Embryonic stem cells allogeneic hematopoietic stem cell transplantation bone marrow transplantation. Medical search. Frequent questions

Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
Progenitor cell therapy is being investigated for the treatment of damaged myocardium resulting from acute or chronic cardiac ischemia and for refractory angina. (southcarolinablues.com)
For individuals who have acute cardiac ischemia who receive progenitor cell therapy, the evidence includes 2 randomized controlled trials (RCTs) with 200 patients, numerous small RCTs, and meta-analyses of these RCTs. (southcarolinablues.com)
Overall, this evidence has suggested that progenitor cell treatment may be a promising intervention, but robust data on clinical outcomes are lacking. (southcarolinablues.com)
For individuals who have chronic cardiac ischemia who receive progenitor cell therapy, the evidence includes a nonrandomized comparative trial and systematic reviews of smaller RCTs. (southcarolinablues.com)
Results of the nonrandomized trial are encouraging, because this is the first controlled trial that has reported a significant mortality benefit for progenitor cell treatment. (southcarolinablues.com)
For individuals who have refractory angina who receive progenitor cell therapy, the evidence includes phase 2 trials and a phase 3 pivotal trial. (southcarolinablues.com)
Additional larger trials are needed to determine whether progenitor cell therapy improves health outcomes in patients with refractory angina. (southcarolinablues.com)
1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
Although hematopoietic stem and progenitor cells (HSPCs) enable autologous treatment of blood disorders, de novo generation of hematopoietic cells from pluripotent stem cells still compromises the unlimited high yield and rich hematopoiesis engraftment potential [ 2 ]. (biomedcentral.com)
Single-cell transcriptomic analysis confirmed inhibition of lineage-committed progenitor cells in physioxic cultures. (stanford.edu)
Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
Collectively, these are referred to as hematopoietic stem and progenitor cells (HSPCs). (stemcell.com)
The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)
Colonies derived from different types of progenitor cells are classified and counted based on morphological and phenotypic criteria. (stemcell.com)
CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
We found that ruxolitinib, a selective JAK1/2 inhibitor, ameliorated aGVHD-related hematopoietic dysfunction through a direct effect on recipient BMSCs, resulting in improved proliferation ability, adipogenesis/osteogenesis potential, mitochondria metabolism capacity, and crosstalk with donor-derived hematopoietic stem/progenitor cells. (bvsalud.org)
In vitro differentiation of GS-2 iPSCs into hematopoietic stem and progenitor cells was done using Op9 feeder layers and specified media. (biomedcentral.com)
This reduced differentiation of CD34+ hematopoietic progenitor stem cells could occur due to both infectious and non-communicable diseases and also due to their drug induced treatments. (hoajonline.com)
Embryonic myogenic progenitor cells express CXCR4, G-protein coupled cell surface receptor, and migrate towards regions of SDF-1 expression during limb muscle development, suggesting that CXCR4/SDF-1 plays a role in muscle cell homing. (biomedcentral.com)
Derived from the fetal allantois, it provides a rich source of multipotent stem cells, including CD34+ and CD38- haematopoietic progenitor cells. (sajbl.org.za)
These progenitor cells have greater clonal expansion and proliferative capacity than normal bone marrow cells. (sajbl.org.za)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

Currently, allogeneic HSC transplantation has been widely used in a clinical setting, yet allogeneic transplantation often leads to graft versus host disease (GVHD) [ 1 ]. (biomedcentral.com)
Treatment of graft-versus-host disease resulting from hematopoietic stem cell transplantation is elaborated. (kean.edu)
When a transplant occurs which includes lymphocytes, monocytes or progenitors thereof, particularly bone marrow, a graft may attack the host as foreign, resulting in graft-versus-host disease. (justia.com)
Notch signaling promotes T cell pathogenicity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT) in mice, with a dominant role for the Delta-like Notch ligand DLL4. (bvsalud.org)
Acute graft-versus-host disease (aGVHD) is a severe complication of allogeneic hematopoietic stem cell transplantation. (bvsalud.org)
Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
Gene delivery through stem cells using specific viral vectors are also utilised to confer lineage specificity of transducedautologous or allogeneic stem cell gene expressionin the recipient while addressing graft versus host disease. (hoajonline.com)

In this study, we established an in vitro differentiation system yielding in vivo hematopoietic reconstitution hematopoietic cells from mouse PSCs through a 3D induction system followed by coculture with OP9 stromal cells. (biomedcentral.com)
The method for isolating bone marrow stromal cells is explained. (kean.edu)
Mesenchymal stem cells (MSCs), or stromal stem cells, can differentiate into many different types of … In contrast, treatments that utilize MSCs from a patientâ s fat (adipose) sample have shown weak or unreliable responses. (tomeipowered.com)
As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs) have emerged as a versatile and frequently utilized cell source in the fields of … MSC have been shown to differ-entiate in vitro into adipocytes, chon-drocytes, osteoblasts, myocytes, and ß-pancreatic islets cells. (tomeipowered.com)
Mesenchymal stem/stromal cells (MSCs) are multipotent cells that are emerging as the most promising means of allogeneic cell therapy. (tomeipowered.com)
Mesenchymal Stem Cells Instruction Manual Product Description Mesenchymal Stem Cells (MSC), also termed Mesenchymal Stromal Cells, are self-renewing multipotent cells that can differentiate into a wide variety of cell types. (tomeipowered.com)
Transcriptional analysis showed that BM mesenchymal stromal cells (BMSCs) were severely affected, with a reduction in cell ratio, abnormal metabolism, compromised differentiation potential, and defective hematopoiesis-supportive function, all of which were validated by functional assays. (bvsalud.org)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
Despite almost 50 years of research and over 20 years of preclinical and clinical studies, the question of curative potential of mesenchymal stem/stromal cells (MSCs) is still widely discussed in the scientific community. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) have the capacity to differentiate into cells and tissues of one germ layer, here the mesodermal lineage, and are consequently multipotent. (frontiersin.org)
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. (issca.us)
Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (issca.us)
This concept started from the observation that bone marrow transplantation can provide stromal cells able to synthesize intact collagen type I, replacing deficient patient cell function and ameliorating disease symptoms [5]. (issca.us)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)
Mesenchymal stem cells ( MSCs) are known to be multipotent stromal cells that can differentiate into a variety of cell types which include osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (stemcellsgroup.com)
Mesenchymal stem/stromal cells (MSCs) can be isolated from neonatal tissues, most of which are discarded after birth, including placental tissues, fetal membranes, umbilical cord, and amniotic fluid. (stemcellsgroup.com)
Table 2 Preclinical spinal cord injury trials using mesenchymal stromal cells (MSCs). (cancerdir.com)

Decades of efforts have attempted to differentiate the pluripotent stem cells (PSCs) into truly functional hematopoietic stem cells (HSCs), yet the problems of low differentiation efficiency in vitro and poor hematopoiesis reconstitution in vivo still exist, mainly attributing to the lack of solid, reproduced, or pursued differentiation system. (biomedcentral.com)
We interestingly found that our 3D+OP9 system enriched a higher percentage of CD201 + c-kit + cells that showed more similar HSC-like features such as transcriptome level and CFU formation ability than CD201 - c-kit + cells, which have not been reported in the field of mouse PSCs hematopoietic differentiation. (biomedcentral.com)
Altogether, our findings lay a foundation for improving the efficiency of hematopoietic differentiation and generating in vivo functional HSC-like cells from mouse PSCs for clinical application. (biomedcentral.com)
moreover, they also promote the hematopoietic differentiation of mouse ESCs and favor the development of definitive HSCs from pre-HSCs in the mouse aorta-gonad-mesonephros (AGM) region [ 8 ]. (biomedcentral.com)
Differentiation: Stem cells can differentiate into specialized cell types, such as muscle cells, nerve cells, or blood cells, based on the signals they receive from their surrounding environment. (stemcellassurance.com)
Differentiation of new neurons from neural stem cells is described. (kean.edu)
these cells can induce neural differentiation. (kean.edu)
Stem cell treatment for Muscular Dystrophy: The Autologous stem cells are recognized to have myogenic differentiation characters. (surgerytoursindia.com)
Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
In vivo differentiation to cells from all three germlines was tested using a teratoma assay. (biomedcentral.com)
Differentiation capacity into cells from all three germ layers was confirmed using the teratoma assay. (biomedcentral.com)
Accordingly, scientists have developed protocols for the expansion, genetic modification and differentiation of stem cells to NK cells. (molcells.org)
Retention of cellular phenotype is the hallmark of differentiation of pluripotent stem cells. (hoajonline.com)
UCB's advantages over other sources of stem cells such as adult bone marrow and embryonic stem cells include easy procurement, minimal risk to the donor, excellent proliferation and differentiation, immediate availability, and autologous use. (sajbl.org.za)
a) The cells should exhibits plastic adherence (b) The cell should possess specific set of cell surface markers, i.e. cluster of differentiation (CD) 73, D90, CD105 and lack expression of CD14, CD34, CD45 and human leucocyte antigen-DR (HLA-DR). (c) The cells should have the ability to differentiate in vitro into adipocyte, chondrocyte and osteoblast. (stemcellsgroup.com)
Research has shown the importance of growth factors in guiding and modulating the differentiation of MSCs in order to obtain the required cell type. (openorthopaedicsjournal.com)
The activation, differentiation, and development of CD8+ T cells can be affected by numerous inflammatory cytokines, transcription factors, and chemokines. (frontiersin.org)
The activation, differentiation, and development of CD8+ T cells is accompanied by large-scale changes in the coordinated expression of numerous inflammatory cytokines, transcription factors (TFs) and chemokines that are correlated with their survival, effector function, and self-renewal ( 7 ). (frontiersin.org)

The Phase 1 trial involves harvesting a patient's mesenchymal stem cells (MSCs), which are primitive cells in the bone marrow, culturing them in a laboratory, and then injecting the MSCs intravenously back into the patient to see if the procedure is safe, decreases disease activity, and leads to improved repair. (case.edu)
MSCs have a wide range of effects that decrease the activity of immune cells while encouraging tissue repair, both of which may be beneficial in MS. In addition, in numerous laboratory studies, MSCs were able to migrate from the blood into areas of inflammation or injury in the nervous system and reduce damage probably by creating a tissue environment that encourages the body's intrinsic repair processes. (case.edu)
The term 'mesenchymal stem cells' (MSCs) is most commonly used to describe multipotent self-renewing cells that can be differentiated in vitro to generate adipocytes, chondrocytes, and osteoblasts. (tomeipowered.com)
The inherent tumor-tropic property of MSCs can be used to target cancer cells. (tomeipowered.com)
Concomitantly, the ability of MSCs to differentiate and give rise to multiple cell types such as adipocytes, chondrocytes, and osteoblasts … These transplants vastly increase the bodyâ s natural healing abilities and have potent anti-inflammatory and immunosuppressive responses.Â. (tomeipowered.com)
Mesenchymal stem cells (MSCs) are an example of tissue or 'adult' stem cells. (tomeipowered.com)
MSCs make the different specialized cells found in the skeletal tissues. (tomeipowered.com)
The original mesengenic process pathway (Figure 1) was hypothesized and fashioned … Two opposing descriptions of so-called mesenchymal stem cells (MSCs) exist at this time. (tomeipowered.com)
The problem is what a mesenchymal stem cell (MSCs) is isn't always clearly defined, which has led to confusion in the scientific community, as well as public misunderstandings exploited by businesses marketing questionable cell-based treatments, the authors argue. (tomeipowered.com)
Properties of Mesenchymal … We found that … Platelets are known to enhance the wound-healing activity of mesenchymal stem cells (MSCs). (tomeipowered.com)
Among the cell types that can be used for this purpose, mesenchymal stem cells (MSCs) are considered as promising source of stem cells in personalized cell-based therapies. (tomeipowered.com)
MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
Therefore, MSCs may help resolve issues restricting the application of hepatocyte transplantation. (springer.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
In this mini review, we will discuss point by point possible pitfalls in the production of human MSCs for cell therapies, without consideration of material-based applications. (frontiersin.org)
Only a careful consideration and standardization of all pretreatment processes/methods for the different applications of MSCs will ensure robust and reproducible performance of these cell populations in the different experimental and clinical settings. (frontiersin.org)
In fact, low levels of telomerase activity have been found in human adult stem cells including haematopoietic and non-haematopoietic stem cells such as neuronal, skin, intestinal crypt, mammary epithelial, pancreas, adrenal cortex, kidney, and mesenchymal stem cells (MSCs) ( Table 1 ). (nature.com)
Pivotal studies by the group of Horwitz in children with osteogenesis imperfecta, an inherited enzyme deficiency of collagen synthesis by mesenchymal cells in bone, opened the field for intravenous use of MSCs. (issca.us)
Therefore, the authors concluded that transplantation of isolated healthy allogeneic MSCs might cure the disease. (issca.us)
This implies homing of transplanted MSCs to sites in bone marrow and/or bone. (issca.us)
In a second study [6], these authors showed that autologous, enzyme-deficient MSCs transduced with a copy of the intact gene resulted in normal collagen production in bone cavities. (issca.us)
The tissue source of the MSCs was in most cases not decisive, and cells from various tissue sources were explored. (issca.us)
and signals from the injected cells were found early after administration of the MSCs at the highest frequencies in the lungs, followed by liver and spleen. (issca.us)
Mesenchymal Stem Cells (MSCs) are multipotent cells with self-renewal ability and form the basis for regenerative treatments. (hacettepe.edu.tr)
Objectives: Evaluation of the therapeutic effects of intrapulmonary transplantation of BM-MSCs to improvement of clinical signs in experimental model of ARDS created by lipopolysaccharide(LPS)E.Coli strains-O55:B5 in sheep is the aim of this study. (ac.ir)
Of sheep in the treatment group after anesthesia with ketamine and xylazine collected bone marrow samples and in the clean room BM-MSCs isolated, amplified and were identified with the evaluation of surface markers. (ac.ir)
After confirming inflammation, the sheep were anesthetized and on sternal position 50×106 cells of BM-MSCs third passage were transferred in treatment group as autograft by the catheter lavage in the bifurcation of the trachea and PBS in control group. (ac.ir)
Results: The data showed transplantation of BM-MSCs caused significant improvement in clinical signs including heart rate, respiratory rate, body temperature, respiratory sounds, cough, mucosal status, nasal secretions, appetite and physical condition compared with control group. (ac.ir)
Conclusions: This study showed that transplantation of BM-MSCs can cause improves and the reduction in the severity of the clinical signs of ARDS, significantly. (ac.ir)
Thus, these properties of MSCs make these cells potentially ideal candidates for tissue technology. (stemcellsgroup.com)
Thus, neonatal tissues are easily available and they have biological advantages in comparison to adult sources that make them a useful source for stem cells including MSCs. (stemcellsgroup.com)
The most commonly used type of stem cells, mesenchymal stem cells (MSCs), can be easily isolated from bone marrow or synovium and cultured in vitro . (openorthopaedicsjournal.com)
These osteoconductive three dimensional constructs seeded with MSCs are highly porous, biodegradable and biomechanically stable scaffolds which do not evoke an immunogenic host cell response. (openorthopaedicsjournal.com)

Stem cells are defined as undifferentiated cells that can differentiate into specialized cell types and can divide to produce more stem cells. (stemcellassurance.com)
They are considered pluripotent, meaning they can differentiate into almost any cell type. (stemcellassurance.com)
Unlike embryonic stem cells, adult stem cells are multipotent, meaning they can differentiate into a limited number of cell types. (stemcellassurance.com)
iPSCs have characteristics similar to embryonic stem cells and can differentiate into various cell types. (stemcellassurance.com)
Plasticity: Some types of stem cells have the ability to differentiate into cell types from other tissues or organs, a property known as plasticity. (stemcellassurance.com)
Our bodies contain a pool of stem cells that have the ability to differentiate into any other cell type in the body. (bmrat.org)
Stem cells are widely defined by two main characteristics: the ability to self-renew (divide in a way that reproduces more identical stem cells) and to differentiate (to turn stem cells into specialized cells that form different organs and tissues). (bmrat.org)
It is therefore of interest to find effective ways to produce cells which may function, proliferate, and differentiate as appropriate, while being safe from attack by a recipient's immune system. (justia.com)
Induced pluripotent stem cells (iPSC) express genes associated with pluripotency, have the capacity for infinite expansion, and can differentiate into cells from all three germ layers. (biomedcentral.com)
GS-2 iPSCs showed the capacity to differentiate into cells of the hematopoietic lineage. (biomedcentral.com)
There already exist several protocols to genetically modify and differentiate iPSCs into NK cells, and each has its own advantages with regards to immunotherapies. (molcells.org)
Embryonic stem cells which are characteristic of totipotency differentiate into generations of the multiple organs. (hoajonline.com)
The totipotentstem cells differentiate further into pluripotency thatpopulate the organs with different sub-divisional components of the various individual organs. (hoajonline.com)
mesenchymal stem cells - placenta) differentiate into multipotency as precursors to formation of the cellular components. (hoajonline.com)
More recently investigators found that some of the cells thought to be NK cell precursors that failed to differentiate into mature NK cells constitute a novel innate lymphoid cell type.Research interest in NK-cell origin, function and potential enhancement of NK cells for tumor immunotherapy is part of a wave of interest in immunotherapy based on significant advances in the field in the past decade. (umn.edu)
Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)
Similarly, they are characterized by an extensive capacity for self-renewal, proliferation, potential to differentiate into multiple lineages and their immune-modulatory role on various cells. (stemcellsgroup.com)
Embryonic stem cells, which as the name suggests are derived from an embryo, can differentiate into nearly any kind of cell type and are the building blocks for the entire body during development. (mssociety.ca)
The more specialized adult stem cells (a category to which mesenchymal stem cells belong), on the other hand, are more limited in the types of cells they can differentiate into, and are generally involved in repairing damaged tissues or replacing aging cells. (mssociety.ca)

Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
Learn more about research in the Bone Marrow Transplant Program . (mayoclinic.org)
See a list of publications about bone marrow transplant by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. (mayoclinic.org)
Hematopoietic stem cell transplant. (mayoclinic.org)
http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
Where transplantation from another allogeneic host occurs, unless the transplant is matched with the host or the host is immunocompromised, the transplant may be attacked and destroyed by the immune system. (justia.com)
There are many situations where one may wish to transplant cells into a recipient host where the recipient's cells are missing, damaged or dysfunctional. (justia.com)
It may be performed using cells from the patient's own body (autologous transplant) or cells from a donor (allogeneic transplant). (mayo.edu)
[11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
Stem cell therapy, or stem cell transplant, is a procedure that aims to restore blood-forming stem cells in patients who have undergone chemotherapy or radiotherapy . (parkwaycancercentre.com)
Autologous stem cell (patient's own stem cells) transplant is used to help patients recover from the effects of chemotherapy. (parkwaycancercentre.com)
Allogeneic stem cell (stem cells from a donor) transplant is used to help patients recover from the effects of chemotherapy and/or radiotherapy as well as to eradicate the remaining cancer cells in the patient after chemotherapy and/or radiotherapy. (parkwaycancercentre.com)
Stem cell transplant is often a part of the treatment plan for blood cancers. (parkwaycancercentre.com)
In allogeneic stem cell (stem cells from a donor) transplant, there is another benefit in addition to replenishing the HSCs in the bone marrow after chemotherapy or radiotherapy. (parkwaycancercentre.com)
The stem cells originate from the patient who will receive the transplant. (parkwaycancercentre.com)
A donor, either related or unrelated to the patient, who donates the stem cells for transplant. (parkwaycancercentre.com)
Therefore, we sought to translate these results to a clinically relevant canine-to-canine allogeneic transplant model for Duchenne muscular dystrophy (DMD) and determine if CXCR4 is important for donor cell engraftment. (biomedcentral.com)
Intramuscular injection of donor muscle-derived cells into chimeric cxmd recipients restored dystrophin expression for at least 24 weeks in the absence of post-transplant immunosuppression, indicating that cell transplantation may be a viable therapeutic option for muscular dystrophy. (biomedcentral.com)
Hemophagocytic lymphohistiocytosis induced by Toxoplasma gondii infection diagnosed by a bone marrow biopsy and DNA next-generation sequencing in an allogeneic hematopoietic stem cell transplant recipient. (umn.edu)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)

Induced pluripotent stem cells (iPSCs): These stem cells are created by reprogramming adult somatic cells, such as skin cells, back into a pluripotent state. (stemcellassurance.com)
Method for generating marmoset-induced pluripotent stem cells, using transcription factors, is also explained. (kean.edu)
In- duced pluripotent stem cells have been used to create active T cells to support cancer immunotherapy. (bmrat.org)
This re- view discusses stem cell applications in transplantation, stem cell-based carriers, induced-pluripotent stem cells, can- cer stem cells, and potential of stem cells engineering to revolutionize cancer treatment. (bmrat.org)
Embryonic stem cells are pluripotent, meaning they are able to produce all cell types in the body. (bmrat.org)
These cells are called induced pluripotent stem cells (iPSCs). (bmrat.org)
2007). As the name implies, pluripotent cells are able to generate all other specialized cell types. (bmrat.org)
Considerable effort has thus been devoted to generating induced pluripotent stem cells (iPSCs) from multiple non-human primate species. (stanford.edu)
Use of this type of stem cell has significantly decreased in recent years due to the discovery of induced pluripotent stem cells. (mayo.edu)
At the same time, the first three trials using cells derived from pluripotent cells have begun. (biomedcentral.com)
The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the door to a new generation of regenerative medicine research. (molcells.org)
Among PSCs, the donors available for induced pluripotent stem cells (iPSCs) are greatest, providing a potentially universal cell source for all types of cell therapies including cancer immunotherapies using natural killer (NK cells). (molcells.org)
Among stem cells, induced pluripotent stem cells (iPSCs) have a number of features that make them ideal as the starting source. (molcells.org)
The pluripotent stem cells (eg. (hoajonline.com)
Specifically, about the paracrine activities of amniotic fluid stem cells, renal stem cells, embryonic stem cells, mesenchymal stem cell, induced pluripotent stem cells as well as other stem cells. (biomedcentral.com)

Overview and choice of donor of hematopoietic stem cell transplantation. (mayoclinic.org)
National Marrow Donor Program. (mayoclinic.org)
This way of making iPSCs from adult cells circumvents the need to destroy an embryo from living donor. (bmrat.org)
In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs. (justia.com)
The only curative treatment for ALF is liver transplantation, but there are many restrictions on the application of liver transplantation because of financial considerations, a shortage of donor livers, and immunosuppression-related complications [ 3 ]. (springer.com)
All GS-2 iPSC clones displayed a normal karyotype (46XX or 46XY) and were shown to express the same RAB27A gene mutation that was present in the original somatic donor cells. (biomedcentral.com)
The process of removing all the cells from a donor organ, such as a heart or lung, leaving behind just a tissue scaffold. (mayo.edu)
The donor immune cells can kill the leftover cancer cells and will exert a "graft-versus-cancer" effect, keeping the cancer cells in check. (parkwaycancercentre.com)
Finding a donor with suitable stem cells is critical to avoid graft rejection or graft-versus-host syndrome. (parkwaycancercentre.com)
Many factors dictate whether the donor stem cells are suitable for the recipient but the most important one is the human leukocyte antigen (HLA) system. (parkwaycancercentre.com)
Starting with cell source, choice of donor and recipient, as well as isolation methods, we will then discuss existing expansion protocols (two-/three-dimensional cultivation, basal medium, medium supplements, static/dynamic conditions, and hypoxic/normoxic conditions) and influence of these strategies on the cell functionality after implantation. (frontiersin.org)
Together, these data suggest that CXCR4 plays an important role in donor cell engraftment. (biomedcentral.com)
We show that CXCR4 expressing cells are important for donor muscle cell engraftment, yet FACS sorted CXCR4-positive cells display decreased engraftment efficiency. (biomedcentral.com)
However, diprotin A, a positive modulator of CXCR4-SDF-1 binding, significantly enhanced engraftment and stimulated sustained proliferation of donor cells in vivo . (biomedcentral.com)
We used a clinically acceptable regimen of hematopoietic stem cell transplantation to establish mixed donor/host blood cell chimerism and immune tolerance in a canine model of Duchenne muscular dystrophy ( cxmd ) [ 9 ]. (biomedcentral.com)
We used the xenotransplant model to show that CXCR4 expression on canine donor muscle cells is also important for cell engraftment, but FACS sorting for CXCR4-positive cells decreased their engraftment efficiency. (biomedcentral.com)
Diprotin A stimulation of CXCR4, however, significantly increased the number of canine dystrophin-positive muscle fibers and canine-derived satellite cells by enhancing donor cell proliferation. (biomedcentral.com)
Engraftment of donor-type MSC-derived osteoblasts was shown using bone specimens and microsatellite DNA marker analysis. (issca.us)
Other treatments are allogeneic, meaning the stem cells are from a donor. (mssociety.ca)

Hematopoietic stem cells (HSCs) are a rare hematopoietic cell type that can entirely reconstitute the blood and immune systems following transplantation. (stanford.edu)
HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
HSCs specifically are defined by their ability for self-renewal and to reconstitute the entire hematopoietic system following transplantation. (stemcell.com)
In experimental settings, the ability of human HSCs to reconstitute hematopoiesis is measured by transplantation into genetically immunocompromised mice (e.g. (stemcell.com)
FLT3 ITD triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly transform HSCs. (biomedcentral.com)
All of the blood cells in the body come from immature cells called hematopoietic stem cells, HSCs (hematopoietic means blood-forming). (parkwaycancercentre.com)
HSCs mostly stay in the bone marrow and mature into blood cells as they grow. (parkwaycancercentre.com)
Bone marrow cancers such as multiple myeloma , leukaemia, and lymphoma , reduce the formation of HSCs in the bone marrow. (parkwaycancercentre.com)
Chemotherapy or radiotherapy used to treat these cancers will destroy the HSCs in the bone marrow and abolish the body's ability to regenerate blood cells. (parkwaycancercentre.com)
This high-dose therapy will also destroy the HSCs in the bone marrow. (parkwaycancercentre.com)
Peripheral blood stem cells are the preferred source of HSCs because of the relative ease of collection. (parkwaycancercentre.com)

Blood-forming stem cell transplants. (mayoclinic.org)
Currently, stem cell research is a rapidly evolving field, with ongoing research and clinical trials exploring the potential applications of stem cells in various fields, such as regenerative medicine, genetic disorders, organ transplants, cosmetic and plastic surgery, and drug development. (stemcellassurance.com)
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
Citation: Mera T, Heimfeld S, Faustman DL (2014) The Spleen Contributes Stem Cells to Peripheral Blood Stem Cell Transplants. (fliphtml5.com)
Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
For induce splenomegaly in most donors and in rare, severe cases splenicautologous stem cell transplants, the use of autologous PBSCT from rupture [13,14]. (fliphtml5.com)
GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
Frequently, stem cells are taken from the pelvic bone, filtered, and stored under special conditions for future transplants. (parkwaycancercentre.com)
Additionally, stem cell transplants can also be categorised based on who donates the stem cells. (parkwaycancercentre.com)
Children who received transplants showed improved growth rates and started to synthesize intact bone. (issca.us)
Moreover, children who received transplants approached growth curves similar to the children transplanted with allogeneic complete bone marrow [6]. (issca.us)
Banks of bone tissue: biological aspects, immunogenicity of transplants. (edu.pl)
4. Alternative ways of nerve repair - vascular transplants, allogeneic nerve transplants, pre-degenerated transplants, transplants from veins, nerve transfers. (edu.pl)
Biological substitutes of skin - autologous transplants, allografts, cultures of autologous and allogeneic keratinocytes, living substitues of skin, complex substitutes of skin. (edu.pl)

Although safety remains a concern, investigators are breaking ground in cell and gene therapy, and many believe that ultimately, a string of cancer cures will follow. (ajmc.com)
Although only a handful of cell and gene therapies are on the market, FDA officials predicted in 2019 that the agency will receive more than 200 investigational new drug applications per year for cell and gene therapies, and that by 2025, it expects to have accelerated to 10 to 20 cell and gene therapy approvals per year. (ajmc.com)
Cell therapy involves cultivating or modifying immune cells outside the body before injecting them into the patient. (ajmc.com)
Gene therapy modifies or manipulates cell expression. (ajmc.com)
Juliette Hordeaux, PhD, senior director of translational research for the University of Pennsylvania's gene therapy program, is cautious about the FDA's predictions, saying she'd be "thrilled" with 5 cell and/or gene therapy approvals annually. (ajmc.com)
Safety has been the main brake around adeno-associated virus vector (AAV) gene therapy," added Hordeaux, whose hospital's program has the institutional memory of both Jesse Gelsinger's tragic death during a 1999 gene therapy trial as well as breakthroughs by Carl June, MD, and others in CAR T-cell therapy. (ajmc.com)
Yescarta), a CAR T-cell therapy for adults with large B-cell non-Hodgkin lymphoma. (ajmc.com)
For a long time, stem cells have been utilized to renew the immune system for radiation or chemo- therapy treated patients. (bmrat.org)
Haematopoietic-cell transplantation (HCT) is a potential therapy for people with such severe intractable diseases. (surgerytoursindia.com)
Stem Cell Therapy for Autism through mesenchymal stem cells, have shown improvement in patients. (surgerytoursindia.com)
Allogeneic HSC transplantation (HSCT) is used clinically as a curative therapy for a range of hematolymphoid diseases, but remains a high-risk therapy due to potential side effects including poor graft function and graft-vs-host disease (GvHD). (stanford.edu)
It is used both by hematopoietic researchers and clinical labs to assess the potency of transplantation units of cord blood (CB) and hematopoietic cellular therapy products. (stemcell.com)
Stem cell therapy holds immense promise of delivering the next generation of future medical breakthroughs. (tomeipowered.com)
Stem cell therapy in India is a safe, affordable, and legal treatment that relieves your ailments without any medicine. (medicaltourismco.com)
Dr. Anand Srivastava: What is Stem Cell Therapy? (medicaltourismco.com)
The Indian stem cell therapy ranges between $1,500 to $30,000 in India*, which further depends on the condition being treated. (medicaltourismco.com)
Therefore, the cost of stem cell therapy in India lets you save nearly 50% of the price back in the USA. (medicaltourismco.com)
All these diseases are readily treated by Stem Cell Therapy in India at a reasonable cost. (medicaltourismco.com)
Medical Tourism Corporation has partnered with the Global Institute Of Stem Cell Therapy and Research (GIOSTAR). (medicaltourismco.com)
The damaged bone marrow will then be replenished with new stem cells to alleviate the side effects of the high-dose therapy. (parkwaycancercentre.com)
A small number of stem cells can be found in the blood, and these can be collected for stem cell therapy. (parkwaycancercentre.com)
The tumor will rapidly recur if the therapy eliminates cancer cells but spares a significant population of the cancer stem cells. (hoajonline.com)
The best hope for regeneration of these permanently damaged cells is optic stem cell therapy combined with continued drug treatments or other exogenous biomaterial implants depending upon the relevant ophthalmological condition. (hoajonline.com)
In view of the fact that UCB has become a valuable, non-invasive source of stem cells for regenerative therapy, establishment of a public cord blood bank (CBB) in South Africa would vastly improve the availability of haematopoietic stem cells for research and therapeutic uses, and increase the tissue genetic diversity that currently impedes the South African bone marrow registry. (sajbl.org.za)
2 UCB is at the forefront of research exploring gene therapy, prenatal diagnosis, immune cell therapy, antibiotic efficacy and identification of new proteins. (sajbl.org.za)
It includes the possible stem cell therapy mechanisms involved and outcomes recorded so far, the limitations of using these regenerative medicines, and the progressive improvement in stem cell therapy by adopting approaches like PiggyBac, Sleeping Beauty, and the Sendai virus. (biomedcentral.com)
Background: ARDS is a lung disorder that causes death in human and livestock and new therapeutic approaches such as stem cell therapy are essential because of lack of specific drug therapies for it. (ac.ir)
Stem cell therapy is an exciting and upcoming branch of tissue engineering with application in the field of orthopaedics. (openorthopaedicsjournal.com)
I hear a lot of questions about stem cell therapy, such as "what is the source of stem cells used in MS research? (mssociety.ca)
and, "what are the risks and benefits of stem cell therapy? (mssociety.ca)
In this post, I will explain mesenchymal stem cells and the MESCAMS study in particular, in the hopes of clarifying any misconceptions surrounding this promising therapy. (mssociety.ca)
Studies exploring the therapeutic benefits of mesenchymal stem cell therapies for MS are in their infancy, but the results to date have been so encouraging so as to warrant a concerted, international effort in the scientific community to accelerate research into testing the safety and feasibility of this therapy in people living with MS. (mssociety.ca)
MESCAMS is a randomized, double-blind, cross-over, phase II clinical trial (that's quite a mouthful, but I'll explain what that means in a moment) investigating the safety and therapeutic potential of mesenchymal stem cell therapy for people with MS. The study will involve40 patients who will receive the treatment one at two sites - The Ottawa Hospital and Health Sciences Centre (HSC) Winnipeg . (mssociety.ca)

Furthermore, we provide evidence that HSC-selective ex vivo cultures deplete GvHD-causing T cells and that this approach can be combined with genotoxic-free antibody-based conditioning HSCT approaches. (stanford.edu)
Our results offer a simple approach to improve PVA-based HSC cultures and the underlying molecular phenotype, as well as highlight the potential translational implications of selective HSC expansion systems for allogeneic HSCT. (stanford.edu)
This article will explain what Haematopoietic stem cell transplantation (HSCT) involves, its benefits/risks, and how it may or may not be helpful for certain neurological conditions. (tomeipowered.com)
A total of 62 patients with dry eye disease caused by GVHD after allogeneic hematopoietic stem cell transplantation (HSCT) were recruited from the First Affiliated Hospital of Soochow University between 2012 and 2020. (bvsalud.org)
His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)

they include hematopoietic stem cells and adult and embryonic stem cells. (ajmc.com)
Adult stem cells: These stem cells are found in various tissues and organs of the body, such as bone marrow, blood, and adipose tissue. (stemcellassurance.com)
For example, embryonic stem cells exist only at the earliest stage of embryo and adult stem cells appear during fetal development and are retained throughout life. (bmrat.org)
A blastocyst contains an inner cell mass including a clump of around 150 cells that eventually will generate the entire body of the adult animal. (bmrat.org)
This is done by re-activating critical genes that define embryonic stem cells to make adult stem cells to revert to an embryonic-like state of pluripotency. (bmrat.org)
Adult stem cells were firstly isolated from bone marrow in mice (Spangrude, Heimfeld, and Weissman, 1988) and later in humans. (bmrat.org)
In full grown organisms, Stem Cells work to mend the body system, restocking adult tissues. (surgerytoursindia.com)
Adult Stem Cells are normally used in medical therapies, for example in bone marrow transplantation. (surgerytoursindia.com)
From "adult stem cells" to "xenotransplantation," learn about common and specialized regenerative medicine terms. (mayo.edu)
Center for Regenerative Biotherapeutics protocols have been developed to generate adult stem cell-derived bonelike, nerve-like and heart-like tissues. (mayo.edu)
Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine satellite cells with robust engraftment potential in mdx mice, and CXCR4-positive murine muscle-derived SP cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice. (biomedcentral.com)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
Adult stem cells exist in many adult tissues and although some go on to develop into tissues, others stay as stem cells which makes them easier to extract from the body. (mssociety.ca)
Mesenchymal stem cells are a type of adult stem cell found predominantly in the bone marrow, but have also been reported to reside in muscle, fat, and umbilical cord blood. (mssociety.ca)

Flow cytometry analysis, RNA-seq, and cell cycle analysis were used to detect the in vitro hematopoietic ability of endothelial protein C receptor (EPCR, CD201) cells generated in our induction system. (biomedcentral.com)
Further, we innovatively demonstrated that notch signaling pathway is responsible for in vitro CD201 + hematopoietic cell induction from mouse PSCs. (biomedcentral.com)
Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)
In most cases, clinically relevant cell numbers for MSC-based therapies can be only obtained by in vitro expansion of isolated cells. (frontiersin.org)
Epidermal stem cells - localization of stem cells, epidermal stem cell markers, epidermal stem cells in vitro and in vivo, application of epidermal stem cells in medicine. (edu.pl)
In vitro cultures of isolated skin cells - 2D and 3D cultures. (edu.pl)
They originate in the bone marrow and lymph nodes and are important effector cells for anti-tumor immunity.Grzywacz was part of a team that developed an in-vitro system for producing NK cells from hematopoietic stem cells and human embryonic stem cells. (umn.edu)
Grzywacz's research with Michael Verneris, Jeffrey Miller and others on the development of NK cells using an in-vitro system revealed that these cells may be derived from myeloid developmental pathway. (umn.edu)
in vitro in vivo in vivotracking technology of SB-334867 free base the cells is at its nascent stages. (cancerdir.com)

In total, 3 CAR T-cell therapies are now on the market, all targeting the CD19 antigen. (ajmc.com)
Recent stem cell therapies for autism are efforts to annul these abnormalities through antibiotics, anti-inflammatory agents and hyperbaric oxygen. (surgerytoursindia.com)
Q. what are the reasons behind regenerative effects of the stem cell therapies? (surgerytoursindia.com)
Q. What diseases can be treated with regenerative stem cell therapies? (surgerytoursindia.com)
Regenerative stem cell therapies can be used to treat heart diseases, diabetes, joint diseases, neurological and endocrine diseases and other degenerative processes. (surgerytoursindia.com)
The field of the subject invention is the use of major histocompatibility complex antigen lacking cells and organs which may serve as universal donors in cellular and organ therapies including transplantation and to produce chimeric non-human mammals. (justia.com)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
Once scientists and researchers realized stem cell potential, they aimed to create therapies and treatments to replace and rebuild. (proficientwriters.net)
d) Experimental therapies of dysfunctional muscles involving the application of stem cells. (edu.pl)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
There are several types of stem cells, each with its own unique characteristics and potential applications. (stemcellassurance.com)
Use of various types of stem cells for conditions such as stroke, ischemia, heart diseases, Alzhemier's disease, and neurogenerative diseases in general, is explained. (kean.edu)
Using specific types of stem cells to repair damaged tissues and treat disease. (mayo.edu)
While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. (biomedcentral.com)

After stem cells are transplanted, they live, grow and travel to damaged-skeletal muscle. (surgerytoursindia.com)
Yet, it remains unclear from murine transplantation experiments which cell population most effectively engrafts into diseased skeletal muscle. (biomedcentral.com)
Initial studies indicate an immense potential for cell based strategies to enhance current orthopaedic approaches in skeletal tissue reconstruction. (openorthopaedicsjournal.com)

The isolation and characterization of embryonic stem cells in the late 1990s opened up new possibilities for studying and utilizing these cells for therapeutic purposes. (stemcellassurance.com)
Researchers continue to work towards overcoming challenges and limitations to harness the power of stem cells for therapeutic purposes. (stemcellassurance.com)
Use of stem cell lines in therapeutic applications is discussed. (kean.edu)
Recently, stem cells are being engineered to carry therapeutic reagents to target tumor sites. (bmrat.org)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. (medsci.org)
Therapeutic regeneration of molecularly engineered and transplanted autologous stem cells in neurological and cardiovascular diseases due to inability of self-regeneration or repair of endogenous stem cells at sites of inflammation or disease at various stages of progress for regeneration of the damaged tissue depending upon the sites and nature of degeneration. (hoajonline.com)
Cancer stem cellsand their susceptibility over their expected to be "downstream or progeny" cancer cells represent a target for therapeutic interventions to prevent latency and consequently relapse or metastasis of the malignant disease. (hoajonline.com)
Autologous hematopoietic stem cell transplantation and reconstitution: Different species and including primates and humans for studies are being used for development, localization, and therapeutic strategies. (hoajonline.com)
As a source of non-embryonic stem cells, UCB has found potential uses as a therapeutic modality in more than 80 clinical applications, both haematological and non-haematological. (sajbl.org.za)
Dr. Grzywacz is a hematopathologist whose research interests include the development, normal function, and diseases involving natural killer (NK) cells as well as their therapeutic potential. (umn.edu)
In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. (biomedcentral.com)
So as a new therapeutic approach, stem cells are under research with a focus on reducing the burden of several kidney diseases. (biomedcentral.com)
The source of stem cells for therapeutic purposes can vary. (mssociety.ca)

CLEVELAND-A team of researchers at three landmark Cleveland institutions have come together to launch a new clinical trial of an experimental treatment for multiple sclerosis (MS). Researchers at the Cleveland Clinic, University Hospitals Seidman Cancer Center, and Case Western Reserve University are collaborating on a ground-breaking study that will test the feasibility and safety of using the body's own stem cells to treat MS. (case.edu)
Hematopoietic dysfunction accompanied by severe aGVHD, which may be caused by niche impairment, is a long-standing clinical problem. (bvsalud.org)
Enrichment of PBSCT by purification of CD34+stem cells fails to produce superior clinical benefits. (fliphtml5.com)
The inferior clinical performance of CD34+-enriched and purified PBSCTs compared tounenriched PBSCTs may be explained by the omission of Hox11+ stem cells. (fliphtml5.com)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)
Therefore, these results establish the efficacy of diprotin A in stimulating muscle cell engraftment, and highlight the pre-clinical utility of a xenotransplantation model in assessing the relative efficacy of muscle stem cell populations. (biomedcentral.com)
Moreover, xenotransplantation accurately predicted results in canine-to-canine allogeneic transplantation experiments, an important pre-clinical model for future human clinical trials. (biomedcentral.com)
Recent medical advances in the field of regenerative medicine and tissue transplantation have highlighted the importance of umbilical cord blood (UCB) as a valuable alternative source of haematopoietic stem cells, which are potentially life-saving in a vast array of clinical applications. (sajbl.org.za)
Mesenchymal stem cells (MSC) are the widely used stem cell type in preclinical research, clinical studies and investigational new drug applications. (hacettepe.edu.tr)
The first source of Mesenchymal stem cells was in the bone marrow and considered to be the gold standard for clinical research, although various other sources have being discovered which include: Adipose tissue, Dental pulp, Mobilised Peripheral blood, Amniotic fluid, Joint synovium, synovial fluid, Endosteum, Periosteum, Menstrual blood and birth-derived tissues. (stemcellsgroup.com)

A wide variety of hematopoietic cells exist, with the major protective lineages being lymphoid and myeloid. (justia.com)
The immune system which results from cells of the lymphoid and myeloid lineages is developed in vivo, so as to recognize self from non-self. (justia.com)
osteoblasts, chondrocytes, endothelial-cells and also non-mesoderm-type lineages e.g. (tomeipowered.com)

Unlike prior immunosuppressive strategies tested in the NHP GVHD model, anti-DLL4 interfered with a T cell transcriptional program associated with intestinal infiltration. (bvsalud.org)
The spleen also uniquely contributes toGraft Versus Host Disease (GVHD) complete B cell memory [11]. (fliphtml5.com)
The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)

Stem cells serve as a valuable tool for studying the development and function of various organs and tissues, as well as for modeling diseases and developing new drugs. (stemcellassurance.com)
Organs and tissues are built up by specialized cells from the pool of stem cells that form shortly after fertilization. (bmrat.org)
The reasons are that the stem cells apply a rejuvenating effect on the organs and tissues that have been weakened or damaged through the aging process or disease. (surgerytoursindia.com)
The same reasons apply to the use of organs for transplantation including but not limited to the heart, lung, liver and kidney. (justia.com)
A type of stem cell found in organs of the body that can be used for regenerative interventions. (mayo.edu)
Transplanting organs, tissues or cells from one person to another. (mayo.edu)
Stem cells are the engines of the body that give rise to tissues and organs, as well as maintain and repair certain tissues when they become damaged. (mssociety.ca)

The history of stem cell research dates back to the 19th century, when scientists first observed that certain cells have the ability to regenerate and repair tissues. (stemcellassurance.com)
Stem Cells can now be artificially grown and changed into specific cell kind with features dependable on cells of various tissues such as muscles or nerves. (surgerytoursindia.com)
Long-term physioxic expansion also afforded culture-based ex vivo HSC selection from whole bone marrow, spleen, and embryonic tissues. (stanford.edu)
However, the accurate quantitation of mixed cell types in chimeric and mosaic tissues is complicated by sample preparation bias, transgenic silencing, phenotypic similarity, and low-throughput analytical pipelines. (stanford.edu)
Transplanting tissues or cells from one area of a person's own body to another. (mayo.edu)
Stem cells are collected from the bone marrow - the spongy soft tissues in the bones. (parkwaycancercentre.com)
Autoimmune diseases are usually complex and multifactorial, characterized by aberrant production of autoreactive immune cells and/or autoantibodies against healthy cells and tissues. (frontiersin.org)
Autoimmune diseases are complex diseases characterized by the loss of immunological tolerance to self-antigens and sustained aberrant immunological response against healthy cells and tissues, leading ultimately to the overproduction of autoreactive immune cells and/or autoantibodies ( 1 , 2 ). (frontiersin.org)
These stem cells can give rise to certain tissues of the body, including cells making up cartilage, bone and fat. (mssociety.ca)

The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)
Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)
Inhibition of hematopoiesis results in reduced populations of blood forming cells. (hoajonline.com)
In the 1970s, Friedenstein and colleagues [1] first reported that locally applied culture-expanded populations of bone marrow stroma-derived fibroblastic cells remained at their injection sites under the kidney capsule, where an ectopic hematopoiesis was initiated. (issca.us)

The in vivo hematopoietic reconstitution potential of c-kit + cells derived from the mouse PSCs was evaluated via m-NSG transplantation assay. (biomedcentral.com)
The c-kit + cells from 3D self-assembling peptide induction system followed by the OP9 coculture system possessed apparently superiority in terms of in vivo repopulating activity than that of 3D induction system followed by the 0.1% gelatin culture. (biomedcentral.com)
In fact, only using the OP9 co-culture system combined with hematopoietic related cytokines, we hardly obtained the in vivo functional reconstitution hematopoietic cells from PSCs [ 9 ]. (biomedcentral.com)
Ex vivo HSC expansion has been suggested as an approach to improve hematopoietic reconstitution from low-cell dose grafts. (stanford.edu)

This field of research focuses on studying the properties and potential applications of stem cells, with the aim of advancing our understanding of the human body and developing new treatments for various diseases and conditions. (stemcellassurance.com)
Stem cell research is of paramount importance because it has the potential to revolutionize medicine by offering new approaches for treating diseases and conditions that were previously considered incurable. (stemcellassurance.com)
Stem cells that reconstitute all types of blood cells treat a number of fatal diseases. (surgerytoursindia.com)
When the host is immunocompromised, there may be an interest in transfusing specific white cells, particularly T-cells, which may protect the host from various diseases. (justia.com)
In other cases, where certain cells are lacking, such as islets of Langerhans in the case of diabetes, or cells which secrete dopamine in the case of Parkinson's disease, or bone marrow cells in various hematopoietic diseases, or muscle cells in muscle wasting disease, or retinal epithelial cells in visual disorders, it would be desirable to be able to provide cells which could fulfill the desired function. (justia.com)
Especially in cases where sufficient cells cannot be obtained due to the rarity of the disorder, iPSC models have shown great potential in providing research material to develop new treatments or diagnostics, but also to study the pathophysiology of the diseases [ 10 , 12 ]. (biomedcentral.com)
Do you know you can use your own body cells to fight diseases? (medicaltourismco.com)
6. Application of non-embryonic stem cells in treatment of nerve system diseases such as brain stroke, Parkinson's disease, Huntington's disease. (edu.pl)
The self-renewal and proliferative nature of stem cells raised the hope to fight against various diseases. (biomedcentral.com)
In each of these diseases, genes that play a role in the proliferation or activation of CD8+ T cells have been found to be affected by epigenetic modifications. (frontiersin.org)
Various cytokines, transcription factors, and other regulatory molecules have been found to be differentially methylated in CD8+ T cells in autoimmune diseases. (frontiersin.org)
However, mounting evidence has suggested that CD8+ T cells, in particular, play an important role in the induction, progression, pathogenesis, and protection for autoimmune diseases ( 5 ). (frontiersin.org)
In autoimmune diseases, these target cells killed by autoreactive CD8+ T cells can release numerous autoantigens to induce the overproduction of autoantibodies, and finally lead to the death of self-cells. (frontiersin.org)

The patient first receives a high dose of chemotherapy and/ or radiotherapy to eliminate the remaining cancer cells in the body. (parkwaycancercentre.com)
UCB may also be used to reconstitute the bone marrow after high-dose chemotherapy or radiotherapy. (sajbl.org.za)

Ectopic expression of gene BCL2 enhances the survival and proliferation of chimpanzee and pig-tailed macaque iPSCs within the pre-implantation embryo, although the identity and long-term contribution of the transplanted cells warrants further investigation. (stanford.edu)
Splenomegaly might reflect dramatic G-CSF-inducedG-CSF stimulation also in multiple studies shows faster recovery of Hox11+ stem cell proliferation. (fliphtml5.com)
WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
MSC derived from placenta have long-term proliferation and immunomodulatory capacity, superior to bone marrow-derived MSC. (stemcellsgroup.com)

When the host lacks the ability to raise a defense against a particular disease, there may also be an interest in administering specific T-cells or B-cells or precursors thereof which may supplement the host's compromised immune system. (justia.com)

From their remarkable ability to transform into different types of cells to their role in regenerative medicine, we will explore how stem cells hold the key to revolutionizing healthcare and transforming lives. (stemcellassurance.com)
Stem cells are not only widely used for regenerative medicine, but are also considered as a useful tool for cancer treatment. (bmrat.org)
Non-reproducible treatment outcomes or even absence of treatment effects in comparison to control groups challenges the potential of these cells for routine application both in tissue engineering and in regenerative medicine. (frontiersin.org)
Although mesenchymal stem cells have traditionally been investigated by researchers for their regenerative potential for bone and cartilage injuries, they also hold promise for people living with MS due to their capacity to suppress inflammation and assist in the repair of damaged nervous tissue. (mssociety.ca)

Compare with "autologous transplantation. (mayo.edu)

Although less controversial than the use of embryonic stem cells obtained from fetal tissue, the practice of UCB biobanking presents several ethical and regulatory challenges surrounding its procurement and use, especially in developing countries like South Africa, where the majority of the population is vulnerable and prone to exploitation. (sajbl.org.za)

Another example is repairing bone defects using mesenchymal stem cells and mesenchymal-derived endothelial cells. (kean.edu)

b) Participation of satellite cell in muscle regeneration. (edu.pl)
These total results demonstrate that DLA mismatched transplantation may be secure for pulp regeneration for 12? (cancerdir.com)

Novartis) for the treatment of B-cell precursor acute lymphoblastic leukemia. (ajmc.com)
The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)

Beta-galactosidase of ROSA26 mice is a useful marker for detecting the definitive erythropoiesis after stem cell transplantation" (PDF). (wikipedia.org)
Embryonic stem cells were first identified in mice (Martin, 1981). (bmrat.org)
NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)
Indeed, CXCR4-positive muscle-derived side population (SP) cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice [ 10 ]. (biomedcentral.com)
106 freshly isolated cells from WT, Rictor/, PDK1/ or Rictor/PDK1/ mice (CD45.2+) and 0.5? (cancerdir.com)
106 competitive cells (CD45.1+) were suspended in PBS and injected into the tail veins of lethally irradiated CD45.1+ recipient mice. (cancerdir.com)

For example, generation of human cardiac muscle cells from adipose-derived stem cells is included. (kean.edu)

A medical procedure in which healthy bone marrow stem cells are injected into the body to replace damaged or diseased bone marrow. (mayo.edu)

Essentially, you can kill any cancer cell that has an antigen that is recognized by the immune cell," Hwu said. (ajmc.com)
The key to curing every single cancer, which is our goal, is to have receptors that can recognize the tumor but don't recognize the normal cells. (ajmc.com)
Cancer vaccines based on the knowledge of cancer stem cells have been studied and applied for cancer treatment. (bmrat.org)
Professor Ma heads the Blood, Stem Cell and Cancer Research Programme at St Vincent's Centre for Applied Medical Research, Sydney. (edu.au)
Adoptive cell transfer (ACT) is the latest arsenal in the battle against cancer. (molcells.org)
These cells can self-renew and the patient can enjoy a long-term cure from blood cancer. (parkwaycancercentre.com)
Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
Tumors contain a minority population of cancer stem cells that maintain the tumor. (hoajonline.com)
In marked contrast to the cancer stem cells, the tumor cells without "stemness" have either no capacity or a markedly diminished capacity, to form new tumors. (hoajonline.com)
Therefore, to treat cancer effectively, the cancer stem cell must be eliminated. (hoajonline.com)
Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population. (biomedfrontiers.org)

Those are due to the unique characteristics of stem cells, such as immunological tolerance, migration, and tissue reparation. (bmrat.org)
Stem cells continue to play a role in repairing damaged tissue and replacing cells that are lost every day. (bmrat.org)
CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)
Explaining the difference between embryonic and cord tissue-derived stem cells. (tomeipowered.com)
White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)
Nevertheless, stem cell based tissue engineering in orthopaedics shows a promising future. (openorthopaedicsjournal.com)
Amidst this, tissue engineering using stem cells has emerged as a hot topic of research and is a promising alternative to the traditional techniques of bone grafting. (openorthopaedicsjournal.com)

The first iPSCs were created from normal cells in the mouse (Takahashi and Yamanaka, 2006). (bmrat.org)
In summary, we disclose transcriptomic and proteomic data, cell lines, and cell culture resources that may be broadly enabling for non-human primate iPSCs research. (stanford.edu)
Unlike primary NK cells, those prepared from iPSCs can be prepared with a homogeneous quality and are easily modified to exert a desired response to tumor cells. (molcells.org)
In this short review, we detail the benefits of using iPSCs in NK cell immunotherapies and discuss the challenges that must be overcome before this approach becomes mainstream in the clinic. (molcells.org)
In this review, we examine the manufacturing and gene engineering of NK cells generated from iPSCs (iPS-NK) for ACT. (molcells.org)

Self-renewal: Stem cells have the ability to divide and produce more stem cells, ensuring a constant supply of undifferentiated cells. (stemcellassurance.com)
Maturation of the terminally differentiated cell loses the phenotype of the self-renewal antigen (eg. (hoajonline.com)

With the majority of umbilical cords simply discarded after childbirth, this source is both non-harmful and readily available.Â Â, The young nature of these cells allows enormous potential for them to transform into whatever type of cell is necessary within the body. (tomeipowered.com)
The blood that is left behind in the placenta and umbilical cord after a baby is delivered contains stem cells, and these can be carefully collected and stored. (parkwaycancercentre.com)

To comprehensively address this question, we used a haplo-MHC-matched transplantation aGVHD murine model and performed single-cell RNA-Seq of nonhematopoietic BM cells. (bvsalud.org)
In this study, we used a canine-to-murine xenotransplantation model to quantitatively compare canine muscle cell engraftment, and test the most effective cell population and modulating factor in a canine model of DMD using allogeneic transplantation experiments. (biomedcentral.com)
Furthermore, the canine-to-murine xenotransplantation model accurately predicted results in canine-to-canine muscle cell transplantation. (biomedcentral.com)

In patients with MS, the immune system abnormally attacks the central nervous system, causing damage to the nerve cells and their protective myelin sheath. (case.edu)
Then autologous haematopoietic cells or allogeneic haematopoietic cells are transferred to restore the host immune system. (surgerytoursindia.com)
Mesenchymal stem cells can control the immune system and help to reverse inflammatory conditions. (surgerytoursindia.com)
In order for the cells to be effective, they must be safe from attack by the host, so that they may function without being destroyed by the immune system. (justia.com)
Dendritic cell as sentinel of the immune system plays an irreplaceable role. (medsci.org)
NK cells are specialized lymphocytes of the innate immune system that possess some of the cell memory capabilities characteristic of cells found in the adaptive immune system. (umn.edu)

At last, scientists had devised a way to reprogram a person's own T cells to attack tumor cells. (ajmc.com)
Furthermore, T cells and NK cells complement each other in that certain immune suppression mechanisms taken by tumor cells that are effective against T cells, such as the downregulation of human leukocyte antigens (HLA), have proven to be stimulatory for NK cells. (molcells.org)
NK cells produced through this process bore biomarkers associated with potent cell-killing activity and are equipped to attack and clear tumor cells. (umn.edu)
These genes are involved in T cell regulation, including interferons, interleukin (IL),tumor necrosis factor (TNF), as well as linker for activation of T cells (LAT), cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), and adapter proteins. (frontiersin.org)

We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. (medsci.org)

Secondary lymphoid organ fibroblastic reticular cells emerged as the critical cellular source of Delta-like Notch ligands for Notch-mediated up-regulation of α4ß7 integrin in T cells after allo-HCT. (bvsalud.org)

TheIntroduction later step is unique to splenic function since splenectomy results in similar accumulations of naïve B cells, reduction of memory B cells and Treatment of malignancies with allogeneic peripheral blood stem well-known susceptibilities to select infections [12]. (fliphtml5.com)

Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)

In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
2 , 3 Normally, the bone marrow serves as the source for replenishing the cellular components of peripheral blood including red and white blood cells and platelets. (sajbl.org.za)

Anatomy37

Organisms14

Diseases47

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment80

Psychiatry and Psychology2

Phenomena and Processes37

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Named Groups6

Health Care17

Progenitor23

Graft-versus-9

Stromal17

Differentiation18

MSCs33

Differentiate19

Transplant21

Pluripotent15

Donor19

HSCs11

Transplants14

Therapy33

HSCT5

Adult16

Vitro9

Therapies12

Types of stem cells5

Skeletal3

Therapeutic14

Clinical14

Lineages3

GVHD4

Organs7

Tissues9

Populations4

Vivo4

Diseases13

Chemotherapy2

Proliferation4

Precursors1

Regenerative4

Autologous transplantation1

Fetal1

Endothelial1

Regeneration2

Acute3

Mice6

Adipose-derived stem cells1

Damaged or diseased1

Cancer12

Tissue9

IPSCs5

Self-renewal2

Umbilical2

Murine3

Immune system6

Tumor4

Severe1

Fibroblastic1

Peripheral blood stem1

Genes1

Cellular3