Embryonic muscle cell cells differentiate embryonic cell differentiation. Medical search. Frequent questions

A subset of epicardial cells undergoes EMT, migrates into the developing heart, and differentiates into cardiac fibroblast, vascular endothelial, and smooth muscle cells. (arizona.edu)
In particular, FUNGENES identified genes controlling the development of pluripotent embryonic stem (ES) cells into heart cells (cardiomyocytes), nerve cells (neurons), smooth muscle cells, vascular endothelial cells, fat cells (adipocytes), liver cells (hepatocytes) and insulin-producing cells of the pancreas. (europa.eu)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells. (justia.com)
Therefore there remains a need for providing effective methods of inducing differentiation of stem cells into specific cell types, such as myocytes or endothelial cells. (justia.com)
Nowadays, more and more studies have revealed that cells in the cardiovascular system (such as cardiomyocytes, vascular smooth muscle cells, endothelial cells, et al. (frontiersin.org)
In their study they show how mouse embryonic stem cells that don't have enough Braveheart lncRNA fail to develop any of the three major types of cell of the cardiovascular system: cardiomyocytes (which make cardiac muscle), smooth muscle cells and endothelial cells. (medicalnewstoday.com)
First, HOXB7, HOXC6 and HOXC8 were identified to be differentially expressed in VW-MPSCs as compared to terminal differentiated human aortic SMC, endothelial cells and undifferentiated pluripotent embryonic stem cells. (lonza.com)
The development of decellularised scaffolds for small diameter vascular grafts is hampered by their limited patency, due to the lack of luminal cell coverage by endothelial cells (EC) and to the low tone of the vessel due to absence of a contractile smooth muscle cells (SMC). (ox.ac.uk)
Low immunogenic endothelial cells maintain morphological and functional properties required for vascular tissue engineering. (biofabrication.info)
Evaluation of autologous tissue sources fort the isolation of endothelial cells and adipose tissue-derived mesemchymal stem cells to pre-vascularize tissue-engineered vascular grafts. (biofabrication.info)
Outgrowing endothelial and smooth muscle cells for tissue engineering approaches. (biofabrication.info)
The malformations have a normal endothelial cell growth cycle that affects the veins, the capillaries, or the lymphatics, and they do not involute. (medscape.com)

Myoblasts fuse from multinucleated skeletal muscle cells known as syncytia in a process known as myogenesis. (wikipedia.org)

The in vitro differentiation of ESCs into cardiomyocytes provides an opportunity to study the developmental aspects of cardiomyogenesis. (bioinbrief.com)
Cardiomyocytes are terminally differentiated muscle mass cells in the adult mammalian heart, which do not divide. (bioinbrief.com)
The greatest goal in cardiac regenerative medicine is normally to make in large-scale, filtered cardiomyocytes which are ideal for cell transplantation highly. (bioinbrief.com)
Such cell transplantation therapies would need the effective seeding of as many as 1 108 donor cardiomyocytes per individual [4]. (bioinbrief.com)
Presently, most protocols make use of stationary lifestyle to differentiate ESCs into cardiomyocytes [5-12]. (bioinbrief.com)
Our data shows that in contrast to static tradition, ESC ethnicities caused to differentiate toward cardiomyocytes in suspension bioreactors retain some capability to exhibit pluripotency indicators, to type. (bioinbrief.com)
Retinoic acid induces the development of neurons, microglia, and astroglia, whereas DMSO initiates beating cardiomyocytes and smooth muscle cell development from P19 cells. (cytion.com)
By demonstrating the generation of cardiomyocytes from murine pluripotent stem cells, their concept shows promise as a regenerative therapy. (shinshu-u.ac.jp)
However, when these pluripotent stem cells were treated after experiencing differentiating conditions for five days, specific marker genes were upregulated, and the cells committed to forming beating cardiomyocytes. (shinshu-u.ac.jp)
We investigated the effect of 5-azacytidine (5-aza) on P19 cells to differentiate into a high-efficacy cardiomyocytes. (korea.ac.kr)
This study has demonstrated that 5-aza induces differentiation of P19 cells into cardiomyocytes in a confluent monolayer culture in the absence of prior embryoid formation and dimethyl sulfoxide exposure, depending in part on alteration of BMP signaling molecules. (korea.ac.kr)

Finally we found that in an mouse model of fracture healing where muscle mass progenitor cells were lineage-traced Nkx3.2 and Sox9 are significantly upregulated while Pax3 is significantly downregulated in the muscle mass progenitor cells that give rise to chondrocytes during fracture restoration. (healthyguide.info)
Therefore our and analyses suggest that the balance of Pax3 Nkx3.2 and Sox9 may act as a molecular Talniflumate switch during the chondrogenic differentiation of muscle mass progenitor cells which may be important for fracture healing. (healthyguide.info)
Satellite cells from your trunk and the limb are derived from an embryonic populace of progenitor cells in the somites transient mesodermal constructions that develop on either part of the neural tube [1]. (healthyguide.info)
Knowledge about the identity, localization, and biology of lung stem/progenitor cells has lagged behind what is known for other organ systems. (bu.edu)
Bober E, Franz T, Arnold HH, Gruss P, Tremblay P. Pax-3 is required for the development of limb muscles:a possible role for the migration of dermomyotomal muscle progenitor cells. (scielo.br)
To varying degrees, these fates also extend to the Such state stability is required in stem and progenitor cells to immediate progeny of stem cells, known as progenitor or support self-renewal and maintenance of the uncommitted transit-amplifying cells. (lu.se)

These ESCs have the ability to remain undifferentiated and proliferate indefinitely in vitro , while maintaining the potential to differentiate into all three embryonic germ layers [1,2]. (bioinbrief.com)
The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)
Thus, we show for the first time that UtMCs could recapitulate in vitro differentiative events of early cardiovascular differentiation and transdifferentiate in cells exhibiting molecular and functional characteristics of VSMCs. (ox.ac.uk)
Mesenchymal stem cells clearly modulate immune responses, as demonstrated by both in vitro and in vivo studies. (vin.com)
Our results suggest that ES cells recapitulate closely the early steps of muscle development in vivo and may serve as an excellent in vitro system to study this process. (uni-luebeck.de)
Endogenous Akt2 expression also is upregulated in fully-differentiated C2C12 myotubes and 3T3-L1 adipocytes, suggesting that these murine cell lines represent useful in vitro models for studies of Akt2 function. (nih.gov)
We show that HA-tagged AKT2 is activated in response to insulin stimulation in vitro and that activation of AKT2 is not induced in cells pretreated with wortmannin, an inhibitor of phosphatidylinositol 3-kinase. (nih.gov)
The neuronal cells expressed numerous genes associated with sub-regions within the brain thus suggesting the usefulness of our in-vitro model. (biomedcentral.com)
To determine their possible roles in tissues and satellite cells in vitro, their expression pattern was examined in tissues from 40-day-old chickens and in satellite cells from the breast muscles of 1-week-old and 2-week-old chickens using RT-PCR and immunocytochemistry analyses. (scielo.br)
The stem cell field witnessed a genuine breakthrough when a combination of solely four transcription factors ( Oct3 / 4 , Sox2 , Klf4 and c-Myc, OSKM ) proved enough to revert, in vitro, the differentiated status of a variety of cell types back to pluripotency, giving rise to so-called induced pluripotent stem (iPS) cells. (springer.com)
A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
MVSCs expressed markers such as Sox 17 and Sox10 and could differentiate into neural cells in vitro. (biomedcentral.com)
These MVSCs can be differentiated into neural cells and mesenchymal cells in vitro. (biomedcentral.com)

Understanding the genetic pathways underlying differentiation of ES cells to somatic cells would contribute to future therapeutic strategies for degenerative diseases such as heart disease, diabetes and Parkinson's. (europa.eu)
Researchers use P19 cells to elucidate cell signaling pathways and cellular and molecular mechanisms involved in these processes. (cytion.com)
However, the molecular pathways that lead to specification and terminal differentiation of specific cell types, such as myocytes, from embryonic stem cells during development are not entirely clear. (justia.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
The capacity of stem cells to divide and differentiate along different pathways is necessary in embryonic development and also makes stem cells suitable for therapeutic uses. (bioknowledgy.info)
One particular interest involves understanding the origin, expansion mechanisms, and differentiation pathways controlling bronchial and pulmonary artery vascular smooth muscle cells during embryogenesis and disease. (bu.edu)
Our new focus on lung mesothelium is another example of our interest in deciphering the origin and differentiation pathways controlling the lung's mesenchymal elements. (bu.edu)
In terminally differentiated cell fate is coupled to appropriate regulation of the alternative cells, transcriptional networks must be stable and irreversible, pathways. (lu.se)

Remarkably, the progenitors derived from embryonic stem cells by dual inhibition efficiently differentiate into cardiac and skeletal muscle cells. (ncbs.res.in)
Significantly, this is the first report of directed differentiation of pluripotent stem cells, without transgenes, into progenitors with muscle/heart dual potential. (ncbs.res.in)
c-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway. (ox.ac.uk)
Our data show that ESC-derived c-Kit+/Sca-1-cells can be differentiated through a Klf4/β-catenin dependent pathway and are a suitable source of vascular progenitors for the creation of superior tissue-engineered vessels from decellularised scaffolds. (ox.ac.uk)
Interestingly recent data indicated that although MyoD is not indicated in quiescent satellite cells in the adult it is transiently indicated in satellite cell progenitors in the embryo suggesting that satellite cells are derived from committed embryonic precursors of myogenic lineage [4] [5]. (healthyguide.info)
One such alternative cell fate is the adipogenic fate as Pax7(+) satellite cells isolated from solitary myofibers used adipogenic fate in addition ARHGAP1 to muscle mass fate significance of these factors we used a mouse fracture healing model inside a genetically altered reporter mouse where muscle mass progenitors were lineage-traced. (healthyguide.info)
We found that in the descendents of muscle mass progenitors that contributed to cartilage formation Nkx3.2 and Sox9 were strongly induced while Pax3 manifestation was strongly repressed. (healthyguide.info)
Gros J, Manceau M, Thomé V, Marcelle C. A common somitic origin for embryonic muscle progenitors and satellite cells. (scielo.br)

It thoroughly investigated the unique ability of mouse embryonic stem cells to develop into cells of any organ ("pluripotency"), created new tools for functional genomic studies and thus provided key knowledge to understanding the commitment of cells to differentiate into cells of a particular germ layer. (europa.eu)

A muscle cell is also known as a myocyte when referring to either a cardiac muscle cell (cardiomyocyte) or a smooth muscle cell, as these are both small cells. (wikipedia.org)
Skeletal muscle cells and cardiac muscle cells both contain myofibrils and sarcomeres and form a striated muscle tissue. (wikipedia.org)
Cardiac muscle cells form the cardiac muscle in the walls of the heart chambers, and have a single central nucleus. (wikipedia.org)
Cardiac muscle cells are joined to neighboring cells by intercalated discs, and when joined in a visible unit they are described as a cardiac muscle fiber. (wikipedia.org)
The cell membrane of a cardiac muscle cell has several specialized regions, which may include the intercalated disc, and transverse tubules. (wikipedia.org)
Cardiac muscle like the skeletal muscle is also striated and the cells contain myofibrils, myofilaments, and sarcomeres as the skeletal muscle cell. (wikipedia.org)
iSN04 treatment under differentiating conditions inhibited stem cell commitment to the cardiac lineage. (shinshu-u.ac.jp)
The P19 embryonal carcinoma cell line is a useful model cells for studies on cardiac differentiation. (korea.ac.kr)
In response to 1 μM of 5-aza, P19 cells expressed bone morphogenetic protein-2 (BMP-2), BMP-4, Bmpr1a and Smad1 at day 6 or 9, and also cardiac markers such as GATA-4, Nkx2.5, cardiac troponin I, and desmin were up-regulated in a time-dependent manner after induction of BMP signaling molecules. (korea.ac.kr)
Immunocytochemistry revealed the expression of smooth muscle α-actin, sarcomeric α-actinin, cardiac myosin heavy chain, cardiac troponin T and desmin, respectively. (korea.ac.kr)
These results suggest that 5-aza treatment could be used as a new method for cardiac differentiation in P19 cells. (korea.ac.kr)
The mechanisms of cellular excitability and propagation of electrical signals in the cardiac muscle are very important functionally and pathologically. (bvsalud.org)
There are areas in the cardiac muscle with anatomical and functional differentiation that present automatism, thus subjecting the rest of the fibers to their own rhythm. (bvsalud.org)

However, in recent years, there has been controversy surrounding the way human embryonic stem cells are obtained. (healthline.com)
Human embryonic stem cells by Sunamas Inc. (bioknowledgy.info)
Stem cells, particularly human embryonic stem cells, are a notoriously labile cell type. (onenucleus.com)
A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)

These unique clones allow for to study into specific epicardial cell lineages and phenotypes. (arizona.edu)
Background Embryonic stem cells (ESCs) can proliferate endlessly and are capable to differentiate into every cell lineages that make up the mature organism. (bioinbrief.com)
The process of differentiation in stem cells involves selective development of immature cells to committed and fully mature cells of various lineages. (justia.com)
Most importantly stem cells possess the ability to differentiate into cell types of multiple lineages including adipocytes, chrondrocytes, and osteocytes. (vin.com)
Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine. (shinshu-u.ac.jp)
Murine embryonic fibroblast cell lines differentiate into three Mesenchymal lineages to different extents - new models to investigate differentiation processes. (biofabrication.info)
versions differentiate into specific lung epithelial lineages nevertheless these studies didn't address the significance of stromal epithelial connections (Wu et al. (morainetownshipdems.org)
2011 These HBECs exhibit markers indicative of many epithelial cell types from both central and distal airway lineages in two-dimensional lifestyle (2D). (morainetownshipdems.org)

A skeletal muscle cell is long and threadlike with many nuclei and is called a muscle fiber. (wikipedia.org)
Skeletal muscle cells are the individual contractile cells within a muscle and are more usually known as muscle fibers because of their longer threadlike appearance. (wikipedia.org)
Skeletal muscle fibers are the only muscle cells that are multinucleated with the nuclei usually referred to as myonuclei. (wikipedia.org)
In skeletal muscle, at the end of each muscle fiber, the outer layer of the sarcolemma combines with tendon fibers at the myotendinous junction. (wikipedia.org)
The mouse blastocyst-derived embryonic stem cell (ES cell) line BLC6 efficiently differentiates into myosin heavy chain-, desmin- and myogenin- positive skeletal muscle cells when cultivated in embryo-like aggregates (embryoid bodies). (uni-luebeck.de)
The myocytes also express functional nicotinic cholinoceptors and exhibit T-type Ca 2+ currents and later L-type Ca 2+ currents, demonstrating physiological properties of skeletal muscle cells. (uni-luebeck.de)
END-2 cells essentially prevent skeletal muscle differentiation, whereas basic fibroblast growth factor, transforming growth factor-β, and WEHI-3 cells have no or an attenuating effect, respectively. (uni-luebeck.de)
We had previously found that iSN04 promoted myogenic precursor cells (myoblasts) to differentiate into skeletal muscle cells and had hypothesized that the aptamer also enhanced differentiation of pluripotent stem cells. (shinshu-u.ac.jp)
These studies demonstrate that Akt2 is especially abundant in brown fat and, to a lesser extent, skeletal muscle and liver, tissues which are highly insulin-responsive and play a role in glucose metabolism. (nih.gov)
2010). Senp2 also regulates fatty acid metabolism in skeletal Downloaded from https://academic.oup.com/jmcb/article-abstract/10/3/258/4763638 by Ed 'DeepDyve' Gillespie user on 26 June 2018 Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1 j 259 muscle (Koo et al. (deepdyve.com)
Intro Satellite cells are the cells specific stem cells in the adult skeletal muscle mass. (healthyguide.info)
In the beginning satellite cells were considered to Talniflumate be unipotent stem cells with the ability of generating a unique specialized phenotype the skeletal muscle mass cells. (healthyguide.info)
Upon increasing culture times in chicken´s primary skeletal muscle satellite cells, SULF1 and SULF2 expression in 1-week-old chickens was significantly higher than in 2-week-old chickens, suggesting that sulfatases play a key role in satellite cell development. (scielo.br)
The formation of skeletal muscle:from somite to limb. (scielo.br)
Cellular and molecular mechanisms regulating skeletal muscle development. (scielo.br)
When skeletal muscle is injured due to physical or chemical insult, a pool of self-renewing muscle stem cells residing within the skeletal muscles, called satellite cells, can give rise to differentiated myofibers to repair injured muscle ( Charge & Rudinicki, 2004 Chargé SBP, Rudnicki MA. (scielo.br)
Satellite cells are essential for skeletal muscle regeneration:the cell on the edge returns centre stage. (scielo.br)
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. (scielo.br)
Isolation and culture of individual myofibers and their satellite cells from adult skeletal muscle. (scielo.br)

During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
In some cases, "master" genes have been described which control differentiation versus self-renewal. (justia.com)
Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
Here, we show that the muscle-specific determination genes myf5. (uni-luebeck.de)
Thus, we know that the simple cells of an egg are preformed in the sense that they contain a preformed instruction set for development which is encoded in their genes. (encyclopedia.com)
In recent years, scientists have discovered areas of DNA that do not give instructions on how to make proteins, are codes for making lncRNA molecules that help to control when genes are switched on and off inside cells. (medicalnewstoday.com)
It appears that Braveheart controls the cascade by influencing the PRC2 protein complex, which normally sits on top of DNA, blocking MesP1 and other genes that are essential for developing heart cells. (medicalnewstoday.com)
In summary, our findings suggest a role for certain HOX genes in regulating differentiation of human VW-MPSC into SMCs that involves epigenetic mechanisms. (lonza.com)
In the present study, we assessed the hypothesis that miR-214 and its target genes play an important role in VSMCs differentiation. (oncotarget.com)
miR-214 overexpression and knockdown in differentiating ESCs significantly promoted and inhibited VSMCs -specific genes expression, respectively. (oncotarget.com)
Transcriptome analysis of AD-iPS derived neuronal cells revealed significant changes in the expression of genes associated with AD and with the constitutive as well as the inducible subunits of the proteasome complex. (biomedcentral.com)
Differentiation involves the expression of some genes and not others in a cell's genome. (bioknowledgy.info)
Upon activation satellite cells rapidly initiate MyoD expression which leads to the activation of myogenin and terminally differentiated structural muscle mass genes such as myosin heavy chain (MHC) [1] [3]. (healthyguide.info)
Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. (springer.com)
explosion further, consider that a fictitious small genome with 2002) More recently and more dramatically, the potential for 260 genes would host the same number of combinations as cell state conversions is exemplified by the reprogramming of the number of atoms in the visible universe! (lu.se)

P19 is a murine embryonal carcinoma cell line. (cytion.com)
An anti-nucleolin DNA aptamer, iSN04, regulates cardiomyogenesis of murine pluripotent stem cells. (shinshu-u.ac.jp)
Using various assays like RNA sequencing, cell staining and imaging, and molecular interaction and pathway analysis, the researchers investigated iSN04's effect on murine ESCs and iPSCs. (shinshu-u.ac.jp)
Murine ESCs were seeded on collagen-coated flasks and cultured in differentiation medium for 2 to 8 days to allow VSMCs differentiation. (oncotarget.com)
Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
While mouse versions have contributed inside our knowledge of lung advancement fix and regeneration inherent distinctions between your murine and individual airways requires the introduction of new versions using individual airway epithelial cells. (morainetownshipdems.org)
2001 Clara cells (generally known as membership cells) are located through the entire murine airways but are enriched just within Aliskiren hemifumarate the distal bronchioles from the individual lung (Boers et al. (morainetownshipdems.org)

An important aspect of ESC research focuses on elucidating the mechanisms of differentiation from the pluripotent ESC to numerous terminally differentiated cell types. (bioinbrief.com)

Unlike many other kinases, GSK3B is believed to be permanently active in resting cells and in neurons without extracellular stimulation and can be inactivated by Ser9 phosphorylation [ 14 ]. (biomedcentral.com)
Gamma motor neurons (γ-MNs) selectively innervate muscle spindle intrafusal fibers and regulate their sensitivity to stretch. (biomedcentral.com)
The mechanisms that control the differentiation of functionally distinct fusimotor neurons are unknown. (biomedcentral.com)
Fusimotor axons originate either from gamma motor neurons (γ-MNs), which only innervate intrafusal fibers of the muscle spindle, or from alpha motor neurons (α-MNs), which innervate extrafusal muscle and also send a β-skeletofusimotor collateral axon to innervate the muscle spindle [ 2 - 4 ]. (biomedcentral.com)
After delamination, NCCs proliferate during migration towards several places inside the embryonic body vigorously, and differentiate right into a wide variety of cell tissue and types, including neurons and glial cells from the peripheral anxious systems (PNS), even muscles from the center and great vessels, bone tissue, cartilage, connective tissues of the true encounter, and melanocytes in your skin. (globaltechbiz.com)
Trunk NCCs (tNCCs) emerge in the trunk region from the neural epithelium, and the ones migrating underneath the ectoderm will type pigment cells in your skin and others going for a ventral pathway via the somites will differentiate into neurons and glia from the PNS aswell as chromaffin cells in the adrenal gland [2]. (globaltechbiz.com)
NC cells differentiate to form a broad array of derivatives, including neurons and glia of the peripheral nervous system, smooth muscle, cartilage, craniofacial mesenchyme, and melanocytes ( Mayor and Theveneau, 2013 ). (jneurosci.org)
CRT aims to replace neurons that have degenerated in PD, with donor cells that have the potential to functionally re-integrate into the host circuitry. (lu.se)
This involves transplantation of developing midbrain cells from aborted fetuses, (the part that form mesDA neurons), into the striatum of a PD patient. (lu.se)
Parkinson's Disease is a neurodegenerative disorder where the dopamine producing neurons in the ventral mesencephalon (VM) progressively die and result in symptoms such as resting tremors, muscle rigidity, slowness and difficulties in initiating movements. (lu.se)

Muscle cells (including myocytes and muscle fibers) develop from embryonic precursor cells called myoblasts. (wikipedia.org)
Next, we show that the proepicardium, which provides the precursor cells required for epicardial and coronary vessel development, migrates to the developing heart via direct contact of multicellular proepicardial villi to the developing myocardium. (arizona.edu)

All these diseases are characterised by the irreversible loss of functional cells. (europa.eu)
Stem cells are undifferentiated cells which can give rise to a succession of mature functional cells. (justia.com)
Functional vascular smooth muscle-like cells derived from adult mouse uterine mesothelial cells. (ox.ac.uk)
A stem cell is a generic term referring to any unspecialized cell that is capable of long-term self-renewal through cell division but that can be induced to differentiate into a specialized, functional cell. (vin.com)
4,6,7 It has been proposed that some of these MSC may actually differentiate into functional renal tubular epithelial cells, though this theory remains controversial. (vin.com)
In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. (frontiersin.org)
They demonstrated that transferring functional mitochondria of bone marrow-derived stem cells to defective parenchymal cells increases the aerobic respiration capacity of recipient mitochondria ( 7 ). (frontiersin.org)
Aptamers are single-stranded pieces of DNA that bind to target proteins and are able to modulate signaling cascades during cell differentiation when a stem cell commits to a specific functional role or phenotype. (shinshu-u.ac.jp)
When seeded ex vivo on a decellularised vessel, c-Kit+/Sca-1-derived cells recapitulated the native vessel structure and upon in vivo implantation in the mouse, markedly reduced neointima formation and mortality, restoring functional vascularisation. (ox.ac.uk)
However, very little is known about its functional role in vascular smooth muscle cells (VSMCs) differentiation from ESCs. (oncotarget.com)
Taken together, we have uncovered a central role of miR-214 in ESC-VSMC differentiation, and successfully identified QKI as a functional modulating target in miR-214 mediated VSMCs differentiation. (oncotarget.com)
The functional motor recovery and cell fate in the regenerated nerve were investigated to understand the therapeutic benefit. (biomedcentral.com)
In vivo therapeutic effects, including functional recovery and cell fate, were investigated. (biomedcentral.com)
Shane Grealish: Cell Replacement Therapy for Parkinson's Disease: The Importance of Neuronal Subtype, Cell Source and Connectivity for Functional Recovery. (lu.se)
The aim of this thesis was to understand how particular factors such as neuronal content, placement and cell source, affect functional outcome after transplantation into the rodent brain. (lu.se)
Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)

This differentiation capacity makes ESCs an attractive cell source for cell/tissue alternative therapies for the treatment of human degenerative diseases. (bioinbrief.com)
As P19 cells have differentiation ability, they can be useful in investigating complex biological processes such as tissue formation and early embryonic development. (cytion.com)
Embryonic stem (ES) cells are derived from the embryo and are pluripotent, thus possessing the capability of developing into any organ, cell type or tissue type. (justia.com)
This means they can potentially produce new cells for any organ or tissue. (healthline.com)
Mesenchymal stem cells are multipotent but not pluripotent, which means they can differentiate into some, or "multiple," but not all tissue types. (vin.com)
Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. (frontiersin.org)
Here, the biomaterial not only assists recruitment of endogenous cells, but also supports cellular activities relevant to bone tissue formation and function. (bvsalud.org)
While such biomaterial-mediated in situ tissue engineering is highly attractive, success of such an approach relies largely on the regenerative potential of the recruited cells, which is anticipated to vary with age. (bvsalud.org)
We also define an efficient and controlled differentiation protocol yielding fully to differentiated ECs and SMCs in sufficient numbers to allow the repopulation of a tissue engineered vascular graft. (ox.ac.uk)
Mesenchymal stem cells (MSCs) are widely regarded to be promising cell sources for bone tissue engineering, due to their multi-lineage differentiation potential and extensive self-renewal capacity [ 5 ]. (biomedcentral.com)
p53 participates in relevant aspects of cell biology, including apoptosis and cell cycle control and must be strictly regulated to maintain normal tissue homeostasis. (molvis.org)
Stem cell therapy is a promising approach to promote neural tissue regeneration. (biomedcentral.com)
Non-germ cell tumors can derive from pineal parenchymal cells, as well as from surrounding tissue. (medscape.com)
These phenotypes possess mainly been mimicked using major tissue from embryonic individual and mouse lungs (Miura and Shiota 2000 Weaver et al. (morainetownshipdems.org)
Use of human fetal tissue raises several ethical issues, but are there alternative cell sources that can substitute effectively? (lu.se)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)

Extremely, nevertheless, our outcomes confirmed that the bioreactor differentiated ESCs maintained their capability to CL 316243 disodium salt manufacture exhibit pluripotency indicators, to type ESC-like colonies, and to generate teratomas upon transplantation, whereas the cells differentiated in adherent lifestyle dropped these features. (bioinbrief.com)
History Embryonic control cells (ESCs) are made from the internal cell mass (ICM) of pre-implantation embryos [1]. (bioinbrief.com)
The team, led by Associate Professor Tomohide Takaya from the Department of Agricultural and Life Sciences at Shinshu University, recently discovered that an anti-nucleolin aptamer, myogenetic oligodeoxynucleotide iSN04, induced myocardial differentiation in embryonic stem cells (ESCs). (shinshu-u.ac.jp)
In this study, we identify a population of vascular progenitor c-Kit+/Sca-1- cells available in large numbers and derived from immuno-privileged embryonic stem cells (ESCs). (ox.ac.uk)
MicroRNA-214(miR-214) has been recently reported to regulate angiogenesis and embryonic stem cells (ESCs) differentiation. (oncotarget.com)
Importantly, miR-214 overexpression in ESCs promoted VSMCs differentiation in vivo . (oncotarget.com)
Luciferase assay showed miR-214 substantially inhibited wild type, but not the mutant version of QKI-3-UTR-luciferase activity in differentiating ESCs, further confirming a negative regulation role of miR-214 in QKI gene expression. (oncotarget.com)
Mechanistically, our data showed that miR-214 regulated VSMCs gene expression during VSMCs differentiation from ESCs through suppression of QKI. (oncotarget.com)

This study demonstrates that suspension bioreactor tradition systems do indeed possess the ability to prevent differentiation, and actually induce 'transient' pluripotency within a defined differentiation protocol, presumably due to influence of shear stress on the cells. (bioinbrief.com)
Placing the cells under conditions which induce specific cell types has been one form of an attempt to regulate the differentiation outcome. (justia.com)
culturing a stem cell in the presence of an embryonic cell and/or extracellular medium of an embryonic cell, under conditions that induce differentiation of the stem cell. (justia.com)
It opens a new door to what we could do, and how we could use lncRNAs to induce specific cell types, that's been completely unexplored. (medicalnewstoday.com)
The intent of vaccination is to induce a combined antibody and T-cell anti-HER-2 immune response, which is intended to target HER-2-expressing tumor cells, and may induce tumor regression or slow progression of disease. (stanford.edu)
a reverse function mutant Talniflumate of Nkx3.2 blocks the ability of Sox9 to both inhibit myogenesis and induce chondrogenesis suggesting that Nkx3.2 is required for Sox9 to promote chondrogenic differentiation in satellite cells. (healthyguide.info)
The practice of dentistry is likely to be revolutionized by biological therapies based on growth and differentiation factors that accelerate and/or induce a natural biological regeneration. (bvsalud.org)
Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)

Pluripotent embryonic carcinoma cell line P19 is a useful model for studying early embryonic development. (cytion.com)

In Drosophila , a population of muscle-committed stem-like cells called adult muscle precursors (AMPs) keeps an undifferentiated and quiescent state during embryonic life. (biologists.com)
Recently, it was reported that early embryonic γ-MN precursors are dependent on GDNF. (biomedcentral.com)

In mammalian visceral organs, vascular smooth muscle cells (VSMCs) originate from an epithelial-to-mesenchymal transition (EMT) of embryonic mesothelial cells (MCs). (ox.ac.uk)
Using a variety of novel genetic mouse models along with embryonic lung cultures, the contribution of mesothelial cells to normal lung development is being investigated. (bu.edu)
check the tag ADOLESCENCE HN - 2008 BX - Nutrition in Adolescence FX - Adolescent Nutrition Physiology MH - Peritoneal Stomata UI - D054048 MN - A01.047.025.600.700 MN - A10.810 MS - Natural openings in the subdiaphragmatic lymphatic plexus in the PERITONEUM, delimited by adjacent mesothelial cells. (bvsalud.org)

Mesenchymal stem cells or mesenchymal stromal cells (MSC) are plastic adherent and assume a fibroblast-like morphology during culture. (vin.com)
2011 When major HBECs are cultured on the contracted fibroblast matrix and elevated to air-liquid user interface (ALI) the HBECs have the ability to differentiate into ciliated and goblet cells (Vaughan et al. (morainetownshipdems.org)

These mouse carcinoma cells possess an epithelial-like morphology. (cytion.com)
The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. (rupress.org)
The 3D book cell culture program recapitulates stromal-epithelial connections that may be useful to understand essential areas of lung advancement and diseases. (morainetownshipdems.org)
2001 Rackley and Stripp 2012 the significance is supported by These differences of developing model systems using individual airway epithelial cells. (morainetownshipdems.org)
In order to recapitulate the indigenous airway structures and differentiation different model systems using individual bronchial epithelial cells (HBECs) possess previously been set up (Bals et Aliskiren hemifumarate al. (morainetownshipdems.org)
2006 Even though ALI culture program demonstrates the power of HBECs to differentiate into lung epithelial cells coating the central lung it generally does not address differentiation within the distal airways. (morainetownshipdems.org)
When cultured in various varieties of 3D systems refined adjustments in the microenvironment bring about the power of HBECs to differentiate into multiple central and distal lung epithelial cell types. (morainetownshipdems.org)

Although a small percentage of the cells may be capable of proliferation [3], this CL 316243 disodium salt manufacture is usually not sufficient for regeneration after myocardial injury. (bioinbrief.com)
Among their other immunological properties, MSC inhibit lymphocyte proliferation and cytokine production, suppress dendritic cell function and alter DC cytokine production, and decrease IFN-g production by NK cells. (vin.com)
AMSBIO has in-depth expertise in extracellular matrices to provide elegant solutions for studying cell motility, migration, invasion, and proliferation. (onenucleus.com)
The proliferation and differentiation of satellite cells are regulated by a number of extracellular signals ( Wang & Rudnicki, 2012 Wang YX, Rudnicki MA. (scielo.br)

In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
Muscle satellite cells make up a stem cell populace that is capable of differentiating into myocytes and contributing to muscle mass regeneration upon injury. (healthyguide.info)
Upon injury or when challenged with a variety of mechanical or biochemical stimuli satellite cells re-enter the cell cycle and give rise to Talniflumate differentiated myocytes which form new muscle mass materials or fuse with existing materials and contribute to muscle mass growth and restoration [1]. (healthyguide.info)

They proliferate easily in culture and can be cryopreserved without loss of phenotype or differentiation potential. (vin.com)
The AD-iPSCs were differentiated into neuronal cells, in order to generate disease-specific protein association networks modeling the molecular pathology on the transcriptome level of AD, to analyse the reflection of the disease phenotype in gene expression in AD-iPS neuronal cells, in particular in the ubiquitin-proteasome system (UPS), and to address expression of typical AD proteins. (biomedcentral.com)
Our data indicate that this signaling system controls key aspects of a mature vascular smooth muscle cell phenotype, including a capacity to respond to vasoactive agonists in post-natal life. (bu.edu)
An important extension of this work is to understand how the phenotype of smooth muscle cell populations becomes altered in disease. (bu.edu)

Second, it results in the modulation of the Wnt signaling pathway that governs cell differentiation. (shinshu-u.ac.jp)
These data suggest that Akt2 expression is fundamental to the differentiated state of fat and muscle cells and that activation of AKT2 kinase by insulin is mediated through the phosphatidylinositol 3-kinase signaling pathway. (nih.gov)

The FUNGENES project aimed to achieve a detailed basic understanding of stem cell self-renewal and differentiation. (europa.eu)
Self-renewal and pluripotency-the capacity to form any cell lineage-are inherent characteristics of induced pluripotent stem cells (iPSCs). (shinshu-u.ac.jp)
MVSCs have a self-renewal ability and express markers of neural crest stem cells (NCSCs) such as Sox10 and Sox17. (biomedcentral.com)

hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
These stem cells come from developed organs and tissues in the body. (healthline.com)
Recent years have brought increased interest in the potential for adult stem cells to help in the treatment of many diseases through both their regenerative properties as well as their apparent ability to alter the environment in injured and diseased tissues. (vin.com)
Adult stem cells can be obtained from many differentiated tissues including but not limited to bone marrow, bone, fat, and muscle. (vin.com)
As a type of MSCs derived from dental tissues, human dental pulp stem cells (hDPSCs) are easily and readily isolated from extracted teeth. (biomedcentral.com)
Specialized tissues can develop by cell differentiation in multicellular organisms. (bioknowledgy.info)
Ethics of the therapeutic use of stem cells from specially created embryos, from the umbilical cord blood of a new-born baby and from an adult's own tissues. (bioknowledgy.info)
Use of a light microscope to investigate the structure of cells and tissues, with drawing of cells. (bioknowledgy.info)
In this Chapter, we dissect the proof-of-principle studies that demonstrated that cellular reprogramming to pluripotency can be induced in vivo, in spite of unfavorable pro-differentiation signals present within the tissues. (springer.com)
All tissues originate from stem cells. (bvsalud.org)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)

The effect of external signals on myogenic differentiation of BLC6 cells was demonstrated by cocultivation with visceral endodermal END-2 cells and the activin A-secreting WEHI-3 cells. (uni-luebeck.de)
The embryonic AMPs are at the origin of all adult fly muscles and, as we demonstrate here, they express repressors of myogenic differentiation and targets of the Notch pathway known to be involved in muscle cell stemness. (biologists.com)

Nevertheless, since we have previously observed that the suspension bioreactor environment enhances ESC pluripotency, while suppressing differentiation effectiveness [17], we wanted to investigate whether this trend would also happen in during cardiomyocyte differentiation. (bioinbrief.com)
The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)

Fusion depends on muscle-specific proteins known as fusogens called myomaker and myomerger. (wikipedia.org)
Therefore, the expression of embryonic proteins, such as alpha-fetoprotein (AFP) and bhCG, are indicative of malignant germ cell elements. (medscape.com)
Neither of these proteins has proven valuable in the diagnosis of pineal parenchymal cell tumors. (medscape.com)

It is widely used in biomedical research, mainly for studying developmental biology, stem cell biology, cell differentiation, and drug screening. (cytion.com)
The unique educational content found on this site was developed collaboratively with award-winning high school educators, international stem cell organizations, and professional medical animators-creating dynamic and engaging educational resources that teach pertinent cellular biology topics through the lens of stem cells and cellular reprogramming. (ca.gov)
It contains stem cell biology, ethics, and policy information and teaching resources. (ca.gov)
Published by Oxford University Press on behalf of Journal of Molecular Cell Biology, IBCB, SIBS, CAS. (deepdyve.com)
Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. (rupress.org)
When this connection was made, it launched a whole new field," says Isidore Rigoutsos, Ph.D., professor of pathology, anatomy, and cell biology and director of the Computational Medicine Center at Thomas Jefferson University. (pharmaceuticalintelligence.com)
He is an-NIH funded Principal Investigator and Director of the Stem Cell Biology Program at the Boston University Pulmonary Center. (bu.edu)
Advancements in the field have also been limited by impediments imposed by the unique biology of the lung, including its marked cellular complexity and slow cell turnover. (bu.edu)
Nature Reviews Molecular Cell Biology 2012;13(2):127-33. (scielo.br)
4 ] in 1951 cell culturing has become one of the most widely used methods with exceptional contribution to the advances in almost all fields of contemporary biology - cell biology, genetics, cell biochemistry, physiology etc. (intechopen.com)
versions our knowledge of stem and advancement cell biology from the individual lung remains to be small. (morainetownshipdems.org)
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. (lu.se)

Investigation of the mechanisms that control γ- from α-MN differentiation has been limited by the lack of available molecular markers to distinguish these functionally distinct subpopulations during development, as molecular differences between postnatal α- and γ-MNs have only recently been demonstrated [ 6 ]. (biomedcentral.com)
Collectively our data suggest that the balance of Nkx3.2 Sox9 and Pax3 can act as a molecular switch during the chondrogenic differentiation of satellite cells which may play an important part in the healing process experiments were normalized to GAPDH. (healthyguide.info)
Taking into consideration a recently available idea of cancers stem cells [7], [8], NCCs may talk about molecular features common to malignant tumors. (globaltechbiz.com)
Cellular and molecular regulation of muscle regeneration. (scielo.br)
In characterizing the molecular differentiation of developing peripheral auditory structures, we discovered that hepatocyte growth factor ( Hgf ) is expressed in the future stria vascularis of the cochlear epithelium. (jneurosci.org)
In addition to their histologic characteristics, germ cell tumors retain molecular characteristics of their primordial lineage. (medscape.com)

This co-culture system allows investigation into the effects of myocyte derived soluble factors uponepicardial EMT and mesenchymal cell differentiation. (arizona.edu)

Whereas the developmental route of trunk muscles from mesoderm is well studied, that of head muscles is ill defined. (ncbs.res.in)
Thus, P19 cells can be useful in studying cell differentiation and developmental processes. (cytion.com)
The developmental capacity of nuclei taken from differentiating endoderm cells of Xenopus laevis. (springer.com)
The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. (springer.com)
The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs. (springer.com)

They also found that without Braveheart, MesP1, the master gene that regulates heart-cell differentiation in vertebrate animals, doesn't work . (medicalnewstoday.com)
We showed that Krüppel-like transcription factor 4 (Klf4) regulates the choice of differentiation pathway of these cells through β-catenin activation and was itself regulated by the canonical Wnt pathway activator lithium chloride. (ox.ac.uk)

In vivo investigation has shown that MVSCs can be activated by vascular injuries, become proliferative, and differentiate into smooth muscle cells (SMCs). (biomedcentral.com)

Its major objective was to produce a gene expression atlas covering the development of ES cells into all three germ layers (ecto-, meso-, and endoderm) and into somatic cells. (europa.eu)
Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity. (springer.com)
Markers have been most helpful in the workup of patients with germ cell tumors. (medscape.com)
Other biological markers for germ cell tumors include lactate dehydrogenase isoenzymes and placental alkaline phosphatase, although these are less specific. (medscape.com)
AFP is a glycoprotein produced by fetal yolk sac elements and is produced by a wide range of cancers , including gastric , liver, and colon adenocarcinoma , as well as extracranial germ cell tumors. (medscape.com)
Significant variability in expression of tumor markers is such that the absence of AFP or bhCG does not rule out a mixed germ cell tumor. (medscape.com)
Pineal parenchymal cell tumor markers are less well characterized than their germ cell counterparts and include melatonin and the S antigen. (medscape.com)
ES cells are pluripotent cells, which mean that they can give rise to all differentiated cell types derived from all three germ layers. (bvsalud.org)

Launch Neural crest cells (NCCs) are cell populations that originate in the first stage from the vertebrate embryo in the dorsal region from the neural pipe. (globaltechbiz.com)
During mouse embryonic development, a subpopulation of neural crest cell-derived melanocytes migrates and incorporates into a subregion of the cochlear epithelium, forming the intermediate cell layer of the stria vascularis. (jneurosci.org)
The neural crest (NC) is comprised of specialized cells that arise from the lateral border of the neural plate and migrate into specific locations during vertebrate embryonic development. (jneurosci.org)
Several types of stem cells have been explored for peripheral nerve regeneration (PNR), including umbilical cord blood stem cells, bone marrow-derived stem cells, adipose-derived stem cells, and neural stem cells [ 5 ]. (biomedcentral.com)
We postulated that MVSCs may benefit PNR by differentiating into neural and/or vascular cell types in the regenerated nerve. (biomedcentral.com)

Stem cell persist through the life of a multi-cellular organism, this enables organisms to digest severely damaged cells and replacement them, i.e. wounds can be healed. (bioknowledgy.info)
Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)

This study demonstrates HOX-dependent differentiation of CD44(+) VW-MPSCs into SMC that involves epigenetic modification of transgelin as a down-stream regulated gene. (lonza.com)

The thin myofilaments are filaments of mostly actin and the thick filaments are of mostly myosin and they slide over each other to shorten the fiber length in a muscle contraction. (wikipedia.org)
In striations of muscle bands, myosin forms the dark filaments that make up the A band. (wikipedia.org)

For example, hematopoietic stem cells are a type of adult stem cell found in bone marrow. (healthline.com)
Doctors have been performing stem cell transplants, also known as bone marrow transplants, for decades using hematopoietic stem cells in order to treat certain types of cancer. (healthline.com)

In reality, gene somatic cells to a pluripotent cell state by a handful of transcrip- expression is graded, making the potential gene expression tion factors (Takahashi and Yamanaka, 2006). (lu.se)

We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. (lu.se)

There are three types of myofilaments: thin, thick, and elastic that work together to produce a muscle contraction. (wikipedia.org)
They can be differentiated into other cell types when exposed to non-toxic drugs such as retinoic acid and dimethyl sulfoxide (DMSO) [1]. (cytion.com)
In any case, the respective cell types may then be selectively cultured to enrich their percentage population to eventually obtain a single cell type and culture. (justia.com)
Next, students identify stages in the development of human embryos and compare the types and potencies of stem cells. (ca.gov)
Since stem cells have the ability to turn into various other types of cells, scientists believe that they can be useful for treating and understanding diseases. (healthline.com)
There are several types of stem cells that can be used for different purposes. (healthline.com)
They make new red blood cells, white blood cells, and other types of blood cells. (healthline.com)
Adult stem cells can't differentiate into as many other types of cells as embryonic stem cells can. (healthline.com)
These new types of cells are called induced pluripotent stem cells (iPSCs). (healthline.com)
They can differentiate into all types of specialized cells in the body. (healthline.com)
Updating and significantly expanding upon the previous editions, Basic Cell Culture Protocols, Fourth Edition provides the novice cell culturist with sufficient information to perform the basic techniques, to ensure the health and identity of their cell lines, and to be able to isolate and culture specialized primary cell types. (dattanibookagency.in)
The intent of this extensive volume is to generate a valuable resource containing clear methodologies pertinent to current areas of investigation, rather than attempting to educate cell culturists on specific cell types or organ systems. (dattanibookagency.in)
Some study the cell growth, or how specialized cell types differentiate from stem cells. (encyclopedia.com)
In a new study published this week, a team describes how some of it codes for a genetic snippet of "long non-coding RNA" (or lncRNA) that controls the destiny of stem cells that differentiate into various types of heart cell. (medicalnewstoday.com)
These three types of specialised human cells are structurally very different and perform certain functions much more efficiently than an unspecialised cell, such as the embryonic cells above, could. (bioknowledgy.info)
Therefore, cNCCs present wider variation within their differentiated cell types than tNCCs Captopril disulfide during regular advancement. (globaltechbiz.com)
The objective of this work is to determine the specific types of differentiated lung cells that arise from the mesothelium along with the key signals involved in these cell fate decisions. (bu.edu)
The lethality of mdm2 −/− mice before implantation makes it impossible to analyze Mdm2 interaction with p53 in vivo at specific times of development, at postnatal/adult stages, or in specific cell types. (molvis.org)
Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)
To date, four types of human dental stem cells have been isolated and characterized: (i) dental pulp stem cells (DPSCs) 12 (ii) stem cells from exfoliated deciduous teeth (SHED) 21 (iii) stem cells from apical papilla (SCAP) 31 (iv) periodontal ligament stem cells (PDLSCs) 28 . (bvsalud.org)
The heart is constituted by three types of muscle: atrial, ventricular, and specialized excitatory and conducting fibers. (bvsalud.org)

Laboratory work has centered on the mechanisms of how cells acquire specific fates during growth and development, providing insights into normal and abnormal mechanisms of growth control. (stanford.edu)
To investigate underlying disease mechanisms, induced pluripotent stem cells (iPSCs) allow the generation of patient-derived neuronal cells in a dish. (biomedcentral.com)
The advantages of a γ-fusimotor system to control spindle sensitivity independently of force-generating extrafusal muscle fibers are not fully understood, nor are the mechanisms that generate the distinct γ- and α-MN subtypes in mammals. (biomedcentral.com)
This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
However, the underlying mechanisms related to paracrine effect or the differentiation of transplanted cells into neurogenic or angiogenetic cells are still not well understood. (biomedcentral.com)

Mitochondria not only serve as power plants in cells but also act as crucial regulators in many biological processes, including reactive oxygen species (ROS) signaling, redox balance, calcium homeostasis, protein quality control, and programmed cell death ( 3 , 4 ). (frontiersin.org)

This occurs during myogenesis with the fusion of myoblasts each contributing a nucleus to the newly formed muscle cell or myotube. (wikipedia.org)
embryologically, this multinucleate condition results from multiple myoblasts fusing to produce each muscle fiber, where each myoblast contributes one nucleus. (wikipedia.org)
In situ hybridization demonstrates transcripts for myogenin and myoD accumulating in mono- and multinucleated myogenic cells, while myf5 mRNA is already found in mononucleated myoblasts. (uni-luebeck.de)

We developed an improved protocol for isolating embryonic myocyte cells, for use in co-cultures with epicardial cells. (arizona.edu)
During myocyte differentiation the density of L-type Ca 2+ channels significantly increases while the density of T-type Ca 2+ channels decreases. (uni-luebeck.de)

Students begin by studying planaria as a model organism using a lab protocol incorporated in the CIRM-developed Unit 2: Adult Stem Cells, Homeostasis, and Regenerative Medicine. (ca.gov)
Unfortunately, regenerative medicine is not yet feasible outside a laboratory setting as available protocols to generate target cells are complicated and expensive. (shinshu-u.ac.jp)
Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. (scielo.br)
Stem cells and regenerative medicine - future perspectives. (springer.com)
Stem cells in regenerative medicine: introduction. (springer.com)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
Regenerative endodontic procedures can be defined as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex. (bvsalud.org)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

This complex process occurs in several steps and controls the development of pluripotent cells into highly specialised cells of an organism. (europa.eu)
With these markers of γ-MN identity, we show after conditional elimination of GDNF from muscle spindles that the survival of γ-MNs is selectively dependent on spindle-derived GDNF during the first 2 weeks of postnatal development. (biomedcentral.com)
These studies address important questions regarding the role of these cells not only in development, but also in homeostasis and disease. (bu.edu)
NC cells contribute to several inner ear structures during embryonic development. (jneurosci.org)
I also describe the development of a novel behavioural task that is predictive of mesDA neuron cell loss in mice. (lu.se)

There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)

We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. (frontiersin.org)
Heparan sulfate proteoglycans (HSPGs) are present on the cell surface and in the extracellular matrix in all metazoans. (scielo.br)
When activated by injury, satellite cells reenter the cell cycle and proliferate in response to extracellular growth factors ( Relaix & Zammit, 2012 Relaix F, Zammit PS. (scielo.br)

Adult stem cells have a misleading name, because they are also found in infants and children. (healthline.com)
Scientists have recently discovered how to turn adult stem cells into pluripotent stem cells. (healthline.com)
To create iPSCs, scientists genetically reprogram the adult stem cells so they behave like embryonic stem cells. (healthline.com)
Adult stem cells don't present any ethical problems. (healthline.com)
In particular, adult stem cells called mesenchymal stem cells can migrate to affected areas and may be able to support the growth of other stem cells as well as moderate the response of the immune system. (vin.com)
Stem cells are generally divided into two groups, embryonic stem cells and adult stem cells. (vin.com)
Obtaining adult stem cells also does not raise ethical concerns. (vin.com)
These adult stem cells have demonstrated promising therapeutic benefits with less concerns about ethics, regulation, and tumor formation, as compared to embryonic stem cells. (biomedcentral.com)

The sarcoplasmic reticulum serves as a reservoir for calcium ions, so when an action potential spreads over the T-tubule, it signals the sarcoplasmic reticulum to release calcium ions from the gated membrane channels to stimulate muscle contraction. (wikipedia.org)
The cell- ations in these signals (see Table 1 for a glossary of terms). (lu.se)
A key challenge is to understand how state, but must also afford flexibility in cell-fate choice to permit the different cell-fate options confronting stem and progenitor cell-type diversification and differentiation in response to cells are selected and coordinated such that adoption of a given intrinsic cues or extrinsic signals. (lu.se)

Pluripotent teratocarcinoma-thymus somatic cell hybrids. (springer.com)

A conclusion This scholarly research demonstrates that although cardiomyocyte difference can CL 316243 disodium salt manufacture end up being attained in stirred suspension system bioreactors, the addition of moderate boosters is certainly not really sufficient to power comprehensive difference as liquid shear factors show up to maintain a subpopulation of cells in a transient pluripotent condition. (bioinbrief.com)

Anatomy75

Organisms22

Diseases10

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes56

Disciplines and Occupations2

Information Science3

Endothelial16

Multinucleated skeletal muscle cells1

Cardiomyocytes11

Progenitor cells6

Vitro13

Pathways8

Progenitors8

Mouse embryonic stem1

Cardiac13

Human embryonic stem4

Lineages8

Skeletal19

Genes16

Murine7

Terminally differentiated cell1

Neurons10

Precursor cells2

Functional16

Tissue18

ESCs8

Induce8

Pluripotent embryonic1

Precursors2

Mesothelial cells3

Fibroblast2

Epithelial7

Proliferation4

Myocytes3

Phenotype4

Signaling pathway2

Self-renewal3

Tissues11

Myogenic differentiation2

Cardiomyocyte differentiation2

Proteins3

Biology12

Molecular6

Mesenchymal cell1

Developmental5

Regulates2

SMCs1

Germ8

Neural5

Cellular2

Study demonstrates1

Myosin2

Bone marrow2

Gene expression1

Hematopoietic1

Types21

Mechanisms5

Processes1

Myoblasts3

Myocyte2

Regenerative10

Development5

Regeneration1

Extracellular3

Adult stem8

Signals3

Somatic1

Demonstrates1