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RNACaenorhabditis elegansNucleic Acid HybridizationCaenorhabditis elegans ProteinsRNA TransportRNA, MessengerRNA-Binding ProteinsOogenesisMolecular Sequence DataDrosophila Proteins3' Untranslated RegionsGenes, HelminthBase SequenceIn Situ HybridizationOocytesAnimals, Genetically ModifiedCell PolarityAmino Acid SequenceDrosophilaMutationCytoplasmProtein BiosynthesisMyosin Type VCell NucleusDrosophila melanogasterRibonucleoproteinsHelminth ProteinsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsNuclear Localization SignalsInsect ProteinsEgg ProteinsTransforming Growth Factor alphaTranscription, GeneticCloning, MolecularMicroscopy, FluorescenceProtein TransportGene Expression RegulationBody PatterningVulvaCell CompartmentationActinsLuminescent ProteinsGerm CellsProtein BindingRNA InterferenceRecombinant Fusion ProteinsBiological TransportRNA, HelminthMicrotubulesNucleic Acid ConformationImmunohistochemistryRNA StabilityDNA, HelminthHeterogeneous-Nuclear RibonucleoproteinsSaccharomyces cerevisiae ProteinsCytoskeletonPhenotypeReverse Transcriptase Polymerase Chain ReactionSequence AlignmentSaccharomyces cerevisiaeTrans-ActivatorsSequence Homology, Amino AcidTranscription FactorsHomeodomain ProteinsSubcellular FractionsActive Transport, Cell NucleusNuclear ProteinsPolyribosomesRNA, FungalTransgenesDNA PrimersRepressor ProteinsCells, CulturedGenes, InsectCell LineDNA-Binding ProteinsRNA SplicingMolecular Motor ProteinsGenome, HelminthTransfectionDyneinsOvaryDisorders of Sex DevelopmentBlotting, WesternProtein IsoformsEndoplasmic ReticulumGenes, ReporterMyosin Heavy ChainsNeuronsMembrane ProteinsIn Situ Hybridization, FluorescenceCytoskeletal ProteinsSignal TransductionBinding SitesBlotting, NorthernDNA, ComplementaryXenopus ProteinsProteins
CaenorhabditisProteinsDrosophilaRegulateRegulationStabilityPost-transcriptionalSubcellular localizationMoleculesTranscriptionFunctionalMutantsHighly conservedCDNAInterferenceSequencesTissuesSynapticMaturationTelomeraseDevelopmentalEmbryosIntronsPathwayNeuronsGermMechanismsNematodesMutationsOskarSiRNAKnockdownNucleotideVariantsVitroMethylationMorphologicalSuggestsAccumulationRegulatesExpressionWormExonMiRNAsMeioticRepeatsIntronBindsStructuresNuclear
Caenorhabditis20
Proteins22
  • Vasa is an RNA binding protein with an ATP-dependent RNA helicase that is a member of the DEAD box family of proteins. (wikipedia.org)
  • The protein product in humans has 724 amino acids, a molecular mass of 79 kDa and 8 conserved domains in all DEAD-box proteins that is involved in RNA helicase activity. (wikipedia.org)
  • As with other Vasa related proteins, human Vasa has a N terminus rich in glycine and RGG motif repeats that function in RNA binding. (wikipedia.org)
  • Nuclear mRNA transcripts acquire a protein coat composed of cap- and RNA-binding proteins that allow nuclear export and dictate the functional program of cytoplasmic mRNAs ( Moore, 2005 ). (rupress.org)
  • Thus, GCGs contain proteins involved in translation initiation, translation control, and mRNA decay, which is consistent with their proposed role in the regulation ofs maternal mRNA expression. (rupress.org)
  • Serine/arginine-rich proteins (SR proteins), a group of proteins that harbor an arginine/serine (RS) domain either at their N' or C' terminus, play crucial roles in a plethora of biological processes such as cell cycle and signaling, developmental pathways, DNA replication and repair, transcription and mRNA splicing. (biologists.com)
  • The 3 spliced mRNAs putatively encode good proteins , altogether 3 different isoforms (1 complete, 2 partial ), some containing a coiled coil stretch [Psort2] . (nih.gov)
  • Here we present a multifunctional anchor, an acrylate epoxide, that enables proteins and RNAs to be equipped with anchors in a single experimental step. (plos.org)
  • We show that this united ExM (uniExM) protocol can be used to preserve and visualize RNA transcripts, proteins in biologically relevant ultrastructures, and sets of RNA transcripts in patient-derived xenograft (PDX) cancer tissues and may support the visualization of other kinds of biomolecular species as well. (plos.org)
  • Although Rab11a subcellular localization has been demonstrated by transgenic zebrafish [10], and molecular function of Rab11 proteins in primary cilia membrane assembly in Kupffer Vesicle has been studied [6], the developmental expression profile of Rab11 proteins in zebrafish remains elusive. (researchsquare.com)
  • The telomeres consist of repeating sequences and a set of special proteins, which interact with these repeats and spatially organize them in a specific manner, resulting in the formation of the nucleoprotein complex known as telomeric heterochromatin [ 6 , 7 ]. (actanaturae.ru)
  • Spermatogenesis produces haploid sperm capable of penetrating the oocyte, whereas oogenesis produces differentiated oocytes that are stockpiled with maternal nutrients, proteins, and mRNAs, and have outer layers that protect the embryo and enable fertilization. (elifesciences.org)
  • DAZ family proteins are found almost exclusively in germ cells in distant animal species. (ijbs.com)
  • These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)
  • Basically, Daz family proteins function as adaptors for target mRNA transport and activators of their translation. (ijbs.com)
  • This family includes three members, Boule (or Boll ), Dazl (or Dazla ) and DAZ , encoding RNA binding proteins. (ijbs.com)
  • The localization of DAZ family proteins suggests that they can regulate mRNA translation occurring in the cytoplasm. (ijbs.com)
  • These proteins have a highly conserved RNA recognition motif (RRM) for binding target mRNAs and at least one characteristic sequence of 24 amino acids, which are termed as DAZ repeats [ 1 ]. (ijbs.com)
  • Dazl can regulate the expression, transport and localization of target mRNAs of proteins which control the differentiation, growth and maturation of germ cells. (ijbs.com)
  • Basically, DAZ family proteins have been proposed to function as adaptors for mRNA transport and activators of their translation. (ijbs.com)
  • The single-stranded mature miRNA can then associate with an Argonaute protein, which mediates its function of mRNA regulation through direct mRNA target cleavage or interactions with associated RNA-induced silencing complex (RISC) proteins [ 24 ]. (biomedcentral.com)
  • We next examined the necessity of synaptic vesicle proteins are transported, sorted, and locally regulated in neurons to control synaptic autophagy for the active zone proteins in regulating mRNA stability Knockdown of decapping in Drosophila, suggesting that DCP1 overexpression does not result in alteration of the fluorescence intensities of nos and pgc puncta were analyzed using the VariantAnnotation package (V1. (tazreenclaimstrust.org)
Drosophila5
  • The vasa gene is essential for germ cell development and was first identified in Drosophila melanogaster, but has since been found to be conserved in a variety of vertebrates and invertebrates including humans. (wikipedia.org)
  • The Vasa gene is a member of the DEAD box family of RNA helicases in Drosophila melanogaster. (wikipedia.org)
  • In Drosophila, zygotic transcription of Vasa occurs at pole cells, and stays germ-line specific throughout the life of the organism. (wikipedia.org)
  • Other post-translational modification includes phosphorylation of the Vasa ortholog in C. elegans, and arginine methylation in a conserved region of mice, Xenopus and Drosophila Vasa genes. (wikipedia.org)
  • Nanos was first identified in Drosophila , where it represses the translation of target mRNAs through binding to their 3′ UTR and has a conserved function in germ cell development across species. (hindawi.com)
Regulate6
  • Developing embryos and adults regulate Vasa expression to cell and tissue specific locations. (wikipedia.org)
  • It uses ATP dependent RNA helicase catalytic activity to regulate the translation of multiple mRNAs. (wikipedia.org)
  • Different classes of RNA granules share some protein components and may use similar mechanisms to regulate mRNA translation/decay. (rupress.org)
  • MicroRNAs (miRNAs) are endogenous short non-coding RNA molecules that can post-transcriptionally regulate gene expression and play a critical role in gonadal differentiation as well as early development of animals. (peerj.com)
  • Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. (embl.de)
  • Thus, the maturing oocyte is reliant on processes such as post-transcriptional gene regulation (PTGR) to regulate the mRNA and protein repertoire. (biomedcentral.com)
Regulation6
  • The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA's influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. (cshlpress.com)
  • Cytoplasmic RNA granules in germ cells (polar and germinal granules), somatic cells (stress granules and processing bodies), and neurons (neuronal granules) have emerged as important players in the posttranscriptional regulation of gene expression. (rupress.org)
  • For example, down-regulation or chemical inhibition of SRPK1 effectively blocks angiogenesis by changing the RNA splicing patterns 4 . (biologists.com)
  • MicroRNAs (miRNAs) are all non-coding RNAs that play vital role in post-transcriptional regulation of various animals and plants ( Bartel, 2009 ). (peerj.com)
  • We further observed that Ras plays an essential role in the regulation of GLR-1 glutamate receptor localization in RMD neurons. (biomedcentral.com)
  • The inability to transcribe mRNA during this stage of development and the probable necessity for post-transcriptional gene regulation (PTGR) suggests an important role for non-coding RNA in the maturing oocyte. (biomedcentral.com)
Stability1
  • Fertilization also leads to changes in mRNA translation and protein stability, which support a period of development driven off of maternal stockpiles. (elifesciences.org)
Post-transcriptional1
  • Introns, commonly found in eukaryotes between exon sequences in the DNA, are removed from RNA molecules through splicing during post-transcriptional RNA processing. (biomedcentral.com)
Subcellular localization1
  • In addition, functional annotations, subcellular localization prediction and taxonomic distribution are reported. (biomedcentral.com)
Molecules1
  • Shortening of the 5'-terminus of the daughter strand, caused by the removal of the terminal RNA-primer and the subsequent incomplete replication of linear DNA molecules, is observed during the genome replication occurring upon cell fission. (actanaturae.ru)
Transcription3
  • Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). (cshlpress.com)
  • Transcription produces 3 alternatively spliced mRNAs . (nih.gov)
  • The MZT marks the transfer of control of development from the mother to the zygote as maternal mRNAs are degraded, transcription from the zygotic genome begins, and embryonic development becomes dependent on zygotic gene products ( Tadros and Lipshitz, 2009 ). (elifesciences.org)
Functional3
  • Previous data from the host lab report that functional RNF12 restricts mESC differentiation to neurons 10 , a finding reinforced in the current study as revealed by gene expression data (RNA-seq and/or qPCR) collected from RNF12 wildtype, phosphorylation, and ubiquitylation impaired mutants. (biologists.com)
  • Murine Rab11a and Rab11b were found to localize in distinct cellular compartment, suggesting functional differentiation [9]. (researchsquare.com)
  • MicroRNA (miRNA) are a class of functional small RNA that target mRNA to affect their abundance and translational efficiency. (biomedcentral.com)
Mutants4
  • Recently, temporal control of cell-specific expression using heat shock factor-1 ( hsf-1 ) mutants has been reported [ 1 ]. (biomedcentral.com)
  • In addition, the effects of gene knockdown can be assessed using various loss-of-function mutants, and researchers recently developed a new method of generating loss-of-function mutations in targeted genes in C. elegans [ 2 ]. (biomedcentral.com)
  • In one data set, mutants of a protein involved in RNA biogenesis and processing, human TAR DNA binding protein 43 (TDP-43), were expressed in S. cerevisiae . (frontiersin.org)
  • Disruption of RBC integrity due to non-specific clinical signs in most of the C. AIY did not reduce the fitness of these RNAs by making double mutants and distribution during embryogenesis. (tazreenclaimstrust.org)
Highly conserved1
CDNA5
  • In the process of retroposition, mRNAs are reverse-transcribed into cDNA and inserted into new genomic positions that lack introns [ 15 ]. (biomedcentral.com)
  • The sequence of this gene is defined by 16 cDNA clones and 18 elements defined by RNA-seq, some from mixed (seen 7 times), embryo (5), l2 (once). (nih.gov)
  • This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones. (nih.gov)
  • Click on any transcript to open the specific mRNA page, to see the exact cDNA clone support and eventual SNPs and to get details on tissues, sequences, mRNA and protein annotations. (nih.gov)
  • RAB11 was first found from cultured MDCK cell cDNA library screening for homologous genes of yeast YPT1/SEC4[3], and later identified as the 11th member of the Rab family[4]. (researchsquare.com)
Interference2
  • Disruption of this graded pattern of Eph activity by double-stranded RNA interference or by ectopic expression of wild-type or dominant-negative transgenes perturbs the establishment of medulla cortical axon topography. (sdbonline.org)
  • To gain insight into the role of Eph in the establishment of topographic connectivity, double-stranded RNA interference was used to reduce or eliminate Eph expression. (sdbonline.org)
Sequences1
  • We resolve chromosomal sequences and infer sex chromosome-specific parasite genes and new potential drug targets. (nature.com)
Tissues2
  • Germ cells contain other granules that may harbor translationally silenced mRNAs important for the development of other early embryonic tissues ( Navarro and Blackwell, 2005 ). (rupress.org)
  • uniExM may find many uses in the simple, multimodal nanoscale analysis of cells and tissues. (plos.org)
Synaptic2
  • How each neuron finds its synaptic partners has been a central question in developmental neurobiology. (stanford.edu)
  • Hence, RIM plays an evolutionarily conserved role in regulating synaptic calcium channel localization and readily releasable pool size. (jneurosci.org)
Maturation3
  • Indeed, several roles for ENDOG have been hypothesized, including maturation of RNA primers during mtDNA replication, splicing of polycistronic transcripts and mtDNA repair. (mdpi.com)
  • With the maturation of deep sequencing methodologies for small RNA identification, the number of reported mature miRNAs has drastically increased. (frontiersin.org)
  • Our results also revealed the presence of tail-length-independent mechanisms that maintained translation despite tail-length shortening during oocyte maturation, and prevented essentially all translation of bicoid and several other mRNAs before egg activation. (elifesciences.org)
Telomerase4
  • Germline mutations in NHP2, encoding for one component of the telomerase cofactor H/ACA RNA binding complex together with Dyskerin, NOP10 and GAR1, have been previously reported in rare cases of TBDs. (bvsalud.org)
  • Although still able to support cell viability, both variants reduce the levels of hTR, the telomerase RNA component, and telomerase activity, expanding the panel of NHP2 pathological variants. (bvsalud.org)
  • It consists of two major components: telomerase RNA (TER) and reverse transcriptase (TERT). (actanaturae.ru)
  • Telomerase consists of two major components: reverse transcriptase (TERT) and telomerase RNA (TER), which contains the template domain for the telomere repeat synthesis [ 9 ]. (actanaturae.ru)
Developmental3
  • Other mRNAs are programmed for delayed translation, allowing transcripts to be transported or stored until developmental or environmental cues call for their translation. (rupress.org)
  • In contrast, the 'facultative' heterochromatin corresponds to the deposition of H3K27me3 on gene-rich regions, whose silencing is transient and dynamic across developmental processes, allowing cell type-specific differentiation and rapid adaptation of gene expression [ 5 ]. (biomedcentral.com)
  • 2022). Interneuron control of C. elegans developmental decision-making. (caltech.edu)
Embryos1
  • The Vasa protein is found primarily in germ cells in embryos and adults, where it is involved in germ cell determination and function, as well as in multipotent stem cells, where its exact function is unknown. (wikipedia.org)
Introns3
  • In multicellular organisms, a pre-mRNA is composed of exons intervened with introns. (researchsquare.com)
  • The interspersed introns can be removed through a large multiprotein splicing complex (the spliceosome) to yield the mature mRNA. (researchsquare.com)
  • In intron retention (IR), introns that are supposed to be spliced appear in mature mRNA and subsequently participate in the translation process. (researchsquare.com)
Pathway6
  • We found that, under poor environmental conditions, mutations in the Ras-MAPK signaling pathway lead to circular locomotion instead of normal exploratory foraging. (biomedcentral.com)
  • We have established a new RNAi method that performs simultaneous time- and cell-specific knockdown and have applied this to reveal temporal profiles of the Ras-MAPK pathway in the control of exploratory behavior under poor environmental conditions. (biomedcentral.com)
  • Therefore, for detailed analysis of multifunctional genes, such as the components of the Ras-MAPK pathway described below, simultaneous time-specific and cell-specific knockdown is necessary. (biomedcentral.com)
  • We found that major cellulase genes ( cel7a , cel7b , and cel3a ) exhibited concomitant decrease in IR rates and increase in their gene expression in T . reesei under cellulase-producing condition (cellulose and lactose) that was accompanied with a more active NMD pathway, as compared to non cellulase-producing condition (glucose). (researchsquare.com)
  • In the presence of the NMD pathway inhibitor that successfully repressed the NMD pathway, the mRNA levels of cellulase genes were sharply down-regulated, but the rates of IR in these genes were significantly up-regulated. (researchsquare.com)
  • In addition, the NMD pathway inhibitor caused the downregulated mRNA levels of two important genes of the target of rapamycin (TOR) pathway, trfkbp12 and trTOR1 . (researchsquare.com)
Neurons3
  • Neuronal connections are made with exquisite accuracy between specific types of neurons. (stanford.edu)
  • Spontaneous foraging is regulated by a neural circuit composed of three classes of neurons: IL1, OLQ, and RMD, and we found that Ras functions in this neural circuit to modulate the direction of locomotion. (biomedcentral.com)
  • This technique revealed that control of GLR-1 localization in RMD neurons requires Ras at the adult stage. (biomedcentral.com)
Germ3
  • An exception to this theory is the presence of Zn-knuckles in all four C. elegans Vasa genes, which are restricted to functions in the germ line. (wikipedia.org)
  • GCGs direct the timing of maternal mRNA translation to promote germ cell development in the early embryo and establish the germ line for the next generation. (rupress.org)
  • The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. (hindawi.com)
Mechanisms1
  • Our goal is to convey a picture of pattern formation that draws attention to the principles rather than solely to specific molecular mechanisms. (mpi-cbg.de)
Nematodes1
  • Bacillary cells and stichocytes are distinctive cell types found only in clade I nematodes 5 and are located in the slender anterior part of the adult whipworm that is burrowed within the intestinal epithelium. (nature.com)
Mutations2
  • We found that aggregation differentiates the effects of mutations in the two different cellular contexts. (frontiersin.org)
  • Specifically, aggregation was found to be associated with increased cell fitness in the case of TDP-43 mutations, as it protects the host from aberrant interactions. (frontiersin.org)
Oskar1
  • For example, oskar protein was found to localize to pole plasm and may be involved in anchoring Vasa to polar granules in the posterior pole of the oocyte. (wikipedia.org)
SiRNA1
  • Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. (mdpi.com)
Knockdown4
  • In particular, RNAi is a powerful tool that enables time- or cell-specific knockdown via heat shock-inducible RNAi or cell-specific RNAi. (biomedcentral.com)
  • To investigate the temporal- and cell-specific profiles of the functions of Ras, we developed a new RNAi method that enables simultaneous time- and cell-specific knockdown. (biomedcentral.com)
  • RNAi-mediated cell-specific knockdown in C. elegans is a currently available technique [ 3 ] based on driving the expression of double-stranded RNA in target cells via cell-specific promoters. (biomedcentral.com)
  • A previous report has shown that RNA hairpins, which are driven by the heat shock promoter, induce knockdown of the target gene [ 5 ], suggesting the possibility of time-specific knockdown. (biomedcentral.com)
Nucleotide1
  • miRNAs are a class of short (∼22 nucleotide) noncoding RNAs (ncRNAs). (frontiersin.org)
Variants2
  • In the current work, they found SRPK1 & 2 deletions and SRPK3 variants in patients suffering from intellectual disabilities. (biologists.com)
  • Furthermore, both variants fail to be incorporated in the H/ACA RNA binding complex when in competition with wild-type endogenous NHP2, and the lack of incorporation causes their drastic proteasomal degradation. (bvsalud.org)
Vitro1
  • In vitro production of enzymatically active O. volvulus prolyl 4-hydroxylase should facilitate identification of specific inhibitors of the parasite enzyme. (embl.de)
Methylation1
  • When present, high levels of DNA cytosine methylation are found in H3K9me3-enriched regions. (biomedcentral.com)
Morphological2
  • Morphological descriptions of RNA granules originated with Metschnikoff (1865) , who described dark staining granules at one pole within Miastor metraloas (fly) larvae. (rupress.org)
  • On the basis of whole-transcriptome analyses, we identify many genes that are expressed in a sex- or life stage-specific manner and characterize the transcriptional landscape of a morphological region with unique biological adaptations, namely, bacillary band and stichosome, found only in whipworms and related parasites. (nature.com)
Suggests2
  • The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. (hindawi.com)
  • The high degree of conservation in structure and specific activity and the coexistence of Mch3 alpha and CPP32 in the same cell suggests that the PARP cleavage activity observed during apoptosis cannot solely be attributed to CPP32 but could also be an activity of Mch3 alpha. (deathbase.org)
Accumulation1
  • We found that one suppressor, the transmembrane protein PTR-23, is co-expressed with osm-8 in the hypodermis and strongly suppresses several Osm-8 phenotypes, including the transcriptional activation of many osmosensitive mRNAs, constitutive glycerol accumulation, and osmotic stress resistance. (prolekarniky.cz)
Regulates2
  • We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger RNA translation/decay. (rupress.org)
  • Cell density regulates prolyl 4-hydroxylase activity independent of mRNA levels. (embl.de)
Expression11
  • Vasa expression localization is directed by repressing these translation inhibitory pathways. (wikipedia.org)
  • Genome-wide transcriptional profiling using RNA-Seq revealed few age-related changes in gene expression in muscle and esophagus tissue. (nature.com)
  • In addition, abnormal midline fasciculation of photoreceptor axons results from the eye-specific expression of the dominant-negative Eph transgene. (sdbonline.org)
  • In this method, one RNA strand is expressed by a cell-specific promoter and the other by a heat shock promoter, resulting in only expression of double-stranded RNA in the target cell when heat shock is induced. (biomedcentral.com)
  • In this organism, various cell-specific promoters can be utilized for cell-specific expression to determine the function of a gene in a specific cell. (biomedcentral.com)
  • In contrast to cell-specific promoters, heat shock promoters drive the expression of genes at arbitrary timing via heat shock [ 4 ]. (biomedcentral.com)
  • Tumor specific expression, expression at the earliest stages of tumor development, and direct exposure to blood, suggest that TVMs are ideal biomarkers for both ovarian cancer diagnosis and targeted immunotherapy. (nih.gov)
  • Here I review recent work in yeast, flies, mice and primates that examines the influences of naturally occurring sequence variation, chromosomal order and speciation on genome-wide expression profiles of both RNA and protein. (biomedcentral.com)
  • A synthetic view from these experiments would suggest that gene expression is not randomly distributed along chromosomes, that variations in mRNA and protein expression within a single species result from a surprising balance between polymorphisms acting in cis and polymorphisms acting in trans to the regulated gene, and consequently that relatively few adaptive changes could have major impacts in remodeling gene expression patterns over the course of evolution. (biomedcentral.com)
  • 13 ] have shown that housekeeping genes cluster more readily than do other gene classes (as measured by breadth of representation in serial analysis of gene expression (SAGE) experiments), but clustering patterns that are more specific have also been reported. (biomedcentral.com)
  • The authors propose that the asymmetric segregation of the NuRD complex in C. elegans is regulated in a V-ATPase-dependent manner, that this plays a crucial role in determining the differential expression of the apoptosis activator egl-1 and that it is therefore critical for the life/death fate decision in this species. (elifesciences.org)
Worm1
  • AceView: gene:dpy-21, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)
Exon1
  • The mRNAs appear to differ by truncation of the 5' end, presence or absence of a cassette exon , overlapping exons with different boundaries. (nih.gov)
MiRNAs1
  • Mature miRNAs act via complementarity with their target mRNAs. (frontiersin.org)
Meiotic1
  • Of particular interest is understanding the role of non-coding RNA in regulating meiotic checkpoints in the oocyte, particularly that of microRNA-21 (MIR21). (biomedcentral.com)
Repeats1
  • We established genome-wide patterns of H3K27me3 and H3K9me3 modifications, and found these marks mutually exclusive within gene-rich regions but not within repeats. (biomedcentral.com)
Intron1
  • The biological functions of intron retention (IR) and nonsense-mediated mRNA decay (NMD) in filamentous fungi is lack of study, let alone their roles in cellulase biosynthesis. (researchsquare.com)
Binds1
  • In rodents and C. elegans , RIM binds to and is an effector of the small GTPase Rab3. (jneurosci.org)
Structures2
  • They may inhibit translation by forming secondary RNA structures or binding trans-acting factors. (wikipedia.org)
  • The conserved domain may act as chaperones by unwinding RNA secondary structures and refolding properly. (wikipedia.org)
Nuclear1
  • Moreover, phosphorylation of all four serines - harbored in the nuclear localization signal - supports RNF12 nuclear retention in mouse embryonic stem cells (mESCs). (biologists.com)