Egfr and erbb 2 receptor erbb2 receptor erbb 2. Medical search. Frequent questions

15. EGFR expression and HER2/neu overexpression/amplification in endometrial carcinosarcoma. (nih.gov)
The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named HER2 in humans and neu in rodents ErbB-3, also named HER3 ErbB-4, also named HER4 v-ErbBs are homologous to EGFR, but lack sequences within the ligand binding ectodomain. (wikipedia.org)
HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. (nih.gov)
capecitabine, for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress human epidermal growth factor receptor 2 (HER2) and who have received prior therapy, including an anthracycline, a taxane, and trastuzumab. (nih.gov)
letrozole for the treatment of postmenopausal women with hormone receptor-positive metastatic breast cancer that overexpresses the HER2 receptor for whom hormonal therapy is indicated. (nih.gov)
The recommended dose of lapatinib tablets for hormone receptor-positive, HER2-positive metastatic breast cancer is 1,500 mg (6 tablets) given orally once daily continuously in combination with letrozole. (nih.gov)
AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2. (adooq.com)
BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. (adooq.com)
ErbB receptor family, also known as the EGF receptor family or I-receptor family, includes epidermal growth factor receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4 [ 11 ], overexpresses, or mutates in many malignancies particularly in breast cancer, ovarian, and NSCLC. (hindawi.com)
The epidermal growth factor receptor (EGF R) subfamily of receptor tyrosine kinases comprises four members: EGF R (also known as HER1, ErbB1or ErbB), ErbB2 (Neu, HER2), ErbB3 (HER3), and ErbB4 (HER4). (rndsystems.com)
EGFR/ErbB1, HER2/ErbB2, and ErbB4, but not ErbB3 receptors, of the epidermal growth factor receptor family were confirmed by Western blot. (skinmicrobiomecongressca.com)
The epidermal development aspect receptor (EGFR) is among the most well analyzed receptors in cell biology and is a member of the ErbB family of receptor tyrosine kinases that also includes ErbB2 (HER2) ErbB3 and ErbB4. (researchassistantresume.com)
HER3 is the human epidermal growth factor (HER) family, which further comprises of HER1/EGFR/erbB1, HER2/erbB2 & HER4/erbB4. (straitsresearch.com)
The human epidermal growth factor receptor-related receptor HER2 is known to trigger intracellular signaling cascades that modulate the activity of coregulators of the estrogen receptor which, in turn, reduces the cell sensitivity to tamoxifen treatment. (biomedcentral.com)
ER and HER2 receptor) specific treatments is affected by an extensive crosstalk of receptor-triggered pathways [ 12 ]. (biomedcentral.com)

Notably, the ErbB1 and ErbB4 are the two most studied and intact among the family of ErbB proteins, Which forms functional intracellular tyrosine kinases. (wikipedia.org)
The ErbB proteins are a family of receptor kinases that include four closely related members: epidermal growth factor receptor (EGFR/ErbB1), ErbB2/neu, ErbB3, and ErbB4. (cdc.gov)
AZD8931 is an oral, equipotent inhibitor of ErbB1, ErbB2 and ErbB3 receptor signaling. (adooq.com)
The receptors for NRG ligands are all members of the EGF receptor (EGFR) family, and include EGFR (or ErbB1), ErbB2, ErbB3, and ErbB4, also known as HER1 through HER4, respectively, in humans (Meyer et al. (justia.com)
Epidermal Growth Factor Receptor (EGF R), also named erythroblastic leukemia viral oncogene homolog 1 (ErbB1), is a member of the type I receptor tyrosine kinase superfamily. (rndsystems.com)
ErbB3 activity is not due to co-precipitation with ErbB1 or ErbB2. (nih.gov)
Coclustering of ErbB2 with ErbB1 and ErbB3 is low and slightly increased by ligands for ErbB1 and 3. (nih.gov)
ErbB2 (10 nm) and ErbB1 (5 nm). (nih.gov)

6. ErbB2, ErbB3 and ErbB4 expression in urothelial tumors of the upper urinary tract and their prognostic significance. (nih.gov)
We used the nCounter expression assay (NanoString®) to measure the expression of EGFR, erb-B2 receptor tyrosine kinase 2 (ERBB2), ERBB3, ERBB4, and estrogen receptor 1 (ESR1) genes using mRNA extracted from paraffin-embedded tumor tissues from 203 patients diagnosed with TNBC. (biomedcentral.com)
Overexpression of the human epidermal growth factor receptor (HER) family members, consisting of epidermal growth factor receptor (EGFR), ERBB2, ERBB3, and ERBB4, is frequently observed in many kinds of human epithelial malignancies [ 4 ]. (biomedcentral.com)

19. HER3 status by immunohistochemistry is correlated with poor prognosis in hormone receptor-negative breast cancer patients. (nih.gov)
Many malignancies show increased expression of the epidermal growth factor (EGF) receptor family member ErbB3 (HER3). (elsevierpure.com)
Similarly, many clinical studies are focusing on the biologic function of HER3 in the progression of erbB2-aberrant breast cancer. (straitsresearch.com)
In the last few years, kinase signaling pathway has been witnessing massive popularity in the pharmaceutical industry as many studies reveal that compensatory upregulation of HER3 along with the sustained PI-3K/Akt signaling is implicated as an important mechanism, resulting in resistance to EGFR-targeted therapy. (straitsresearch.com)
In addition, elevated expression of the HER3 ligand (HRG) is a possible mechanism of resistance to anti-EGFR antibody (Ab)-cetuximab in the treatment of patients with colorectal cancer. (straitsresearch.com)
ErbB3, also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. (proteinkinase.biz)

The intracellular/cytoplasmic region of the ErbB receptor consists mainly of three subdomains: A juxtamembrane with approximately 40 residues, a kinase domain containing approximately 260 residues and a C-terminal domain of 220-350 amino acid residues that become activated via phosphorylation of its tyrosine residues that mediates interactions of other ErbB proteins and downstream signaling molecules. (wikipedia.org)
These groups of receptors are activated by the binding of ligands to the external domain of receptors to form homo- or hetero-dimers with each other, which leads to the phosphorylation of the tyrosine kinase domain and the subsequent activation of multiple downstream signaling molecules involved in mitogenic and survival signaling pathways [ 3 ]. (e-crt.org)
Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. (neobiotechnologies.com)
Ligand binding induces EGF R homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, tyrosine phosphorylation and cell signaling. (rndsystems.com)
1 μm2) of ligand-receptor complex generated lower EGF receptor phosphorylation per ligand than smaller assemblies ( (researchassistantresume.com)
Otto Warburg in 1956 described for the first time a specific metabolic characteristic of neoplasms by demonstrating that a cancer cell, unlike an untransformed cell, relies mainly on a higher glycolytic flux without a change in oxidative phosphorylation even in the presence of oxygen [ 2 ]. (biomedcentral.com)
However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. (proteinkinase.biz)

Formalin-fixed, paraffin-embedded human breast carcinoma stained with HER-2 Monospecific Mouse Monoclonal Antibody (ERBB2/3257). (neobiotechnologies.com)
SDS-PAGE Analysis Purified HER-2 Monospecific Mouse Monoclonal Antibody (ERBB2/3257). (neobiotechnologies.com)
Analysis of Protein Array containing more than 19,000 full-length human proteins using HER-2 Monospecific Mouse Monoclonal Antibody (ERBB2/3257). (neobiotechnologies.com)
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. (neobiotechnologies.com)
This product is a recombinant mouse antibody Fab fragment that recognizes EGFR β-hairpin domain. (creativebiolabs.net)
Phospho-EGFR (Tyr992) Antibody detects endogenous levels of EGFR only when phosphorylated at Tyr1016, which site historically referenced as Tyr992. (affbiotech.cn)
The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. (bioss.com.cn)

The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member. (wikipedia.org)
The figure below shows the tridimensional structure of the ErbB family proteins, using the pdb files 1NQL (ErbB-1), 1S78 (ErbB-2), 1M6B (ErbB-3) and 2AHX (ErbB-4): The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher-order oligomers upon activation by a subset of potential growth factor ligands. (wikipedia.org)
Overexpression of ErbB proteins in breast cancer patients is generally associated with poor prognosis. (cdc.gov)
Transmembrane signaling mediated by ErbB proteins is stimulated by peptide growth factors and is blocked by monoclonal antibodies such as trastuzumab and pertuzumab. (unideb.hu)
ErbB receptors exert their function in conjunction with non-ErbB proteins, e.g. (unideb.hu)
The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. (bioss.com.cn)
Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. (bioss.com.cn)

In this study we selected three breast cancer cell lines (SKBR3, SUM149 and SUM190) with different oncogene expression levels involved in ERBB2 and EGFR signaling pathways as a model system for the evaluation of selective integration of subsets of transcriptomic and proteomic data. (nih.gov)
We assessed the oncogene status with reads per kilobase per million mapped reads (RPKM) values for ERBB2 (14.4, 400, and 300 for SUM149, SUM190, and SKBR3, respectively) and for EGFR (60.1, not detected, and 1.4 for the same 3 cell lines). (nih.gov)
We used bioinformatics sites GeneGo, PathwayCommons and NCI receptor signaling networks to identify pathways that contained the four main oncogenes and had good coverage in the transcriptomic and proteomic data sets as well as a significant number of oncogene interactors. (nih.gov)
10. Immunohistochemical study of apoptosis-related Bcl-2 protein and its correlation with proliferation indices (Ki67, PCNA), tumor suppressor genes (p53, pRb), the oncogene c-erbB-2, sex steroid hormone receptors and other clinicopathological features, in normal, hyperplastic and neoplastic endometrium. (nih.gov)
The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral oncogene. (wikipedia.org)

Here, we retrospectively evaluated the importance of HER4 expression on the outcome of tamoxifen- and aromatase inhibitor-treated estrogen receptor-positive breast cancer patients ( n = 258). (biomedcentral.com)
In accordance with this finding, the sensitivity to tamoxifen treatment of estrogen and HER4 receptor-positive ZR-75-1 breast cancer cells can be significantly enhanced by HER4 knockdown. (biomedcentral.com)
We suggest an HER4/estrogen receptor interaction that impedes tamoxifen binding to the estrogen receptor and reduces treatment efficiency. (biomedcentral.com)

16. Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer. (nih.gov)
EGF R has been shown to bind a subset of the EGF family ligands, including EGF, amphiregulin, TGF alpha, betacellulin, epiregulin, heparin-binding EGF and neuregulin-2 alpha , in the absence of a coreceptor. (rndsystems.com)
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. (bioss.com.cn)

Epidermal growth factor receptor (EGFR) overexpression in TNBC indicates poor prognosis. (biomedcentral.com)
In some studies, it has been reported that the overexpression of EGFR in colon cancer may be involved in potential metastasis and poor prognosis [ 2 ]. (e-crt.org)

CRC is frequently associated with a high expression of epidermal growth factor receptors (EGFRs). (e-crt.org)
HN - 2019 MH - Afatinib UI - D000077716 MN - D2.65.132 MN - D3.633.100.786.188 MS - A quinazoline and butenamide derivative that acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER. (nih.gov)

Chrysophanic acid (Chrysophanol) blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. (adooq.com)
Our results indicate that stimulation of the early metastatic steps of motility and invasion by ErbB3 requires activation of the PI3-kinase pathway by the ErbB3 receptor. (elsevierpure.com)
The signalling pathway terms "PI3K-Akt", "transforming growth factor-β receptor", "ErbB", and "HIF-1" from the functional annotation analysis were studied. (nature.com)
It often co-expresses and forms heterodimers with other receptor tyrosine kinases (RTKs) in cancer cells to activate oncogenic signaling pathway, particularly the PI-3K/AKT pathway and SRC kinases. (straitsresearch.com)
In addition, epidermal growth factor (EGF) was reported to induce PD-L1 expression through the IL‐6/JAK/STAT3 signaling pathway in EGFR-mutant NSCLC cells [ 4 ]. (ijbs.com)
The gene list on this page consists of all genes in the KEGG "Insulin Signaling Pathway and KEGG "ErbB Signaling Pathway" . (nih.gov)

5. Tumor-associated macrophages, epidermal growth factor receptor correlated with the triple negative phenotype in endometrial endometrioid adenocarcinoma. (nih.gov)
Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease, while excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. (wikipedia.org)
Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. (wikipedia.org)
Our study suggests that overexpression of ErbB2 may augment ethanol-elicited signaling and promote ethanol-stimulated tumor metastasis. (cdc.gov)
The expression levels of PD-L1 on the surface of tumor cells were positively correlated with the induction of the inflammatory cytokine interferon-γ [ 2 ]. (ijbs.com)
The main indication for an adjuvant treatment of breast cancer with anti-estrogens is the immunohistochemical identification of estrogen receptor (ER)-positive tumor cells that was suggested in 1987 [ 3 ] and has since evolved into a standardized diagnostic procedure. (biomedcentral.com)

The ability ('+') or inability ('-') of each growth factor to activate each of the ErbB receptors is shown in the table below: The dimerization occurs after ligand bind to the extracellular domain of the ErbB monomers and monomer-monomer interaction establishes activating the activation loop in a kinase domain, that activates the further process of transphosphorylation of the specific tyrosine kinases in the kinase domain of ErbB's intracellular part. (wikipedia.org)
Overexpression of ErbB2 enhances ethanol-stimulated intracellular signaling and invasion of human mammary epithelial and breast cancer cells in vitro. (cdc.gov)
Ethanol triggered divergent intracellular signaling among cells expressing different ErbB2 levels. (cdc.gov)
Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. (neobiotechnologies.com)
Expression of (ZEGFR:1907)(2-)KDEL resulted in 80% reduction ofthe cell surface level of EGFR, and fluorescent staining for EGFR and the (ZEGFR:1907)(2-)KDEL construct showed overlapping intracellular localisation. (uni-bielefeld.de)
Immunocapture of EGFR from cell lysates showed that an intracellular complex between EGFR and the affibody construct had been formed, further indicating aspecific interaction between the affibody construct and EGFR. (uni-bielefeld.de)

The agents that target EGFR are composed of monoclonal antibodies (mAbs), such as cetuximab and panitumumab, and small molecule tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib [ 4 , 5 ]. (e-crt.org)
Tyrosine kinase inhibitors are small molecules that bind to the kinase enzyme receptor site available on the cell surface. (straitsresearch.com)
membrane after treatment with ErbB kinase inhibitors and further upregulated by EGF. (nih.gov)
Furthermore, knockdown of MUC3A and tyrosine kinase inhibitors (TKIs) in EGFR-mutant NSCLC cells play a synergistic effect on inhibited proliferation and promoted apoptosis in vitro . (ijbs.com)
Previous studies suggested that stable expression of mutated epidermal growth factor receptor (EGFR) in immortalized bronchial epithelial cells promoted PD-L1 expression, and that EGFR tyrosine kinase inhibitors (TKIs) inhibited PD-L1 expression in EGFR-mutant NSCLC cells [ 3 ]. (ijbs.com)

13. Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. (nih.gov)
However, there is no previous study of the relationship between expression of the entire human epidermal growth factor receptor (HER) family genes and patient prognosis in TNBC. (biomedcentral.com)
In addition to the known role of ERBB2, research on other HER family genes in breast cancer is now ongoing. (biomedcentral.com)
EGFR and ERBB2 were selected as the downstream-regulation target genes. (degruyter.com)
The four NRG genes, NRG-1, NRG-2, NRG-3, and NRG-4, map to distinct chromosomal loci (Pinkas-Kramarski et al. (justia.com)
1998. Survival of patients with glioblastoma multiforme is not influenced by altered expression of p16, p53, EGFR, MDM2 or Bcl-2 genes. (stjohns.edu)

HM781-36B is a novel and irreversible pan-human epidermal growth factor receptor (HER) inhibitor with TEC cytoplasmic kinase inhibition. (e-crt.org)
Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. (bioss.com.cn)

ErbB2 has no known binding ligand and absent of an active kinase domain in ErbB3 make this duo preferable to form heterodimers & share each other's active domains to activate transphosphorylation of the tyrosine kinases. (wikipedia.org)
In the cells overexpressing ErbB2, ethanol was more effective in the activation of c-Jun NH2 terminal protein kinases (JNKs) and p38 mitogen-activated protein kinase (p38 MAPK) as well as the induction of reactive oxygen species (ROS) than the cells with normal ErbB2 expression. (cdc.gov)
From NCBI Gene: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. (nih.gov)
Selective for EGFR and ErbB-2 versus other proliferative kinases. (tocris.com)
Activation of the ErbB family of receptor tyrosine kinases is involved in a range of human cancers. (unideb.hu)

Triple negative breast cancer (TNBC), defined as the absence of both hormone receptor expression and erb-B2 receptor tyrosine kinase 2 (ERBB2) overexpression, accounts for approximately 15-20 % of all breast cancers [ 1 ]. (biomedcentral.com)
In preclinical studies, EGFR overexpression was detected more frequently and at higher levels in TNBC cell lines than in other subtypes and the combination of an EGFR targeting agent and cytotoxic agent inhibited cell growth more effectively than cytotoxic chemotherapy alone [ 24 ]. (biomedcentral.com)
The addition of HM781-36B induced potent growth inhibition in both DiFi cells with EGFR overexpression and SNU-175 cells (IC 50 , 0.003 µM and 0.005 µM, respectively). (e-crt.org)

Our experiments point to an unexpected, but potentially important mechanism of action of ErbB receptor-targeted monoclonal antibodies used in the treatment of cancer. (unideb.hu)

Nuclear translocation of PDGFRβ was dependent on PDGF-BB-induced receptor dimerization, clathrin-mediated endocytosis, β-importin, and intact Golgi, occurring in both normal and cancer cells. (silverchair.com)
Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. (bioss.com.cn)

In direct ELISAs, no cross-reactivity with recombinant human (rh) ErbB2, rhErbB3, or rhErbB4 is observed. (rndsystems.com)
1989. Phase IB study of low-dose intraperitoneal recombinant Interleukin-2 in patients with refractory advanced ovarian cancer: Rationale and preliminary report. (stjohns.edu)

Biomedical investigators have since developed substantial understanding of the biology underlying the dependence of cancers on aberrant ERBB receptor signaling. (nih.gov)
ErbB-1 and ErbB-2 are found in many human cancers, and their excessive signaling may be critical factors in the development and malignancy of these tumors. (wikipedia.org)
CC occurs in approximately 2 per 100,000 people and accounts for approximately 13% of primary liver cancers [ 2 , 3 ]. (gastrores.org)
and (3) distal extrahepatic bile duct cancers (20-25%) [ 2 ]. (gastrores.org)
Isoform 2 is also expressed in ovarian cancers. (affbiotech.cn)
The sensitivity of estrogen receptor-positive breast cancers to tamoxifen treatment varies considerably, and the molecular mechanisms affecting the response rates are manifold. (biomedcentral.com)

We investigated the mechanism of EGFR clustering by treating cells with compounds that disrupt the cytoskeleton (Latrunculin-B) clathrin-mediated endocytosis (Pitstop2) and inhibit EGFR activation (Gefitinib). (researchassistantresume.com)

EGFR is a glycoprotein with a transmembrane domain, one of the four members of tyrosine kinase receptor ErbB family. (hindawi.com)
Our study shows that transmembrane mucin MUC3A induces PD-L1, thereby promoting immune escape in NSCLC, while downregulation of MUC3A enhances TKIs effects in EGFR-mutant NSCLC. (ijbs.com)

Activation of the tyrosine kinase domain leads to the activation of the whole range of downstream signaling pathways like PLCγ, ERK 1/2, p38 MAPK, PI3-K/Akt and more with the cell. (wikipedia.org)
Therefore, the blockade of EGFR-mediated signaling pathways have been proposed as a specific therapeutic approach for metastatic CRC. (e-crt.org)
MUC3A is a potent regulator of epidermal growth factor receptor (EGFR) stability, and MUC3A deficiency downregulates the activation of the PI3K/Akt and MAPK pathways, which subsequently reduces the expression of PD-L1. (ijbs.com)
an adapter protein coupling the receptor to downstream signaling pathways. (bioss.com.cn)

2. EGFR family expression in breast carcinomas. (nih.gov)
4. Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma. (nih.gov)
ErbB protein family signaling is important for development. (wikipedia.org)
All four ErbB receptor family members are nearly same in the structure having single-chain of modular glycoproteins. (wikipedia.org)
It is a complex process due to the domain specificity and nature of the members of ErbB family. (wikipedia.org)
However, it does form heterodimers with other EGF receptor family members which do have kinase activity. (nih.gov)
C-erbB-2/HER-2 is a member of the EGFR family. (neobiotechnologies.com)
This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. (neobiotechnologies.com)
Afatinib is an ErbB family irreversible blocker that was authorized by the FDA and EMA in 2013 for the treatment of advanced EGFR mutation-positive NSCLC. (hindawi.com)
PDGF family members stimulate mitogenesis and chemotaxis of fibroblasts, pericytes, and smooth muscle cells ( Heldin and Westermark, 1999 ) and exert their effects via binding to α- and β-tyrosine kinase receptors (PDGFRα and PDGFRβ, respectively). (silverchair.com)
distributions of ErbB family members in SKBR3 breast cancer cells. (nih.gov)
This protein is a receptor for members of the epidermal growth factor family. (bioss.com.cn)

The recommended dosage of lapatinib tablets for advanced or metastatic breast cancer is 1,250 mg (5 tablets) given orally once daily on Days 1 to 21 continuously in combination with capecitabine 2,000 mg/m 2 /day (administered orally in 2 doses approximately 12 hours apart) on Days 1 to 14 in a repeating 21- day cycle. (nih.gov)

9. Nucleobindin 2 (NUCB2) in human endometrial carcinoma: a potent prognostic factor associated with cell proliferation and migration. (nih.gov)

It inhibits EGFR kinase (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25 μM), in vitro. (adooq.com)
HN - 2019 (1979) MH - 2-Methoxyestradiol UI - D000077584 MN - D4.210.500.365.415.248.830 MN - D6.472.334.851.437.500.750 MS - A metabolite of estradiol that lacks estrogenic activity and inhibits TUBULIN polymerization. (nih.gov)
inhibits EGFR-dependent activation of MAPK/ERK. (bioss.com.cn)

Human breast cancer cells or mammary epithelial cells with a high expression of ErbB2 exhibited an enhanced response to ethanol-stimulated cell invasion in vitro. (cdc.gov)

1995. Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors. (stjohns.edu)
1991. Biologic response to intracavitary Interleukin-2/ lymphokine activated killer (LAK) cells in the treatment of primary malignant brain tumors. (stjohns.edu)

3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2 H -tetrazolium, clone formation, transwell migration, and transwell invasion assays were used to assess the proliferation, migration, and invasion ability of LSCC cells. (degruyter.com)
Surface depletion of EGFR led to a dramatic decrease in the amount of kinase domain phosphorylated EGFR, coincident with a significant decrease in the proliferation rate. (uni-bielefeld.de)
mediates EGFR downstream signaling in cell proliferation. (bioss.com.cn)

1. Expression and potential role of ErbB receptors in type II endometrial cancer. (nih.gov)
7. The relationship of cerb B 2 expression with estrogen receptor and progesterone receptor and prognostic parameters in endometrial carcinomas. (nih.gov)
Up-regulation of PTPN12 significantly suppressed EGFR expression. (degruyter.com)
Accordingly, the miR-146b-3p mimic significantly up-regulated the EGFR expression. (degruyter.com)
However, up-regulation of PTPN12 and miR-146b-3p mimic suppressed ERBB2 protein expression but induced its gene expression. (degruyter.com)
Here we demonstrated that amplification of ErbB2 expression sensitized a specific cellular response to ethanol. (cdc.gov)
In this study, functional knockdown of EGFR was achieved through expression of an affibody construct, (ZEGFR:1907)(2-)KDEL, with high affinity for EGFR and extended with the amino acids KDEL to make it resident in the secretory compartments. (uni-bielefeld.de)
1997. Bcl-2 protein expression in astrocytomas in relation to patient survival and p53 gene status. (stjohns.edu)
1993. Prognostic relevance of epidermal growth factor receptor (EGF-R) and c-neu/erbB2 expression in glioblastomas (GBMs). (stjohns.edu)
1991. Expression of epidermal growth factor receptor (EGF-R) and erb-B2 (HER 2/neu) in glioblastoma (GBM): Prognostic relevance. (stjohns.edu)

Binding of the ligand triggers homo- and/or heterodimerization of the receptor triggering its autophosphorylation. (bioss.com.cn)

This result was confirmed by tuning the lateral set up of ligand-receptor complexes on the top of living cells using patterned backed lipid bilayers. (researchassistantresume.com)

EGFR is a cell surface protein that binds to epidermal growth factor. (bioss.com.cn)

Receptor Tyrosine Protein Kinase ERBB 3 Market Size is Expected to grow at higher CAGR 6.3% Over the Forecast Period. (straitsresearch.com)
Globally, the prevalence of cancer is rising at an alarming rate, subsequently boosting the R&D activities on receptor tyrosine-protein kinase ERBB 3. (straitsresearch.com)

ERBB receptors were linked to human cancer pathogenesis approximately three decades ago. (nih.gov)
11. Epidermal growth factor receptor immunostaining and epidermal growth factor receptor-tyrosine kinase activity in proliferative and neoplastic human endometrium. (nih.gov)

Accordingly, the invention is directed to establishing a dosing regimen whereby the therapeutic benefits conferred by administration of a neuregulin such as glial growth factor 2 (GGF2) or a subsequence thereof are maintained and/or enhanced, while concomitantly minimizing any potential side effects. (justia.com)
More specifically, the invention is directed to an improved dosing regimen whereby the therapeutic benefits of administration of a neuregulin, such as glial growth factor 2 (GGF2) or fragment thereof, are maintained and/or enhanced, while minimizing any potential side effects. (justia.com)

Heterodimer with ERBB2. (bioss.com.cn)

Canertinib (CI-1033) is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). (adooq.com)
Erlotinib hydrochloride is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). (adooq.com)

AIs are designed to inhibit the endogenous synthesis of the estrogen receptor ligand estradiol and it has been demonstrated that a sequential targeting of the endocrine receptor ligand system prolongs the period of remission by circumventing molecular mechanism that cause treatment resistance [ 9 , 10 ]. (biomedcentral.com)

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. (neobiotechnologies.com)

The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. (adooq.com)

involved in signaling downstream of EGFR. (bioss.com.cn)

For the activation of kinase domain in the ErbB dimer, asymmetric kinase domain dimer of the two monomers is required with the intact asymmetric (N-C lobe) interface at the site of adjoining monomers. (wikipedia.org)
Upon activation the epidermal growth aspect (EGF) receptor becomes phosphorylated and sets off a massive signaling network which has profound results on cell development. (researchassistantresume.com)

In the BALB/c nude mice xenograft model, MUC3A deficiency enhances EGFR-mutated NSCLC sensitivity to TKIs. (ijbs.com)

Anatomy2

Organisms1

Diseases4

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes13

Disciplines and Occupations1

HER215

ErbB18

Erbb43

Her36

Phosphorylation7

Antibody7

Proteins7

Oncogene5

HER43

Ligands3

Poor prognosis2

Epidermal growth factor re2

Pathway6

Tumor6

Intracellular6

Inhibitors5

Genes6

Cytoplasmic2

Kinases5

Overexpression3

Monoclonal antibodies1

Dimerization2

Recombinant2

Cancers6

Clathrin-mediated endocytosis1

Transmembrane2

Pathways4

Family12

Metastatic1

Potent1

Inhibits3

Vitro1

Tumors2

Proliferation3

Expression10

Heterodimerization1

Ligand-receptor1

Binds1

Protein kinase2

Human2

Therapeutic2

Heterodimer1

Kinase inhibitor2

Estrogen1

Surface receptor1

Inhibition1

Downstream1

Activation2

NSCLC1