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  • generate
  • Stem cells cannot perform any specialized functions but have the potential to generate cells with specialized functions (a process known as 'differentiation'), such as pulsating heart muscle cells or defensive immune cells. (bioedonline.org)
  • For example, brain stem cells may be able to generate blood and skeletal muscle cells. (bioedonline.org)
  • Dr. Mitalipov said the technique was efficient enough that one donation - which can include multiple eggs - would probably be enough to generate a stem cell line, even accounting for failures. (nytimes.com)
  • reprogram
  • Vipul Dev M.D., Chief Executive Officer of Healtheuniverse stated, "Our research is a promising example that adult stem cells are not necessarily locked into their current fate and we have the potential to reprogram them into becoming other cell types. (marketwired.com)
  • fibroblasts
  • piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. (addgene.org)
  • The heart is made up predominantly of two types of cells, Genin says: the fibroblasts, which maintain the collagen and other structural proteins within the heart, and the cardiomyocytes, which do the pumping. (wustl.edu)
  • If blood pressure is high enough to provoke fibroblasts to become myofibroblasts, the cells also may get stuck in their helper state. (wustl.edu)
  • gene
  • Reporting last week in Cell Stem Cell , the team altered a gene responsible for causing the rare blood disease paroxysmal nocturnal hemoglobinuria, or PNH, establishing for the first time a useful system to learn more about the disease. (jhu.edu)
  • We've been able to improve gene targeting and editing in human embryonic stem cells more than 200-fold. (jhu.edu)
  • Of the cells surviving selection, they picked and grew eight iPS cell lines to study further, and five of those contained a targeted insertion at the gene site. (jhu.edu)