Elegans rna helminth. Medical search. Frequent questions

These nematodes are only distantly related to Caenorhabditis elegans and have evolved to occupy an unusual niche, tunneling through epithelial cells of the large intestine. (nature.com)
Romanelli-Cedrez L, Carrera I, Otero L, Miranda-Vizuete A, Mariotti M, Alkema MJ, Salinas G. (2017) Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans. (pasteur.uy)
These concerns underpin efforts to extend the utility of planarian biology to the study of nearly-related parasites [ 12 ], mirroring the important role that Caenorhabditis elegans has played in furthering our understanding of the biology of parasitic nematodes [ 13 ]. (biomedcentral.com)
We previously identified a novel role for the nuclear hormone receptor transcription factor, NHR-23, in promoting Caenorhabditis elegans spermatogenesis. (bvsalud.org)
One among the Caenorhabditis elegans Hox genes is egl-5. (ox.ac.uk)

WormBase ParaSite, a database for the genomics for parasitic helminths (both Nematodes and Platyhelminthes). (wikipedia.org)
In parasitic helminths, such as hookworms, TIMPs have been proposed to play key roles in the host-parasite interplay, including invasion of and establishment in the vertebrate animal hosts. (biomedcentral.com)
Currently, knowledge of helminth TIMPs is limited to a small number of studies on canine hookworms, whereas no information is available on the occurrence of TIMPs in other parasitic helminths causing neglected diseases. (biomedcentral.com)
A total of 15 protein sequences with high homology to known eukaryotic TIMPs were predicted from the complement of sequence data available for parasitic helminths and subjected to in-depth bioinformatic analyses. (biomedcentral.com)
Given the limited knowledge of the molecular mechanisms linked to the development of drug resistance in parasitic helminths [ 16 ], as well as the unavailability of effective vaccines, much attention is now directed towards the identification of novel targets for intervention [ 7 , 17 ]. (biomedcentral.com)
A detailed understanding of the molecular biology of parasitic helminths, and in particular of the structure and function of key genes and gene products playing essential roles in host-parasite interactions, could provide a basis for the design of novel therapeutics. (biomedcentral.com)

Whipworms are common soil-transmitted helminths that cause debilitating chronic infections in man. (nature.com)
They are one of three major groups of soil-transmitted helminths (STHs), the others being Ascaris and hookworms, that impede the socioeconomic development of entire populations. (nature.com)
Amongst these parasites, soil-transmitted helminths (STHs), including Ancylostoma duodenale and Necator americanus (hookworms), Ascaris sp. (biomedcentral.com)

SignificanceEosinophils contribute to type 2 immunity against helminths and allergens. (stanford.edu)

Vega, a vertebrate genome annotation resource Several databases were initiated at the Sanger Institute but are now hosted elsewhere: MEROPS, a peptidase database Pfam, a protein family database Rfam, an RNA family database TreeFam, a database of phylogenetic trees for animal genes WormBase, a database on the biology and sequence of the model organism C. elegans and other related Nematodes. (wikipedia.org)
Through RNA-seq, we determined that NHR-23 and SPE-44 regulate distinct sets of genes. (bvsalud.org)
Together these findings extend the complexity of regulation and function of Hox genes in C. elegans and demonstrate the importance of their tissue-specific expression for correct development and response to infection. (ox.ac.uk)

Founded in 2016, SunyBiotech Co., Ltd is committed to providing high-quality and efficient C. elegans gene editing services to p restigious university laboratories worldwide. (sunybiotech.com)
Since May 2017, SunyBiotech has undertaken C. elegans gene editing services. (sunybiotech.com)
Supported by the availability of gene manipulation technologies such as RNA interference and/or transgenesis, this work provides a basis for future functional explorations of helminth TIMPs and, in particular, of their role/s in fundamental biological pathways linked to long-term establishment in the vertebrate hosts, with a view towards the development of novel approaches for the control of neglected helminthiases. (biomedcentral.com)
The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum. (ox.ac.uk)
A NGS approach to the encrusting Mediterranean sponge Crella elegans (Porifera, Demospongiae, Poecilosclerida): transcriptome sequencing, characterization and overview of the gene expression along three life cycle stages. (edu.ni)

Among several groups of helminth molecules involved in the host-parasite interplay, protease inhibitors have been the subject of intense investigations due to their roles in a range of fundamental molecular processes, including regulation of host proteases and modulation of the host's immune response [ 18 ]. (biomedcentral.com)

Lionel Pintard (PI) published a paper entitled "Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans" in the well-known academic journal Developmental Cell , in which the strain PHX207 npp-1(syb207) IV was used. (sunybiotech.com)

In August of the same year, Oliver Hobert (PI) published a paper in Nature entitled "Unique homeobox codes delineate all the neuron classes of C. elegans" using up to 14 strains of "SunyBiotech C.elegans ", which also sets a record for the number of strains edited by SunyBiotech in a single paper. (sunybiotech.com)

Neglected diseases caused by helminth infections impose a massive hindrance to progress in the developing world. (biomedcentral.com)

Jerome Goudeau team published a paper entitled "Addendum: A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage" using our strain PHX798 gld-1(syb798) . (sunybiotech.com)

We report the high-coverage sequencing (RNA-Seq) and assembly of the transcriptome of the planarian Girardia tigrina across a set of dynamic conditions. (biomedcentral.com)

Selective AHR deletion in eosinophils depleted Clec4a4+ eosinophils, augmented innate lymphocytes producing type 2 cytokines, and enhanced helminth clearance. (stanford.edu)

While many hosts of human helminths are able to eat normal dietary amounts of coconut products without affecting their worms, others find that some forms of this food will affect their worms sufficiently to impair their beneficial effects. (helminthictherapywiki.org)

We believe that in the future, "SunyBiotech C.elegans " will provide a good experiment model for more researchers, reveal more scientific secrets hidden in C. elegans , and make greater contributions to the cause of life science. (sunybiotech.com)

In the nematode Caenorhabditis elegans, approximately 60% of mRNA species are trans-spliced to the 22-nucleotide SL1 leader, and another approximately 10% of mRNAs receive the 22-nucleotide SL2 leader. (ucsb.edu)
Of the 2258 representative ESTs, 1159 (51.3%) had homologues in the free-living nematode C. elegans , 1174 (51.9%) in parasitic nematodes, 827 (36.6%) in organisms other than nematodes, and 863 (38%) had no significant match to any sequence in the current databases. (biomedcentral.com)
Study of the nematode Caenorhabditis elegans has provided important insights in a wide range of fields in biology. (tamu.edu)

WormBase ParaSite, a database for the genomics for parasitic helminths (both Nematodes and Platyhelminthes). (wikipedia.org)
Helminths, more commonly called parasitic worms, represent an incredibly diverse group of organisms that exploit a variety of life-history strategies for their survival and persistence. (springernature.com)
Parasitic helminths always create troubles throughout human as well as veterinary clinic treatments, plus in farming. (ikk-signal.com)

Vega, a vertebrate genome annotation resource Several databases were initiated at the Sanger Institute but are now hosted elsewhere: MEROPS, a peptidase database Pfam, a protein family database Rfam, an RNA family database TreeFam, a database of phylogenetic trees for animal genes WormBase, a database on the biology and sequence of the model organism C. elegans and other related Nematodes. (wikipedia.org)

WormBase (http://wormbase.org), the public database for genomics and biology of Caenorhabditis elegans, has been restructured for stronger performance and expanded for richer biological content. (nih.gov)

Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. (tamu.edu)
Here we report a method to edit the C. elegans genome using the clustered, regularly interspersed, short palindromic repeats (CRISPR) RNA-guided Cas9 nuclease and homologous recombination. (tamu.edu)
Together our results outline a flexible methodology to produce essentially any desired modification in the C. elegans genome quickly and at low cost. (tamu.edu)

the biological process in which protein is synthesized using the Genetic Information contained in the messenger RNA (mRNA) template. (studysmarter.co.uk)

RNA interference, in vitro drug assays). (springernature.com)

Now, the RNA polymerase is ready to "read" the bases in the sequence of the unwound DNA strand and produce RNA with a complementary base sequence. (studysmarter.co.uk)
Because the end-product of transcription is RNA, the base adenine (A) is encoded as (complemented by) uracil (U) instead of thymine (T) when the complementary bases are added. (studysmarter.co.uk)

The SL1 trans-spliced leader RNA performs an essential embryonic function in Caenorhabditis elegans that can also be supplied by SL2 RNA. (ucsb.edu)
Of the C. elegans homologues, 569 had observed 'non-wildtype' RNAi phenotypes, including embryonic lethality, maternal sterility, sterility in progeny, larval arrest and slow growth. (biomedcentral.com)

Here we characterize the prevalence and functional consequences of microRNA tailing in vivo, using Caenorhabditis elegans. (nih.gov)
Our findings demonstrate that SL1 RNA is essential for embryogenesis in C. elegans and that SL2 RNA can substitute for SL1 RNA in vivo. (ucsb.edu)

This research directed to spot the actual substances energetic towards helminths coming from Antibody Services Ejaculate pharbitidis, and to Plant-microorganism combined remediation create the particular procedure involving activity of the active materials. (ikk-signal.com)
Brief, non-coding RNA substances named microRNAs (miRNAs) can easily equine parvovirus-hepatitis control post-transcriptional gene term and they've a substantial role in numerous physical cellular processes along with pathologies, which include cancer malignancy. (ikk-signal.com)

These data show nearly complete conservation of chromosome content with C. elegans and brings insight into transcriptional regulation and chromosome-wide genetic diversity in this important pathogen. (springernature.com)

Helminth GSTs play pertinent roles during sequestration of harmful xenobiotics since most helminths lack the cytochrome P-450 detoxifying enzyme. (biomedcentral.com)
Initiation of transcription begins with the enzyme RNA polymerase binding to a specific sequence on the DNA double-strand known as the promoter , which represents the start of the gene. (studysmarter.co.uk)

While the emergence of resistance by human-infective helminths is less well established, resistance is clearly established in helminths of veterinary importance throughout the world, such that in some regions, treatment options are running out. (springernature.com)

Both proteins display a similar degree of sequence similar to the hypothetical protein CeMAK16 from Caenorhabditis elegans. (nih.gov)
the biological process in which a copy of a gene's DNA sequence is produced and written into RNA. (studysmarter.co.uk)
During elongation , a DNA sequence GCATGG would be encoded as CGUACC in the growing RNA strand. (studysmarter.co.uk)

A cell involving D. elegans mutant strains proof against significant presently used anthelmintic drug treatments was adopted to look around the device involving actions from the energetic materials. (ikk-signal.com)

MicroRNA tailing in C. elegans consists mostly of mono-uridylation of mature microRNA species, with rarer mono-adenylation which is likely added to microRNA precursors. (nih.gov)
The RNA-seq mappings were also used in braker to train species parameters and generate an initial set of annotations. (wormbase.org)

Because the RNA polymerase is physically blocked, transcription cannot take place. (studysmarter.co.uk)

How do Bacteria and other prokaryotes convert DNA into RNA and protein? (studysmarter.co.uk)
the process of converting instructions in our DNA into RNA and protein. (studysmarter.co.uk)

Surprisingly, when overexpressed, SL2 RNA, which performs a distinct function from that of SL1 RNA in wild-type animals, can rescue the lethality of embryos lacking SL1 RNA. (ucsb.edu)

The effectiveness of gene knockdown was confirmed by achieving a 60 percent reduction in TGM-2 transcript levels through the use of TGM-2-specific small interfering RNA (siRNA) in human scleral fibroblasts (SFs). (bvsalud.org)

Searching is case insensitive, and allows for only partial terms (e.g. seq with pickup both RNA-Seq and sequencing) matching. (ageing-map.org)

He is a PhD student in the MCIP Program, and is elucidating the neural basis of CO 2 response in C. elegans . (hallemlab.com)

Anatomy16

Organisms50

Diseases31

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Psychiatry and Psychology1

Phenomena and Processes62

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science5

Health Care4

Geographicals2

Caenorhabditis5

Parasitic helminths6

Soil-transmitted helminths3

Immunity1

Genes3

Gene5

ParaSite1

Developmental1

Homeobox1

Infections1

Lineage1

Transcriptome1

Innate1

Hosts1

Scientific1

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Nematodes1

Genomics1

Genome3

MRNA1

Interference1

Complementary2

Embryonic2

Vivo2

Substances2

Genetic1

Enzyme2

Veterinary1

Sequence3

Mutant1

Species2

Transcription1

Protein2

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