The primary trade names for l-asparaginase in the U.S. are Elspar and Kidrolase. (pancreatica.org)
Erwinia5
The most common side effects of asparaginaseerwinia chrysanthemi (recombinant) when given in combination with chemotherapy for the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma are abnormal liver tests, nausea, muscle and bone pain, and fatigue. (wikipedia.org)
With the loss of the commercial product Elspar ® , a product derived from Erwinia chrysanthemum (Erwinaze ® ) has been released. (marvistavet.com)
2 Patients can receive asparaginaseErwinia chrysanthemi (ERWASP), as a 25,000 -IU/m 2 dose, administered IV over 1 hour every other day or IM on a Monday/Wednesday/Friday schedule for 2 consecutive weeks (6 doses replace 1 dose of PEGASP). (theoncologypharmacist.com)
The enzyme L-Asparaginase destroys asparagine outside the cells forcing the cells to rely completely on what they can produce on their own. (vin.com)
L-asparaginase is an enzyme produced by bacteria. (vin.com)
L-asparaginase may interfere with blood clotting, may raise blood sugar levels, may raise liver enzyme blood tests, and may cause liver disease in some patients. (vin.com)
Asparaginase is an enzyme that is used as a medication and in food manufacturing. (wikipedia.org)
Asparaginase derived from Escherichia coli (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine by catalyzing L-asparagine into Laspartic acid and ammonia. (affygility.com)
In late March 2017, the French biotech firm Erytech presented results of a IIb clinical trial of eryaspase (trade name: GRASPA) which is the enzyme l-asparaginase encapsulated in red blood cells as added to gemcitabine or FOLFIRINOX treatment regimens for patients with advanced pancreatic cancer (ductal adenocarcinoma of the pancreas), versus these standard therapies alone. (pancreatica.org)
are intriguing and carry the effect of resurrecting the enzyme l-asparaginase, now as a potential part of a chemotherapy regimen for advanced pancreatic cancer. (pancreatica.org)
Similar to PEGASP, calaspargase pegol (CALASP) is a PEGylated asparaginase with the same E coli -derived enzyme and polyethylene glycol moiety found in PEGASP. (theoncologypharmacist.com)
Asparaginase (EC 3.5.1.1) is an enzyme which is used to treat acute lymphoblastic leukemia (ALL). (the-medical-dictionary.com)
Pegaspargase2
Pegaspargase is also used with other chemotherapy drugs to treat a certain type of ALL in people who have had some types of allergic reactions to medications similar to pegaspargase such as asparaginase (Elspar). (medlineplus.gov)
tell your doctor and pharmacist if you are allergic to pegaspargase, asparaginase (Elspar), any other medications, or any of the ingredients in pegaspargase injection. (medlineplus.gov)
Asparagine9
L-asparaginase works by exploiting the unusually high requirement tumor cells have for the amino acid asparagine. (vin.com)
When L-asparaginase destroys asparagine, ammonia is a by-product. (vin.com)
Asparaginase works by breaking down the amino acid known as asparagine without which the cancer cells cannot make protein. (wikipedia.org)
Since that time, l-asparaginase has emerged as a stalwart in the treatment especially of blood tumors with under-expressed asparagine synthetase, most notably acute lymphoblastic leukemia (ALL). (pancreatica.org)
Solid tumors that also tend to show low levels of asparagine synthetase (and thus, which may be promising targets for asparaginase) include ovarian and pancreatic cancers. (pancreatica.org)
Interestingly, the survival advantage obtained regardless of asparagine synthetase expression level (AS), though the researchers noted that the AS may be prognostic in pancreatic cancer treated by asparaginase, promising further study. (pancreatica.org)
The rationale behind asparaginase is that it takes advantage of the fact that ALL cells are unable to synthesize the non-essential amino acid asparagine whereas normal cells are able to make their own asparagine. (the-medical-dictionary.com)
As a medication, L-asparaginase is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL). (wikipedia.org)
One of the primary concerns in acute lymphoblastic leukemia treatment is the occurrence of adverse events (AEs) associated with asparaginase therapy. (wikipedia.org)
Hypersensitivity3
The neutralization of asparaginase activity, known as silent inactivation, may also occur, with or without signs of hypersensitivity. (theoncologypharmacist.com)
LASP) is an asparaginase preparation that was historically used beginning in the 1970s and is associated with high immunogenicity and increased hypersensitivity reactions. (theoncologypharmacist.com)
It is also indicated for use in patients with hypersensitivity to native forms of L-asparaginase. (medscape.com)
ASNase1
In 1963, asparaginase (ASNase) was identified as an effective antileukemic agent, and subsequent efforts were made to isolate it from bacterial sources and scale up production for clinical trials. (wikipedia.org)
Nadir1
The main efficacy outcome measure was demonstration of the achievement and maintenance of nadir serum asparaginase activity (NSAA) above the level of 0.1 U/mL. (wikipedia.org)
Chemotherapy2
Toxicity of vincristine , another chemotherapy agent, may be more likely if vincristine and L-asparaginase are given at the same time. (vin.com)
Perhaps one might be forgiven for additionally wondering if pegylated l-asparaginase also might be worthy of consideration as an adjunct to standard chemotherapy regimens? (pancreatica.org)
Methotrexate1
L-asparaginase and methotrexate work against each other and should be given at least 48 hours apart. (vin.com)
Intramuscularly1
2,4,5,8 PEGASP achieves greater asparaginase activity levels and can be administered either intramuscularly (IM) or intravenously (IV). (theoncologypharmacist.com)
Chemotherapeutic1
Indicated as part of a multiagent chemotherapeutic regimen as a substitute for asparaginase (Elspar), which was discontinued by the manufacturer in August 2012. (medscape.com)
Reactions1
Anaphylactic reactions to L-asparaginase are much more common in dogs than in cats. (vin.com)
Associated with pancreatitis2
The use of L-asparaginase has been associated with pancreatitis. (vin.com)
tell your doctor if you have or ever had pancreatitis (swelling of the pancreas), blood clots, or severe bleeding, especially if these happened during an earlier treatment with asparaginase (Elspar). (medlineplus.gov)
Leukemia2
On July 22, the US Food and Drug Administration sent a warning letter to Merck and Company (Whitehouse Station, NJ) concerning the company's manufacture of asparaginase intermediate used in the drug Elspar to treat acute lymphocytic leukemia. (pharmtech.com)
5 Failure to receive the entire prescribed course of asparaginase therapy has been associated with poorer outcomes and higher rates of relapse in pediatric leukemia. (theoncologypharmacist.com)
Treatment2
However, despite these earlier findings, Dr. Daniel Von Hoff in his concluding keynote speech as President of the American Association of Clinical Research in year 2000 in San Francisco, pointed out that l-asparaginase was a potential intriguing agent for the treatment of pancreatic cancer. (pancreatica.org)
Liver disease does not preclude the use of L-asparaginase but it is important to watch for symptoms referable to liver disease (generally neurologic abnormalities/hepatic encephalopathy). (vin.com)
Cells1
The company also instituted a re-isolation procedure for selecting cells for use in production of asparaginase intermediate without characterizing the new isolate prior to use in production. (pharmtech.com)
Cancer1
On a personal note, the author of this Pancreatica Blog entry was involved in an early study of l-asparaginase in guinea pigs as a first-year medical student working with colleagues at the Ellis Fischel Cancer Center in Columbia, Missouri. (pancreatica.org)
Agent1
L-asparaginase is an interesting drug agent from a number of standpoints. (pancreatica.org)
Asparaginase was approved for medical use in the United States in 1978. (wikipedia.org)
Therapy1
There are currently 3 formulations of asparaginase therapy available in the United States, which differ based on bacterial source and pharmacokinetic properties. (theoncologypharmacist.com)
Activity1
2,5,6 E coli -derived LASP has a short half-life (8-30 hours), which requires a frequent administration schedule (3 times per week) to maintain adequate asparaginase activity. (theoncologypharmacist.com)
Production1
In 2012, the only commercial manufacturer of Elspar® decided to discontinue production indefinitely for business reasons. (vin.com)
Greater1
Prednisolone tends to raise blood sugar levels to a greater extent when used in combination with L-asparaginase. (vin.com)