most robust cell lines," Dr Verma said. (medicalxpress.com)
Professor Tuch's team will also use their proficiencies in characterising human embryonic stem cell lines and bioinformatics. (medicalxpress.com)
Banking of multiple cell lines with varying genetic spectrum that can be matched to patients is one possibility. (spiked-online.com)
It might be expected that the richest nation on Earth would encourage its top scientists to pursue this work with vigor rather than limiting funding opportunities, creating legal barriers and fencing off any newly developed cell lines. (spiked-online.com)
Scientists are unlikely to rush into creating human embryonic stem cell lines. (bioedge.org)
The other is that co-authors Jin-Soo Kim at Seoul National University in South Korea and Juan Carlos Belmonte at the Salk institute in California - both pioneers of the CRISPR technique - had meticulously optimized the choice of 'guides' for the CRISPR editor by testing them in iPS cell lines that carried the same genetic fault. (cosmosmagazine.com)
In principle, scientists could produce a series of cell lines that would allow a close match for the majority of would-be cell recipients - just as transplant surgeons currently seek a close match for organ donors. (usf.edu)
But he says this does mean we could be getting closer to being able to go beyond cloned cell lines to cloning an entire human being. (usf.edu)

PORTLAND, Ore, and LA JOLLA, Calif.-Families struggling with infertility or a genetic predisposition for debilitating mitochondrial diseases may someday benefit from a new breakthrough led by scientists at OHSU and the Salk Institute for Biological Studies. (salk.edu)
The cloning breakthrough is instead being spun as skin cells into stem cells! (nationalrighttolifenews.org)

Retrieved on December 04, 2023 from https://www.news-medical.net/life-sciences/Cloning-Human-Cells.aspx. (news-medical.net)
Animal eggs no good for cloning? (the-scientist.com)
Somatic cell nuclear transfer is a technique for cloning in which the nucleus of a somatic cell is transferred to the cytoplasm of an enucleated egg. (wikipedia.org)
Over the past few years, the debate over stem cells and cloning has grown both more complex and more profound. (eppc.org)
But if we are to make wise policy the stem cell/cloning arena, we need to step back, sort out the various scientific alternatives and moral issues, and search for a way forward that all citizens can embrace. (eppc.org)
To this end, we offer a detailed analysis of the stem cell/cloning question-where is the science, what are the political alternatives, and what moral obligations should guide us? (eppc.org)
Cloning in biotechnology refers to processes used to create copies of DNA fragments ( molecular cloning ), cells (cell cloning), or organisms . (wikiquote.org)
Given that we have an efficiency of 1% cloning for livestock species and if only one in a thousand cells are viable then around 100,000 cells would need to be transferred. (wikiquote.org)
What we show for the first time is that you can actually take skin cells, from a middle-aged 35-year-old male, but also from an elderly, 75-year-old male" and use the DNA from those cells in this cloning process, Lanza says. (usf.edu)
If reliable hair cloning ever does come about to allow for unlimited donor hair, I could see possibly more people having their existing hair thickened. (baldingblog.com)
1. Cloning is an umbrella term traditionally used by scientists to describe different processes for duplicating biological material. (who.int)

Both conventional sources (IVF Clinics) and novel sources (adult ovaries and altruistic donors) will be explored. (medicalxpress.com)
I volunteered to harvest eggs for a friend, whose ovaries had ceased producing eggs in her early 30's. (cbc-network.org)

At present, this is only possible with mice, using so-called embryonic stem cells. (newscientist.com)

Anatomy49

Organisms13

Diseases7

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Psychiatry and Psychology2

Phenomena and Processes49

Disciplines and Occupations15

Anthropology, Education, Sociology and Social Phenomena4

Technology, Industry, Agriculture6

Humanities11

Information Science8

Named Groups7

Health Care13

Geographicals1

Cloned human embryos4

Embryos52

Embryo32

Researchers28

Potential of embryonic stem-cel2

Blastocyst5

Behave like embryonic stem2

Therapeutic14

Genes12

Reprogramming of human somatic cells1

Genetically identical5

Regenerative medicine3

Oocyte9

Genetic material5

Research84

Oocytes9

Parkinson's4

Humans8

Differentiation4

Tissues14

Germ10

SCNT15

Generate2

Bone7

Therapies2

Patient's2

Vitro fertilization2

Tissue9

Differentiate9

Human stem cells3

Nuclei3

Controversy2

Create stem cells2

Somatic cell nucleus1

Organism5

Successfully1

Laboratory8

Hwang4

Harvard Stem Cell Institute1

Mitochondrial replacement therapy1

Clinical trials4

Adult cell2

Precursors1

Pluripotent stem1

Immune system1

Lines13

Breakthrough2

Cloning11

Ovaries2

Mice1