Embryonic stem cells for therapeutic reproductive derivation of stem cells from cloned human embryos. Medical search. Frequent questions

The information presented here covers the legal implications of embryonic stem cells (ES), rather than induced pluripotent stem cells (iPSCs). (wikipedia.org)
While embryonic stem cells are taken from embryoblasts, induced pluripotent stem cells are undifferentiated from somatic adult cells. (wikipedia.org)
In contrast to multipotent stem cells, embryonic stem cells are pluripotent and are thought to be able to give rise to all cells of the body. (wikipedia.org)
In addition, the possibility of reprogramming adult stem cells back to a "pluripotent" (or embryonic-like) state raises the biological prospect of going back too far. (eppc.org)
Therapeutic Cloning - Use of a donor cell to create pluripotent stem cells suitable for growing tissues for implantation into the donor or other patient. (schlich.co.uk)
But what is not getting such wide reporting is the use of pluripotent stem cells (as well as many other types of cells and genetic engineering techniques) for reproductive purposes . (lifeissues.net)
Induced Pluripotent Stem Cells (iPSCs) are cells derived from non-pluripotent cells, such as adult somatic cells, that are genetically manipulated so as to return to an undifferentiated, pluripotent state. (asu.edu)
In 2015, biologist Helena D. Zomer and colleagues published the review article "Mesenchymal and Induced Pluripotent Stem Cells: General Insights and Clinical Perspectives" or "Mesenchymal and Induced Pluripotent Stem Cells" in Stem Cells and Cloning: Advances and Applications. (asu.edu)
The authors reviewed the biology of three types of pluripotent stem cells, embryonic stem cells, or ESCs, mesenchymal stem cells, or MSCs, and induced pluripotent stem cells, or iPS cells. (asu.edu)
Pluripotent stem cells are a special cell type that can give rise to other types of cells and are essential for development. (asu.edu)
The developing embryo, from which pluripotent stem cells originate, undergoes a series of dynamic metabolic transitions synchronized to its molecular development. (conditionmed.org)
We have previously shown that human kidney tissue can be generated from human pluripotent stem cells. (atlas-d2k.org)
The emergence and development of induced pluripotent stem cells (iPSCs) provides an approach to understand the regulatory mechanisms of cell pluripotency and demonstrates the great potential of iPSCs in disease modeling. (bvsalud.org)

Because ES cells are cultured from the embryoblast 4-5 days after fertilization, harvesting them is most often done from donated embryos from in vitro fertilization (IVF) clinics. (wikipedia.org)
France prohibits reproductive cloning and embryo creation for research purposes, but enacted laws (with a sunset provision expiring in 2009) to allow scientists to conduct stem cell research on imported a large amount of embryos from in vitro fertilization treatments. (wikipedia.org)
… "human clone" means an embryo that, as a result of the manipulation of human reproductive material or an in vitro embryo, contains a diploid set of chromosomes obtained from a single - living or deceased - human being, fetus, or embryo. (hinxtongroup.org)
This study aims to provide information to answer the following question: While some scientists claim they can indefinitely culture a stem cell line in vitro, what are the consequences of those culturing practices? (asu.edu)
SSCs can be isolated from the testis and cultured in vitro for longterm periods in the presence of feeder cells (often mouse embryonic fibroblasts). (molcells.org)
Although several in vitro SSC culture systems without feeder cells have been previously described, our Matrigel-based feeder-free culture system is time- and cost- effective, and preserves self-renewability of SSCs. (molcells.org)
Established SSCs are useful stem cell lines that allow not only to study basic reproductive biology but also to develop an in vitro model for applications in assisted reproductive medicine. (molcells.org)
When primary SSCs are derived from the testis and proliferated in vitro , mouse embryonic fibroblasts (MEFs) are the most commonly used feeder cells that play a role of such microniche by allowing secure attachment and proliferation of SSCs. (molcells.org)
We discuss what is known about the distinct metabolic states captured in vitro by the 2-cell-like, naïve, blastocyst-like, formative, and primed states of pluripotency. (conditionmed.org)
2019). Akin to the dynamic nutrient requirements of the developing embryo, discrete in vitro cell states have distinct metabolic profiles (Zhou et al. (conditionmed.org)
It is only through understanding embryonic metabolism and development that we can derive and maintain different in vitro stem cell states for disease modeling and therapies. (conditionmed.org)
Cells are collected from donor (a) and cultured in vitro (b). (biomedcentral.com)
The somatic cell and the oocyte is then fused (f) and the embryos is allowed to develop to a blastocyst in vitro (g). (biomedcentral.com)
Moreover, the knockdown of circ_0082319 might repress HCC cell proliferation, invasion, angiogenesis, and induce apoptosis in vitro. (bvsalud.org)
Cells grown in vitro from neoplastic tissue. (lookformedical.com)

A minority of mouse embryonic stem cells (ESCs) display totipotent features resembling 2-cell stage embryos and are known as 2-cell-like (2C-like) cells. (bvsalud.org)

Today, we can derive stem cells from a range of adult and newborn tissues: liver cells, kidney cells, brain cells, fat cells, and umbilical cord blood. (eppc.org)
Stem cell technologies promise to be the next transformative medical technology offering therapies for conditions and diseases that are currently beyond medical science by creating replacement or supplementary tissues for a patient. (schlich.co.uk)
reagents made using a patient's own cells used to regenerate disease or damaged tissues 14,15 , once the stuff of science fiction, may become science fact. (schlich.co.uk)
The stem cells suits human needs, does not cause harm and can be obtained from both adult and fetal does not conflict with religious beliefs, it has tissues, umbilical cord and early embryos. (who.int)
Robert describes part-human animals, otherwise known as chimeras, as those resulting from the intentional combination of human and nonhuman cells, tissues, or organs at any stage of development. (asu.edu)
Some of these concerns, such as ensuring the welfare of research animals and obtaining appropriate consent for the use of human tissues, also apply to many other areas of research, but may require special consideration for research with human neural organoids, cell transplants, and chimeras. (nationalacademies.org)
Given the complexity of the human brain and the particularly human nature of many key symptoms of these disorders, especially psychiatric disorders, animal and cell culture models of the types currently used to investigate diseases of other organs and tissues are valuable but inadequate. (nationalacademies.org)
Stem cells may be derived from adult tissues but the most potent are extracted from developing human embryos. (edu.au)
The fertilized oocyte is totipotent, with resultant blastomeres capable of generating all three primary germ layers, ectoderm, mesoderm, and endoderm, in addition to the extra embryonic tissues. (conditionmed.org)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)

Although the latest scientific work related to cloning has been focused on potential medical applications, much of that research is relevant to the creation of cloned children. (thenewatlantis.com)
That is what New Jersey legislators did when they passed and then Governor James McGreevey signed S-1909 last year, a law that was sold to the public as outlawing human cloning but which actually permits the creation of cloned human life, and its implantation and gestation up to and including the very moment prior to the emergence of the cloned baby from the birth canal. (cbc-network.org)

Research advocates attack President Bush for "banning stem cell research," while pro-life advocates lament a Republican administration and Congress that have banned nothing-not embryo destruction, not human cloning, not fetal farming, not genetic engineering. (eppc.org)
But we can only wonder about the ethical propriety of producing the first human child with this technique, knowing that the hoped-for newborn would be a reproductive experiment, one that may end initially in numerous fetal failures. (eppc.org)
The aim of this study was to morphologically examine nephrogenesis in fetal human kidneys from 20 to 41weeks of gestation. (atlas-d2k.org)

There are now two ways to create new mammalian life, including humans. (cbc-network.org)
Scientists have applied somatic cell nuclear transfer to clone human and mammalian embryos as a means to produce stem cells for laboratory and medical use. (asu.edu)
Cloning by nuclear transfer using mammalian somatic cells has enormous potential application. (biomedcentral.com)

The report offers an ethical and policy analysis, articulating what makes cloning morally repugnant and calling for the practice to be definitively prohibited in the United States. (thenewatlantis.com)
While stem-cell research holds enormous potential for treating or even curing some diseases, the cloning of a human being is morally and ethically unacceptable…Any attempt to clone a human being is in direct conflict with the public policies of this state. (cbc-network.org)
if you have a choice of starting material and are forced to use embryonic stem cells to carry out the invention, ensure you describe the use of embryonic stem cells from morally acceptable sources in your patent application. (schlich.co.uk)
Human enhancement, Harris argues, is a good thing--good morally, good for individuals, good as social policy, and good for a genetic heritage that needs serious improvement. (philpapers.org)

The New Atlantis is building a culture in which science and technology work for, not on, human beings. (thenewatlantis.com)
Finally, and inexorably, a true professional scientist poses clearly challenging questions to his research colleagues, and to the scientific enterprise in general, about the dubious "scientific" justification for the current rush to clone human beings - for both "therapeutic" and for "reproductive" purposes. (lifeissues.net)
And now Washington joins the infamous list with Senate Bill 5594, a thoroughly disingenuous piece of legislation that purports to outlaw the cloning of human beings, but by manipulating language and redefining terms, actually permits human cloning and gestation of the resulting cloned embryos through the ninth month. (cbc-network.org)
One such concern is the possibility of altering the capacities or consciousness of a research animal in ways that may blur the lines between human beings and nonhuman animals. (nationalacademies.org)
The report arose out of a recommendation for the Committee to review the report of the Australian Health Ethics Committee (AHEC) of the NHMRC entitled Scientific, Ethical and Regulatory Considerations Relevant to Cloning of Human Beings (hereafter the AHEC Report ). (edu.au)
Scientists and physicians from around the world have presented a declaration on human rights for nascent human beings . (blogspot.com)

These developmental defects have been attributed to incomplete reprogramming of the somatic nuclei by the cloning process. (biomedcentral.com)
Developmental defects, including abnormalities in cloned fetuses and placentas, in addition to high rates of pregnancy loss and neonatal death have been encountered by every research team studying somatic cloning. (biomedcentral.com)
The declaration adds: "We declare that every stage in the developmental continuum of human life has the same right to life and right to protection from harm as all others. (blogspot.com)

Reproductive cloning versus germ cell (egg, ovum). (who.int)
We confirmed that the feeder-free cultured SSCs expressed germ cell markers both at the mRNA and protein levels. (molcells.org)
Furthermore, the functionality of feeder-free cultured SSCs was confirmed by their transplantation into germ cell-depleted mice. (molcells.org)

The second way to reproduce is a strictly human invention - known as "asexual" reproduction - or more commonly, cloning. (cbc-network.org)
Cloning of a human being" means asexual reproduction by implanting or attempting to implant the product of nuclear transplantation [e.g., an embryo] into a uterus or substitute for a uterus with the purpose of producing a human being. (cbc-network.org)
This is junk biology since implanting isn't the act of asexual reproduction: SCNT cloning is. (cbc-network.org)

If research cloning is not stopped now, we face the prospect of the mass farming of human embryos and fetuses, and the transformation of the noble enterprise of biomedical research into a grotesque system of exploitation and death. (thenewatlantis.com)

your supposed cloning ban actually authorizes human cloning, implantation, and gestation through the ninth month. (cbc-network.org)
The blastocyst can then be transferred to a recipient (h) and cloned animals are born after completion of gestation (i). (biomedcentral.com)
BACKGROUND: During normal human kidney development, nephrogenesis (the formation of nephrons) is complete by term birth, with the majority of nephrons formed late in gestation. (atlas-d2k.org)
The proportions of podocytes, endothelial and non-epithelial cells within mature glomeruli were stable throughout gestation. (atlas-d2k.org)

Up to the 2-cell embryo, blastomeres remain totipotent (Garner and McLaren, 1974). (conditionmed.org)

Embryonic stem cells were isolated in mice in 1981, and in humans in 1998. (wikipedia.org)
However, following the successful derivation of human embryonic stem cells in 1998, the debate over human cloning largely shifted to the question of whether it is acceptable for scientists to create human embryos only to destroy them. (thenewatlantis.com)

The laws surrounding the two differ because while both have similar capacities in differentiation, their modes of derivation are not. (wikipedia.org)
Somatic cells are cells that have gone through the differentiation process and are not germ cells. (asu.edu)
To establish protocols for the safe and efficient differentiation of healthy cells for therapies, we must develop a better understanding of the dynamic continuum of metabolic states that span pluripotency and differentiation, and how to influence them. (conditionmed.org)

It is quite possible that the advances in human biology in the remainder of the twentieth century will be remembered as the most significant scientific achievement of the animal species known as Homo sapiens . (lifeissues.net)
One of the greatest controversies triggered tissue, a stem cell encoding for heart tissue by the rapid pace of evolution in biology, will eventually develop into heart tissue particularly in genomics and biotechnology, and so on. (who.int)
The signatories include human-biology research scientists, obstetricians, gynaecologists, professors of a range of disciplines, doctors in general practice and nurses. (blogspot.com)

The recent desperation to clone human embryos may be seriously undermining accepted ethical principles of medical research, with potentially profound wider consequences. (lifeissues.net)
The holy grail of regenerative medicine-whatever one's ethical beliefs about destroying embryos-is to "reprogram" regular cells from one's own body so that individuals can be the source of their own rejection-proof therapies. (eppc.org)
But adult stem cells also raise some interesting ethical dilemmas alongside their great therapeutic promise. (eppc.org)
It is the policy of Washington state that research involving the derivation and use of human embryonic stem cells, human embryonic germ cells, and human adult stem cells from any source, including somatic cell nuclear transplantation , is permitted upon full consideration of the ethical and medical implications of this research. (cbc-network.org)
In Enhancing Evolution, leading bioethicist John Harris dismantles objections to genetic engineering, stem-cell research, designer babies, and cloning and makes an ethical case for biotechnology that is both forthright and rigorous. (philpapers.org)
In particular, scientific developments in areas such as iPS cells open new possibilities of research and, at mid term, of therapeutic applications, but they also bring new ethical challenges and problems requiring further reflection and debate. (lifeissues.net)
Cloning technology, however, is perceived as having the potential for reproductive cloning, which raises serious ethical and moral concerns. (who.int)
There, he reviews the scientific and ethical justifications and restrictions on creating part-human animals. (asu.edu)
Ethical issues common to human neural organoids, transplants, and chimeras include (1) the ethical value of relieving human suffering and disease, (2) concerns about encroachment on divine roles, and (3) ethical issues related to human donors of biological materials. (nationalacademies.org)
The ethical and legal controversies that were aroused in the ART debates during the 1980s have been re-ignited with the development of stem cell technology. (edu.au)
This issue was considered by the House of Representatives Standing Committee on Legal and Constitutional Affairs in its report entitled Human Cloning: Scientific, Ethical and Regulatory Aspects of Human Cloning and Stem Cell Research (hereafter the Andrews Report , after the Chair of the Committee, Mr Kevin Andrews, MP) released in September 2001. (edu.au)

Stem cell laws are the law rules, and policy governance concerning the sources, research, and uses in treatment of stem cells in humans. (wikipedia.org)
The European Union has yet to issue consistent regulations with respect to stem cell research in member states. (wikipedia.org)
Whereas Germany, Austria, Italy, Finland, Portugal and the Netherlands prohibit or severely restrict the use of embryonic stem cells, Greece, Sweden, Spain and the United Kingdom have created the legal basis to support this research. (wikipedia.org)
Germany has restrictive policies for stem cell research, but a 2008 law authorizes "the use of imported stem cell lines produced before May 1, 2007. (wikipedia.org)
According to modern stem cell researchers, Spain is one of the leaders in stem cell research and currently has one of the most progressive legislations worldwide with respect to human embryonic stem cell (hESC) research. (wikipedia.org)
The new Spanish law allows existing frozen embryos - of which there are estimated to be tens of thousands in Spain - to be kept for patient's future use, donated for another infertile couple, or used in research. (wikipedia.org)
In 2003, Spain's laws state that embryos left over from IVF and donated by the couple that created them can be used in research, including ES cell research, if they have been frozen for more than five years. (wikipedia.org)
In 2001, the British Parliament amended the Human Fertilisation and Embryology Act 1990 (since amended by the Human Fertilisation and Embryology Act 2008) to permit the destruction of embryos for hESC harvests but only if the research satisfies one of the following requirements: Increases knowledge about the development of embryos, Increases knowledge about serious disease, or Enables any such knowledge to be applied in developing treatments for serious disease. (wikipedia.org)
The United Kingdom is one of the leaders in stem cell research, in the opinion of Lord Sainsbury, Science and Innovation Minister for the UK. (wikipedia.org)
A new £10 million stem cell research centre has been announced at the University of Cambridge. (wikipedia.org)
The primary legislation in South Africa that deals with embryo research is the Human Tissue Act, which is set to be replaced by Chapter 8 of the National Health Act. (wikipedia.org)
But cloning research continued, and American scientists announced in 2013 that they had for the first time successfully obtained stem cells from cloned human embryos. (thenewatlantis.com)
Cloning-for-biomedical-research is also profoundly unethical, as it turns human reproduction into a manufacturing process in the most literal sense: human embryos are created to serve as raw materials for the production of biomedical research supplies. (thenewatlantis.com)
Cloning-for-biomedical-research also endangers the health and safety of the women called on to undergo dangerous hormone treatments to serve as egg donors. (thenewatlantis.com)
The Threat of Human Cloning concludes by calling for laws prohibiting both human cloning and the creation of embryos for research. (thenewatlantis.com)
Ethically, since eventually all such "research" will be applied to people, he cautions against the abuse of women "egg" donors, and against the premature use of vulnerable sick human patients for testing supposedly "patient-specific" stem cells in supposed "therapies", pointing to the obvious violations of standard international research ethics guidelines such clinical trials would necessarily entail. (lifeissues.net)
And he also agrees that if we don't find global agreement on human cloning, "we can probably expect dire consequences for the future of biomedical research and its impact on society at large. (lifeissues.net)
But he is equally concerned about the unethical aspects inherent in the rush to perform " therapeutic " human cloning research, including the abuses to all vulnerable human patients who would be required to participate in clinical trials. (lifeissues.net)
As he has questioned the HFEA before, would not the use of vulnerable human patients in clinical trials be premature, dangerous, and unethical given the already acquired knowledge in the research community that such supposed "patient-specific" stem cells would most probably cause serious immune rejection reactions in these patients? (lifeissues.net)
But they are also less equipped to produce every cell type of the body and less able to reproduce themselves indefinitely, which makes them less appealing to scientists interested in basic research. (eppc.org)
These moral perils are surely not a reason to oppose adult stem cell research, which deserves vigorous and expanded public support. (eppc.org)
Since 1995, Congress has annually reauthorized a law-called the "Dickey Amendment"-prohibiting federal funding for research "in which" embryos are destroyed while leaving embryo destruction in the private sector entirely unregulated. (eppc.org)
Before leaving office, President Clinton sought to get around the existing law without actually changing it, by funding research on embryonic stem cells so long as the actual embryo destruction was paid for with private dollars. (eppc.org)
The bill purports to promote stem-cell research, while outlawing the cloning of a human being. (cbc-network.org)
The use of various types of stem cells for research purposes to make disease "models" in the lab for regenerative medicine and for "therapies" to cure sick patients for diseases is constantly in the news. (lifeissues.net)
increased public sensitivity and awareness together with the development of national regulations of governance of human cloning and embryo research in general. (lifeissues.net)
An in-depth analysis aiming at re-defining this terminology according to the new developments in human embryo research would be highly beneficial . (lifeissues.net)
3. National regulations of governance of human cloning and embryo research in general adopted so far confirm the convergence of views of the refusal to adopt legislation or guidelines permitting reproductive cloning , while they still show variations on the legitimacy of human cloning carried out as part of research agendas. (lifeissues.net)
This paper outlines the debates prompted through a reproduction mechanism involv- by progress in cloning research, with special ing male and female germ cells. (who.int)
Research on iPSCs, initiated by Shinya Yamanaka in 2006 and extended by James Thompson in 2007, has so far revealed the same properties as embryonic stem cells (ESCs), making their discovery potentially very beneficial for scientists and ethicists alike. (asu.edu)
Somatic cell nuclear transfer (SCNT) is a technology applied in cloning, stem cell research and regenerative medicine. (asu.edu)
An analysis of a cluster of articles from the Embryo Project Encyclopedia provides information to suggest possible solutions to some potential problems in cell culturing, recognition of benefits for existing or historical culturing practices, and identification of gaps in scientific knowledge that warrant further research. (asu.edu)
Research involving human neural organoids, transplants, and chimeras has an ultimate goal of preventing and treating the great suffering caused by serious neurological and psychiatric conditions for which no effective treatment is available. (nationalacademies.org)
A main justification for carrying out research, both basic and translational, with human neural organoids, transplants, and chimeras is that it will help in the discovery of new ways to understand and treat neurological and psychiatric disorders, which, as discussed previously, cause immense suffering and for which treatments are ineffective or lacking. (nationalacademies.org)
Assisted reproductive technology (ART) and embryo research have posed many challenges to the different timeframes of science, ethics and law. (edu.au)
Embryonic stem cell technology is still at a preliminary research stage and announcements about its potential may be premature. (edu.au)
Experts from around the world are assessing the difficult issue of the extent to which embryonic stem cell research should be allowed to proceed, and to date there is little international consensus on this matter. (edu.au)
How, then, should embryonic stem cell research be regulated in Australia? (edu.au)
In this article we examine embryonic stem cell research and explore the current regulatory framework associated with this research in Australia, with particular reference to the Andrews Report . (edu.au)
International bi-monthly journal of cell signaling, tissue protection, and translational research. (conditionmed.org)
Chief among these are the legalisation of abortion and approval for research that harms or destroys human embryos. (blogspot.com)

We now see a patent landscape where stem cell technologies and related therapies can, with very few exceptions, be protected via patents, provided the appropriate form of claim wording is used. (schlich.co.uk)

Therapeutic cloning possesses enormous potential for revolutionizing medical and thera- peutic techniques. (who.int)

In the case of asexually creating a human, the biotechnologist removes the nucleus from a mature human egg (an oocyte). (cbc-network.org)
Somatic cell cloning (cloning or nuclear transfer) is a technique in which the nucleus (DNA) of a somatic cell is transferred into an enucleated metaphase-II oocyte for the generation of a new individual, genetically identical to the somatic cell donor (Figure 1 ). (biomedcentral.com)
A matured oocyte (c) is then enucleated (d) and a donor cell is transferred into the enucleated oocyte (e). (biomedcentral.com)

Here, we report that the overexpression of negative elongation factor A (Nelfa), a maternally provided factor, enhances the conversion of ESCs into 2C-like cells in chemically defined conditions, while the deletion of endogenous Nelfa does not block this transition. (bvsalud.org)
Interestingly, we found that the co-overexpression of Nelfa and Bcl2 robustly activates the 2C-like state in ESCs and endows the cells with dual cell fate potential. (bvsalud.org)

This kind of cloning is today being performed at several scientific labs in the United States, despite the availability of alternative techniques that produce cells of nearly the same scientific and medical value but that require neither the creation nor destruction of human embryos. (thenewatlantis.com)
Other policy options, such as supposed compromises that would prohibit "reproductive cloning" but permit "therapeutic cloning" by prohibiting not the act of creating a cloned embryo but the act of transferring a cloned embryo to a woman's uterus, would inherently mandate the wide-scale destruction of human embryos. (thenewatlantis.com)
That is to say, we risk turning developed cells into developing embryos, and thus risk engaging in the very activities of embryo destruction and human cloning that we seek to avoid. (eppc.org)

In the article published in the journal Nature on 1 October 2005, the authors say they wrote the article to dispel misconceptions about what stem cells are, what they do, address some controversies surrounding stem cells, and discuss potential uses of stem cells. (asu.edu)

In this study, we derived skin fibroblasts from a patient with acute myelitis (P-HAF) and then reprogrammed P-HAF cells to iPSCs using eight exogenous factors (namely, OCT4, SOX2, c-MYC, KLF4, NANOG, LIN28, RARG, and LRH1). (bvsalud.org)

In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)

Reproductive Cloning - Use of a donor cell to create a new human genetically identical to the donor. (schlich.co.uk)

The primary cloning technique is called "somatic cell nuclear transfer" (SCNT). (cbc-network.org)
If the authors of this bill really meant what they appear to have written, their legislation would ban all human cloning, since as we have seen, biologically, a new human organism, that is, a new human being, comes into existence with the completion of SCNT. (cbc-network.org)

In 1964, authors James Till, Ernest McCulloch, and Louis Siminovitch, published A Stochastic Model of Stem Cell Proliferation, Based on The Growth of Spleen Colony-Forming Cells, which discussed possible mechanisms that control stem cell division. (asu.edu)
MEFs used as feeder cells may also secrete certain components into the media that support SSC proliferation. (molcells.org)
HuR-mediated circ_0082319 might accelerate HCC cell proliferation, invasion, angiogenesis, and suppress apoptosis by the miR-505-3p/PTK2 axis, hinting at a promising therapeutic target for HCC treatment. (bvsalud.org)

Meanwhile, the ability of the mature egg to transform and begin embryonic development remains fully potent. (cbc-network.org)
… "embryo" means a human organism during the first 56 days of its development following fertilization or creation, excluding any time during which its development has been suspended, and includes any cell derived from such an organism that is used for the purpose of creating a human being. (hinxtongroup.org)
Recording and contextualizing the science of embryos, development, and reproduction. (asu.edu)
As explained in Chapter 2 , human neural organoids, transplants, and chimeras provide new models for such conditions and may lead to new knowledge about brain development and function, the discovery of disease mechanisms, new therapeutic targets, and better screening of potential new treatments. (nationalacademies.org)
Stem cell technology is the latest development in this controversial branch of science. (edu.au)
Here, we consider the metabolism of the early embryo through development, and look at the nutrient milieu within the developing stem cell niche. (conditionmed.org)
2020). This places metabolism at the forefront of development and cell state decisions. (conditionmed.org)
The revised ontology will be an important tool for researchers studying urogenital development/malformation in mouse models and will improve our capacity to appropriately interpret these with respect to the human situation. (atlas-d2k.org)

Long before the controversy emerged over human embryonic stem cells, scientists and doctors began using first-generation stem cells from adult bone marrow. (eppc.org)
In July 2005, for example, scientists announced that they had engineered adult mouse stem cells into usable mouse eggs, a technique that might one day allow for the creation of human eggs from ordinary human cells. (eppc.org)
The con- is removed and replaced by a nucleus of cept of human cloning has long been in the another cell type, the stem cell will then imagination of many scientists, scholars and be reprogrammed to produce the product fiction writers [ 1 ]. (who.int)
In the second half of the twentieth century, scientists learned how to clone organisms in some species of mammals. (asu.edu)

Already, non-embryonic stem cells are being used to treat a variety of diseases-most notably certain cancers of the blood. (eppc.org)
Stem cells offer the prospect of treatments for diseases and injuries that are currently beyond medical science. (schlich.co.uk)
Stem cells may underpin the next generation of pharmaceuticals, with even greater promise for successful treatment of diseases that are intractable or scarcely treatable now. (schlich.co.uk)
Current models for such diseases, which are essential for discovering mechanisms and testing therapeutic interventions, have significant limitations. (nationalacademies.org)
For example, mouse models of age-related neurodegenerative diseases fail to capture key features because the diseases typically strike humans in their 60s and 70s, whereas mice live for only 2 or 3 years. (nationalacademies.org)

The United States government can, and must, outlaw human cloning. (thenewatlantis.com)

When the world learned in 1997 of Dolly the sheep, the first clone produced from an adult mammal, a broad public discussion about the ethics of human cloning ensued, largely focused on the nature, meaning, and future of human procreation. (thenewatlantis.com)
In a new preface, Harris offers a glimpse at the new science and technology to come, equipping readers with the knowledge to assess the ethics and policy dimensions of future forms of human enhancement. (philpapers.org)

Cloning-to-produce-children could also be used to attempt to control the physical and even psychological traits of children, extending the eugenic logic of those who would use reproductive biotechnology to have the perfect child. (thenewatlantis.com)

The signatories' action is a collective response to this week's meeting in Paris of UNESCO's international bioethics committee , which is discussing whether so-called therapeutic cloning should be banned worldwide. (blogspot.com)

Stem cells are cells found in most, if not all, multi-cellular organisms. (wikipedia.org)
Unicellular for those cells that are derived from human organisms are primed to replicate (clone) pre-embryos, which seem to have a high themselves by nature. (who.int)

Stem cells have been used to repair tissue damaged by disease. (wikipedia.org)
XI - embryonic stem cells: embryonic cells that are capable of modifying the cells of any organism tissue. (hinxtongroup.org)
The blastocyst comprises the inner cell mass (ICM), which gives rise to the three primary germ layers and consequently the fetus, and the trophectoderm (TE), which gives rise to the extraembryonic and placental tissue. (conditionmed.org)
In the long term, human kidney tissue generated in this way may be used for drug screening, tissue regeneration or cell therapy. (atlas-d2k.org)
Ontology changes include new structures, tissue layers and cell types within the LUT, external genitalia and lower reproductive structures. (atlas-d2k.org)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)

Citizens disagree about whether we should destroy human embryos for their stem cells-and if so, which embryos, with whose money, under what regulatory guidelines. (eppc.org)

Reproductive rights" is a term commonly used to include abortion on demand. (blogspot.com)

Stem cell treatments are a type of cell therapy that introduce new cells into adult bodies for possible treatment of cancer, somatic cell nuclear transfer, diabetes, and other medical conditions. (wikipedia.org)

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). (lookformedical.com)

We, in our capacity as members of society who undertake scientific discovery and deliberate on scientific knowledge, herein pledge to respect the inherent rights of human embryos and foetuses during our quest for beneficial knowledge, just as we respect the inviolable and inalienable rights of children and adults. (blogspot.com)

The authors wrote the article following their experiments with spleens of irradiated mice to demonstrate the existence of stem cells, had unknown properties. (asu.edu)
He probes the male mouse's reaction to chemical signals from female mice to advance understanding of pattern recognition and learning in the much more complex human brain. (vetscite.org)

Ontology changes were based on recently published insights into the cellular and gross anatomy of these structures, and on new analyses of epithelial cell types present in the pelvic urethra and regions of the bladder. (atlas-d2k.org)

But in order to become a part of medical history, parahuman reproduction and human genetic engineering must circumvent the recalcitrance of an antiquated culture. (lifeissues.net)

Spermatogonial stem cells (SSCs), also called germline stem cells, are unipotent precursor cells that self-renew and contribute to spermatogenesis in the testis. (molcells.org)

Over the past few years, the debate over stem cells and cloning has grown both more complex and more profound. (eppc.org)

Adult stem cells are easier to control than embryonic stem cells and thus less likely to form tumors. (eppc.org)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)
B-cell lymphoid tumors that occur in association with AIDS. (lookformedical.com)

Not only would cloning-to-produce-children be a dangerous experimental procedure, one that cannot be consented to by its subjects (the children created by it), it is also a profound distortion of the moral meaning of human procreation. (thenewatlantis.com)
Stem cell technologies have been dogged by controversy because of objections over the morality of sacrificing human embryos to produce the first human embryonic stem cell lines. (schlich.co.uk)
Spermatogonial stem cells (SSCs, also called germline stem cells) are self-renewing unipotent stem cells that produce differentiating germ cells in the testis. (molcells.org)

Last May, the House of Representatives passed a bill to create a cord blood stem cell bank, legislation that is likely to become law with virtually unanimous support. (eppc.org)
Moreover, while the term "human being" is not defined in the legislation, in this context, it can only mean the birth of a cloned baby. (cbc-network.org)

However, it appears that the ability of the In its simplest form, cloning is defined stem cells to transform is limited, except as the exact replication of cells. (who.int)

Or to put it the other way around, cloning, not implantation, is what produces a new and distinct human organism. (cbc-network.org)

The unique properties of human stem cells have aroused considerable optimism about their potential as new pathways for alleviating human suffering caused by disease and injury. (edu.au)

Italy has a 2004 law that forbids all sperm or egg donations and the freezing of embryos, but allows, in effect, using existing stem cell lines that have been imported. (wikipedia.org)
Our project focuses on characterizing and optimizing this approach to improve tubular maturation and cellular function and generating reporter lines for the isolation of specific cell types. (atlas-d2k.org)
Circ_0082319, PTK2, and HuR were highly expressed, and miR-505-3p was reduced in HCC samples and cell lines. (bvsalud.org)

Anatomy55

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