Filter...

AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care

Select a category...

Anemia, AplasticImmunosuppressive AgentsGraft RejectionAntilymphocyte SerumAnemiaHydrazinesImmunosuppressionReceptors, ThrombopoietinBenzoatesBone Marrow TransplantationOxymetholoneCyclosporineTransplantation, HomologousHemoglobinuria, ParoxysmalPyrazolesGraft vs Host DiseaseFanconi AnemiaPancytopeniaTransplantation ConditioningHistocompatibility TestingGraft vs Host ReactionBlood TransfusionHistocompatibilityTissue DonorsBone MarrowPlatelet CountAnemia, HemolyticHematologic AgentsMyelodysplastic SyndromesHematopoietic Stem Cell TransplantationTreatment OutcomeCyclophosphamidePurpura, Thrombocytopenic, IdiopathicHLA AntigensGraft SurvivalThrombocytopeniaMethylprednisoloneAnemia, RefractoryAnemia, Hemolytic, AutoimmuneDrug Therapy, CombinationHematopoiesisLeukemiaAnemia, HypochromicGranulocyte Colony-Stimulating FactorHorsesSurvival AnalysisAnemia, MegaloblasticCord Blood Stem Cell TransplantationAnemia, MacrocyticAnemia, PerniciousThrombopoietinFollow-Up StudiesRetrospective StudiesSiblingsInfectionTime FactorsFluoxymesteroneSurvival RateVidarabineAnemia, Sickle CellBlood Cell CountAgranulocytosisHemoglobinsAnemia, SideroblasticTransplantation ChimeraBone Marrow DiseasesRecurrenceLiving DonorsBone Marrow CellsDyskeratosis CongenitaInfectious Anemia Virus, EquinePlatelet TransfusionHepatitis, Viral, HumanThrombopoiesis

Antithymocyte globulinCyclosporineThrombopoietin receptor agonistParoxysmal Nocturnal HemoIdiopathicPlateletsPediatric patientsHematopoieticThrombocytopeniaDiagnosisBoneImmunePancytopeniaDisorderTelomereImmunosuppressive therapyTreatmentErythropoiesisPatient educationSymptomsClinicalAgesSignsGeneRelapseResponseInfectionBlood cellsDiseaseResearchersStudyCareTrialReceivePeople

Antithymocyte globulin6

• He directed the first multicenter clinical trial using antithymocyte globulin for the treatment of aplastic anemia in the United States. (wikipedia.org)
• Only two-thirds of patients with acquired aplastic anaemia respond to standard immunosuppressive treatment with horse antithymocyte globulin plus cyclosporine. (bjh.be)
• The standards of care for aplastic anemia are allogeneic hematopoietic stem cell transplantation (HSCT) or immunosuppression with horse antithymocyte globulin and cyclosporine. (thalassaemia.org.cy)
• Treatment usually involves immunosuppression with equine antithymocyte globulin and cyclosporine , or bone marrow transplantation. (merckmanuals.com)
• Inpatient care for patients with aplastic anemia may be needed during periods of infection and for specific therapies, such as antithymocyte globulin (ATG) or HCT. (medscape.com)
• The British Committee for Standards in Haematology also recommends irradiated blood products for all patients receiving antithymocyte globulin (ATG) therapy. (medscape.com)

Cyclosporine2

• Are you or your child taking cyclosporine for aplastic anemia? (nih.gov)
• This study is testing whether the medicine sirolimus helps prevent the return of aplastic anemia after stopping cyclosporine. (nih.gov)

Thrombopoietin receptor agonist2

• Promacta (eltrombopag olamine) is a thrombopoietin receptor agonist that is used to increase low blood platelet counts (thrombocytopenia) in certain people with chronic immune thrombocytopenia (ITP) and severe aplastic anemia. (drugs.com)
• The thrombopoietin-receptor agonist eltrombopag is approved for use in patients with severe aplastic anemia who fail to respond adequately to immunosuppressive therapy. (medscape.com)

Paroxysmal Nocturnal Hemo2

• Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
• Some individuals with acquired aplastic anemia also have another disorder at the same time, called paroxysmal nocturnal hemoglobinuria (PNH). (rarediseases.org)

Idiopathic2

• True aplastic anemia (most common in adolescents and young adults) is idiopathic in about half of cases. (merckmanuals.com)
• In this issue of Blood , 2 papers deal with HLA in patients with acquired idiopathic aplastic anemia (AA). (ashpublications.org)

Platelets2

• Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (merckmanuals.com)
• In acquired aplastic anemia, an almost complete absence of hematopoietic stem cells results in low levels of red and white blood cells and platelets (pancytopenia). (rarediseases.org)

Pediatric patients2

• Some pediatric patients with newly diagnosed acquired aplastic anemia may be more likely to have a complete response with immunosuppressive treatment combined with eltrombopag (ELTR) compared with immunosuppression alone, according to research published in Blood Advances . (thalassaemia.org.cy)
• For this randomized phase 2 study, researchers compared the safety and efficacy of immunosuppression plus ELTR vs immunosuppression alone among pediatric patients with newly diagnosed severe or very severe aplastic anemia. (thalassaemia.org.cy)

Hematopoietic3

• The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
• The term aplastic anemia commonly implies a panhypoplasia of the bone marrow with cytopenias in at least two hematopoietic lineages. (merckmanuals.com)
• The specific medications administered for aplastic anemia depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation (HCT). (medscape.com)

Thrombocytopenia1

• Symptoms are dependent on the severity of the anemia, leukopenia, and thrombocytopenia. (rarediseases.org)

Diagnosis2

• [ 6 ] The Pediatric Haemato-Oncology Italian Association has issued guidelines on diagnosis and management of acquired aplastic anemia in childhood. (medscape.com)
• Patients with aplastic anemia require transfusion support until the diagnosis is established and specific therapy can be instituted. (medscape.com)

Bone7

• Aplastic anemia is a syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia (see the image below). (medscape.com)
• Paul Ehrlich introduced the concept of aplastic anemia in 1888 when he reported the case of a pregnant woman who died of bone marrow failure. (medscape.com)
• Different factors contribute to residual anemia during eculizumab treatment: underlying bone marrow dysfunction, residual intravascular hemolysis and the emergence of C3-mediated extravascular hemolysis. (frontiersin.org)
• Acquired aplastic anemia is a rare, serious blood disorder, due to failure of the bone marrow failure to produce blood cells. (rarediseases.org)
• Although bone marrow failure can occur secondary to other disorders, most aplastic anemia is due to the immune system mistakenly targeting the bone marrow (autoimmunity). (rarediseases.org)
• The symptoms of acquired aplastic anemia occur as a consequence of the bone marrow failing to produce enough blood cells. (rarediseases.org)
• It is believed that PNH arises in the setting of autoimmune acquired aplastic anemia and bone marrow failure. (rarediseases.org)

Immune1

• He is credited with contributing to understanding the pathophysiology of the disease as immune-mediated and with developing immunotherapy for aplastic anemia that has dramatically improved survival rates for the disease. (wikipedia.org)

Pancytopenia1

• Aplastic anemia is suspected in patients, particularly young patients, with pancytopenia. (merckmanuals.com)

Disorder4

• Background: Severe aplastic anemia is a rare and serious blood disorder. (centerwatch.com)
• However, it was not until 1904 that Anatole Chauffard named this disorder aplastic anemia. (medscape.com)
• Pure Red Blood Cell Aplasia Acquired pure red blood cell aplasia is a disorder of erythroid precursors that results in an isolated normocytic anemia. (merckmanuals.com)
• Individuals affected with acquired aplastic anemia are also at risk that it will evolve into another similar disorder known as myelodysplasia. (rarediseases.org)

Telomere1

• Participants in this study must be 3 years or older and have a telomere disease and signs of aplastic anemia, lung disease such as pulmonary fibrosis, or liver disease. (nih.gov)

Immunosuppressive therapy6

• In combination with standard immunosuppressive therapy for the first-line treatment of severe aplastic anemia. (drugs.com)
• It is unclear exactly how quickly Promacta + combination immunosuppressive therapy works in previously untreated patients with severe aplastic anemia. (drugs.com)
• To treat patients with severe aplastic anemia who have had insufficient response to immunosuppressive therapy. (drugs.com)
• It is unclear exactly how quickly Promacta works in patients with severe aplastic anemia who have not responded to previous immunosuppressive therapy. (drugs.com)
• The British Committee for Standards in Haematology recommends treating infection or uncontrolled bleeding before administering immunosuppressive therapy, including in patients scheduled for HCT. (medscape.com)
• [ 5 ] The Pediatric Haemato-Oncology Italian Association recommends HCT from a matched sibling donor for severe aplastic anemia, and if a matched donor is not available, options include immunosuppressive therapy or unrelated donor HCT. (medscape.com)

Treatment2

• He is primarily known for his work in the pathophysiology and treatment of aplastic anemia, and is also known for his contributions to the pathophysiology of parvovirus B19 infection. (wikipedia.org)
• This therapy is now the standard treatment for the disease worldwide. (wikipedia.org)

Erythropoiesis2

• Although the anemia is often normocytic, mild macrocytosis can also be observed in association with stress erythropoiesis and elevated fetal hemoglobin levels. (medscape.com)
• Overview of Decreased Erythropoiesis Anemia, a decrease in the number of red blood cells (RBCs), hemoglobin (Hb) content, or hematocrit (Hct), can result from decreased RBC production (erythropoiesis), increased RBC destruction. (merckmanuals.com)

Patient education1

• For patient education information, see What Is Aplastic Anemia? . (medscape.com)

Symptoms1

• Symptoms of aplastic anemia are those of anemia, bleeding, and infection. (rarediseases.org)

Clinical3

• The onset is insidious, and the initial clinical manifestation is frequently related to anemia or bleeding, although fever or infections may be noted at presentation. (medscape.com)
• Importantly, the selection of the studies discussed here was made by PROF. DR. DOMINIQUE BRON (Haematologist at Institut Jules Bordet, Brussels and member of the BJH editorial board), based on the added value of the studies in daily clinical practice. (bjh.be)
• Background: To date, fewer than 20 patients have been identified as having germline biallelic mutations in the coronin-1A gene (CORO1A) and its protein with clinical features of combined immunodeficiency characterized by T-cell lymphopenia ranging from the severe phenotype to the mild phenotype, recurrent infections, and lymphoproliferative disorders. (bvsalud.org)

Ages1

• At baseline, in the ELTR and immunosuppression-only groups, the median ages were 10.5 and 8.7 years, 71.4% and 61.2% of patients were male sex, and 36.7% and 42.9% had SAA within their respective group while 63.3% and 57.1% had vSAA, respectively. (thalassaemia.org.cy)

Signs1

• This study is testing whether low doses of the medicine danazol help prevent telomeres from getting shorter and reduce signs of damage from aplastic anemia or related conditions. (nih.gov)

Gene2

• In 2005, he and his postdoctoral fellow, Rodrigo Calado, described the first mutations in the telomerase gene, TERT, in patients with aplastic anemia. (wikipedia.org)
• Conclusion: Collectively, we added new data about the CORO1A gene as a key player in actin cytoskeleton dynamics and cell signaling. (bvsalud.org)

Relapse1

• Pregnant women with aplastic anemia have a 33% risk of relapse. (medscape.com)

Response2

• Complete normalization of hemoglobin (complete and major hematological response), is seen in no more than one third of patients, while the remaining continue to experience some degree of anemia (good and partial hematological responses), in some cases requiring regular red blood cell transfusions (minor hematological response). (frontiersin.org)
• In approximately one third of patients with aplastic anemia, there is no response to immunosuppression. (medscape.com)

Infection1

• [ 5 ] In the presence of severe infection, however, it may be necessary to proceed directly to HCT to provide the patient with the best chance for early neutrophil recovery. (medscape.com)

Blood cells1

• A low level of circulating red blood cells is called anemia. (rarediseases.org)

Disease1

• Furthermore, some aplastic anemia that is genetically inherited may, first manifest in adulthood, sometimes without a family history of blood disease. (rarediseases.org)

Researchers2

• This registry seeks to collect information from patients who have Diamond-Blackfan anemia (DBA), in order to help researchers and doctors learn more about the condition. (nih.gov)
• Acquired aplastic and PNH have a close relationship that is not fully understood by researchers. (rarediseases.org)

Study3

• In the 1990s, Young initiated and implemented a formal epidemiologic study of aplastic anemia in Thailand, which revealed a much higher incidence rate than in the West. (wikipedia.org)
• Participants in this study must be 2 years or older and have severe aplastic anemia. (nih.gov)
• This study is testing whether adding the medicine eltrombopag to standard treatments is a better way to treat severe aplastic anemia. (nih.gov)

Care2

• Severe or very severe aplastic anemia is a hematologic emergency, and care should be instituted promptly. (medscape.com)
• Patients with aplastic anemia should be treated by physicians who are experts in the care of immunocompromised patients and in consultation with a hematologist and/or an HCT physician. (medscape.com)

Trial1

• Therefore, the phase III POLARIX trial evaluated the efficacy and safety of a modified regimen of R-CHOP (pola-R-CHP), in which vincristine was replaced with polatuzumab vedotin, as compared with standard R-CHOP. (bjh.be)

Receive1

• 49 were randomly assigned to the ELTR group while 49 were assigned to receive immunosuppression only. (thalassaemia.org.cy)

People1

• Some people who have aplastic anemia have very short telomeres, which protect the ends of DNA in chromosomes. (nih.gov)