Elegans protein. Medical search. Frequent questions

Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. (nih.gov)
RNAi phenotypes of two of the down-regulated genes, R07H5.8 (adenosine kinase) and rla-0 (ribosomal protein), in CN were similar to that of larval arrest in CS, and RNAi of a down-regulated gene, R07H5.8, in CS further enhanced the effects of CS, suggesting that down-regulation of these genes is likely responsible for the larval arrest in CS. (molcells.org)
Discover related pathways, diseases and genes to TRIM50C Recombinant Protein (H00378108-P01). (novusbio.com)
Partial sequencing of the 16S rRNA genes of both isolates confirmed they were the same G. elegans strain. (cdc.gov)
Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. (lu.se)

C. elegans is a small soil worm or nematode, and it shares a common ancestor with humans that lived in the pre-Cambrian era, 500-600 million years ago. (ku.edu)
While there are clear and important differences in human and nematode development, scientists can study developmental mechanisms in C. elegans to understand the basic, core mechanisms that also operate in humans. (ku.edu)
The research group Genetics and Behavioral Disorders from the Maimonides Institute for Biomedical Research (IMIBIC) and the University of Cordoba has analyzed the effects of testosterone on the behavior of the nematode ("worm") Caenorhabditis elegans. (uco.es)
This domain is hugely expanded in the nematode C. elegans. (nih.gov)
Here, we used a genomics/proteomics approach (including immunoblot experiments from pigs infected with T. suis ) to prioritize putative immunogenic excretory/secretory (E/S) proteins conserved across and specific to several gastrointestinal (GI) parasitic nematode species. (frontiersin.org)
A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)
In this study, the adaptive behavioural response of the nematode C. elegans to food is used to investigate the fundamental mechanisms underlying feeding behaviour. (bl.uk)

RNA binding protein, fox-1 homolog (C. elegans) 3 (Rbfox3) is a protein that in humans is encoded by the RBFOX3 gene. (wikipedia.org)
We have found that the C. elegans homolog of Lgl, LGL-1, has a role in polarity but is not essential. (biologists.com)
Kindlin-1 is a human homolog of the Caenorhabditis elegans protein UNC-112, a membrane-associated structural/signaling protein that had been implicated in linking the actin cytoskeleton to the extracellular matrix (ECM). (medscape.com)
Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome. (medscape.com)

We show that the Caenorhabditis elegans egl-2 gene encodes an eag K + channel and that a gain-of-function mutation in egl-2 blocks excitation in neurons and muscles by causing the channel to open at inappropriately negative voltages. (jneurosci.org)
The genome is approximately 97Mb in size, and encodes over 19,000 proteins. (genome.gov)
This gene encodes a 677-amino acid protein, kindlin-1, which is thought to play a regulatory role in inhibiting oversecretion of basement membrane components by basal keratinocytes at the dermoepidermal junction. (medscape.com)

Studies of mutations affecting lifespan in Caenorhabditis elegans show that mitochondrial generation of reactive oxygen species (ROS) plays a major causative role in organismal aging. (warwick.ac.uk)
These mutations lead to a loss of functional DPY19L2 protein. (medlineplus.gov)
Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome. (medscape.com)
In 5 of 6 gene mutations that have been shown to cause EDMD, the affected protein is present in the LINC (linker of nucleoskeleton and cytoskeleton) complex. (medscape.com)
EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)
New mutations have been found in the synaptic nuclear envelope protein 1 ( SYNE1 ) gene and in the synaptic nuclear envelope protein 2 ( SYNE2 ) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)
Lastly, mutations in the transmembrane protein 43 (TMEM43), also termed LUMA, which binds to emerin and SUN2, has also been reported to cause an EDMD phenotype in a few families. (medscape.com)
Whatever the true mechanism, the discovery of mutations in several different nuclear membrane proteins that cause similar diseases will likely eventually lead to a better understanding of nuclear membrane physiology and the pathophysiology of diseases caused by mutations in these proteins. (medscape.com)

We leveraged Caenorhabditis elegans ' touch receptor neurons as a simple model amenable to in vivo whole-cell patch-clamp recording and an integrated experimental-computational approach to dissect the mechanisms underlying the spatial and temporal dynamics we observed. (nih.gov)
green fluorescent protein (GFP) fusions revealed egl-2 expression in a subset of neurons and muscles that could explain the mutant behavioral defects. (jneurosci.org)
Neuroendocrine regulation of diverse behaviors of Caenorhabditis elegans is under the control of the DAF-7/TGF-β ligand that is secreted from sensory neurons. (elifesciences.org)
Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans . (elifesciences.org)
The sensory neurons that release DAF-7 are found in both sexes of C. elegans but the specific way that the male worms express this signal encourages them to search for mates. (elifesciences.org)
C. elegans with green fluorescent protein ( gfp ) expression in neurons. (ku.edu)

Because of evolutionary conservation of gene function and experimental tractability, C. elegans represents an ideal "model organism" to study basic genetic and molecular mechanisms of human development and disease. (ku.edu)
The genome of C. elegans was the first of any multicellular organism to be sequenced in its entirety. (genome.gov)

Overexpression of active, spliced XBP-1 (XBP-1s), a transcription factor that acts downstream of the UPRER kinase/endoribonuclease IRE-1, in the nervous system of C. elegans increases the lifespan and healthspan of worms through UPRER induction in the intestine cell non-autonomously. (cam.ac.uk)
Here, we describe a novel mechanism for regulating mitochondrial ROS production and lifespan in C. elegans: progressive mitochondrial protein modification by the glycolysis-derived dicarbonyl metabolite methylglyoxal (MG). We demonstrate that the activity of glyoxalase-1, an enzyme detoxifying MG, is markedly reduced with age despite unchanged levels of glyoxalase-1 mRNA. (warwick.ac.uk)
Over-expression of the C. elegans glyoxalase-1 orthologue CeGly decreases MG modifications of mitochondrial proteins and mitochondrial ROS production, and prolongs C. elegans lifespan. (warwick.ac.uk)
In contrast, knock-down of CeGly increases MG modifications of mitochondrial proteins and mitochondrial ROS production, and decreases C. elegans lifespan. (warwick.ac.uk)
In C. elegans, patr-1 is involved in determination of adult lifespan. (wormbase.org)

Is an ortholog of human KIFAP3 (kinesin associated protein 3). (wormbase.org)

One example is the conserved Drosophila tumor-suppressor protein Lethal giant larvae (Lgl). (biologists.com)
Originalmente fueron identificadas como una clase de proteínas relacionadas con la proteína mothers against decapentaplegic, Drosophila y proteínas sma de CAENORHABDITIS ELEGANS. (bvsalud.org)
They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS. (bvsalud.org)

Neuronal homeodomain-interacting protein kinase (HPK-1) extends longevity and promotes healthspan. (elifesciences.org)
Predicted to enable protein kinase regulator activity. (wormbase.org)
In the early embryo, a myosin II-dependent contraction of the cortical meshwork asymmetrically distributes the highly conserved PDZ proteins PAR-3 and PAR-6, as well as an atypical protein kinase C (PKC-3), to the anterior. (biologists.com)
The PAR proteins include the PDZ domain-containing PAR-3 and PAR-6, the atypical protein kinase PKC-3, the serine/threonine kinase PAR-1 and, in nematodes, the putative ubiquitin E3 ligase PAR-2. (biologists.com)
They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)

mutants will be broadly useful as a method for identifying multiple types of post-translationally modified proteins and analyzing their synthesis pathways with the power of C. elegans genetic analysis.The second method that I developed is an experimental strategy for identifying proteins that contain different post-translational modifications between samples (Chapter 5). (unr.edu)
Investigation of the role of neurohormonal signalling was assessed by analysis of neuropeptide deficient and synaptic protein mutants. (bl.uk)
Examination of mutants of MRG15 and BRCA2 C. elegans orthologs revealed phenocopy by accumulation of RPA-1 (human RPA1) nuclear foci and aberrant chromosomal compactions in meiotic cells. (lu.se)
Studied on ribosomal proteins and elongation factor structure and function: Worked on 3D structures of elongation factor G (EF-G), ribosomal recycling factor (RRF), ribosomal proteins L1, L22, S8, TL5 and some mutants and complexes of these. (lu.se)

Studies on iron homeostasis in mitochondria: X-ray structures of yeast frataxin, a mitochondrial protein involved in iron storage and detoxification, also known as a factor in the neurodegenerative disease Friedrich's Ataxia. (lu.se)

These nematodes are only distantly related to Caenorhabditis elegans and have evolved to occupy an unusual niche, tunneling through epithelial cells of the large intestine. (nature.com)
Proteins that activated immunity are potential antigens for immunization and the multi-omics phylum-spanning prioritization database that was created is a valuable resource for identifying target proteins in a wide array of different parasitic nematodes. (frontiersin.org)

A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans. (babraham.ac.uk)
Aging is a risk factor for several neurodegenerative diseases involved in protein aggregation, including Alzheimer's, Parkinson's, Huntington's, and ALS. (medscape.com)
This is a summary of the article, "Cold Temperature Extends Longevity and Prevents Disease-Related Protein Aggregation Through PA28γ-Induced Proteasomes," published in the journal Nature Aging on April 3, 2023. (medscape.com)

CB5161 -- and subsequent analyses to compare the resulting data to the existing roundworm genomes should allow for more thorough annotation of the C. elegans genome. (genome.gov)

An antibody-protein array of putative immunogenic proteins was developed from a combined bioinformatic, experimental, and literature-based prioritization of homologous parasite proteins. (frontiersin.org)

Wnt signaling has been demonstrated to regulate diverse cell processes throughout the development of the Caenorhabditis elegans embryo. (nih.gov)
The one-cell C. elegans embryo serves as a model for studying the establishment and maintenance of polarity. (biologists.com)

Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. (nih.gov)
This protein was produced in an in vitro wheat germ expression system that should preserve correct conformational folding that is necessary for biological function. (novusbio.com)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)

Others change single protein building blocks (amino acids) in the DPY19L2 protein. (medlineplus.gov)

Firstly, the research team has identified a C. elegans gene (named NHR -69), which acts as a testosterone receptor. (uco.es)

In addition to the PAR proteins, other proteins are required for polarity in many metazoans. (biologists.com)
In metazoans, cell polarity is mediated in part by a conserved set of regulatory proteins, known collectively as the PAR (partitioning-defective) proteins. (biologists.com)

We show that the Caenorhabditis elegans SIR-2.2 and SIR-2.3 orthologs of SIRT4 are ubiquitously expressed, also localize to mitochondria and function during oxidative stress. (edu.sa)

Abstract from 15th Biennial International C. elegans Conference. (cmich.edu)

In addition, over 80 % of its proteins are homologous to human', says Professor Ruiz. (uco.es)
Screening the array with sera and ileal fluid samples from immunized pigs suggested cross-reactivity among homologous proteins and a general activation of immunity. (frontiersin.org)

The IMIBIC research group has pioneered the use of Caenorhabditis elegans as an experimental system to analyze basic neurobiological mechanisms involved in autism in vivo. (uco.es)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)

C. elegans are easily cultured in the laboratory, have a short (4-day) generation time, and come with a "toolkit" of genetic and molecular techniques by which gene function in development can be experimentally dissected. (ku.edu)
A team of scientists from the city of Cordoba has studied the effect of testosterone on behavior of the worm Caenorhabditis elegans, with the aim to analyze at the molecular level the interaction between the male hormone and the nervous system. (uco.es)
Western blot analysis of HD brain tissue shows full-length huntingtin protein in the nuclear fraction as well as abundant immunopositive bands at lower molecular weight, suggesting proteolytic products in the nucleus. (jci.org)
Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. (lu.se)

Furthermore, the data gained from experiments using these methods have contributed new insights into our understanding of the glycosylation of proteins with mitochondrial function.The first such method is a chemical biology approach for the discovery of glycoproteins in Caenorhabditis elegans (C. elegans). (unr.edu)

Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. (novusbio.com)

Using both C. elegans and mammalian models, we have significant progress in understanding the signal transduction mechanism as well its biological roles. (umassmed.edu)

Here, we show that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. (elifesciences.org)
It is also possible to analyze the underlying factors that contribute to behavior in C. elegans , because it has a relatively simple and well-defined nervous system. (elifesciences.org)
The research study, entitled "Epigenetic effect of testosterone in the behavior of C. elegans. (uco.es)
This research study, published in the journal Frontiers in Cellular Neuroscience as "Epigenetic effect of testosterone in the behavior of C. elegans. (uco.es)

B ) Venn diagram depicting TFs with significant age-associated differential expression alongside hpk-1 within 3 or more of the 36 neuronal and/or 11 non-neuronal cell clusters (yellow and blue, respectively), and the intersection with TFs that have previously been implicated in C. elegans longevity (red). (elifesciences.org)
There are several other neuronal proteins that regulate SV fusion by directly or indirectly affecting SNARE complex assembly and its function. (uic.edu)
My thesis focuses on understanding the role of three such neuronal proteins: UNC-13 (Uncoordinated), SAX-7 (Sensory Axon Guidance), and VPS-39 (Vacuolar Protein Sorting). (uic.edu)

Confocal immunofluorescent analysis of HeLa cells, insulin-treated (left) and LY294002-treated (#9901, right), using Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP ® Rabbit mAb (Alexa Fluor 488 ® Conjugate) (green). (cellsignal.com)

To address this issue, I developed a method using C. elegans primary embryonic cells for azido-sugar metabolic labeling and then used this method to identify novel C. elegans glycoprotein candidates (Chapter 2). (unr.edu)

Is the Subject Area "Protein interactions" applicable to this article? (plos.org)
The Massi lab uses their expertise in NMR Spectroscopy to understand the dynamics of protein-RNA interactions. (umassmed.edu)
Methods: Protein physical interactions were screened using the yeast two-hybrid system. (lu.se)

The nervous system of C. elegans plays a role in the orchestration of systemic stress responses. (cam.ac.uk)

Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize pathway components. (lu.se)

Hilbert and Kim showed that the biological sex in combination with multiple other inputs - including the animal's past diet and age - regulate how the DAF-7 signal is expressed in C. elegans . (elifesciences.org)

In these reactions, precursor proteins converted themselves into active enzymes that were not peptidases. (ebi.ac.uk)
Processing of the precursor proteins exposes an N-terminal threonine residue that is the nucleophile in catalysis ( Aronson, 2004 ). (ebi.ac.uk)

Assays that utilized their naïve attractive response were performed on N2 wild-type C. elegans and the pkc-1 mutant nj1, to determine how long the effects of the associative conditioning to these odors would last. (technologynetworks.com)
Here we report that the behavioral defects in the C. elegans egl-2 mutant are caused by a gain-of-function ( gf ) mutation in an eag-like K + channel. (jneurosci.org)

Caenorhabditis elegans, a cholesterol auxotroph, showed defects in larval development upon cholesterol starvation (CS) in a previous study. (molcells.org)

We primarily focus on a intracellular signaling pathway known as the mitochondrial unfolded protein response (or UPR mt ), which allows cells to monitor the function of the entire cellular pool of mitochondria and adapt transcription accordingly. (umassmed.edu)
Cold temperatures activate a cellular cleansing mechanism called proteasome that breaks down defective protein aggregations and helps prevent proteins from clumping together. (medscape.com)
Here, we aimed to investigate the potential neuroprotective effects of Carpesii fructus extract (CFE) in both cellular and Caenorhabditis elegans (C. elegans) models of PD. (bvsalud.org)

The X-ray structures of trimers of the protein and their complexes with various metals, single-particle electron microscopic structure of iron-free and iron-loaded 24-subunit oligomers. (lu.se)

What is C. elegans and why do scientists use it to study human development and disease? (ku.edu)
Studies on C. elegans are relevant to human diseases such as cancer, neurodegeneration (e.g. (ku.edu)
Granulicatella elegans , a bacterium found in normal human oral flora, is generally associated with infective endocarditis. (cdc.gov)

The roundworm Caenorhabditis elegans has two sexes, hermaphrodites and males. (elifesciences.org)

Dr. Pryciak studies how protein kinases regulate cell signaling and the cell cycle. (umassmed.edu)

Overall, this thesis provides new insight into the neural substrates of behavioural plasticity in C. elegans. (bl.uk)

One of these stress responses, the unfolded protein response of the endoplasmic reticulum (UPRER), is activated to re-establish protein homeostasis (proteostasis) upon the detection of ER stress. (cam.ac.uk)

Transport vesicles can move molecules between locations inside the cell, e.g., proteins from the rough endoplasmic reticulum to the Golgi apparatus . (wikipedia.org)
Membrane-bound and secreted proteins are made on ribosomes found in the rough endoplasmic reticulum . (wikipedia.org)

Anatomy5

Organisms5

Diseases1

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Psychiatry and Psychology1

Phenomena and Processes12

Information Science3

Genes5

Nematode7

Homolog4

Encodes3

Mutations8

Neurons6

Organism2

Lifespan5

Ortholog1

Drosophila3

Kinase5

Mutants4

Mitochondrial protein1

Nematodes2

Aging3

Annotation1

Putative1

Embryo2

Germ3

Amino acids1

Receptor1

Polarity2

Orthologs1

Abstract1

Homologous2

Experimental2

Molecular4

Glycosylation1

SuperFamily1

Mammalian1

Behavior4

Neuronal3

Ribosomal1

Metabolic1

Interactions3

Nervous system1

Biochemical1

Biological1

Precursor2

Mutant2

Defects1

Cellular3

Electron1

Human3

Roundworm1

Kinases1

Substrates1

Homeostasis1

Endoplasmic reticulum2