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  • late embryonic
  • Importantly its sex chromosome dependence, late embryonic/fetal differential development, complex morphogenic changes, long time-course, hormonal sensitivity and hormonal influences make it a system prone to many different abnormalities. (edu.au)
  • In this study, they examined mRNA and smRNA expression at two developmental stages, zygotes 0 to 1 hours post fertilization (hpf) and late embryonic stages (15 to 30 hpf). (biomedcentral.com)
  • regenerate
  • Neural cells, for example, express growth-associated proteins, such as GAP-43 , tubulin , actin , an array of novel neuropeptides , and cytokines that induce a cellular physiological response to regenerate from the damage. (wikipedia.org)
  • functionally
  • ESCs are obtained from inner cell mass, characterized by unlimited self-renewal and pluripotentiality, which allow them to differentiate into various specialized cells types in a morphologically and functionally way, characteristics that make them attractive for developing differentiated kidney cells (DKCs) [ 9 ]. (biomedcentral.com)
  • wound
  • Certain commonalities, such as blastema formation and basement membrane breakdown at the wound site, suggest that MRL mice may share other features with classical regenerators. (pnas.org)
  • As reported here, MRL fibroblast-like cells have a distinct cell-cycle (G2/M accumulation) phenotype and a heightened basal and wound site DNA damage/repair response that is also common to classical regenerators and mammalian embryonic stem cells. (pnas.org)
  • limbs
  • Targeted disruption of the mouse Sonic hedgehog gene shows that Shh plays a critical role in patterning of embryonic tussues, including the brain and spinal cord, the axial skeleton and limbs. (sdbonline.org)
  • Mitotic
  • Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis. (hindawi.com)
  • Mitotic cells might undergo senescence by failing to replicate. (hindawi.com)
  • Whereas a high number of proliferating cells appear in control animals next to the blastema and some mitotic cells still remain 3 days after irradiation, no divisions are detected after 14 days, showing that neoblasts are completely eliminated at that time. (biomedcentral.com)
  • Accordingly, microgravity has been shown to alter the structure of cells, as well as their apoptotic and mitotic responses [ 10 - 12 ]. (hindawi.com)
  • proximal
  • The intracellular location of Yap is tightly associated with different cell densities along the blastema proximal-distal axis, which correlate with alterations in cell morphology, cytoskeleton and cell-cell contacts in a gradient-like manner. (biologists.org)
  • development
  • The genetic and protein experiments proved the obtention of DKCs that passed through the chronological stages of embryonic kidney development. (biomedcentral.com)
  • Our results indicated that we obtained DKCs from mPSCs, which passed through the chronological stages of embryonic kidney development. (biomedcentral.com)
  • While it is commonly accepted as an aging-related phenomenon, senescence might happen also during the embryonic development with the biological meaning of replacing transient structures or specific cell types with other ones [ 3 - 5 ]. (hindawi.com)
  • In a similar manner to CYR61, CTGF also figures prominently in vascularisation (endothelial cells and myocardium) and cartilage development (presented by K Lyons). (bmj.com)
  • This month was notable for a preponderance of plant development preprints, many molecular maps (supported by single cell sequencing), a hearty helping of human development and a multiplicity of (Drosophila) melanogaster mechanics. (biologists.com)
  • No apparent effects of altered gravity were found during the embryonic development. (hindawi.com)
  • fibroblasts
  • Similar to mouse ES cells, the p53-target p21 was not expressed in MRL ear fibroblasts. (pnas.org)
  • Each individual bony ray consists of two concave hemirays that enclose a mesenchymal compartment composed of blood vessels, nerves, pigment cells, fibroblasts, and osteoblasts. (biomedcentral.com)
  • Although other cell types contribute to blastema formation, fibroblasts appear to play a central role [ 5 , 6 ]. (jcancer.org)
  • distinct
  • Regarding vibrational spectroscopy analysis by FTIR, bands related with biomolecules were shown on mPSCs and DKCs spectra, observing distinct differences between cell lineages and maturation stages. (biomedcentral.com)
  • processes
  • therefore, these cells are of great interest for the study of these processes. (jcancer.org)
  • At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. (hindawi.com)
  • Further, it must take place when those offspring are still a collection of just a few cells, as these processes would be highly disruptive and probably fatal if they took place throughout a more developed, complex organism. (fightaging.org)
  • But perhaps such processes of rejuvenation could be selectively targeted to small and vital collections of cells. (fightaging.org)
  • lineages
  • Next, underlying cells from different lineages (ex. (jove.com)
  • Chakrabarti S, Paek AL, Reyes J, Lasick KA, Lahav G, Michor F. Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages. (harvard.edu)
  • overexpression
  • Moreover, we show that overexpression of lin-28 after retinectomy was sufficient to induce transdifferentiation of the RPE in the absence of FGF2. (biomedcentral.com)
  • Histological analysis indicated that the loss due to BMP-2 overexpression was the result of increased cell condensation and apoptosis while the loss caused by Noggin was due to a decrease in cell division. (biomedcentral.com)
  • cytokines
  • Macrophages are an important source of both inflammatory and anti-inflammatory signals, arriving in mammalian wounds 48-96 h after injury, where they clear dead cells, release proinflammatory cytokines, and subsequently produce factors that dampen inflammation and stimulate angiogenesis, fibroblast migration, and replication ( 17 ). (pnas.org)
  • metabolism
  • These discoveries were published in leading journals including Cell Stem Cell, Cell Metabolism, The Journal of Experimental Medicine, The Journal of Clinical Investigation, Developmental Cell, Nature Medicine and Nature Communications. (spotidoc.com)
  • cellular
  • Meanwhile, cellular studies ongoing at Wistar revealed that MRL cells behaved very differently than cells from "non-healer" mouse strains in culture. (thinkatheist.com)
  • Therefore a form of cellular rejuvenation takes place somewhere between the start and the end of reproduction in multicellular organisms, whether they are nematode worms of a few hundred cells, or vastly larger and more complex species such as our own. (fightaging.org)
  • and it has remained unsettled whether adult newts possess a cellular population that is equal to mammalian satellite cells. (rupress.org)
  • Regulation
  • We present evidence that upon injury, the quiescent (p27 Kip1 +/BrdU-) RPE cells transiently dedifferentiate and express sox2 , c-myc and klf4 along with eye field transcriptional factors and display a differential up-regulation of alternative splice variants of pax6 . (biomedcentral.com)
  • Simón Mendez-Ferrer, whose group investigates the regulation of stem cell niches, received a highly prestigious career award from the Howard Hughes Medical Institute. (spotidoc.com)
  • chromosome
  • Among them, whole mount in situ hybridization revealed that chromosome segregation 1-like and interleukin 11 were expressed in the broad area of the tail blastema, while brevican, lysyl oxidase, and keratin 18 were mainly expressed in the notochord bud in regenerating tails. (jove.com)
  • types
  • The kidney is a complex organ composed of several cell types, and it is conformed approximately by 11,000 nephrons. (biomedcentral.com)
  • During the process of transdifferentiation, the RPE loses its pigmentation and is reprogrammed to become neuroepithelium, which differentiates to reconstitute the different cell types of the neural retina. (biomedcentral.com)
  • The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo. (harvard.edu)
  • occurs
  • Importantly, Yap inactivation occurs in high cell density areas, conditional to F-actin distribution and polymerization. (biologists.org)
  • The earliest detectable defect occurs in the future forbrain region at embryonic day 9.5. (sdbonline.org)
  • Additionally
  • Additionally, a neutral and alkaline comet assay displayed a persistent level of intrinsic DNA damage in cells derived from the MRL mouse. (pnas.org)
  • Additionally, we dissect the effects of aging on the cardiac endogenous and exogenous reservoirs of stem cells. (hindawi.com)
  • Additionally, pathological description of the changes induced by congenital obstructive uropathy is neither well defined nor correlated with functional parameters. (nih.gov)