Elevated plasma total homocysteine. Medical search. Frequent questions

Background Observational studies show that low concentrations of folate and elevated concentrations of homocysteine are associated with poor cognitive performance in the general population. (drjohnlapuma.com)
We have tested whether baseline concentrations of homocysteine relate to the subsequent rate of cognitive decline in patients with established Alzheimer's disease (AD). (ox.ac.uk)
Low levels of these vitamins have been associated with high concentrations of homocysteine (Hcy) and can lead to health complications. (unboundmedicine.com)

Smoking-related elevations in CRP are also accompanied with a rise in serum homocysteine levels [ 15 ]. (hindawi.com)
In an elderly population with cognitive impairment, we investigated the association between serum uric acid (sUA) and serum homocysteine (sHcy), known risk factors for cerebrovascular disease. (mdpi.com)
a serum homocysteine level higher than 15 micromol/L, for example, suggests vitamin B12 deficiency [ 11 ]. (nih.gov)

One of the most important folate-dependent reactions is the conversion of homocysteine to methionine in the synthesis of S-adenosyl-methionine, an important methyl donor. (nih.gov)
B vitamins control homocysteine levels by stimulating the conversion of homocysteine to methionine. (fatsoflife.com)

Homocysteine - An elevated concentration of homocysteine is an independent risk factor for cardiovascular disease. (ammoliteprodukties.nl)

Methylmalonic acid may be elevated due to inborn errors of metabolism. (cdc.gov)
A number of defects in methionine metabolism lead to accumulation of homocysteine (and its dimer, homocystine) with adverse effects including thrombotic tendency, lens dislocation, and central nervous system and skeletal abnormalities. (msdmanuals.com)
This test measures the levels of the primary forms of folate (B-9) in plasma, and can be used to assess folate status and disorders in essential folate metabolism. (clinical-nutrients.com)
Assessment of plasma folate species provides clinical insight into aberrant folate metabolism that can significantly affect crucial methylation processes, DNA/RNA metabolism, and neurotransmitter metabolism. (clinical-nutrients.com)
We assume that the violation of homocysteine (Hcy) metabolism and vitamin D level in mothers' utero causes various abnormalities in offspring, including hard-woven teeth and periodontium impairments. (ukrbiochemjournal.org)
The work is dedicated to creation of the mathematical model of folate-dependent one-carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS). (ukrbiochemjournal.org)
Those vitamins are involved in the homocysteine metabolism. (lasa-vu.nl)
T polymorphism is a genetic alteration in an enzyme involved in folate metabolism that causes elevated homocysteine concentrations, but its relevance to risk of CHD is uncertain. (ckbiobank.org)
These results support the hypothesis that impaired folate metabolism, resulting in high homocysteine levels, is causally related to increased risk of CHD. (ckbiobank.org)

Elevated plasma total homocysteine (tHcy) concentrations are associated with increased risk of vascular disease, and there is a strong inverse association between dietary and blood folate and blood tHcy concentrations. (unboundmedicine.com)
The objective was to determine the most appropriate means of increasing dietary folate to reduce plasma tHcy. (unboundmedicine.com)
Total homocysteine (tHcy) in plasma is measured by the Abbott Homocysteine assay on the Abbott AxSym analyzer, a fully automated FPIA method. (cdc.gov)
Vegetarians are known to be susceptible to vitamin B12 deficiency, due to a lack of dietary animal produce, which can elevate plasma total homocysteine (tHcy). (uwl.ac.uk)
There is positive evidence that links elevated plasma (tHcy) with cardiovascular disease (CVD). (uwl.ac.uk)
The specific objective of the present study was to establish if supplementary MeCbl will optimise elevated levels of plasma tHcy of vitamin B12 deficient vegetarians. (uwl.ac.uk)
Observational studies have shown an association between moderately elevated levels of plasma total homocysteine (tHcy) and a number of common diseases, including cardiovascular disease, pregnancy complications, foetal abnormalities, cognitive impairment and dementia, depression, osteoporosis, and mortality (see Refsum(1, 2) for relevant literature). (bristol.ac.uk)
EDTA plasma samples were analyzed for total homocysteine (tHcy) with the Abbott IMx analyzer at the Laboratory of Clinical Chemistry of the VUMC. (lasa-vu.nl)

Methylmalonic acid (MMA) is extracted from plasma along with an added internal standard using an anion exchange resin. (cdc.gov)
Increased concentrations of methylmalonic acid in plasma or serum and excessive urinary excretion of MMA are believed to be direct measures of tissue stores of cobalamin (vitamin B12) and to be the first indication of cobalamin deficiency. (cdc.gov)
The range of methylmalonic acid in plasma from "healthy adults" is 0.05 to 0.26 umol/L. (cdc.gov)
Serum folate, vitamin B12, methylmalonic acid and plasma homocysteine were determined. (degruyter.com)
Methylmalonic acid (MMA), which was determined in subjects living in the Amsterdam region, was measured in 0.5-mL plasma by stable-isotope-dilution capillary gas chromatography-mass spectrometry. (lasa-vu.nl)
In most cases, vitamin B-12 deficiency is associated with an elevation in plasma homocysteine and methylmalonic acid levels, whereas folate deficiency is associated with elevated homocysteine levels only. (medscape.com)

The mean plasma total homocysteine level was 11.5 micromol/l (standard deviation 4.1). (ox.ac.uk)
The most commonly used cutoff value for elevated homocysteine levels is 16 micromol/L, although slightly lower values of 12 to 14 micromol/L have also been used [ 2 ]. (nih.gov)
A homocysteine cutoff of 10 micromol/L has been proposed for assessing folate status in populations [ 3 ]. (nih.gov)

Plasma total homocysteine may be a potentially modifiable risk factor for stroke and dementia. (ox.ac.uk)
We … conclude that elevated plasma total homocysteine is a modifiable risk factor for the development of cognitive decline, dementia, and Alzheimer's diseases in older persons. (bottomlineinc.com)

Homocysteine can be remethylated through the major folic cycle path. (uwl.ac.uk)
Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. (jamanetwork.com)
Deficiencies of vitamin B6, B12, and folic acid cause a rise in homocysteine levels. (lasa-vu.nl)
The aims of this study were to assess folate, vitamin B12 and homocysteine status in distinct Brazilian individuals after the initiation of folic acid fortification by Brazilian authorities and to investigate the effects of RFC1 A80G, GCPII C1561T and MTHFR C677T polymorphisms on folate, vitamin B12 and Hcy levels in these populations. (unboundmedicine.com)
Plasma homocysteine levels are elevated in vitamin B-12 deficiency, vitamin B-6 deficiency and in folic acid deficiency. (medscape.com)
Lower plasma folate concentrations were observed in coffee drinkers in a cross-sectional study, but dietary folate or supplemental folic acid were not taken into account [ 23 ]. (cdc.gov)

The interaction between copper and homocysteine generates free radicals and, consequently, leads to oxidized low-density lipoprotein. (adjustedlifestylesf.com)
One hundred thirty-two adult heavy smokers completed a randomized, double blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on serum cholesterol, triglyceride, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), high-sensitivity C-reactive protein (hs-CRP), and homocysteine. (hindawi.com)
These include increased release of reactive oxygen species from phagocytes, such as superoxide from peripheral blood neutrophils, oxidized low density lipoprotein cholesterol (LDL), increased lipid hydroperoxides and malondialdehyde, and decreased plasma antioxidant capacity [ 4 - 11 ]. (hindawi.com)
The fact that cigarette smoke increases total cholesterol and triglycerides, as well as decreases high density lipoprotein cholesterol (HDL), has long been established. (hindawi.com)
In general, overt and subclinical hypothyroidism is associated with hypercholesterolemia mainly due to elevation of low density lipoprotein (LDL) cholesterol levels, whereas high density lipoprotein (HDL) cholesterol concentration is usually normal or even elevated 3-5 . (hormones.gr)
In hypothyroid patients, despite the reduced activity of HMG-CoA reductase, there is often an increase in the serum total cholesterol concentration, mainly due to raised levels of serum LDL cholesterol and intermediate density lipoprotein (IDL) cholesterol 4,12 . (hormones.gr)
In this study we report on the effect of this intervention with and without fiber supplementation on plasma homocysteine, lipoprotein (a) [Lp(a)], C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α). (biomedcentral.com)
Elevated plasma levels of the cholesteryl-ester rich lipoprotein (a) [Lp(a)] increase the risk for development of cardiovascular disease through both proatherogenic and prothrombotic properties [ 4 ]. (biomedcentral.com)
A lipoprotein test system is a device intended to measure lipoprotein in serum and plasma. (medicregister.com)

Elevated copper can interact with glycated proteins in the formation of free radicals and increase oxidative stress. (adjustedlifestylesf.com)
Additionally, several markers of oxidative stress are elevated in cigarette smokers. (hindawi.com)
Oxidative stress, as measured by serum malondialdehyde concentration, is positively correlated to elevated triglyceride and cholesterol levels in smokers [ 18 ]. (hindawi.com)

deficiency of cystathionine beta-synthase, which catalyzes cystathionine formation from homocysteine and serine. (msdmanuals.com)

Population-based studies have also revealed that markers of systemic inflammation, such as C-reactive protein (CRP), are also elevated in smokers as well as those exposed to second-hand smoke [ 13 , 14 ]. (hindawi.com)
C-reactive protein (CRP) is a plasma marker of inflammation that, when elevated, has been found to be a risk factor for atherosclerosis. (lifeextension.com)

OBJECTIVE: Moderately elevated levels of plasma total homocysteine are associated with an increased risk of developing Alzheimer's disease. (ox.ac.uk)
CONTEXT: In observational studies, individuals with elevated levels of plasma homocysteine tend to have moderately increased risk of coronary heart disease (CHD). (ckbiobank.org)
Plasma homocysteine levels are usually severely elevated in homozygous cystathionine-β synthase deficiency and moderately elevated in heterozygous cystathionine-β synthase deficiency. (medscape.com)

Of interest, the VITACOG trial revealed that the efficacy of the B vitamins in lowering cognitive decline was better in people with higher levels of homocysteine . (fatsoflife.com)
Insufficient vitamin B 12 and folate correlate with plasma homocysteine levels, and supplemental B vitamins and folate can be part of an effective dietary treatment [ 4 ]. (biomedcentral.com)

The cross-sectional relation of total homocysteine with silent infarcts and white matter lesions was analyzed with adjustment for cardiovascular risk factors. (ox.ac.uk)
We concluded that total homocysteine levels are associated with silent brain infarcts and white matter lesions independent of each other and of other cardiovascular risk factors. (ox.ac.uk)
This study determined the distribution of homocysteine (Hcy) levels in healthy Tunisian subjects and evaluated the relationship between Hcy levels and some cardiovascular risk factors. (who.int)
T genotype, case-control status, and plasma levels of homocysteine, folate, and other cardiovascular risk factors. (ckbiobank.org)

Results: The mean level of plasma homocysteine in the subjects was 14.9 mmol/l. (psu.edu)
An increase of 1 mmol/L in total serum copper accounted for 80% of the risk of having AD. (adjustedlifestylesf.com)

That's because low levels of these nutrients increase levels of homocysteine, an amino acid that is neurotoxic in elevated amounts. (bottomlineinc.com)
Methionine synthase catalyzes the conversion of homocysteine to the essential amino acid methionine [ 1 , 2 ]. (nih.gov)

The concentration of MMA in plasma or serum was found to be a useful indicator of cobalamin deficiency, especially in patients with few or no hematological abnormalities, normal results for the Schilling test, or normal or only slightly depressed serum cobalamin concentrations. (cdc.gov)
Additionally, a defect in homocysteine methyltransferase or a deficiency of vitamin B12 may lead to a so-called "methyl-trap" of tetrahydrofolate (THF), in which THF is converted to a reservoir of methyl-THF which thereafter has no way of being metabolized, and serves as a sink of THF that causes a subsequent deficiency in folate. (wikipedia.org)
Plasma homocysteine concentration is a commonly used functional indicator of folate status because homocysteine levels rise when the body cannot convert homocysteine to methionine due to a 5-MTHF deficiency [ 9 ]. (nih.gov)
The cutoff between normal vitamin B12 levels and deficiency varies by method and laboratory, but most laboratories define subnormal serum or plasma values as those lower than 200 or 250 pg/mL (148 or 185 pmol/L) [ 2 ]. (nih.gov)

The aim was to determine the alterations in levels of vasculair endothelial growth factor (VEGF), homocysteine (HC) and lipid profile in patients with acute ischemic stroke (AIS), to establish the relationship between them. (ukrbiochemjournal.org)
The study found that increasing concentration of plasma HC is associated with intensity of hyperlipidemia, and hyperhomocysteinemia severity prevails over the changes in the lipid profile components. (ukrbiochemjournal.org)

Zhang F, Li X, Dong Q, Wang Y, Zhang H. Risk of Acute Cerebral Infarction and Plasma Asymmetrical Dimethylarginine and Homocysteine Levels: A Clinical Correlation Analysis of Chinese Population. (medscape.com)

Levels of plasma total adrenomedullin are related with two acute phase inflammatory reactants (fibrinogen and sialic acid) but not with markers of endothelial dysfunction in Type 1 diabetes Adrenomedullin and vascular risk factors in Type 1 DM. (phoenixpeptide.com)

Logistic regression model was used to analyze the association of homocysteine levels to the progression of carotid plaque development, while adjusting for demographics and vascular risk factors. (psu.edu)
The risk of silent brain infarcts increased with increasing total homocysteine levels (odds ratio 1.24/standard deviation increase, 95% confidence interval 1.06-1.45). (ox.ac.uk)
The overall risk of having either a silent brain infarct or severe white matter lesions was strongly associated with total homocysteine levels (odds ratio 1.35/standard deviation increase, 95% confidence interval 1.16-1.58). (ox.ac.uk)
Since 2002, studies have linked elevated copper to the increased risk of developing AD. (adjustedlifestylesf.com)
A study in the journal Life Sciences showed that people with the highest levels of homocysteine have a 31 percent higher risk of developing dementia. (bottomlineinc.com)
And research published in the New England Journal of Medicine showed that high homocysteine doubles a person's risk of progressive brain atrophy. (bottomlineinc.com)
Homocysteine is a known risk factor for vascular damage and associated with hypoperfusion of the neocortex and atrophy of the medial temporal lobe in AD patients. (fatsoflife.com)
TMAO and its precursors do not appear to be substantial prognosis factors for HFrH, beyond usual cardiac- and kidney-related risk factors, whereas homocysteine is an independent risk factor for all-cause death in patients with T2D. (biomedcentral.com)
Though traditional markers of cardiovascular risk are still an integral part of initial cardiovascular risk assessment, several additional risk factors have emerged that provide a more complete picture of total risk status. (biomedcentral.com)
Homocysteine levels and the risk of osteoporotic fracture. (lasa-vu.nl)
In the present study, we examined plasma total AM levels, and their association with different markers of endothelial dysfunction and with other established risk factors for cardiovascular diseases, in patients with Type 1 DM. (phoenixpeptide.com)
1-3 There are many factors affecting the risk and prognosis of ICH, and high plasma homocysteine (Hcy) concentration, also known as hyperhomocysteinemia (HHcy), is a notable risk factor. (bmj.com)
Even where diagnosed by history, medical examina- hyper homocysteinaemia is a well estab- tion, electrocardiogram, echocardiogram lished risk factor, we do not know the exact and blood tests, including enzymes (tro- mechanism whereby high homocysteine ponin T and creatine phosphokinase). (who.int)
Whether elevated plasma and urine homocysteine levels represent a cardiovascular risk factor is debatable. (medscape.com)
Inadequate vitamin D status has been associated with elevated cardiometabolic disease risk, although results are inconsistent, as evidenced by recent meta-analyses pooling multiple study populations (6-8). (cdc.gov)

Homocysteine accumulates and dimerizes to form the disulfide homocystine, which is excreted in the urine. (msdmanuals.com)
Plasma and urine homocysteine tests are indicated in the screening and diagnosis of different types of homocystinuria. (medscape.com)
The reference range of urine homocysteine (24-hour urine collection) varies with the technique used, from 0-9 µmol/g creatinine. (medscape.com)

DTT reduces homocysteine bound to albumin and to other small molecules, homocysteine, and mixed disulfides, to free thiol. (cdc.gov)
in plasma, it undergoes oxidization and transforms to disulfides homocystine and cysteine-homocysteine, the measured plasma level reflects these 3 components. (medscape.com)

However, little is known about the association between plasma homocysteine levels and peripheral microvascular endothelial dysfunction (PMED), which is an integrated index of vascular health. (elsevierpure.com)
Thus, the link between homocysteine and MACE could be mediated by endothelial dysfunction, and will require further clarification with future studies. (elsevierpure.com)

METHODS: In 97 patients with AD, 73 pathologically-confirmed, we analysed the decline of global cognitive test scores (CAMCOG) over time from the first assessment for at least three 6-monthly visits up to a maximum of 9.5 years (in total 689 assessments). (ox.ac.uk)

The increases in total cholesterol and triglycerides, with the corresponding decreases in HDL, were found to be dose-dependent when the data were analyzed by smoking frequency. (hindawi.com)
On the other hand, hyperthyroidism (both overt and subclinical) is accompanied by a decrease in serum levels of total, LDL and HDL cholesterol 6 . (hormones.gr)
Levels of total and LDL cholesterol tend to increase as the thyroid function declines 3 . (hormones.gr)
Subjects with hyperhomocysteinaemia had significantly elevated total cholesterol, LDL cholesterol, apolipoprotein A and apolipoprotein B and lower vitamin B levels compared with subjects with 12 normohomocysteinaemia. (who.int)
Hcy levels correlated with total cholesterol ( r = 0.09), apolipoprotein A ( r = 0.012), and B ( r = 0.013) levels and total/HDL cholesterol ratio ( r = -0.085). (who.int)
This group showed reduction in plasma LDL-cholesterol and triglycerides and elevations in HDL-cholesterol as well as reductions in large and medium VLDL particles and increases in LDL particle size. (biomedcentral.com)
In particular, CRD have been repeatedly shown to promote weight loss and improve fasting and postprandial triglycerides, and plasma HDL-cholesterol (HDL-C), which indicates that such an approach may be an important treatment option for the dyslipidemia associated with the metabolic syndrome [ 2 ]. (biomedcentral.com)

Conclusion: The findings suggest that plasma level of homocysteine may be associated with advanced carotid plaque, which constitutes high risks of stroke, in male Chinese adults. (psu.edu)
High levels of homocysteine are also linked to heart disease, osteoporosis, depression, and kidney problems. (bottomlineinc.com)
The same is true for vitamin B12: when a subject uses multivitamin or vitamin B-complex tablets, or receives B12 injections, his or her plasma B12 level can be very high (f.i. 1500 pmol/L instead of around 400-500 pmol/L). In some studies, persons having levels above 800 pmol/L were excluded, in order to exclude those using vitamin B supplements. (lasa-vu.nl)
In the other mutations associated with homocystinuria, plasma levels can vary from high to intermediate. (medscape.com)

MTHFR polymorphisms and serum cobalamin affect plasma homocysteine concentrations differentially in females and males. (medscape.com)
Pirouzpanah S, Taleban FA, Mehdipour P, Atri M, Foroutan-Ghaznavi M. Plasma Total Homocysteine Level in Association With Folate, Pyridoxine, and Cobalamin Status Among Iranian Primary Breast Cancer Patients. (medscape.com)

Significant accumulation of Homocysteine was caused by alcohol treatment in embryos and 5-mehtyltetrahydrofolate restores neural crest migration and alleviates homocysteine accumulation, resulting in inhibition of the alcohol-induced neurocristopathies. (biomedcentral.com)

Homocysteine levels, however, are not a highly specific indicator of folate status because they can be influenced by other factors, including kidney dysfunction and deficiencies of vitamin B12 and other micronutrients [ 1 , 3 , 9 , 10 ]. (nih.gov)
Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. (lasa-vu.nl)
Vitamin B12 status is typically assessed by measurements of serum or plasma vitamin B12 levels. (nih.gov)

Elevated creatinine levels in and of themselves aren't a problem. (bodybuilding.com)

S-adenosylhomocysteine (SAH) hydrolase catalyzes conversion of homocysteine to SAH in the presence of added adenosine. (cdc.gov)

In the general population, a mildly elevated plasma level of homocysteine, termed hyperhomocysteinemia, is a common condition. (lasa-vu.nl)

Trans fatty acid intake was significantly reduced (-38.6%) while dietary folate was unchanged, as was plasma homocysteine. (biomedcentral.com)

RESULTS: Baseline homocysteine levels showed a concentration-response relationship with the subsequent rate of decline in CAMCOG scores: the higher the homocysteine, the faster the decline. (ox.ac.uk)
Diabetic patients have higher plasma copper concentrations. (adjustedlifestylesf.com)

9.5% of the participants of the Colorado prevalence study had elevated levels of thyroid stimulating hormone 3 . (hormones.gr)

Elevated copper may be linked to atherosclerosis. (adjustedlifestylesf.com)

Hyperhomocysteinaemic diet caused by long-term use of methionine reduced the level of total and ionized calcium and phosphates in the blood of pregnant females and their offspring. (ukrbiochemjournal.org)

Studies link elevated homocysteine levels to memory loss and dementia. (bottomlineinc.com)

Background and Purpose: This study aimed to explore the possible association of plasma total homocysteine with carotid plaque stability. (psu.edu)
we perform a metagenome-wide association study on stools and plasma from 66 individuals with ACS and 46 healthy controls (HC). (researchsquare.com)

Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study. (ox.ac.uk)
We examined whether elevated total homocysteine levels are associated with silent brain infarcts and white matter lesions. (ox.ac.uk)
The severity of periventricular white matter lesions and extent of subcortical white matter lesions were also significantly associated with total homocysteine levels, even after excluding those with silent brain infarcts. (ox.ac.uk)

Anatomy2

Organisms1

Diseases7

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Psychiatry and Psychology1

Phenomena and Processes5

Technology, Industry, Agriculture5

Health Care11

Concentrations of homocysteine3

Serum homocysteine3

Conversion of homocysteine to methionine2

Concentration of homocysteine1

Metabolism9

THcy8

Methylmalonic6

Micromol3

Modifiable risk factor2

Folic6

Lipoprotein9

Oxidative stress3

Cystathionine beta-syn1

Protein2

Moderately3

Vitamins2

Cardiovascular risk factors4

Mmol2

Amino acid2

Deficiency4

Lipid2

Cerebral Infarction1

Inflammatory1

Risk15

Urine3

Disulfides2

Endothelial2

Methods1

Cholesterol7

High4

Cobalamin2

Accumulation1

Status3

Creatinine levels1

Catalyzes1

Hyperhomocysteinemia1

Dietary folate1

Higher2

Participants1

Atherosclerosis1

Level1

Dementia1

Association2

Lesions3