Elucidate the action mechanisms. Medical search. Frequent questions

The mechanism of action has not been fully elucidated, but defibrotide is thought to enhance the enzymatic activity of plasmin to hydrolyze fibrin clots. (medscape.com)
The mechanism of action has not been fully elucidated. (medscape.com)
However, the action mechanism for the antidepressant-like effect of DSS is still not fully elucidated. (hindawi.com)

The pharmacological targets and molecular mechanisms related to risperidone-induced lipogenesis (RIL) remain to be elucidated. (frontiersin.org)
Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
This chapter summarizes the main molecular mechanisms to C. albicans antifungal drug resistance, besides offering an overview of new antifungal agents and new antifungal targets to combat fungal infections. (intechopen.com)
By multi-faceted approaches using the reference plant Arabidopsis, my lab has made major breakthroughs in elucidating the sites and regulatory mechanisms of GA biosynthesis, and the conserved molecular events of GA perception and the early GA signaling pathway. (duke.edu)
We also elucidated the conserved molecular events of GA perception and the early GA signaling pathway. (duke.edu)
Proteomic analysis of these cells can elucidate their molecular properties and mechanism of action. (cns.org)
Through proteomic analyses the molecular mechanisms of tumorigenesis and malignant behaviors of tumoral cells can be elucidated. (cns.org)
Thus, the aim of this work is to carry out a review of the literature on the role of bacterial endotoxin in the etiology of periapical lesions, its mechanism of action, and to elucidate molecular mechanisms involved in endotoxin's recognition by the immune system and cell activation. (bvsalud.org)

An outline of the porphyrin pathway reveals the pathophysiological mechanisms that cause porphyria. (medscape.com)
Many naturally occurring compounds from foods such as rice, vegetables, fruits, and animal products possess properties that help to slow disease progression, inhibit pathophysiological mechanisms, or suppress activities of pathogenic molecules. (routledge.com)

The development of this draft global action plan on antimicrobial resistance, requested by the Health Assembly in resolution WHA67.25 in May 2014, reflects a global consensus that antimicrobial resistance poses a profound threat to human health. (who.int)
It is expected that countries will develop their own national action plans on antimicrobial resistance in line with the global plan. (who.int)
However, there is today considerable awareness of the need for, and political support for, action to combat antimicrobial resistance. (who.int)

Functional Genome Screening to Elucidate the Colistin Resistance Mechanism. (cdc.gov)

We also elucidated the distinct regulatory mechanisms for the protein variants, mutant IDH1, and mutant IDH2, in AML. (genengnews.com)
By multi-faceted approaches using the model system Arabidopsis, my lab has made major breakthroughs in revealing the sites and regulatory mechanisms of GA biosynthesis. (duke.edu)

We aimed to determine the signaling pathway regulating cell metabolism and the mechanism related to the regulation of human tumor-associated macrophages (TAMs) in gastric cancer (GC). (cancerindex.org)
Although the GA biosynthetic pathway had been characterized biochemically, little was known about the sites of GA production and the mode of GA action. (duke.edu)

In contrast, nongenomic actions are mediated by rapid cellular mechanisms, and induce transient vasoconstriction in the airway, thereby reversing inflammatory hyperperfusion. (ersjournals.com)
In this review article, recent advances into the understanding of cellular mechanisms and the clinical implications of the interaction of inhaled corticosteroids and the airway vasculature in asthma are reviewed. (ersjournals.com)
Recent advances in the understanding of the cellular mechanisms responsible for these vascular abnormalities may ultimately lead to new therapeutic approaches for the treatment of asthma. (ersjournals.com)
however, the underlying cellular mechanisms are clearly incompatible with the transcriptionally mediated (genomic) actions. (ersjournals.com)
Their biochemical and cellular mechanisms of action have meanwhile been elucidated. (tum.de)

All the information obtained is thus used to enhance existing or developing methods to assess the joint toxic action of environmental chemicals. (cdc.gov)
The methods consisted in examining FAP logical framework steps to elucidate courses of actions for the therapist in response to the clinical problem. (bvsalud.org)

however, the actual effect and underlying mechanisms are still unclear. (researchgate.net)
Purified components of ginger relax airway smooth muscle (ASM), but the mechanisms are unclear. (nih.gov)

DTHHS) has developed and coordinated a mixtures program that includes trend analysis to identify the mixtures most often found in environmental media, in vivo and in vitro toxicological testing of mixtures, quantitative modeling of joint action, and methodological development for assessment of joint toxicity. (cdc.gov)
We aimed to stop superficial bleeding from minor abra- elucidate if the in vitro properties of alum sions or cuts. (who.int)

Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)

However, relatively few studies have focused on their metabolic features and mechanisms. (cancerindex.org)

Dynein function is essential in higher eukaryotes, yet its basic mechanisms of action including coupling to cargo and cellular regulation remain to be determined. (nih.gov)
He also works on the hydrolysis of waste seafood proteins for bioactive peptide generation and their action as antioxidants and in antidiabetic, anticancer, and high blood pressure regulation. (routledge.com)

The therapist contingent responding to clinically relevant behaviors (CRB) corresponds to Functional Analytic Psychotherapy (FAP) mechanism of change. (bvsalud.org)

The draft global action plan covers antibiotic resistance in most detail but also refers, where appropriate, to existing action plans for viral, parasitic and bacterial diseases, including HIV/AIDS, malaria and tuberculosis.1 Many of the actions proposed in this plan are equally applicable to antifungal resistance. (who.int)

The researchers found that also the female hormones have a synergistic action in sperm. (innovations-report.com)
In fact, synergistic actions of endocrine disruptors have also been observed in other cells and tissues. (innovations-report.com)

The eicosanoid family encompasses thromboxanes, prostacyclins, leukotrienes, hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienic acids (EETs), lipoxins, and isoprostanes, the last of which can be generated by nonenzymatic oxidative mechanisms and may serve as markers of oxidative stress in humans. (jci.org)

This study elucidates the mechanisms employed by endophytes in protecting the plant from diseases and different bioactivities of importance to humans with a focus on endophytic bacteria and fungi. (frontiersin.org)
The results of our new study can be easily summarized," says Dr. Christoph Brenker from the CeRA, head of the study: "If the chemicals teams up in cocktails, their individual actions do not simply add up, but amplify each other. (innovations-report.com)
This study aims to investigate the mechanism(s) underlying the antidepressant-like action of DDS. (hindawi.com)
In this study, we aim to explore different antidepression mechanisms of DSS by investigating its effect on the monoamine neurotransmitter systems. (hindawi.com)
However, no study in any models has elucidated the complete interplay and sequence of events contributing to the cytotoxicity. (uea.ac.uk)
Effectiveness of Exclusive Enteral Nutrition in Crohn's Disease This study aimed to elucidate the mechanisms of action in exclusive enteral nutrition in Crohn's disease. (medscape.com)

This thorough understanding of AML driven by IDH mutant proteins allows us to better understand the mechanisms of action of AML-targeted therapies. (genengnews.com)

Over a number of years, ATSDR scientists in collaboration with mixtures risk assessors and laboratory scientists have developed approaches for the assessment of the joint toxic action of chemical mixtures. (cdc.gov)
The purpose of an Interaction Profile is to evaluate data on the toxicology of the "whole" priority mixture (if available) and on the joint toxic action of the chemicals in the mixture in order to recommend approaches for the exposure-based assessment of the potential hazard to public health. (cdc.gov)

However, cGMP analogs have previously been shown to interact with numerous targets, so to better understand the therapeutic action of Rp-8-Br-PET-cGMPS, it is necessary to elucidate its target-selectivity and hence what potential cellular mechanism(s) it may affect within. (lu.se)

Corticosteroids are now known to exert their effects on the airway vasculature through genomic and nongenomic mechanisms. (ersjournals.com)
The vascular actions of corticosteroids contribute to controlling clinical symptoms of asthma primarily by influencing airway calibre in the lung periphery and airway hyperreactivity. (ersjournals.com)

Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAEL) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
We compare the predictions of our analysis with physiological dose-response curves taken from the literature, in order to provide a quantitative comparison of the effects of different mechanisms of cooperativity on calcium-calmodulin interactions. (biomedcentral.com)
To elucidate the effects of TMT on the cochlea, a single injection of 4 or 8 mg/kg TMT was administered intraperitoneally to adult rats. (cdc.gov)
Chlorpromazine's mechanisms responsible for relieving nausea and vomiting include blocking postsynaptic mesolimbic dopamine receptors, anticholinergic effects, and depression of RAS. (medscape.com)

By elucidating these mechanisms, we can explore the use of phytotherapeutics in combination with traditional asthma therapies. (nih.gov)

This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-06-185 , that solicits applications under the Exploratory/Developmental (R21) grant mechanism. (nih.gov)

Prostanoids, as they are known today, are a specific class of bioactive mediators generated via initial actions of cyclooxygenase. (jci.org)

The new results are important for assessing their toxic action: so far, "safety limits" are determined only for each chemical individually. (innovations-report.com)
This pragmatic approach allows identification of pertinent issues and their resolution as well as enhancement of our understanding of the mechanisms of joint toxic action. (cdc.gov)
Joint toxic action includes additivity and interactions. (cdc.gov)

In studies of animals' imitation abilities one has often overlooked a central aspect of imitation in humans, especially in children: an integration of the actions in a social and affective context. (lu.se)

Peter and Rosemary Grant are distinguished for their remarkable long-term studies demonstrating evolution in action in Galápagos finches. (balzan.org)
Similarly, additional mechanistic studies are warranted to elucidate the mechanisms through which nutrition can impact the brain. (biomedcentral.com)
In this collection of articles, we welcome research which provides new insight into the impact, and mechanisms of action, of nutrition on brain health, including (but not restricted to): cellular and animal model investigations, intervention studies with human participants, population-level epidemiological analyses, and systematic reviews and meta-analyses. (biomedcentral.com)

Scientists have discovered a new mechanism by which cancerous cells in acute myeloid leukemia (AML) regulate the protein IDH2 (isocitrate dehydrogenase2) known to be mutated in cancer, to increase the buildup of cancer cells in the blood. (genengnews.com)
The compound action potential (CAP) threshold was used to assess the functional status of the cochlea and histological techniques were used to assess the condition of the hair cells and auditory nerve fibers. (cdc.gov)
Several possible mechanisms were considered for the induction of human leukemia, such as clastogenic damage to circulatory stem cells. (who.int)
Evidence the fate of stem cells has broad ramifications for biomedical suggests that during development or differentiation, cells make science from elucidating the causes of cancer to the use of very precise transitions between apparently stable ``network stem cells in regenerative medicine. (lu.se)

The Solution Structures and Interaction of SinR and SinI: Elucidating the Mechanism of Action of the Master Regulator Switch for Biofilm Formation in Bacillus subtilis. (ncsu.edu)
We also present the solution NMR structure of the antagonist SinI dimer and probe the mechanism behind the SinR-SinI interaction using a combination of biochemical and biophysical techniques. (ncsu.edu)

Considering that in cocktails, the actions of individual chemicals become amplified, such an isolated risk assessment is prone to underestimate the risk potential of endocrine disrupters. (innovations-report.com)

and (2) define the mechanism(s) of action responsible for this potentiation. (nih.gov)
The goal of the draft global action plan is to ensure, for as long as possible, continuity of successful treatment and prevention of infectious diseases with effective and safe medicines that are quality-assured, used in a responsible way, and accessible to all who need them. (who.int)

contradiction in the mechanism of action of alum, we evaluated the in vivo effect of Alum (aluminium potassium sulfate) is a alum in terms of collagen-induced platelet food additive and traditional remedy used to aggregation and bleeding time. (who.int)
In addition, a mediating analysis was used to examine the mechanisms through which the Dunning-Kruger effect occurs. (bvsalud.org)

The inherited eye disease retinitis pigmentosa (RP) causes the loss of photoreceptors by a still unknown cell death mechanism. (lu.se)

These new insights on IDH2-related mechanisms in AML will allow physicians to better understand how current IDH2-targeting medications work and will allow for the development of better treatment options for patients with AML. (genengnews.com)

Despite of the advances reached through refinement in FAP description and the empirical validation of FAP' mechanism of change, the task of specifying therapist contingent responding is still unfinished. (bvsalud.org)

Electronic case reporting (eCR) ( 1 ) is a promising rapid reporting mechanism, whereby electronic health records (EHRs) automatically generate and transmit a disease report to jurisdictional public health agencies in real time using previously established criteria. (cdc.gov)

They have also elucidated the mechanisms by which new species arise and how genetic diversity is maintained in natural populations. (balzan.org)

The anti-inflammatory actions of corticosteroids occur with a considerable delay (within hours or days) because of the multiple steps of cellular actions required to change protein expression. (ersjournals.com)

The actions to optimize use of antimicrobial medicines and to renew investment in research and development of new products must be accompanied by actions to ensure affordable and equitable access by those who need them. (who.int)

There is also strong support for a mechanism of action for nasopharyngeal carcinogenesis in which inhaled formaldehyde causes DNA-protein crosslinks in nasopharyngeal tissue. (who.int)

cGMP analogs selectively modified to have inhibitory actions on PKG have aided in impeding photoreceptor death, and one such cGMP analog is Rp-8-Br-PET-cGMPS. (lu.se)

Despite this attributes, a deep understanding of the mechanism employed by endophytes in protecting the plant from diseases is still required for both effectiveness and commercialization. (frontiersin.org)
This review aimed to present the various mechanisms of action used by endophytes in protecting a plant and report some bioactivities of importance to people with special emphasis on endophytic bacteria and fungi. (frontiersin.org)
The compounds that are found in some spices and produced by herbs act as self-defense mechanisms to protect the plant against infectious organisms [ 3 ]. (hindawi.com)

Ces résultats semblent indiquer que l'utilisation de l'alun en tant qu'antiplaquettaire oral pourrait faire l'objet d'études complémentaires, en tenant compte des effets secondaires éventuels notamment chez les patients dont la fonction rénale est altérée. (who.int)

Finally, we provide an evidence-based mechanism that confirms how disruption of the SinR tetramer by SinI regulates gene expression. (ncsu.edu)

Anatomy3

Organisms2

Diseases3

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes4

Disciplines and Occupations1

Information Science3

Fully elucidated3

Molecular8

Pathophysiological mechanisms2

Antimicrobial resistance3

Resistance mechanism1

Regulatory mechanisms2

Pathway2

Cellular mechanisms5

Methods2

Unclear2

Vitro2

Suppress1

Metabolic1

Regulation2

Behaviors1

Viral1

Synergistic2

Oxidative1

Study6

Proteins1

Approaches2

Therapeutic1

Airway2

Effects5

Therapies1

Parallel1

Bioactive1

Toxic action3

Humans1

Studies3

Cells4

Interaction2

Potential1

Responsible2

Effect2

Cell death1

Treatment1

Description1

Disease1

Genetic1

Steps1

Research1

Support1

Death1

Plant3

Patients1

Provide1