Embryonic stem cells vertebrate animal clone cells. Medical search. Frequent questions

The course will focus on genetic and molecular approaches, but will also cover the comparative anatomy of developing embryos to the extent necessary to understand the conserved aspects of embryonic patterning. (upenn.edu)
But that's far enough to produce embryonic stem cells that can be harvested for research and medicine - without the ethical quandaries presented by taking stem cells from human embryos discarded in IVF. (chemistryworld.com)
Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. (axonmedchem.com)
The inductive functions of the Nodal-related factors of the TGFβsuperfamily in the control of basic axis formation in vertebrate embryos were the focus of the presentations by Liz Robertson (Harvard University, Boston,MA, USA) and Alex Schier (Skirball Institute, NYU School of Medicine, New York, NY, USA). (silverchair.com)
Moreover, as is the case in vertebrate embryos, confining the ANE to the anterior end of the embryo requires a Wnt/β- catenin -dependent signaling mechanism. (echinobase.org)
A) foxq2 , fzl5/8, and six3 expression in 32-cell and late blastula-stage control embryos (Aa-d), ΔFzl5/8 mRNA-injected embryos (Af-i), and embryos treated with JNK inhibitor (Ak-n). (echinobase.org)
A) foxq2 expression at stages from 32-cell to hatched blastula, as well as fzl5/8 and six3 expression at mesenchyme blastula stage in control embryos (Aa-f), Fzl1/2/7 morpholino-injected embryos (Ah-m), and embryos treated with PKC inhibitor (Ao-t). (echinobase.org)

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. (wikipedia.org)
There is an immense functional heterogeneity among stem cell within a population, considering proliferative capacity and differentiation potential. (uni-heidelberg.de)
1 Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan. (jci.org)
The present invention relates to methods of inducing differentiation of stem cells. (justia.com)
In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. (justia.com)
The process of differentiation in stem cells involves selective development of immature cells to committed and fully mature cells of various lineages. (justia.com)
Differentiation of stem cells is known be triggered by various growth factors and regulatory molecules. (justia.com)
During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
Whilst differentiation of some lineage specific stem cells can be induced with a degree of certainty, a differentiation outcome of a population of pluripotent stem cells is less predictable. (justia.com)
Placing the cells under conditions which induce specific cell types has been one form of an attempt to regulate the differentiation outcome. (justia.com)
These conditions include growing the cells to high or low density, changing media, introducing or removing cytokines, hormones and growth factors, creating an environment which suits differentiation toward a specific cell type, such as providing a suitable substrate. (justia.com)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)
However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)
Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)
culturing a stem cell in the presence of an embryonic cell and/or extracellular medium of an embryonic cell, under conditions that induce differentiation of the stem cell. (justia.com)
The proliferation and differentiation of satellite cells are regulated by a number of extracellular signals ( Wang & Rudnicki, 2012 Wang YX, Rudnicki MA. (scielo.br)
Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19. (axonmedchem.com)
Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. (mdpi.com)
Chromatin conformation and stem cell differentiation were minimally affected. (bvsalud.org)
FHS is also working on the new differentiation methods to make heart and other organ cells as well as the development of the optimal culture condition for cell transplantation. (um.edu.mo)

Special emphasis will be placed on organisms with particular advantages for the study of embryonic development: e.g., mouse, frog, zebrafish, and Drosophila. (upenn.edu)
Now running his own laboratory at Yale, Giraldez has stuck with zebrafish and investigates how miRNAs shape gene expression to orchestrate embryonic development ( 6 ). (rupress.org)
In the zebrafish, rprma mRNA is expressed in the olfactory placodes (OP) and olfactory epithelium (OE), rprmb is observed in the tectum opticum (TeO) and trigeminal ganglion (Tg), whereas rprml is found primarily in the telencephalon (Tel). At protein level, RPRM is present in a subset of cells in the OP, and neurons in the OE, TeO, hindbrain and sensory peripheral structures. (frontiersin.org)
To this end, the zebrafish ( Danio rerio ) is an established model to study early nervous system development, which combines the complexity of a vertebrate organism with the easy-to-use and high-throughput capabilities of in vitro models ( MacRae and Peterson, 2015 ). (frontiersin.org)
This molecule is highly conserved in vertebrates enabling the investigation of its function in the developing zebrafish. (nature.com)
We observed miR-137 expression and activity in sensory neurons including Rohon-Beard neurons and dorsal root ganglia, two neuronal cell types that confer touch-sensitivity in normal zebrafish, suggesting a role of these cell types in the observed phenotype. (nature.com)
The zebrafish ( Danio rerio ) is an attractive and versatile model to gain insight into vertebrate brain development and function. (nature.com)
In an effort to identify elusive regulators of nephron segmentation, our lab conducted a high-throughput drug screen using a bioactive chemical library and developing zebrafish, which are a conserved vertebrate model and particularly conducive to large-scale screening approaches. (mdpi.com)

While eggs chemically triggered to develop don't have what it takes to make a viable embryo, it's a different story if the egg has been given the chromosomes of a cell from a more mature organism, through the technique of somatic-cell nuclear transfer used in cloning. (chemistryworld.com)
In collaboration with mathematicians, we focus on how many stem cells and stem cell types are required to setting up a functional organ during embryogenesis and in an already developed organism. (uni-heidelberg.de)
Internal signals producing apoptosis depend on interactions of several proteins and may serve to protect the organism from cancer by killing cells that have pre-cancerous changes. (agemed.org)
On the other hand, a chimera is defined as an organism in which cells from two or more different organisms have contributed. (frontiersin.org)
Are we like the hundreds of different types of cells in our body that are constantly dying and being replaced, part of a complex organism greater than ourselves? (netrepsites.com)
If we could see before the first single-cell organism, and after the last man and woman, only you would remain - you, the Great Face behind, that consciousness whose mode of thinking that contains the world. (netrepsites.com)
The cells in its stems and branches transport food and water from the leaves and roots to the whole organism. (netrepsites.com)
I have learned, as a biologist and biocentrist, that life is a complex play of cells, some that are around when you're young, some when you're old, but that all, regardless of species, are parts of one organism expanding and contracting in space and time in whatever shape and form it can. (netrepsites.com)
1] In a broader sense, ageing can refer to single cells within an organism which have ceased dividing, or to the population of a species. (stevechase.org)
Early life forms on Earth, starting at least 3.7 billion years ago,[12] were single-celled organisms (an organism that consists of a single cell, unlike a multicellular organism that consists of multiple cells). (stevechase.org)
Aging and mortality of the individual organism became possible with the evolution of sexual reproduction,[15] which occurred with the emergence of the fungal/animal kingdoms approximately a billion years ago, and the evolution of seed-producing plants 320 million years ago. (stevechase.org)
Nonetheless, there is limited understanding of how Akt signaling controls the response of stem cells during cellular turnover and tissue injury in the complexity of the whole organism. (biomedcentral.com)
This organism is well known for its stem cell-based regenerative capability. (biomedcentral.com)

One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages. (bioquote.com)
Apoptosis Programmed Cell Death (PCD). (agemed.org)
Signals to trigger apoptosis may come from within the cell or from outside, by stimulating suicide receptors in the cell's external membrane. (agemed.org)
Programmed ageing should not be confused with programmed cell death (apoptosis). (stevechase.org)
The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS. (lookformedical.com)

The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. (wikipedia.org)
The pathway is equally important during vertebrate embryonic development and is therefore of interest in evolutionary developmental biology. (wikipedia.org)
He has performed postdoctoral research at the University of California, San Francisco, where he cloned the human hyaluronidase genes, which are involved in fertilization, embryonic development, and cancer. (howard.edu)
We have generated several transgenic lines to explore how neuromasts are created after embryonic development (Development 144, 687-697), which are their cells of origin and which and how they integrate the signals from the environment to trigger organ formation. (uni-heidelberg.de)
Both methods have contributed extensively to our current knowledge on the lineage relation of differentiated cells during embryogenesis, the potential of stem cell populations to generate or re-generate missing cell types, and the cell autonomous or non cell autonomous effects of many genes during development and disease. (uni-heidelberg.de)
While miR-137 overexpression was not associated with an observable specific phenotype, downregulation by antisense morpholino and/or transgenic expression of miR-sponge RNA induced significant impairment of both embryonic and larval touch-sensitivity without compromising overall anatomical development. (nature.com)
This process gets rid of unneeded cells and is particularly important for "sculpting" tissue and organ structure during development of the embryo (or larval metamorphosis in insects), but may occur at any time even in adult cells when a tissue needs to be remodeled. (agemed.org)
Circadian rhythms are established very early during vertebrate development. (researchgate.net)
Calcium signaling are conserved from invertebrates to vertebrates and plays critical roles in many molecular mechanisms of embryogenesis and postnatal development. (biomedcentral.com)
In this study, we identified both temporal and localization changes in expression of DmFKBP12, a translational and transcriptional regulator of Drosophila RyR (DmRyR) and FKBP12, through embryonic development. (biomedcentral.com)
Upon increasing culture times in chicken´s primary skeletal muscle satellite cells, SULF1 and SULF2 expression in 1-week-old chickens was significantly higher than in 2-week-old chickens, suggesting that sulfatases play a key role in satellite cell development. (scielo.br)
Bober E, Franz T, Arnold HH, Gruss P, Tremblay P. Pax-3 is required for the development of limb muscles:a possible role for the migration of dermomyotomal muscle progenitor cells. (scielo.br)
Revealing cell populations catching the early stages of the human embryo development in naïve pluripotent stem cells. (axonmedchem.com)
The protein kinase Akt also known as PKB, regulates multiple cellular functions including proliferation, survival, and growth during embryonic development and adult tissue homeostasis [ 1 - 5 ]. (biomedcentral.com)
A single migratory somatic cell termed the distal tip cell (DTC),which is positioned at the tip of each arm, acts as a specialised signalling centre to control the development and the shape of the gonad through a series of inductive events. (silverchair.com)
Hedgehog signaling is important in embryonic development and tumorigenesis. (nih.gov)
5) the development of 24-hours anti-cancer drug screening biochip assay that integrates cutting-edge scientific expertise in precision medicine, microfluidic chip and image processing to screen cancer cells and tumor cells for drug sensitivity. (um.edu.mo)
Research and development in the field of stem cell and developmental biology in FHS has found immense success and established a promising niche for both basic and translational research in the last five years. (um.edu.mo)
and 5) the identification of how the DNA modification enzyme controls the β-cell lineage specification during pancreas development. (um.edu.mo)

The first half of the course will cover cell fate restrictions, cloning animals using nuclear transfer, stem cell biology, formation of the embryonic axes in vertebrates and Drosophila, and patterning of the neural tube and mesodermal tissues. (upenn.edu)
in Molecular Pathology and Toxicology from the University of Leicester, U.K., and his Ph.D. in Cell and Molecular Biology from the University of Debrecen, Hungary. (howard.edu)
The real experts to ask about the accurate scientific facts of human embryology are the scientific experts in human embryology who are academically credentialed Ph.D. human embryologists - not the "experts" in cell biology, genetics, doctors, nurses, theologians, lawyers or politicians, secretaries, news journalists, etc. (lifeissues.net)
P.J. Donovan's present address is Stem Cell Program and Dept. of Biological Chemistry and Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697. (rupress.org)
To take human organ generation via BC and transplantation to the next step, we reviewed current emerging organ generation technologies and the associated efficiency of chimera formation in human cells from the standpoint of developmental biology. (frontiersin.org)
Your degree and research area is bespoke to you, however, our supervisors can provide projects in many areas of current interest in genetics and genomics, ranging from fundamental questions in cell biology to variation and disease in humans. (nottingham.ac.uk)
Nature Reviews Molecular Cell Biology 2012;13(2):127-33. (scielo.br)
Thus, Akt signaling regulates neoblast biology and mediates in the distribution of injury-mediated cell death during tissue repair in planarians. (biomedcentral.com)
Rather, the issues that so beguiled pioneering developmental biologists have now become crucial to the understanding of such disparate fields as cancer biology, cloning and stem cell totipotency. (silverchair.com)
This emphasis almost certainly reflects the fact that one of the major recent advances of modern developmental biology has been the elucidation of many of the inductive cues that pattern plants and animals. (silverchair.com)
FHS has accomplished several remarkable outputs in stem cell research and developmental biology. (um.edu.mo)
Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press (CSHLP) announced the release of The Digital Cell: Cell Biology as a Data Science, available on its website in hardcover format. (cshlpress.com)

CiR builds up in the cell and diffuses into the nucleus, where it acts as a co-repressor for Hedgehog (Hh) target genes. (wikipedia.org)
Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
Cells become cancerous by accumulating, stepwise, a series of several mutations that alter the function of genes important for cell growth. (agemed.org)
Prevention of congenital heart anomalies: the secret… CITED2 is a transcriptional modulator involved in the regulation of the expression of many other genes in vertebrates. (atlasofscience.org)

cells for allogeneic transplantation without immunosuppression 6,153,428 .alpha. (europeanstrokenetwork.eu)
Historically, lineage analysis in vertebrates was performed on entire populations of cells using either transplantation approaches or genetic tools like Cre/LoxP mediated recombination. (uni-heidelberg.de)
The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)
In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
Robust allogeneic immune reactions after transplantation impede the translational pace of human embryonic stem cells (hESCs)-based therapies. (bvsalud.org)
This discovery not only laid the foundation for the research field of reprogramming, but also provided priceless sources for stem cell transplantation. (atlasofscience.org)
As a result, we can theoretically perform stem cell transplantation between iPSCs, and these mice could mimic the transplantation of iPSCs from the patients into themselves. (atlasofscience.org)
Compared with current mouse models for stem cell transplantation, our "Mouse Clone Model" has several advantages. (atlasofscience.org)
Firstly, we can test immuno-rejection of iPSCs and various tissue specific stem cells, and to select suitable stem cell lines for transplantation. (atlasofscience.org)
Furthermore, after the selection of applicable stem cells, we can investigate the appropriate stages of different stem cells for transplantation. (atlasofscience.org)

In insect, Drosophila melanogaster ryanodine receptor ( DmRyR ) cDNA was cloned from lava and the physical features of DmRyR single channel were characterized with in vitro overexpression system [ 16 ]. (biomedcentral.com)

The method had already been known to work in other animals, including mice and monkeys, but it had hitherto failed in humans. (chemistryworld.com)
My lab is interested in understanding stem cells, a fascinating type of cell that can self-renew and is responsible to generate once and again the cells that we humans (and most other animals) lose on daily basis - skin cells, blood cells, intestine cells. (uni-heidelberg.de)
In several protozoans, the status of this mechanism remains elusive, such as in Leishmania , the causative agent of the disease leishmaniasis in humans and a wide array of vertebrate animals. (mdpi.com)
The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. (stevechase.org)
Even within humans and other mortal species, there are cells with the potential for immortality: cancer cells which have lost the ability to die when maintained in a cell culture such as the HeLa cell line,[17] and specific stem cells such as germ cells (producing ova and spermatozoa). (stevechase.org)

As an assistant Professor in the Department of Anatomy at Howard University, Dr. Csoka is developing animal models of progeria, studying the role of nuclear lamina dysfunction in human aging, and investigating the potential of induced pluripotent stem cells, cellular reprogramming and epigenetic rejuvenation for the treatment of age-related diseases. (howard.edu)
Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
The « Pluripotent Stem Cells » facility proposes training into the culture of embryonic stem cells (ESCs) and induced Pluripotent Stem Cells (iPSCs). (cnrs.fr)
Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. (axonmedchem.com)
This is by 4 early protein factors, the differentiated cells-such as fibroblasts, T and B cells-can return to pluripotent stem cells. (atlasofscience.org)
It is well known that pluripotent stem cells, including embryonic stem cells (ESCs) and iPSCs can give rise to tumors and also result in immune rejection based on the research using immunodeficient mouse models. (atlasofscience.org)
Mouse Clone Model" for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells. (atlasofscience.org)

Nor do only the cells of the inner cell mass of the blastocyst become the later adult and none of the cells from the inner cell mass become part of the placenta, umbilical cord, etc. (lifeissues.net)
This method grants us the ability to generate a grand population of cloned mice, and each of them would be originated from the same and sole inner cell mass of the blastocyst. (atlasofscience.org)

We are particularly interested in learning how organs can adapt to the changing organismal size , with a focus on the molecular mechanisms for stem cell coordination within and among organs. (uni-heidelberg.de)
However, though BC is emerging as a potential organ transplant option, challenges regarding organ size scalability, immune system incompatibilities, long-term maintenance, potential evolutionary distance, or unveiled mechanisms between donor and host cells remain. (frontiersin.org)
The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. (axonmedchem.com)
However, the mechanisms by which Akt signaling regulates stem cell behavior in the complexity of the whole body are poorly understood. (biomedcentral.com)
Cells have various mechanisms to restore length (TELOMERE HOMEOSTASIS. (lookformedical.com)
The 3-day meeting held in April was divided into five, loosely themed, sessions with topics ranging from embryonic inductive mechanisms to developmental models of human disease. (silverchair.com)
Our findings provide strong support for the idea that the sea urchin ANE regulatory state and the mechanisms that position and define its borders represent an ancient regulatory patterning system that was present in the common echinoderm/vertebrate ancestor. (echinobase.org)

Here we employ ChIP-seq and RNA-seq approaches in Xenopus tropicalis gastrulae and find that occupancy of the corepressor, TLE/Groucho, is a better indicator of tissue -specific cis-regulatory modules (CRMs) than the coactivator p300 , during early embryonic stages. (xenbase.org)

Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. (wikipedia.org)
and b) how do stem cells in different tissues coordinate their functions for the fish to maintain its shape during permanent growth? (uni-heidelberg.de)
Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues. (mpi-cbg.de)
Consciousness is like an embryonic stem cell, the master cell of the body, which - instead of giving rise to muscle, bone and all the other tissues and organs of the body - gives rise to the biodiversity around us, to the entire ecosystem of the planet. (netrepsites.com)
To determine their possible roles in tissues and satellite cells in vitro, their expression pattern was examined in tissues from 40-day-old chickens and in satellite cells from the breast muscles of 1-week-old and 2-week-old chickens using RT-PCR and immunocytochemistry analyses. (scielo.br)
The neoblasts are the only dividing cells in planarians and constantly proliferate to repair tissues and support systemic cellular turnover [ 21 ]. (biomedcentral.com)
The most obvious of the recurrent concepts to emerge from the meeting was the central role that similar inductive cues play across a variety of organisms and tissues in specifying cell fate. (silverchair.com)
Stem cells possess the potential to become any cell type in the body and are present in many organs and tissues with the remarkable ability to repair and replace the damaged cells. (um.edu.mo)
FHS is making a concerted effort to understand how stem cells differentiate into various cell types and how they repair the damaged tissues and cells in the body, with an ultimate goal for developing innovative methods that make use of stem cells in the bedside applications. (um.edu.mo)

Ecdysone is a steroid hormone of the ecdysteroids family which is found in animals (vertebrates and invertebrates) and in plants. (bioquote.com)

A view of how an animal embryo is specified to develop and differentiate into a wide spectrum of cell types, and how the spatial patterns and axes of embyros are determined. (upenn.edu)
Nor is the embryo just a "fertilized egg", or just a "clump of cells", or appear only when the zygote is formed, or appear later after the zygote is formed, or appear after implantation - or even a week after that at 14-days. (lifeissues.net)
Remarkably, the anterior neuroectoderm (ANE) of the deuterostome sea urchin embryo expresses many of the same transcription factors and secreted modulators of Wnt signaling, as does the early vertebrate ANE (forebrain/eye field). (echinobase.org)

Y-27632 was found to increases human embryonic stem cell (hESC) survival. (bioquote.com)
Compared with wide-type hESCs, HLA-A11R hESC-derived endothelial cells elicited much weaker immune responses to human HLA-A11+ T cells, while maintaining HLA-I molecule-mediated inhibitory signals to natural killer (NK) cells. (bvsalud.org)
In conclusion, we customized a pilot immunocompatible hESC cell line based on Chinese HLA typing characteristics with safety insurance. (bvsalud.org)

By using a quantitative 4D analysis on the stem cells we aim at linking the metabolic state of a stem cell to its future clonal progression in its intact niche. (uni-heidelberg.de)
Cancer A clonal growth (cells all descended from one ancestral cell) that undergo continuing mitotic divisions and are not inhibited in their growth when they come in contact with neighboring cells (contact inhibition). (agemed.org)
The CellenONE allows automated cell sorting and best-in-class clonal out-growth cloning using a monocellular sorter based on acoustic manipulation. (cnrs.fr)

To overcome this confusion, we designed a new mouse model by combining the theory of somatic animal cloning, tetraploid complementation, ESCs and iPSCs (Figure). (atlasofscience.org)

In addition, the iPSCs and their derivative tissue-specific stem cells should not form tumor. (atlasofscience.org)
We suggest the stem cell researchers all over the world to investigate the applicability of iPSCs and tissue specific stem cells for therapeutic applications and take advantage of this model. (atlasofscience.org)

J Cell Biol (2009) 185 (7): 1132-1133. (rupress.org)
Nat Rev Mol Cell Biol , Art. (mpi-cbg.de)
Cell Biol. (nature.com)
Trends Cell Biol. (nature.com)

Heparan sulfate proteoglycans (HSPGs) are present on the cell surface and in the extracellular matrix in all metazoans. (scielo.br)
When activated by injury, satellite cells reenter the cell cycle and proliferate in response to extracellular growth factors ( Relaix & Zammit, 2012 Relaix F, Zammit PS. (scielo.br)

So when I was recently contacted by an earnest and amiable member of a local school board who was concerned about the questionable manner in which the issue of "stem cell" research - both human embryonic and adult - was presented to the high school students in his district in a currently-used science textbook, I agreed to evaluate that section in the text for him. (lifeissues.net)
In my opinion there is no question but that the scientific information on stem cell research included in this science text book being used in Illinois schools incorporates some inaccurate scientific facts, and seems to be very partial to the use of human embryonic "stem cell" research. (lifeissues.net)
Graham, F .L. and van der Eb, A. J. (1973) Transformation of rat cells by DNA of human adenovirus 5. (thermofisher.com)
In this review, we summarize the history of interspecies chimerism in various animal models to find hints for BC application and describe the challenges and prospects of utilizing BC for human organ generation. (frontiersin.org)
You can contact the engineer for any projects involving 3D cultures, such as spheroids, organoids, tumoroids of human, animal or vegetal origin. (cnrs.fr)
Human Democratic National Committee beings and members of other species, especially animals, age and die. (stevechase.org)
Republican National Committee Normal human cells however die after about 50 cell divisions in laboratory culture (the Hayflick Limit, discovered by Leonard Hayflick in 1961). (stevechase.org)
This study defined the role of Smed-Akt in abnormal cell proliferation triggered by the abrogation of the phosphatase PTEN, an upstream component of the Akt signaling pathway, which is highly mutated in human cancers. (biomedcentral.com)
The human body develops from stem cells through a programmed process. (um.edu.mo)
Because of their unique properties, stem cells are increasingly becoming the central player in regenerative medicine and in treating many human degenerative diseases. (um.edu.mo)

Mihaylova, M. M. & Shaw, R. J. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. (nature.com)
This paucity is likely due to the ubiquitous nature of this signaling pathway and the difficulty of analyzing stem cells in their natural environment during physiological cell turnover and regeneration in conventional animal models [ 15 - 17 ]. (biomedcentral.com)

Animals sexually derived from the fusion of gametes from two different organisms, such as mules, are considered "hybrids. (frontiersin.org)

Occupancy of tissue -specific cis-regulatory modules by Otx2 and TLE/Groucho for embryonic head specification. (xenbase.org)
Because these different Wnt pathways converge on the same cell fate specification process, our data suggest they may function as integrated components of an interactive Wnt signaling network. (echinobase.org)

However, karyotypes carrying fused chromosomes 1 and 2 resulted in arrested mitosis, polyploidization, and embryonic lethality, whereas a smaller fused chromosome composed of chromosomes 4 and 5 was able to be passed on to homozygous offspring. (bvsalud.org)

In vertebrates, naturally-occurring gonadotropins regulate the growth and function of the gonads, known as testes in males and ovaries in females. (asu.edu)

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. (axonmedchem.com)

The present invention also provides methods of using the differentiated cells of the present invention for therapeutic purposes. (justia.com)

Statistically derived geometrical landscapes capture principles of decision-making dynamics during cell fate transitions. (axonmedchem.com)
Investigators have now turned their attention to the events downstream of these initial signals and how they are integrated to co-ordinate growth, pattern and cell fate. (silverchair.com)

Among these, the citric acid cycle intermediate succinate stands out owing to its multiple roles in disparate pathways, its dramatic concentration changes and its selective cell release. (nature.com)

Functional disruption of Smed-Akt alters the balance between cell proliferation and cell death leading to systemic impairment of adult tissue renewal. (biomedcentral.com)

Because the stem cells and the mouse clones are biologically "selves", this model provides stronger and more direct evidences for stem cell therapy. (atlasofscience.org)

Secondly, we can assess the tumor formation of iPSCs and other stem cell lines and select suitable stem cells for therapy. (atlasofscience.org)

Small molecules, identified by screening, have been used to switch differentiated cells directly from one tissue type to another - cardiac fibroblasts to muscle, say - both outside and inside the body. (chemistryworld.com)
18] In artificial cloning, adult cells can be rejuvenated to embryonic status and then used to grow a new tissue or animal without ageing. (stevechase.org)
Planarians are flatworms with large populations of stem cells capable of dividing to support adult tissue renewal and regeneration. (biomedcentral.com)
Cells grown in vitro from neoplastic tissue. (lookformedical.com)
In vivo 2-color multiphoton imaging of genetic… Fibroblasts are cells that synthesize collagen and support the maintenance of connective tissue in the skin, tendons, and joints. (atlasofscience.org)

Permanent growth in fish depends on stem cells, and in the lab we are mainly interested in two topics: a) are the same individual stem cells driving growth and maintaining homeostasis? (uni-heidelberg.de)
We follow stem cell derived lineages in different organs to learn whether fish use the same stem cells to maintain homeostasis replacemente and to drive growth, or if they have dedicated populations for each feature. (uni-heidelberg.de)

Insect cells express a full size zinc-finger transcription factor Cubitus interruptus (Ci), which forms a complex with the kinesin-like protein Costal-2 (Cos2) and is localized in the cytoplasm bound to cellular microtubules (Figure 2). (wikipedia.org)
In the absence of Hh (Figure 3), a cell-surface transmembrane protein called Patched (PTCH) acts to prevent high expression and activity of a 7 membrane spanning receptor called Smoothened (SMO). (wikipedia.org)
The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. (bioquote.com)
GCNA is a histone binding protein required for spermatogonial stem cell maintenance. (axonmedchem.com)
A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. (lookformedical.com)

Surprisingly simple chemistry can induce other profound changes in cells too. (chemistryworld.com)

We are tackling functional heterogeneities on somatic stem cells by combining metabolic reporters in vivo with lineage progression. (uni-heidelberg.de)
Stem cells are undifferentiated cells which can give rise to a succession of mature functional cells. (justia.com)

In mammals, Akt is ubiquitously expressed and is associated with regulation of cellular proliferation, metabolism, cell growth and cell death. (biomedcentral.com)

Larvae without Hh are short and spiny, resembling the hedgehog animal. (wikipedia.org)

Since fish grow during their entire post-embryonic life, their organs have to adapt to an increasing body size. (uni-heidelberg.de)

This was how Chinese scientists in Shanghai recently managed to clone macaque monkeys 3 - the first cloning of primates. (chemistryworld.com)

The lack of obvious anatomical or histological pathology in these cells, however, suggested that subtle axonal network defects or a change in synaptic function and neural connectivity might be responsible for the behavioral phenotype rather than a change in the cellular morphology or neuroanatomy. (nature.com)

In this context, cell lines represent alternative experimental models for in vitro studies that complement in vivo assays. (researchgate.net)

Satellite cells are essential for skeletal muscle regeneration:the cell on the edge returns centre stage. (scielo.br)
Our results also reveal novel roles for Akt signaling during regeneration, specifically for the timely localization of cell death near the injury site. (biomedcentral.com)

Capecchi, M. R. (1980) High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. (thermofisher.com)
To make these guidelines easily accessible to anyone planning a CRISPR genome editing experiment, we built a new website ( http://crispor.org ) that predicts off-targets and helps select and clone efficient guide sequences for more than 120 genomes using different Cas9 proteins and the eight efficiency scoring systems evaluated here. (biomedcentral.com)

Anatomy44

Organisms14

Diseases4

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Psychiatry and Psychology1

Phenomena and Processes65

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science3

Embryos8

Differentiation21

Zebrafish8

Organism13

Apoptosis5

Development19

Biology12

Genes4

Transplantation10

Drosophila1

Humans5

Pluripotent7

Inner cell mass of the blast2

Mechanisms7

Stages1

Tissues9

Invertebrates1

Embryo3

HESC3

Clonal3

ESCs1

Specific stem cells2

Biol4

Extracellular2

Human10

Pathway2

Different organisms1

Specification2

Mitosis1

Regulate1

Chromatin1

Therapeutic1

Fate2

Selective1

Impairment1

Biologically1

IPSCs1

Tissue5

Homeostasis2

Protein5

Induce1

Functional2

Growth1

Hedgehog1

Organs1

Primates1

Neural1

Vitro1

Regeneration2

Efficiency2