Embryonic cadmium levels were significantly level of exposure. Medical search. Frequent questions

Comparative transcriptome analysis showed that the expression levels of 9152 genes changed under Cd stress (4658 upregulated and 4494 downregulated). (biomedcentral.com)
Kyoto Encyclopedia of Genes and Genomes (KEGG) indicated that the carbon metabolism, glutathione metabolism, metabolism of xenobiotics by cytochrome P450, and ABC transporters were significantly differentially expressed components between Cd stress and NaHS treatment under Cd stress in T. thermophila . (biomedcentral.com)
To survive against the stresses, different organisms have evolved a complex of mechanisms involving multiple genes and strategies at physiological, molecular and metabolic levels, such as activating antioxidants, increasing efflux, and overexpressing metal chelators. (biomedcentral.com)
During preimplantation embryonic development, imprinting genes are susceptible to methylation changes by artificial manipulation, which may lead to developmental abnormalities. (ndltd.org)
Epigenetic control of genes that are silent in embryonic stem cells, but destined for expression during differentiation, includes distinctive hallmarks, such as simultaneous activating/repressing (bivalent) modifications of chromatin and DNA hypomethylation at enhancers of gene expression. (pdgf-receptor.com)

I exposed these invertebrates to stress using elevated concentrations of trace metals, W. subatra to copper in the field, and S. plicata to cadmium and zinc via seawater or food in the laboratory. (edu.au)
To assess the uptake and loss of metals with repeated exposure, I exposed S. plicata twice to cadmium and/or zinc in seawater. (edu.au)
This case-control study during 2003-04 compared serum zinc levels and other variables in 23 mothers of neonates affected with NTD and 36 mothers with normal healthy neonates in Dezyani hospital in Gorgan. (who.int)
To estimate the zinc level in mothers of in Scandinavian countries [ 4 ]. (who.int)

In addition, the gestational window is critical because exposures outside certain gestational periods may be nontoxic, while the same doses can cause devastating results within the window. (medscape.com)
We quantified urine cotinine concentrations in mothers once from 12th to 20th gestational weeks and excluded those whose urine cotinine levels exceeded 42.7 ng/ml to represent SHS exposure in early pregnancy. (biomedcentral.com)

Sex differences at the genetic/epigenetic level in early development. (ubc.ca)
Furthermore, using the developed, assay the epigenetic effects of three endocrine disruptors, simazine, propiconazole, and cadmium chloride (CdCl2) on in-vitro cultured single blastocysts were revealed. (ndltd.org)

However, the exposure of these cells to excessive levels of oxidative stress by too high levels of ROS or too low levels of antioxidative protection will render these cells dysfunctional thereby failing the fertilization process and causing couples to be infertile. (hindawi.com)
Consistently, both CdSO 4 and ANF caused significant oxidative stress , including decreases in the reduced glutathione (GSH) level, inhibition of superoxide dismutase (SOD) activity, as well as increases in malondialdehyde (MDA) content in zebrafish embryo s, but these mixtures produced much more significant alterations on the biomarkers. (zju.edu.cn)
Our findings led us to conclude that a low level of MWirradiation-induced oxidative stress not only suppresses implantation, but it may alsolead to deformity of the embryo in case pregnancy continues. (nomedicalcare.com)
Exposure to BaP induced DNA damage directly, or oxidative stress-related damage, resulting in cell apoptosis and carcinogenesis in human respiratory system, digestive system, reproductive system, etc. (biomedcentral.com)

[ 2 ] A number of modalities may be required for diagnosis and treatment of exposures in pregnancy. (medscape.com)
The association between exposure to secondhand smoke (SHS) during pregnancy and a child's neurodevelopment has not been established yet. (biomedcentral.com)
Maternal exposure to SHS during pregnancy may result in delayed MDI in early childhood. (biomedcentral.com)
If you're health conscious, there's a good chance you've read up on foods and supplements to optimize your health in pregnancy, but have you thought about exposure to toxins? (lilynicholsrdn.com)
Discuss that exposure to secondhand smoke during pregnancy also appears to have adverse effects, including stillbirth and low birth weight. (medilib.ir)

Therefore, more attention should be paid to pregnant women and infants who are susceptible to SHS exposure. (biomedcentral.com)

Prolonged exposure to high concentrations of ZDTPs, calcium alkyl phenates, and magnesium, sodium, and calcium sulphonates had significant effects on the reproductive organs of male rabbits (testicular atrophy and reduction or absence of spermatozoa) which appeared to be species specific. (cdc.gov)
Thirty-day treatment of rats with piperine significantly increased serum T levels without affecting LH concentrations. (frontiersin.org)
A significant increase of the bpm in adults exposed to high concentrations of smoked CB leachate was observed after 48 h of exposure. (easychair.org)
Finally, the nasal lesions associated with exposure to high concentrations of MeI in rats are best supported by a mode of action that involves glutathione (GSH) depletion in the nasal epithelial tissue. (cdc.gov)

Here we summarized the changes in DNA methylation in BaP exposure, and revealed the methylation of DNA plays a role in cancer development. (biomedcentral.com)

Reproductive risk of toxicant exposure includes fetal effects, especially congenital anomalies. (medscape.com)
Harmful exposure to these environmental risks could begin in the mother's womb and affect fetal development. (biomedcentral.com)
Recent studies have indicated that exposures to methyl iodide (MeI) produce a number of effects in laboratory animals, including fetal toxicity, neurotoxicity, and degeneration of the nasal epithelium. (cdc.gov)
Recent studies have indicated that exposures to methyl based pharmacokinetic (PBPK) modeling, and evaluat- iodide (MeI) produce a number of effects in laboratory ani- ing the relevance of the observations in animals to human mals, including fetal toxicity, neurotoxicity, and degenera- health. (cdc.gov)

Exposure to active smoking and secondhand smoke (SHS) causes health concern. (biomedcentral.com)

Paternal sperm DNA damage has negative effects on the integrity of early embryonic development as the percentage of good quality embryos as well as implantation rates was significantly reduced in patients exhibiting high DNA damage [ 27 ] and it appears that the second and third mitoses are the sensitive periods [ 28 ]. (hindawi.com)
Marine tests showed an inhibition of growth with the two different algal species (P. tricornutum and D. tertiolecta), an inhibition of bioluminescence in the bacterium A. fischeri, an alteration on the correct early development of the serpulid F. enigmaticus larvae and immobilization of the copepod A. tonsa individuals at both 24 and 48 hours of exposure. (easychair.org)
A deep and proliferative root system helps extract sufficient water and nutrients under these stress conditions 74 .Since roots grow underground, they are the ﬁrst to sense abiotic stresses and adjust their genetic program for post-embryonic development to survive the stress 43 . (oap-onlinejournals.org)
Individual and joint toxic effects of cadmium sulfate and α-naphthoflavone on the development of zebrafish embryo[J]. Journal of Zhejiang University Science B, 2014, 15(9): 766-775. (zju.edu.cn)

Vincristine formulated in the targeted liposomes showed significantly higher levels of cytotoxicity towards Raji cells than the nontargeted liposomal drug. (dna-pksignal.com)
Modulation of intracellular GSH levels showed that the cytotoxicity and induction of the Nrf2-mediated pathway by MGO, GO and 3-DG was significantly enhanced by depletion of GSH, while a decrease in Nrf2-activation by MGO and GO but not 3-DG was observed upon an increase of the cellular GSH levels. (ebsco.com)

It is well known that SHS exposure brings about almost the same adverse health outcomes as active smoking [ 3 ]. (biomedcentral.com)
For this reason, implies a more detailed understanding and description of a risk assessment is required to characterize the potential events, often at the molecular level, than is meant by mode for adverse health effects associated with acute exposures. (cdc.gov)

Public health authorities are concerned that electronic cigarettes may increase overall nicotine exposure for young people and increase use of burned tobacco products among young and older people by acting as a gateway drug for non-smokers and sustaining or restarting nicotine addiction among smokers and former smokers, respectively. (wikipedia.org)
The Canadian Cancer Society has stated that, "A few studies have shown that there may be low levels of harmful substances in some e-cigarettes, even if they don't have nicotine. (wikipedia.org)

A general linear model was used to assess the relationship between maternal urinary cotinine level and neurodevelopment. (biomedcentral.com)

The Influence of Intracellular Glutathione Levels on the Induction of Nrf2-Mediated Gene Expression by α-Dicarbonyl Precursors of Advanced Glycation End Products. (ebsco.com)
This study aimed to investigate the role of intracellular glutathione (GSH) levels in the induction of Nrf2-mediated gene expression by α-dicarbonyl compounds. (ebsco.com)

In one example, an electromagnetic field generator is disposed on a substrate and configured to deliver power via electromagnetic energy to a thin region proximate to (above) a surface of the substrate, wherein electromagnetic field intensity decreases significantly beyond the thin region. (patentsencyclopedia.com)

It is therefore difficult to generalize the harmful effects, but a certain number of effects can be identified, at the cellular level but also at the level of the various large "systems" of the human body. (veillenanos.fr)

Irradiation methods and apparatus configured to deliver power, via electromagnetic fields at a variety of frequencies and power levels, in a localized fashion to a target area. (patentsencyclopedia.com)

The disruption of the levels of steroid hormones Animal Genetics and Breeding of the Ministry of Agriculture, Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and caused the mature failure of in vitro cultured oocytes. (sagepub.com)

The exposure of 30 μM Cd resulted in T. thermophila growth inhibition, cell nigrescence, and malondialdehyde (MDA) content considerably increase. (biomedcentral.com)

Two determinations must be made when a physician responds to a patient's concerns about a specific exposure: (1) whether any quantity of the toxicant has known adverse effects on reproduction in humans and (2) whether the substance is present in sufficient quantity to affect the patient or population exposed. (medscape.com)
Cadmium (Cd) is a nonessential heavy metal with potentially deleterious effects on different organisms. (biomedcentral.com)
Although the health effects of high levels of EROD are unknown, the mechanism of enzyme induction produces highly reactive intermediates of certain contaminants which may cause the onset of carcinogenesis, cell death and embryonic mortality. (gov.scot)
Although effects of prenatal exposure to SHS on early neurodevelopment vary among studies, they remain significant issues. (biomedcentral.com)
possibly, these Effects are unit-level Not to Make outdated of the own Accountants of download fundamentals of three dimensional digital image processing, some of which go it new to motivation. (ohlookprod.com)
An understanding of the mode(s) of action by which these with incomplete information, and because mode of action effects are produced by MeI is important to guide criti- is used to guide critical decisions, it is important to provide cal decisions used in the acute exposure risk assessment. (cdc.gov)
In a context of increasing exposure (whether by inhalation, ingestion or skin application ), the scientific literature highlights many potential undesirable health effects… which however differ according to the chemical nature of nanos, their size, shape and other physicochemical parameters. (veillenanos.fr)

At the end of a total of 45 days of exposure, mice weresacrificed, implantation sites were monitored, blood was processed to study stress parame-ters (hemoglobin, RBC and WBC count, and neutrophil/lymphocyte (N/L) ratio), the brainwas processed for comet assay, and plasma was used for nitric oxide (NO), progesterone andestradiol estimation. (nomedicalcare.com)
We observed that implantation sites were affected significantly inMW-irradiated mice as compared to control. (nomedicalcare.com)

Special cellular machinery should be activated to fight against increased reactive oxygen species (ROS) level to protect from oxidative injury. (springer.com)
The diﬀerent interactions of a root with its environment depend on its organization and structure, from the cellular to whole-plant level. (oap-onlinejournals.org)

Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase 1, 17α-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels. (frontiersin.org)
We find that maturation of the parvalbumin (PV)-cell network that controls plasticity onset is regulated by a selective re-expression of the embryonic Otx2 homeoprotein. (dna-pksignal.com)

Investigating the way convergent traits evolve at the genome level is important for identifying the molecular mechanisms that regulate this kind of adaptation. (edu.au)
ASAG22 was codon-optimized and co-expressed with five different molecular chaperones (PDI, CPR5, ERO1, HAC1, and Bip) in order to improve the expression level of FumDM in Pichia pastoris (also known as Komagataella phaffii) GS115. (inra.fr)

By the late 2000s, the levels of imposex at many sites had decreased to background so the monitoring programme was reduced. (gov.scot)

Serum levels of testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured. (frontiersin.org)
However, piperine treatment reduced serum FSH levels. (frontiersin.org)

ment phase suppressed the subsequent growth to ovulation, found that heat stress retarded the growth of follicles [1] accompanied by decreased LH receptor level and estradiol and reduced steroid hormone production, which is related synthesis activity in the follicles [3]. (sagepub.com)
re- that heat stress strongly inhibited gonadotropin receptor ported that HS caused relatively low plasma concentration levels and aromatase activities in granulosa cells. (sagepub.com)

The estra- of the luteinizing hormone (LH), reduced progesterone diol levels in the follicular fluid of early antral, antral and preovulatory follicles were also reduced [6]. (sagepub.com)

Co-treatment of CdSO 4 and ANF significantly down-regulated the mRNA level of multidrug resistance-associated protein ( mrp ) 1 and cytochrome P450 ( cyp ) 1a , which constituted the protective mechanisms for zebrafish embryo s to chemical toxins. (zju.edu.cn)

Hyperglycemic myocardial microenvironment significantly alters chromatin architecture and the transcriptome, resulting in aberrant activation of signaling pathways in a diabetic heart. (diagenode.com)

level in olfactory epithelium is the most appropriate internal dose measure for use in risk assessment for this endpoint. (cdc.gov)

The use of radiation for diagnostic imaging in the pregnant woman is usually associated with a high level of anxiety for the woman, her family, and, often, the physician. (medscape.com)
Nest predation levels exceeded 90%, with short nest survival timelines suggesting relatively high predation pressures on these sites. (pdgf-receptor.com)
From the results, the level of acceptance of ACTs and other Artemisinin products is high (50%) probably because more information is available on ACTs to both healthcare personnel and patients through mass media like television, radio, newspapers. (edu.ng)

As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. (intechopen.com)
The chemicals found in the coatings on non-stick cookware are one source of toxin exposure you especially want to avoid. (lilynicholsrdn.com)

Therapeutic experiments in SCID mice implanted with Raj] cells showed significantly prolonged survival time with targeted liposomal vincristine compared to either free VCR or vincristine formulated in nontargeted liposomes. (dna-pksignal.com)

We explored the association between prenatal exposure to SHS and neurodevelopment at 24 months of age considering genetic polymorphism and breastfeeding in 720 mothers and their offspring enrolled in the Korean multicenter birth cohort study (Mothers and Children Environmental Health, MOCEH). (biomedcentral.com)
No association was evident in children whose mothers had cotinine levels ≤1.90 ng/ml. (biomedcentral.com)

The relative expression levels of six DEGs were further confirmed through quantitative real-time polymerase chain reaction (qRT-PCR). (biomedcentral.com)

Results: Supplementation with resveratrol (2.0 μmol/L) not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos' PA from oocytes that underwent HS by increasing their glutathione (GSH) level, reducing reactive oxygen species (ROS) and up-regulating the expression of Sirtuin 1 (SIRT1). (sagepub.com)
In this topic, when discussing study results, we will use the terms "woman/en" or "patient(s)" as they are used in the studies presented. (medilib.ir)

Inhalation Toxicology Downloaded from informahealthcare.com by CDC Information Center on 07/06/12 alternative to methyl bromide as a fumigant, there is potential here as a sequence of key events and processes, starting for human exposures to MeI. (cdc.gov)

The enzyme activities of recombinant strains over-expressing PDI and CPR5 reached the highest levels of 259.47 U/mL and 161.34 U/mL, 635% and 357% higher than the original enzyme activity, respectively. (inra.fr)

Low levels of imposex appear to cause no significant harm, but at higher levels females may become sterile. (gov.scot)

Because the baseline risk is small, if an exposure conveys a modestly increased risk, a large population of infants is required to detect an increase in anomalies. (medscape.com)

In recent times, the level of EMR in ourenvironment has increased manifold due to a large-scale expansion of communicationnetworks such as mobile phones, base stations, WLAN, Wi-Fi, Wi-MAX, etc. (nomedicalcare.com)

When the frequency of exposure differed, colonies altered the quality of larvae. (edu.au)

Both rads and grays typically refer to single-time exposures (eg, diagnostic procedures). (medscape.com)
The roentgen equivalent man (rem) unit of measure and sievert (Sv) unit are used to quantify radiation exposure over time (eg, environmental releases). (medscape.com)

Diseases1

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Health Care2

Genes5

Zinc4

Gestational2

Epigenetic2

Oxidative stress4

Pregnancy5

Susceptible1

Concentrations4

Methylation1

Fetal4

Secondhand smoke1

Development4

Cytotoxicity2

Adverse health2

Nicotine2

Maternal1

Intracellular2

Decreases1

Harmful1

Frequencies1

Genetics1

Inhibition1

Effects7

Implantation2

Cellular2

Cell2

Molecular2

Background1

Serum2

Stress2

Early1

Cytochrome1

Transcriptome1

Dose1

High3

Found2

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