Embryonic stem cell stem cell institute. Medical search. Frequent questions

Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development. (mpg.de)
the EST, which assesses the effects of compounds on the differentiation of mouse embryonic stem cells into contracting cardiomyocytes, can be used to rank the potency of chemicals within a series of alkoxyacetic acid metabolites formed from The implementation of the European REACH (Registration, glycol ethers. (cdc.gov)

This is a time-sensitive RFI to determine how best to accelerate research directed toward targeted differentiation of human embryonic stem cells (hESCs) into specific neuronal and glial cell types. (nih.gov)
Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage. (mpg.de)
FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast. (mpg.de)

the medical group denounced embryonic stem cell research as a tremendous waste of money and resources. (cellmedicine.com)

Comparative Analysis of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells Reveals Current Drawbacks and Possible Strategies for Improved Differentiation. (mpg.de)
Epigenetic Analysis of Human Embryonic Stem Cells: Basics, Computational Methods, Applications. (mpg.de)
Multivariate statistical analysis of epigenetic regulation with application to the analysis of human embryonic stem cells. (mpg.de)

The ESCRO Committee's review shall be specific to the scientific and ethical issues presented by proposals to use human gametes, human embryos, human embryo models, and the development and study of human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hIPSCs) and their pluripotent derivatives in covered research in particular research projects. (washington.edu)
The UW Institute for Stem Cell and Regenerative Medicine (ISCRM) has been established for the purpose of facilitating and encouraging basic research on hESCs to develop therapies and cures for human disease. (washington.edu)
Accordingly, researchers at this institution were quick to appreciate the enormous promise of human embryonic stem cells (hESCs) as research tools for understanding how the body normally works, thus laying the groundwork to identify disease-related aberrations. (ca.gov)
Would we abide by these unprecedented restrictions, which meant that research would be limited to first-generation cells, or could we find ways to develop second-generation, higher-quality hESCs? (ca.gov)
By voting in favor of Proposition 71, which funds research involving human embryonic stem cells (hESCs) that is not supported by the federal government, the citizens of California sent a clear message that they want scientists in our state to play an important role in research that could revolutionize medical treatments and render significant economic benefits. (ca.gov)
We studied human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) measuring the SNPs and CNVs with Affymetrix SNP 6 microarrays and expression values with Affymetrix Exon microarrays. (biomedcentral.com)

Human embryos reach the blastocyst stage 4-5 days post fertilization, at which time they consist of 50-150 cells. (wikipedia.org)
Isolating the inner cell mass (embryoblast) using immunosurgery results in destruction of the blastocyst, a process which raises ethical issues, including whether or not embryos at the pre-implantation stage have the same moral considerations as embryos in the post-implantation stage of development. (wikipedia.org)
Embryonic stem cells (ESCs), derived from the blastocyst stage of early mammalian embryos, are distinguished by their ability to differentiate into any embryonic cell type and by their ability to self-renew. (wikipedia.org)
One reason for these differences may be the development of induced pluripotent stem cells, which are derived from adult body cells rather than from embryos. (scienceblog.com)
In 2000, the National Institutes of Health issued guidelines for the use of embryonic stem cells in research, specifying that scientists receiving federal funds could use only extra embryos that would otherwise be discarded. (cnn.com)
It seems like it has the benefits of adult stem cell research (no controversry over destroying embryos) and the benefits of embryonic stem cell research (the possibility of discovering therapies that can't be derived from adult stem cells). (nationalgeographic.com)
Embryos are destroyed when embryonic stem cells are taken from them. (chronicle.com)
A gene for a green fluorescent protein was inserted into the genomes of stem cells, which were then injected into macaque embryos grown for around four days in vitro. (planer.com)
But the embryonic fantasy will continue to be fermented of exclusive miracles just around the corner, for as long as biotech companies need to ensure access to human embryos for more practical research. (catholicleader.com.au)
Researchers reported in Nature on November 22, 2007, that they successfully isolated 2 embryonic stem cell lines from cloned embryos made using cells from the skin of an adult rhesus macaque. (nih.gov)
IPSCs can also be tailor-made to match particular disease, ethnic, or other genetic profiles, and these cells do not require embryos-a continued source of debate. (the-scientist.com)

Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. (wikipedia.org)
Rapid cell division allows the cells to quickly grow in number, but not size, which is important for early embryo development. (wikipedia.org)
Human Embryo and Embryonic. (washington.edu)
UW's policy governing human embryo and human embryonic stem cell research has been changed to include oversight of research involving human embryo models and human gametes. (washington.edu)
The chickenpox, rubella, hepatitis A, shingles and one rabies vaccine all derive from fetal embryo fibroblast cells cultivated in the 1960s -- and Catholic leadership has wrestled with the ethics of using those vaccines. (salon.com)
The RGI researchers have figured out how to derive stem cells from a four-day old embryo-a stage known as a morula. (nationalgeographic.com)
But when the RGI team took a single cell from a morula, it still had the capacity to develop into a normal embryo. (nationalgeographic.com)
That means that parents who are doing IVF could conceivably agree to have a cell removed from their morula, which could then give rise to a line of stem cells, while the morula developed into an embryo ready for implanting. (nationalgeographic.com)
Scientifically, for serious technical reasons - that of tumour formation and immune rejection - embryo stem cells are highly unlikely ever to be trialled in humans, while adult stem cells are already making dramatic advances in human trials even here in Australia - spinal injury (at Brisbane's Princess Alexandra Hospital), heart disease (Newcastle's John Hunter Institute), and in the months ahead, Parkinson's (Melbourne's Peter McCallum Institute). (catholicleader.com.au)
The egg then "reprograms" the adult nucleus so that the cell behaves like an embryo but has the genes of the adult cell. (nih.gov)
In another strategy, called therapeutic cloning, the embryo can instead be used to create stem cells that are genetically identical to a patient. (nih.gov)
Since embryonic stem cells have the ability to form virtually any cell type in the body, those taken from a cloned embryo could potentially be used to treat many diseases. (nih.gov)
A mouse embryo is being injected with stem cells. (harvard.edu)
Embryonic stem cells are pluripotent cells derived from embryonic tissue in a process that usually results in the destruction of the embryo. (biopharminternational.com)

Researchers are currently focusing heavily on the therapeutic potential of embryonic stem cells, with clinical use being the goal for many laboratories. (wikipedia.org)
The researchers, based at Tsinghua University, Beijing, China, and Drexel University, Philadelphia, USA, used extrusion-based 3-D printing to produce a grid-like 3-D structure to grow embryoid body that demonstrated cell viability and rapid self-renewal for 7 days while maintaining high pluripotentcy. (phys.org)
Researchers hope to use these cells to grow healthy tissue to replace injured or diseased tissues in the human body. (medlineplus.gov)
Our work is important because the researchers who use our laboratory are studying the causes of major human diseases that occur as the result of trauma (e.g., paralysis), cell death (e.g. (ca.gov)
Researchers previously had been able to produce neurons - the impulse-conducting cells in the brain and spinal cord - from human embryonic stem cells. (sciencedaily.com)
The researchers of the paper from Advanced Cell Technology, collaborated with scientists from the Institute of Regenerative Medicine at Wake Forest University School of Medicine, Winston-Salem, North Carolina, and the University of Chicago, Chicago, Illinios. (news-medical.net)
Researchers investigating many other conditions, including Parkinson's , also have been known to use embryonic stem cells. (salon.com)
Two years ago, two researchers filed a case challenging the legality of the National Institutes of Health's new guidelines on the federal funding of human embryonic stem cell (hESC) research. (the-scientist.com)
In January 2014, researchers announced they had developed a new method of making stem cells: by placing skin cells in an acidic environment. (cnn.com)
But in an ironic bit of timing researchers at the Reproductive Genetics Institute have just published some results at Reproductive BioMedicine Online that could-possibly-short-circuit some of the arguments against using embryonic stem cells. (nationalgeographic.com)
And Michael M. Gottesman, the NIH's deputy director for intramural research, said researchers at the agency's headquarters in the Washington suburb of Bethesda could resume work involving embryonic stem cells, though he suggested "prudence" in carrying out such activities given the still-tenuous legal situation, Nature reported. (chronicle.com)
Researchers used stem cells obtained from the embryonic tissue of cynomolgus monkeys, a type of macaque commonly used in genetics research because of their similarity to humans. (planer.com)
Before this new study was published, Nature asked another group of researchers to confirm that the stem cells were genetically identical to the donor skin cells. (nih.gov)
The stem cells, the researchers showed, could turn into heart or nerve cells in the laboratory, and had other characteristics of established embryonic stem cell lines. (nih.gov)
And researchers working on human ES cells had to use separate facilities from other stem-cell research. (nature.com)
Researchers there were able to press forward, and with that as the foundation, they also stole the lead in iPS-cell research," he says. (nature.com)
The latest guidelines also remove the secondary approval step for working with ES cells: a local review committee must still approve the work, but researchers then need only notify the science ministry of this. (nature.com)
The move was celebrated by researchers hoping to use such cells for research, but it is likely that the decision will be appealed. (biopharminternational.com)
Below you can see some examples of the infrastructure for research on genes and cells, available for researchers at Lund University. (lu.se)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)

The cells are being studied to be used as clinical therapies, models of genetic disorders, and cellular/DNA repair. (wikipedia.org)
Due to their plasticity and potentially unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. (wikipedia.org)
Experts in the field of regenerative medicine believe one of the first areas of success when using stem cell-derived therapies will be the treatment of macular degeneration, which causes progressive loss of sight, and other retinal diseases. (cnn.com)
In addition to these patents, iZumi has expanded its reach to include nonexclusive partnerships with Kyoto University's Shinya Yamanaka, aimed at developing new methods for deriving high-quality iPSC lines, and with the University of California at San Francisco's Gladstone Institute, primarily focused on developing cardiovascular therapies. (the-scientist.com)
This is a momentous day-not only for science, but for the hopes of thousands of patients and their families who are relying on NIH-funded scientists to pursue life-saving discoveries and therapies that could come from stem cell research. (biopharminternational.com)
The petition recognizes that many "Canadians suffer from debilitating illnesses and diseases" and that the petitioners "support ethical stem cell research that has already shown encouraging potential to provide cures and therapies for these illnesses and diseases. (lifesitenews.com)
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)

Since UCSF contributed two hESC lines to the federal registry, our team members participated in the government's program to distribute these cells, which entailed teaching scientists how to use them. (ca.gov)
Scientists were able to produce from human embryonic stem cells a highly pure, large quantity of functioning neurons that will allow them to create models of and study diseases such as Alzheimer's, Parkinson's, prefrontal dementia and schizophrenia. (sciencedaily.com)
Levine reasons this could be a result of the fact that there are many incentives for scientists to work with existing human embryonic stem cell lines rather than creating new ones. (scienceblog.com)
An interesting question going forward is how committed these scientists are to stem cell research or if they are relating their work to stem cells now simply to be eligible for state funding - that's unknown right now. (scienceblog.com)
Scientists view stem cells as a possible gateway to curing many medical conditions, from Parkinson's disease to diabetes. (cnn.com)
In February 2012, early research published by scientists at Cedars-Sinai Medical Center and Johns Hopkins University showed that a patient's own stem cells can be used to regenerate heart tissue and help undo damage caused by a heart attack. (cnn.com)
Neither the article nor the abstract I linked to makes it clear whether this could be a viable source of stem cells for the large-scale research that scientists really want to do. (nationalgeographic.com)
Douglas Melton (left) and David Scadden, directors of the Harvard Stem Cell Institute, are among the university scientists who study the cells for cures to several devastating diseases. (chronicle.com)
The new appeals-court action was especially welcome to stem-cell scientists because Judge Lamberth's injunction had prevented the National Institutes of Health from distributing millions of dollars in research money at a time, near the end of the federal fiscal year on September 30, when the NIH often awards many of its grants, said Anthony J. Mazzaschi, senior director for scientific affairs at the Association of American Medical Colleges. (chronicle.com)
An NIH spokeswoman, Marin P. Allen, declined to say whether the agency would restart research involving embryonic stem cells at its own laboratory facilities or resume awarding grants for such research by outside scientists. (chronicle.com)
A recent open letter to all Australian parliaments from nine senior medical scientists tries to counter these fantasies, warning that 'undue expectations have been created in the community, particularly in those with various medical afflictions, as to the imminence and likely scope of embryonic stem cell therapy. (catholicleader.com.au)
She has also been training scientists from the Australian Institute of Marine Science and the Taronga Conservation Society in coral reef cryopreservation techniques so that they can continue to grow their Great Barrier Reef bank. (si.edu)
Scientists use the cells daily in their quest for treatments for complex and debilitating conditions. (consumerwatchdog.org)
Late last year federal parliament passed legislation allowing scientists to use more powerful research techniques to explore the secrets of ES cells. (consumerwatchdog.org)
Until April, Japanese scientists had to run separate facilities for human embryonic and other stem cells. (nature.com)
They allowed scientists to derive new human embryonic stem (ES) cell lines and research both home-grown and imported cell lines. (nature.com)
The case began when a lawsuit was brought against the National Institutes of Health (NIH) by Dr. James Sherley and Dr. Theresa Deisher, scientists opposed to embryonic stem cell research. (biopharminternational.com)
The scientists also claimed that funding embryonic stem cell research hurt their ability to receive federal funding for their own research using adult stem cells. (biopharminternational.com)

Lobbying for the passage of a bill authorizing federal funding for embryonic stem-cell research, Rekha and others who have been affected by Lou Gehrig's Disease (ALS), were in Washington D.C. earlier this month. (cellmedicine.com)
Even the American College of Pediatricians (ACP) called for an end to embryonic stem-cell research, "which prolongs needless suffering by delaying the development of more promising adult stem-cell treatments and cures. (cellmedicine.com)
Heartless and cruel are only a few of the words being used to describe opponents of embryonic stem-cell research. (cellmedicine.com)
Thus, we have a great deal of experience that is directly relevant to achieving the California Institute for Regenerative Medicine's (CIRM's) goal of establishing Shared Research Laboratories that also offer hands-on courses. (ca.gov)
Institute of Medicine and National Research Council. (nationalacademies.org)
THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. (nationalacademies.org)
But the story has taken a new twist as religious groups are now beginning to discourage followers from participating -- because ALS research at times relies on embryonic stem cells. (salon.com)
She added that donors "can stipulate where their money goes and can ask that it not pay for embryonic stem cell research. (salon.com)
The Archdiocese suggests people who want to do the challenge contribute to the John Paul II Medical Research Institute, "where the research is only conducted using adult stem cells. (salon.com)
Early polio research included the use of embryonic tissue . (salon.com)
there are reasons to have conversations about embryonic stem cell research and fetal tissue research. (salon.com)
States, not the federal government, now fund the majority of human embryonic stem cell research conducted in the United States, according to a recent study in the journal Nature Biotechnology . (scienceblog.com)
In addition, states varied substantially in the extent to which they prioritized human embryonic stem cell research, and much of the research performed in the states could likely have been funded by the National Institutes of Health under federal guidelines established by President Bush in 2001. (scienceblog.com)
While the federal government still contributes more to stem cell research overall, each year since 2007 these six states have funded more human embryonic stem cell research than the federal government," said Aaron Levine, assistant professor at Georgia Tech. (scienceblog.com)
Levine created an online searchable database ( http://www.stemcellstates.net/ ) that allows users to find detailed information about each grant given out by the six states that adopted programs specifically to fund stem cell research. (scienceblog.com)
From what I could tell, only a relatively small portion of the stem cell research supported by these states was clearly ineligible for federal funding," said Levine, who is on the faculty of the School of Public Policy in the Ivan Allen College of Liberal Arts. (scienceblog.com)
He said he was surprised at how great the difference was among states in the share of grants that supported human embryonic stem cell research. (scienceblog.com)
Supporting the scientific spirit of transparency, the Stowers Institute for Medical Research makes the data underlying its scientific publications freely accessible to the scientific community. (stowers.org)
Some are worried that the judges scheduled to hear arguments on the legality of federal support for human embryonic stem cell research will rule against stem cell funding. (the-scientist.com)
Click through the gallery to learn more about stem cell research. (cnn.com)
In 1998, President Bill Clinton requested a National Bioethics Advisory Commission to study the question of stem cell research. (cnn.com)
President Clinton approved federal funding for stem cell research, but Congress did not fund it. (cnn.com)
Above, a human stem cell colony, which is no more than 1 millimeter wide and comprises thousands of individual stem cells, grows on mouse embryonic fibroblast in a research laboratory in September 2001. (cnn.com)
In 2005, Connecticut and Illinois designated state funds to support stem cell research in their states. (cnn.com)
In March 2009, President Barack Obama signed an executive order that removed restrictions on embryonic stem cell research. (cnn.com)
His action overturned an order approved by President George W. Bush in August 2001 that barred the National Institutes of Health from funding research on embryonic stem cells beyond using 60 cell lines that existed at that time. (cnn.com)
Above, dozens of packages containing frozen embryonic stem cells remain in liquid nitrogen in a laboratory at the University of Sao Paulo's human genome research center in Sao Paulo, Brazil, in March 2008. (cnn.com)
Dr. Bo Chen's research focuses on mechanistic and therapeutic studies of retinal degenerative diseases caused by loss of photoreceptors or retinal ganglion cells, such as age-related macular degeneration, retinitis pigmentosa, and glaucoma. (nih.gov)
The stem cell line could be banked for therapy, or used for research. (nationalgeographic.com)
Let's say you object to stem cell research because each blastocyst is a unique human being with a unique genome and the capacity for life. (nationalgeographic.com)
The federal government can continue to finance embryonic-stem-cell research, temporarily, because a federal appeals court on Thursday lifted an injunction that had blocked such work. (chronicle.com)
During that trial, Judge Lamberth will hear a full set of arguments over the legality of the Obama administration's policy of expanded federal support for embryonic-stem-cell research. (chronicle.com)
Ms. Allen, however, cited a report by the journal Nature quoting Sally J. Rockey, the NIH's deputy director for extramural research, as saying that 24 existing grants due for annual renewal this month "should be fast-tracked, as should new human-embryonic-stem-cell grants competing to get funded a first time. (chronicle.com)
Two separate research teams have figured out how to "reprogram" cells with just a handful of genes to give them the characteristics of embryonic stem cells. (nih.gov)
Their work was supported by NIH's National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Child Health and Human Development (NICHD) and National Center for Research Resources (NCRR). (nih.gov)
It covers the biological nuts and bolts of one of the hottest fields in medical research: human embryonic stem cells. (consumerwatchdog.org)
A long-sought loosening of Japan's guidelines on human embryonic stem-cell research came into effect on 21 August. (nature.com)
Even in the United States, where until this year federal funding was limited to ES-cell lines derived by August 2001, ES-cell research moved ahead, says Suemori. (nature.com)
Last December, Yamanaka was widely quoted for remarks made at a science-ministry assembly in which he appraised Japan's 2008 record against other iPS-cell research groups, mostly in the United States: "One win, and about 10 losses," he said. (nature.com)
The state of Illinois has passed a law allowing human embryonic stem cell research, but banning human cloning. (bioedge.org)
Stem cell research has limitless potential to help cure devastating diseases, from Parkinson's to diabetes and even many forms of cancer," said Governor Rod Blagojevich. (bioedge.org)
29, 2011, a federal appeals court has lifted a ban on federal funding for embryonic stem cell (ESC) research. (biopharminternational.com)
In August 2010, a district court agreed with the plaintiffs that embryonic stem cell research violated federal law and blocked funding, but a three-judge appeals court temporarily lifted the ban in September. (biopharminternational.com)
The issue is whether that law's restrictions apply to research conducted on stem cell lines that had been developed without federal funding. (biopharminternational.com)
NIH has interpreted the law narrowly, and argued that creating embryonic stem cells is not the same as using lines created without federal funding for research purposes. (biopharminternational.com)
In a form letter response the Cancer Society said, "Human embryonic stem cell research offers great promise in advancing our knowledge of cancer. (lifesitenews.com)
NHS EED (National Institute for Healthe Research - Economic Evaluation Database) produzido pelo Centre for Reviews and Dissemination da University of York no Reino Unido. (bvsalud.org)
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)

MedlinePlus links to health information from the National Institutes of Health and other federal government agencies. (medlineplus.gov)

Retinoblastoma proteins that inhibit the transcription factor E2F until the cell is ready to enter S phase are hyperphosphorylated and inactivated in ESCs, leading to continual expression of proliferation genes. (wikipedia.org)
Sun and her team confirmed that the two embryonic stem cell lines were different through gene expression analysis -- neurons that perform different functions in different parts of the brain express different genes. (sciencedaily.com)
Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma. (vchri.ca)
A chimeric monkey has been created using embryonic stem cells with two different sets of genes, a new study has demonstrated. (planer.com)
Our results revealed altogether 217 genes and 584 SNPs whose genomic alterations affect the transcriptome in the same cells. (biomedcentral.com)
Our results revealed that in the human pluripotent stem cells, the expression values of several genes, transcripts and exons were affected due to the genomic variation. (biomedcentral.com)
Below is a non-exhaustive list of in-house infrastructures that are categorized into three overarching themes: bio-imaging, proteins, genes & cells and other resources. (lu.se)
In addition to infrastructures for bioimaging, protein and genes & cells, we also provide other resources e.g., databases, networks and specialized labs. (lu.se)
The model also predicts that reprogramming the network from a differentiated state, in particular the endoderm state, into a stem cell state, is best achieved by over-expressing Nanog, rather than by suppression of differentiation genes such as Gata-6. (lu.se)

Cultured human embryonic stem cell (hESC) lines are an invaluable resource because they provide a uniform and stable genetic system for functional analyses and therapeutic applications. (nih.gov)

The ACP cites these strong pro-adult stem cell results further noting, "catastrophic results…producing the wrong tissue, forming tumors and triggering immune rejection," when describing the abysmal failure that embryonic stem cell trials have produced. (cellmedicine.com)
In addition to their potential in regenerative medicine, embryonic stem cells provide a possible alternative source of tissue/organs which serves as a possible solution to the donor shortage dilemma. (wikipedia.org)
According to a 2002 article in PNAS, "Human embryonic stem cells have the potential to differentiate into various cell types, and, thus, may be useful as a source of cells for transplantation or tissue engineering. (wikipedia.org)
In tissue engineering, the use of stem cells are known to be of importance. (wikipedia.org)
These cells - capable of generating all cell types in the body - could be used as the 'lego bricks' to build tissue constructs, larger structures of tissues, and potentially even micro-organs. (phys.org)
Current estimates suggest that surprisingly few cell lines may be required to facilitate rudimentary tissue matching. (ox.ac.uk)
Cloning describes the processes used to create an exact genetic replica of another cell, tissue or organism. (medlineplus.gov)
cells that were extracted from fetal tissue, which was donated. (salon.com)
They could study what goes awry as the cells grow into disease-affected tissue. (consumerwatchdog.org)
Several genome-wide studies have reported genomic variants that correlate with gene expression levels in various tissue and cell types. (biomedcentral.com)
The ban on funding did not apply to stem cells derived from adult tissue. (biopharminternational.com)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)

Pluripotent stem cells have shown promise in treating a number of varying conditions, including but not limited to: spinal cord injuries, age related macular degeneration, diabetes, neurodegenerative disorders (such as Parkinson's disease), AIDS, etc. (wikipedia.org)
According to CIRM, this is an image of "human embryonic stem cells differentiated into dopaminergic neurons, which are the ones that degenerate in Parkinson's disease. (stanford.edu)
Working with these cells in a lab dish provides a way to study the origins and possible treatments for Parkinson's disease. (stanford.edu)
The best and first application for [iPSCs] is really to change the paradigm of drug discovery," says John Walker, chief executive of iZumi Bio, a South San Francisco-based biotech company focused on using reprogrammed skin cells from patients to screen for new drug compounds to treat neurodegenerative diseases, such as spinal muscular atrophy, amyotrophic lateral sclerosis, and Parkinson's disease. (the-scientist.com)
Numerous studies have shown that cell replacement therapy can replenish lost cells and rebuild neural circuitry in animal models of Parkinson's disease . (bvsalud.org)
Transplantation of midbrain dopaminergic progenitor cells is a promising treatment for Parkinson's disease . (bvsalud.org)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)

Pluripotency factors Oct4 and Nanog play a role in transcriptionally regulating the embryonic stem cell cycle. (wikipedia.org)
A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells. (mpg.de)
In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach. (mpg.de)
Background: Recent studies have associated the transcription factors, Oct4, Sox2 and Nanog as parts of a self-regulating network which is responsible for maintaining embryonic stem cell properties: self renewal and pluripotency. (lu.se)
At the core of the network reside Oct4, Sox2 and Nanog, into embryonic stem cells [1,2,3,4,5], have made major inroads which form a self-organized core of the TFs maintaining into stem cell biology. (lu.se)

Self-renewal conditions must prevent the cells from clumping and maintain an environment that supports an unspecialized state. (wikipedia.org)
BACKGROUND: Glioma stem cells (GSCs) have self-renewal and tumor-initiating capacities involved in drug resistance and immune evasion mechanisms in glioblastoma (GBM). (providence.org)

In May 2011, stem cell therapy in sports medicine was spotlighted after New York Yankees pitcher Bartolo Colon was revealed to have had fat and bone marrow stem cells injected into his injured elbow and shoulder while in the Dominican Republic. (cnn.com)
Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow. (cdc.gov)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)

Nevertheless, despite their immunogenicity in vivo, transplantation tolerance may be readily established by using minimal host conditioning with nondepleting monoclonal antibodies specific for the T cell coreceptors, CD4 and CD8. (ox.ac.uk)
Finally, there are major shortages of cells and organs for use in transplantation procedures. (ca.gov)
This study describes for the first time, a differentiation system that does not require co-culture with animal cells or products, thus allowing the production of pathogen-free RPE cells suitable for transplantation into patients. (news-medical.net)
However, transplanted cells can be injured by mechanical damage during handling and by changes in the transplantation niche. (bvsalud.org)

To determine how the pathogenesis of these viruses differs, we compared their ability to induce disease in mice and replicate and induce cell death in vitro. (cdc.gov)
These beads allow midbrain dopaminergic progenitor cell differentiation and cryopreservation without digestion , effectively maintaining axonal integrity in vitro . (bvsalud.org)
In vitro toxicity data of these metabolites derived in the development of validated and accepted in vitro and in silico embryonic stem cell test were used as input in the PBK model to extrapolate in vitro concentration-response curves to predicted approaches is urgently needed. (cdc.gov)

Reactivation of a developmentally silenced embryonic globin gene. (ox.ac.uk)
We show that in embryonic erythroid cells, the ζ-gene lies within a ~65 kb sub-TAD (topologically associating domain) of open, acetylated chromatin and interacts with the α-globin super-enhancer. (ox.ac.uk)
By contrast, in adult erythroid cells, the ζ-gene is packaged within a small (~10 kb) sub-domain of hypoacetylated, facultative heterochromatin within the acetylated sub-TAD and that it no longer interacts with its enhancers. (ox.ac.uk)
These cells will be excellent for doing gene expression studies and biochemical and protein analyses. (sciencedaily.com)

Embryonic stem cells of the inner cell mass are pluripotent, meaning they are able to differentiate to generate primitive ectoderm, which ultimately differentiates during gastrulation into all derivatives of the three primary germ layers: ectoderm, endoderm, and mesoderm. (wikipedia.org)
When provided with the appropriate signals, ESCs initially form precursor cells that in subsequently differentiate into the desired cell types. (wikipedia.org)
Sun's method prodded human embryonic stem cells to differentiate into neural stem cells, the cells that give rise to neurons. (sciencedaily.com)
Using the same techniques to prod the two embryonic stem cells lines to differentiate, Sun found that one line had a bias to become neurons that are found in the forebrain. (sciencedaily.com)
Human pluripotent stem cells, with their ability to proliferate indefinitely and to differentiate into virtually all cell types of the human body, provide a novel resource to study human development and to implement relevant disease models. (mdpi.com)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)

For the treatment of injuries and diseases, only adult stem cell have been proven effective. (cellmedicine.com)

A closeup of a microscope slide taken in 2000 at the Reproductive Genetics Institute's Chicago laboratory shows transplanted stem cells taken from the umbilical cord blood of a baby named Adam Nash. (cnn.com)

Here, we developed a one-step biomanufacturing platform that uses small-aperture gelatin microcarriers to produce beads carrying midbrain dopaminergic progenitor cells . (bvsalud.org)
Several academic and industry efforts are well under owned subsidiary Cyto Therapeutics, it had received way to produce dopaminergic neurons from stem approval by the Australian government to conduct a cells under conditions compliant with use in patients. (lu.se)
Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)

Genomic alterations in cultured human embryonic stem cells. (nih.gov)
100 predicted genomic off-target loci in 293T and 293FT cells. (cdc.gov)

Huntington's disease, for example, is a forebrain disease, so the neurons should be differentiated from a cell line that is biased to produce neurons from the forebrain. (sciencedaily.com)
Sun said there are ways to prod an embryonic stem cell line biased to become neurons found in the rear brain to become neurons found in the forebrain. (sciencedaily.com)

This is the first application of transcriptomics to assess ES cell derivatives and their in vivo counterparts -- a 'differentiomics' outlook. (news-medical.net)

Recent studies have extended the role of Notch signaling to thymic epithelial cells (TECs), showing that Notch regulates TEC progenitor maintenance and emergence of medullary TECs (mTECs) in fetal thymopoiesis. (ox.ac.uk)
1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

However, the percentage of neurons in the cell culture was not high and the neurons were difficult to isolate from the other cells. (sciencedaily.com)
UCLA's Yi Sun, an associate professor of psychiatry and biobehavioral sciences, and Howard Hughes Medical Institute investigator Thomas Südhof at the University of Texas Southwestern Medical Center were able to produce 70 to 80 percent of neurons in cell culture. (sciencedaily.com)
We're excited because we have been able to purify so many more neurons out of the cell culture and they were, surprisingly, healthy enough to form synapses. (sciencedaily.com)
When the time was right, Sun's team added protein growth factors into the cell culture that stopped the neural stem cells from self-renewing and prodded them into differentiating into neurons. (sciencedaily.com)
The neurons could then be separated from the neural stem cells that had not yet differentiated, a sort of chemical round-up that isolated the neurons. (sciencedaily.com)
The cells were then put into a cell strainer that allowed passage through of the isolated neurons. (sciencedaily.com)
If you're studying a disease found in a certain part of the brain, you should use a human embryonic stem cell line that produces the neurons from that region of the brain to get the most accurate results from your study. (sciencedaily.com)

This propensity for tolerance could be attributed to the paucity of professional antigen-presenting cells and the expression of transforming growth factor (TGF)-?2. (ox.ac.uk)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
The stage-specific embryonic antigen 4 (SSEA4) is brain. (lu.se)

This week's image is from the California Institute for Regenerative Medicine's Flickr photo stream . (stanford.edu)
In addition to retinal cells, other stem-cell derivatives are likely to play an important role in the future of regenerative medicine. (news-medical.net)
Advanced Cell Technology is a leading biotechnology company in the emerging field of regenerative medicine. (news-medical.net)
iPS cells Courtesy of California Institute for Regenerative Medicine A decade ago, the United States granted a series of patents that some say changed the embryonic stem cell (ESC) field forever. (the-scientist.com)
Such an approach is highly relevant to regenerative medicine since it allows for a rapid search over the host of possibilities for reprogramming to a stem cell state. (lu.se)
Regenerative endodontic procedures can be defined as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex. (bvsalud.org)
The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)

To address this issue using a mouse model of CRT, we have derived a panel of ES cell lines that differ from CBA/Ca recipients at defined genetic loci. (ox.ac.uk)
A second important discovery in Sun's study showed that two embryonic stem cells lines derived in similar manners, and therefore expected to behave similarly when differentiating, did not. (sciencedaily.com)
The realization that not all human embryonic stem cell lines are born equal is critical," Sun said. (sciencedaily.com)
With therapeutic cloning, or the creation of banks of stem cells generated using parthenogenesis (perhaps as few as 40-400 lines), a limitless supply of immune-matched cells could be generated for most of the population. (news-medical.net)
We differentiated several human embryonic stem cell lines into RPE," said Irina Klimanskaya, Senior Scientist at ACT, and first author of the study. (news-medical.net)
In August 2001, President George W. Bush announced that he would allow federal funding for about 60 existing stem cell lines created before this date. (cnn.com)
The team that isolated the embryonic stem cell lines was led by Dr. Shoukhrat Mitalipov at Oregon Health and Science University in Portland. (nih.gov)
They're keen to use procedures such as therapeutic cloning to create ES cell lines based on genetic material collected from people with specific diseases. (consumerwatchdog.org)
There, he developed a method of ensuring that mouse ES cell colonies, or lines, don't follow their natural bent and develop into specialised cells, like heart or brain cells, until they're encouraged to do so. (consumerwatchdog.org)
Surprisingly, they don't dispute Thomson's claim that he grew ES cell lines, even though John Gearhart simultaneously conducted similar experiments at Johns Hopkins University. (consumerwatchdog.org)
And the two-stage approval pro-cess remains for deriving new cell lines. (nature.com)
Norio Nakatsuji, director of Kyoto University's Institute for Integrated Cell-Material Sciences, who created all five of Japan's human ES-cell lines, has given up plans to make any more. (nature.com)

To investigate the functional impact of Notch activation in postnatal TEC biology, we used a mouse model in which RPBJκ, the transcriptional effector of canonical Notch signaling, is deleted in epithelial cells, including TECs, under the control of the transcription factor Foxn1. (ox.ac.uk)
Therefore, impaired Notch signaling induced in embryonic development impacts postnatal TECs and leads to an accelerated mTEC degeneration and a premature thymus involution. (ox.ac.uk)
Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)

Their parents wanted to have a child who could be a stem cell donor for Molly. (cnn.com)
Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations. (mpg.de)
Only one of the macaques born carried the donor cell line. (planer.com)
Publishing their results in Cell, the authors analysed 26 different tissues, showing that donor cells accounted for 21 to 92 percent of the constituent cells, with an average incidence of 67 percent. (planer.com)
We have a very high level of contribution, with the donor cells forming a big part of the tissues (and) complex structures all over the monkey body. (planer.com)
Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
The possible donor-host rejection of human ES cells is another concern 3 . (bvsalud.org)

Not so for the field of reprogrammed embryonic-like stem cells known as induced pluripotent stem cells (iPSCs), which are created by turning the developmental clock back on adult or other specialized cell types through the use of viruses, plasmids, transposons, or other reprogramming factors. (the-scientist.com)
Title: "A scRNAseq study of human embryonic tanycyte: heterogeneity and developmental trajectory" 28th of November, 10-11, Segerfalkssalen and zoom. (lu.se)

2002). In humans, SSEA4 is expressed by building the nervous system but also for their prospec- nonneural cells such as the erythrocytes (Kannagi et al. (lu.se)

Dr. Heike Kroeger received an undergraduate degree in Biochemistry from Free University Berlin in Germany and earned her PhD in Structural Medicine and Cell Biology at Cambridge University, UK. (nih.gov)
Make a donation to the Smithsonian's National Zoo and Conservation Biology Institute today! (si.edu)
Advances in human stem cell biology may one day allow the frozen stem cells to produce new adults. (si.edu)
Working at the Hawaii Institute of Marine Biology for the past 11 years, Hagedorn created the first frozen Hawaiian coral repository with sperm and stem cells from two species of corals from Kaneohe Bay. (si.edu)
Our facilities provide the opportunity to study protein structure, molecular probes and drug design, system biology and molecular interactions in cells and tissues. (lu.se)

It's obvious from yesterday's vote that embryonic stem cells will continue to split the country (California versus Washington DC, for one thing). (nationalgeographic.com)

DESCRIPTION (provided by applicant): The capacity to evaluate the teratoma forming potential of differentiated embryonic stem cell populations represents an urgent need before widespread therapeutic application of these cells is possible. (sbir.gov)

Together, these factors contribute to a state of acquired immune privilege that favors the polarization of infiltrating T cells toward a regulatory phenotype. (ox.ac.uk)
Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotyp" by Borja Sesé, Sandra Íñiguez-Muñoz et al. (providence.org)
Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype. (providence.org)
and Marzese, Diego M, "Glioblastoma Embryonic-like Stem Cells Exhibit Immune-Evasive Phenotype. (providence.org)

Exclusive use of adult stem cells has resulted in the successful treatment of dozens of conditions and diseases over the last decade. (cellmedicine.com)
But offering false promises to millions of desperate people who are suffering from diseases and conditions that could be treated with adult stem cells right now may be even more heartless. (cellmedicine.com)
Besides use in the aging retina, human embryonic stem cells have now demonstrated the potential to change the face of several age-related degenerative diseases, perhaps one day allowing physicians to prescribe young cells they way they dispense pills today. (news-medical.net)

Despite this difference in the cell cycle when compared to ESCs grown in media containing serum these cells have similar pluripotent characteristics. (wikipedia.org)
WARF , in this and two other patents, in essence owns virtually all imaginable characteristics of human embryonic stem cells. (consumerwatchdog.org)

For example, human cells carry unique identifiers-molecular "bar codes"-that must be closely matched or the transplant will be rejected. (ca.gov)
These cells expressed RPE-specific molecular markers and were capable of phagocytosis, an important RPE function. (news-medical.net)
Differentiomics could also be a valuable predictive tool for quality assessment of other ES cell derivatives based on their molecular signature. (news-medical.net)
Comparative molecular portraits of human unfertilized oocytes and primordial germ cells at 10 weeks of gestation. (mpg.de)

Millions of patients with retinal degeneration might conceivably benefit from these cells in the future," said Robert Lanza, Medical Director at ACT, and senior author of the study. (news-medical.net)
This study was supported by The Ellison Medical Foundation, The Greenwall Foundation, and the Howard Hughes Medical Institute. (nationalacademies.org)
This week, the Archdiocese of Cincinnati specifically asked Catholic school leaders at 113 schools to "immediately cease" any fundraising plans connected to the challenge, because the ALS Association funds at least one study using embryonic stem cells -- "in direct conflict with Catholic teaching. (salon.com)
Women may make new eggs throughout their reproductive years, suggests a new stem-cell study that challenges a long-held biological tenet. (nationalgeographic.com)
In this study, we have provided strong evidence that naïve monkey pluripotent stem cells possess the capability of differentiating in vivo into all the various tissues composing a monkey body,' co-author Professor Miguel Esteban from the University of Chinese Academy of Sciences, Guangzhou, China told Nature. (planer.com)
said Professor Mu-Ming Poo, study co-author and scientific director of the Institute of Neuroscience at the Chinese Academy of Sciences. (planer.com)
Our facilities provide the opportunity to study molecules, cells, organs and entire organisms. (lu.se)

Although human embryonic stem (ES) cells may one day provide a renewable source of tissues for cell replacement therapy (CRT), histoincompatibility remains a significant barrier to their clinical application. (ox.ac.uk)

Anatomy53

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