• Prestin is the transmembrane protein underlying the OHC's ability to elongate and contract, a process essential for OHC electromotility. (wikipedia.org)
  • Positive Darwinian evolutionary changes in the mammalian α10 subunit resulted in increased calcium permeability and parallels the evolution of the anion chloride transporter SLC26A5 (prestin) and somatic electromotility in cochlear OHCs. (frontiersin.org)
  • A recent promising finding is that chronic treatment with high-dose salicylate (the active ingredient of aspirin) for several weeks enhances expression of the outer hair cell (OHC) motor protein (prestin), resulting in strengthened OHC electromotility and enhanced distortion product otoacoustic emissions (DPOAE). (cdc.gov)
  • Importantly, the outer hair cells with the Ikzf2 mutation showed significantly reduced electromotility. (mrc.ac.uk)
  • Both of these genes code for proteins that are required for electromotility, reinforcing helios as an important factor regulating outer hair cell functional maturation. (mrc.ac.uk)
  • In addition, they also displayed outer hair cell-like properties, such as increased expression of outer hair cell genes (including the two key outer hair cell-specific genes helios controls), and even electromotility. (mrc.ac.uk)
  • The outstanding acuity of the mammalian ear relies on cochlear amplification, an active mechanism based on the electromotility (eM) of outer hair cells. (bvsalud.org)
  • PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal cochlear morphology and physiology with no detectable alterations in outer hair cell morphology, electromotility or nonlinear capacitance. (utsouthwestern.edu)
  • Mammalian hearing relies upon active cochlear mechanics, which arises from outer hair cell electromotility and hair bundle movement, to amplify acoustic stimulations increasing hearing sensitivity and frequency selectivity. (uky.edu)
  • We find that targeted-deletion of connexin 26 in Deiters cells and outer pillar cells, which constrain outer hair cells standing on the basilar membrane, causes a leftward shift in outer hair cell electromotility towards hyperpolarization, and reduces active cochlear amplification with hearing loss. (uky.edu)
  • This process is known as electromotility and is critical for these cells to be able to amplify low-level sounds and function properly. (mrc.ac.uk)
  • Prestin is the transmembrane protein underlying the OHC's ability to elongate and contract, a process essential for OHC electromotility. (wikipedia.org)
  • Electromotility and prestin expression in OHCs were normal in CaV1.3−/− mice. (whiterose.ac.uk)
  • Interestingly, it has been reported that a long-term salicylate application up-regulated expression of prestin, the OHC motor protein, consequently leading to an increase of OHC electromotility and DPOAE. (cdc.gov)
  • A recent promising finding is that chronic treatment with high-dose salicylate (the active ingredient of aspirin) for several weeks enhances expression of the outer hair cell (OHC) motor protein (prestin), resulting in strengthened OHC electromotility and enhanced distortion product otoacoustic emissions (DPOAE). (greenmedinfo.com)
  • We showed that a mutation in the Ikzf2 gene, which encodes helios, resulted in a reduction in prestin-dependent electromotility and early-onset hearing loss. (nih.gov)
  • Prestin responds to transmembrane voltage fluctuations by changing its cross-sectional area, a process underlying the electromotility of outer hair cells and cochlear amplification. (feedspot.com)
  • Prestin belongs to the SLC26 family of anion transporters yet is the only member capable of displaying electromotility. (feedspot.com)