• Lymphatic filariasis (LF) is caused by filarial worms that live in the lymphatic system and commonly lead to lymphoedema, elephantiasis, and hydrocele. (rti.org)
  • Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients.Dysregulated host inflammatory responses leading to systemic immune activation are thought to play a central role in filarial disease pathogenesis.Thereafter, we tested for group effects among all the four groups using linear models on the log transformed responses of the markers. (nih.gov)
  • Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients. (nih.gov)
  • When lymphatic filariasis develops into chronic conditions, it leads to lymphoedema (tissue swelling) or elephantiasis (skin/tissue thickening) of limbs and hydrocele (fluid accumulation). (blogspot.com)
  • Patients with chronic disabilities like elephantiasis, lymphoedema, or hydrocele are advised to maintain rigorous hygiene and take necessary precautions to prevent secondary infection and aggravation of the disease condition. (blogspot.com)
  • Lymphatic filariasis (LF), which can cause elephantiasis or hydrocele, swelling of the limbs or scrotum and onchocerciasis, also known as river blindness, affect millions of people in some of the world's poorest communities. (lstmed.ac.uk)
  • Filarial parasites are a major cause of morbidity and therefore hinder socioeconomic growth in parts of Asia, Africa, and the Western Pacific [ 1 , 10 ]. (hindawi.com)
  • Treatment with two common FDA-approved gout medications have been found to cause rapid death to the parasites that cause elephantiasis. (news-medical.net)
  • By targeting Wolbachia, a bacterial symbiont that the filarial parasites need to live, the team has discovered a drug synergy that enables effective treatment over a shorter time. (news-medical.net)
  • There are chronic, acute and 'asymptomatic' manifestations of lymphatic filarial disease, as well as a number of syndromes associated with these infections that may or may or not be caused directly by the parasites. (gaelf.org)
  • Infection occurs when filarial parasites are transmitted to humans through mosquitoes. (blogspot.com)
  • Both are caused by filarial parasites for which the bacterial symbiont Wolbachia is essential for development. (lstmed.ac.uk)
  • Patients with chronic lymphoedema or elephantiasis rarely are microfilaraemic. (gaelf.org)
  • Acute episodes of local inflammation involving skin, lymph nodes and lymphatic vessels often accompany the chronic lymphoedema or elephantiasis. (blogspot.com)
  • These comprise filarial fever, lymphangitis, lymphadenitis and lymphoedema of the various parts of the body and epididymo - orchitis in the male. (aarogya.com)
  • A similar volume of blood was used to determine the presence of circulating filarial antigen. (biomedcentral.com)
  • Microfilariae prevalence was 4.6 % (43/941) whiles 8.7 % (75/861) were positive for circulating filarial antigen. (biomedcentral.com)
  • This calls for a greater urgency for research and development aimed at discovering new or repurposed anti-filarial agents which will augment ivermectin if global onchocerciasis eradication targets are to be achieved. (ntdsupport.org)
  • Filarial infection can also cause tropical pulmonary eosinophilia syndrome. (cdc.gov)
  • Comparisons between the two actively infected groups (CP Ag+ compared to INF) and those without active infection (CP Ag- compared to EN) were used preliminarily to identify markers of pathogenesis. (nih.gov)
  • Our data suggest that circulating levels of microbial translocation products (lipopolysaccharide and LPS-binding protein), acute phase proteins (haptoglobin and serum amyloid protein-A), and inflammatory cytokines (IL-1β, IL-12, and TNF-α) are associated with pathogenesis of disease in lymphatic filarial infection and implicate an important role for circulating microbial products and acute phase proteins. (nih.gov)
  • Lymphedema of the limb is a physically deforming and socially stigmatizing consequence of filarial infection that affects ≈15 million persons worldwide ( 6 ). (cdc.gov)
  • In some elephantiasis cases, the infection does not produce any external symptoms. (jharaphula.com)
  • Depending on the level of the infection, the Treatments of Elephantiasis tend to vary. (jharaphula.com)
  • River blindness and elephantiasis are debilitating diseases caused by parasitic worms that infect as many as 150 million people worldwide. (news-medical.net)
  • unclear how, when or even whether these individuals will progress to develop one of the more overt clinical manifestations of filarial disease. (gaelf.org)
  • It has become a very common health disorder found in many parts of this planet that the World Health Organization elephantiasis is known as the second most common cause that might lead us to a long-term disability. (jharaphula.com)
  • For years, many scientists and medical professionals likely misunderstood how a commonly prescribed medication for elephantiasis battled the disease, but a new study sets the record straight. (news-medical.net)
  • A further manifestation described in the past as 'filarial fever' was caused by inflammation in the lymph node (commonly the inguinal node) with 'retrograde' extension down the lymphatic tract and an accompanying 'cold' oedema. (gaelf.org)
  • Podoconiosis, also known as nonfilarial elephantiasis, is a disease of the lymphatic vessels of the lower extremities that is caused by chronic exposure to irritant soils. (wikipedia.org)
  • In patients with W. bancrofti infections, a high proportion of microfilaria (mf) positive (MF) and low proportions of patients with chronic pathology (CP) and endemic normals (EN) showed the presence of CFA. (elsevier.com)
  • Reasons for this discrepancy are unclear but may be related to differences in the "preferred" anatomic location of the adult filarial worm between men and women ( 18 ) and biologic factors, particularly pregnancy, that further stress the lymphatic system in women. (cdc.gov)
  • Most of the time, elephantiasis affects some parts of your body including your limbs, lower trunk, breasts and external genitalia. (jharaphula.com)
  • Filarial Neglected Tropical Diseases are prioritised for elimination, in line with fulfilment of the 2030 United Nations Sustainable Development Goals. (lstmed.ac.uk)
  • Agosti J. Filarial Diseases. (iamat.org)
  • Elephantiasis is a disease that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals. (news-medical.net)
  • Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease. (nih.gov)
  • Dysregulated host inflammatory responses leading to systemic immune activation are thought to play a central role in filarial disease pathogenesis. (nih.gov)
  • The rare occurrence of these infections in Western nations makes scrotal elephantiasis an uncommon disease outside of Africa and Asia. (lymphedemapeople.com)
  • Although the factors responsible for the initiation and progression of filarial lymphedema to its most severe form, elephantiasis, have been debated, recurrent episodes of bacterial acute dermatolymphangioadenitis (ADLA) play a major role ( 7 - 9 ). (cdc.gov)
  • Heatmap depicting circulating microbial products, acute phase proteins and inflammatory cytokines in CP Ag+ individuals compared to EN, INF and CP Ag− individuals.Data (and scale) are log10 geometric mean fold change from EN for each of the analytes measured for each of the groups. (nih.gov)
  • As shown in figure 5, CP Ag+ individuals exhibit a distinct biomarker signature characterized by elevated levels of LPS, acute phase proteins, and certain inflammatory cytokines compared with the other 3 groups (EN, INF, and CP Ag−), again reiterating the important association of these factors with pathogenesis of filarial pathology. (nih.gov)
  • An example that illustrates the difference between SP and Stasis Papillomatosis and the histology diagnosis is … "a markedly obese, 41-year-old Japanese man who had suffered from psoriasis vulgaris for several years visited hospital with elephantiasis-like swelling of his lower legs of three months' duration. (wikipedia.org)
  • We also compiled the comparative analysis of all the 12 parameters in the 4 groups of individuals as a heat map, depicting the log transformed data on a scale relative to EN. (nih.gov)