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  • models of embryonal tumors
  • The quassinoid analogue NBT-272 has been reported to inhibit MYC, thus warranting a further effort 7to better understand its preclinical properties in models of embryonal tumors (ET), a family of childhood malignancies sharing relevant biological and genetic features such as deregulated expression of MYC oncogenes. (ugent.be)
  • nervous system tumors
  • See the PDQ summary on Adult Central Nervous System Tumors Treatment for more information on the treatment of adults. (cancer.gov)
  • The PDQ childhood brain tumor treatment summaries are organized primarily according to the World Health Organization (WHO) classification of nervous system tumors. (cancer.gov)
  • 1 ] For a full description of the classification of nervous system tumors and a link to the corresponding treatment summary for each type of brain tumor, refer to the PDQ summary on Childhood Brain and Spinal Cord Tumors Treatment Overview . (cancer.gov)
  • I discuss issues pertaining to the practice of neuropathology -- including nervous system tumors, neuroanatomy, neurodegenerative disease, muscle and nerve disorders, ophthalmologic pathology, neuro trivia, neuropathology gossip, job listings and anything else that might be of interest to a blue-collar neuropathologist. (blogspot.com)
  • teratoid
  • Not until some 20 years later did Bielschowsky and Unger use the term 'Rosenthal fibers' when describing structures in the gliotic capsule of a cystic teratoid tumor. (blogspot.com)
  • cancer
  • Although cancer is rare in children, brain tumors are the third most common type of childhood cancer , after leukemia and lymphoma . (cancer.gov)
  • All such embryonal tumors growths are characterized by their precocious age incidence and by their tendency towards rapid growth and extreme invasiness, although as everywhere in cancer variants can occur, with some examples exhibiting slower growth and with clinical recognition delayed until late childhood. (curepages.com)
  • In this review we examine approaches to DNA targeted cancer therapy, summarize the recent developments of G-quadruplex ligands as anticancer drugs and speculate on the future direction of such structures as a potential novel therapeutic strategy for embryonal tumors of the nervous system. (duhnnae.com)
  • Also searched for Cancer and Tumor . (clinicaltrials.gov)
  • Therapeutic potency of oncolytic virotherapy-induced cancer stem cells targeting in brain tumors, current status, and perspectives. (brainlife.org)
  • We apply NMF and our model selection criterion to the problem of elucidating cancer subtypes by clustering tumor samples. (pnas.org)
  • Although several studies have failed to show an excess incidence of cancer following conception by ART ( 18 - 22 ), fertility treatment in general has been associated in single studies with hepatoblastoma ( 23 ), retinoblastoma ( 24 ), and imprinting disorders that predispose to several embryonal tumors ( 25 ). (aacrjournals.org)
  • cell tumor
  • We have suggested that papillary renal cell tumor (PRCT) of the kidney arises from nephrogenic rest-like lesions. (ijbs.com)
  • ETMR
  • Consequently they deserve a separate nosologic designation in future tumor classifications, where CNS MEPL could be designated as a histological variant of CNS ETMR. (duke.edu)
  • targets
  • Prospective candidate targets will be evaluated by proteomic analysis including Westerns and immunohistochemistry of normal and tumor tissues. (frontiersin.org)
  • molecular
  • Immunohistochemical analysis, cytogenetic and molecular genetic findings, and measures of mitotic activity are increasingly used in tumor diagnosis and classification. (cancer.gov)
  • Molecular studies have substantiated the differences between tumors arising in different areas of the brain and give partial credence to this classification approach. (cancer.gov)
  • However, molecular genetic studies are employed increasingly to subclassify embryonal tumors. (cancer.gov)
  • Biological/molecular tumor cell characteristics. (cancer.gov)
  • The most recent update (2016) has significantly changed the classification of a number of tumor families, introducing a greater reliance on molecular markers. (radiopaedia.org)
  • Despite a move towards molecular markers for some entities, the classification continues to be organized according to the cell of origin (e.g. ependymal tumors) or anatomical origin (e.g. tumors of the sellar region). (radiopaedia.org)
  • It has been successfully used to analyze temporal expression patterns ( 1 ), to predict patient outcome among lymphoma patients ( 2 ), and to provide molecular portraits of breast tumors ( 3 ). (pnas.org)
  • ependymal
  • Other histologic and immunohistochemical features, such as the degree of apparent cellular transformation along identifiable cell lineages (ependymal, glial, etc.), can be used to separate these tumors to some degree. (cancer.gov)
  • xenograft
  • Several compounds that target these structures have shown promising anticancer activity in tumor xenograft models and some of them have entered Phase II clinical trials. (duhnnae.com)
  • entities
  • DNA methylation patterns were also strikingly different between these two tumor entities, suggesting that they do not share common origins and biological behaviors. (duke.edu)
  • Cenacchi G and Giangaspero F. (2004) Emerging tumor entities and variants of CNS neoplasms. (upmc.edu)
  • examination
  • The tumor was stable at 19 months of follow-up for the first case while in the second case the patient died of disease 6 months after initial examination. (upmc.edu)
  • radiotherapy
  • Determine the feasible dose and duration of carboplatin combined with craniospinal and local radiotherapy and adjuvant chemotherapy in children with newly diagnosed, high-risk CNS embryonal tumors (Phase I completed as of 11-25-03). (knowcancer.com)
  • patients
  • In their series, the tumors were aggressive and most of the patients died from their disease 5-14 months after initial presentation. (upmc.edu)
  • infants
  • Because infants of multiple pregnancies are generally smaller than singletons ( 15 ), reports of reduced risk of these tumors in twins may be confounded by birth weight. (aacrjournals.org)
  • cerebral
  • reported two cases that arose in 4-year-old children, one was a midpontine tumor and the other was a large cerebral lesion. (upmc.edu)
  • Central Nervou
  • However, a convention, which has been accepted by the WHO, also separates these tumors on the basis of presumed location of origin within the central nervous system (CNS). (cancer.gov)
  • alterations
  • As relapsing embryonal tumors often present with p53 pathway alterations, these findings have potential implications for therapy approaches targeting cdks. (ugent.be)