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  • Proteins
  • The incomplete organizer in boz mutants is deficient in expression of a number of factors such as Chordin that antagonize Bone morphogenetic proteins (Bmps), and Dickkopf 1, a Wnt antagonist. (zfin.org)
  • Also, candidate organizer/activator proteins in fungi and amoeba are identified and hypothetical activation models are suggested. (biomedcentral.com)
  • Although most of these secreted factors bind to and antagonize the activity of Wnt and/or BMP proteins produced by non-organizer cells, these factors do not repress Wnt or BMP transcription, and are therefore not sufficient to exclude Wnt and BMP expression from the organizer. (biologists.org)
  • zona limitans intra
  • A central diencephalic organizer, the zona limitans intrathalamica (ZLI), appears after neurulation in the central diencephalic alar plate, establishing additional antero-posterior positional information inside diencephalic alar plate. (frontiersin.org)
  • The two main brain internal organizers are the isthmus organizer (IsO) and the zona limitans intrathalamica (ZLI). (biomedcentral.com)
  • genes
  • Despite the plethora of genes already mined from Spemann organizer tissue, Bighead encodes a secreted protein that proved to be a potent inhibitor of Wnt signaling in a number of embryological and cultured cell signaling assays. (pnas.org)
  • These organizers are located at the interface of the expression domains of key patterning genes ( Fezf - Irx and Otx - Gbx , respectively). (biomedcentral.com)
  • (A) Topological location of the ZLI and IsO organizers and the key genes determining their position in a schematic view of a generalized developing vertebrate central nervous system. (biomedcentral.com)
  • amphibian
  • Here, we take an in-depth look at the structure and function of organizers across species and note that, whereas the amphibian organizer is a contingent collection of elements, each performing a specific function, the elements of organizers in other species are dispersed in time and space. (biologists.org)
  • goosecoid
  • We find that removal of the morphological shield does not remove all goosecoid- and floating head-expressing cells, suggesting that the morphological shield does not comprise the entire organizer region. (zfin.org)
  • nodal
  • boz cooperates with the Nodal-related secreted factors, Cyclops and Squint, in organizer formation. (zfin.org)
  • experiments
  • The experiments which finally led to the discovery of the phenomena which are now designated as "organizer-effect" were prompted by a question which actually goes back to the beginnings of developmental mechanics, indeed to the beginnings of the history of evolution in general. (nobelprize.org)
  • forebrain
  • a Horizontal view of embryonic brains through the anterior forebrain, highlighting the morphological diversity of the hypothalamic recesses (ventricular zones are shown in black). (biomedcentral.com)
  • promotes
  • Bozozok itself acts as a transcriptional repressor, and promotes organizer formation by directly inhibiting expression of the bmp2b (swirl) gene and by negatively regulating Wnt signaling by an unknown mechanism. (zfin.org)
  • comprise
  • Organizers, which comprise groups of cells with the ability to instruct adjacent cells into specific states, represent a key principle in developmental biology. (biologists.org)
  • adult
  • Somehow during the metamorphosis from sphere to salamander (or sparrow, or sperm whale), an embryonic cell must learn its adult identity. (nautil.us)
  • notochord
  • Complete removal of the embryonic shield and adjacent marginal tissue, however, leads to a loss of both prechordal plate and notochord. (zfin.org)
  • cell
  • The organizer is a non-homogenous cell population in terms of inductive signals, morphogenetic activities and cell fate. (biologists.org)
  • The RAM can be divided into three main zones: (a) the meristematic zone at the root tip containing the stem cell niche, (b) the elongation zone, containing the cells that after cell divisions have left the meristematic zone and are now elongating, and (c) the differentiation zone, containing cells that have acquired their destined cell fates. (frontiersin.org)
  • node
  • The tissue he was transplanting contained a structure known as the node (see Glossary, Box 1 ), and led to a conceptual association between the node and the organizer. (biologists.org)
  • invertebrates
  • Despite an overtly bilateral-symmetric body-plan, all vertebrates (and many invertebrates) exhibit a striking left-right (LR) asymmetry of the heart, viscera and brain that is conserved through evolution, and in all normal individuals. (biologists.org)