Embryo LossEmbryonic Stem CellsGenes, LethalEmbryo, MammalianFetal DeathGene TargetingStem CellsEmbryonic DevelopmentGene Expression Regulation, DevelopmentalMice, KnockoutHomozygoteHeterozygoteCell DifferentiationBlastocystEmbryonic and Fetal DevelopmentPhenotypeMice, Mutant StrainsMice, Inbred C57BLMice, TransgenicMutationPluripotent Stem CellsGene DeletionCell LineCells, CulturedIntegrasesTranscription FactorsPregnancyCrosses, GeneticAllelesMesodermCell ProliferationDNA-Binding ProteinsSignal TransductionNuclear ProteinsStem Cell TransplantationApoptosisBase SequenceOctamer Transcription Factor-3FibroblastsGenotypeCell LineageReverse Transcriptase Polymerase Chain ReactionRNA, MessengerCarrier ProteinsTumor Suppressor ProteinsMolecular Sequence DataIn Situ HybridizationHematopoietic Stem CellsExonsCell Cycle ProteinsCell SurvivalInduced Pluripotent Stem CellsChimeraHomeodomain ProteinsCell Culture TechniquesTime FactorsMammalsEmbryoid BodiesCell DivisionTumor Suppressor Protein p53Amino Acid SequenceSOXB1 Transcription FactorsPlant StemsAdult Stem CellsEndodermEmbryo ResearchTeratomaNeural Stem CellsYolk SacNeoplastic Stem CellsGene Expression RegulationEmbryo, NonmammalianTransgenesGene Expression ProfilingGene ExpressionDNA PrimersTotipotent Stem CellsCardiovascular AbnormalitiesNeuronsGreen Fluorescent ProteinsRNA InterferenceImmunohistochemistryGerm CellsMultipotent Stem CellsMyocytes, CardiacCaenorhabditis elegans ProteinsNeural Tube DefectsCaenorhabditis elegansHematopoiesisModels, BiologicalLeukemia Inhibitory FactorRecombination, GeneticGene Knockout TechniquesGerm LayersRepressor ProteinsFlow CytometryAnimals, Genetically ModifiedTranscription, GeneticSequence Homology, Amino AcidGenetic Vectors