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  • Genes
  • We identified mutations in the pavarotti (pav) and tumbleweed (tum) genes needed for cytokinesis by a phenotype of large and multinucleate cells in the embryonic epidermis and nervous system. (mit.edu)
  • Yamanaka found four genes that provide cells pluripotency, that means the same capacity to generate all the body's specialized cell types, than embryonic stem cells do have. (salem-news.com)
  • We believe chronic injury to the lungs by cigarette smoking re-activates genes in the Hedgehog pathway to repair cell damage in the lining of the lungs. (scienceblog.com)
  • In this work we evaluated several genes involved in gluconeogenesis, glycolysis and glycogen metabolism, the major pathways for carbohydrate catabolism and anabolism, in the BME26 Rhipicephalus microplus embryonic cell line. (mdpi.com)
  • BME26 cells in media were investigated using three different glucose concentrations, and changes in the transcription levels of target genes in response to carbohydrate utilization were assessed. (mdpi.com)
  • In addition, RNAi data from this study revealed that the transcription of gluconeogenic genes in BME26 cells is controlled by GSK-3. (mdpi.com)
  • Derivation
  • Judge Douglas Ginsburg, appointed by President Ronald Reagan, wrote that it was "entirely reasonable" for the NIH to interpret the law as "permitting funding for research using cell lines derived without federal funding, even as it bars funding for the derivation of additional lines. (reuters.com)
  • Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property. (springer.com)
  • research
  • With this news may end the controversy over keeping embryonic stem cells for research. (emaxhealth.com)
  • Having Geron's study given the go-ahead, "is an important milestone for the whole field," said Alan Trounson, president of the California Institute for Regenerative Medicine, a state agency that promotes research with human embryonic stem cells. (mercurynews.com)
  • The ongoing and regular assault to the lungs by cigarettes causes the usually dormant pathway to be stuck in activation mode making too many new cells, ultimately resulting in cancer," says Neil Watkins, Ph.D., research associate at the Kimmel Cancer Center and lead author of the study. (scienceblog.com)
  • This study represents one of the first attempts to therapeutically manipulate this cell pathway, and it's a perfect example of how basic developmental science can have clinical implications in a relatively short period of time," says Stephen B. Baylin, M.D., Ludwig professor of oncology and director of research at the Kimmel Cancer Center. (scienceblog.com)
  • Shortly after taking office in 2009, President Barack Obama expanded federal funding for research involving human embryonic stem cells in hopes it would lead to cures for diseases. (reuters.com)
  • They soon recognized the research potential of these intriguing entities, which can both replicate themselves and be nudged into becoming any of the body's 200-plus cell types 3 , 4 . (nature.com)
  • In 2001, US President George W. Bush restricted government funding to research on just a few existing ES-cell lines. (nature.com)
  • The decision effectively forced those intent on carrying out the research in the United States to seek private or state funding , and often to create duplicate laboratories - one for ES-cell research and another for work funded by the US federal government. (nature.com)
  • Other research has detailed the use of stem cells for the treatment of cardiovascular disease, brain disorders and blood diseases. (medicalnewstoday.com)
  • The research team was inspired by the ability of a plant callus - a collection of plant cells that grow into a new plant after being injured on an existing plant. (medicalnewstoday.com)
  • Unless you can make this process look as simple as a cheek scraping for human cells (allergy research, for instance) the objections will not abate. (slashdot.org)
  • I'm sorry, but the idea that embryonic stem cells could have become a baby is precisely the objection that most of the people who object to ESC research have. (slashdot.org)
  • With the stroke of a pen, President Barack Obama this morning removed the limits on federal funding of research on human embryonic stem cells (ESCs) imposed by his immediate predecessor. (newscientist.com)
  • As a compromise, President George Bush announced on 9 August 2001 that federal funds would only be made available for research on cell lines derived prior to that date. (newscientist.com)
  • For US biologists who work on human ESCs, Obama's executive order means the end to an administrative nightmare that has seen them set up separate lab space and equipment to ensure that federal dollars are not inadvertently used for research on non-authorised cells. (newscientist.com)
  • teleost
  • They have been transfected using liposomes with a commercial plasmid vector containing a reporter gene, thus suggesting a possible importance as an alternative expression system of recombinant vertebrate proteins in teleost cells. (sigmaaldrich.com)
  • findings
  • They confirmed these findings by looking at SCLC cell lines in which five of seven lines examined showed similar activation of the Hedgehog pathway and Gli1 gene. (scienceblog.com)
  • embryogenesis
  • To identify cell-cycle components whose maternal pools are depleted in embryogenesis or that have specific functions in embryogenesis, we screened for mutants defective in cell division during embryogenesis. (mit.edu)
  • During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in all germ-layers. (xenbase.org)
  • somatic
  • and Somatic Cell Nuclear Transfer, which has been largely forgotten, but offers very interesting possibilities. (brighttalk.com)
  • type
  • After that, the doctors can then decide what cell type to make it. (emaxhealth.com)
  • After 9-15 days, when clumps of cells have formed, cells from the periphery are separated and replated in the same type of culture medium. (bioedonline.org)
  • ESCs can develop into any other cell type found in the body, and so have huge potential for use in medicine, to repair lost or damaged tissues. (newscientist.com)
  • types
  • This means that doctors can than take these cells and create different types of cells from them, including pancreatic cells or other cells that may help treat many conditions. (emaxhealth.com)
  • mutations
  • The mutations causing truncation of the protein affect cell fate of the NB6-4 neuroblast, whereas the weak missense mutation has no effect. (mit.edu)
  • fate
  • These permitted us to investigate the requirements for Cyclin E function in neuroblast cell fate determination, a role previously shown for a null Cyclin E allele. (mit.edu)
  • Yet, Sox2 is more sensitive than Cdx2 to Yap1/Wwtr1 dosage, leading cells to a state of conflicted cell fate when YAP1/WWTR1 activity is moderate. (elifesciences.org)
  • hopes
  • Santa Monica-based Advanced Cell Technology hopes to win approval soon to study a treatment it has developed for patients suffering from an eye disease called Stargardt's macular dystrophy. (mercurynews.com)
  • found
  • The cells, found in amniotic fluid, can be harvested without harm to the donor or the donor's unborn child. (slashdot.org)