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  • antibodies
  • As demonstrated by clinical trials (14) , these antibodies are well tolerated and clinically active in patients with metastatic breast cancer overexpressing c-erbB-2 and result in an increase in the objective clinical response rates when used in combination with chemotherapy. (aacrjournals.org)
  • Antibodies to the EGFR, like Erbitux and TGFα fused to a mutated form of pseudomonas exotoxin, TP-38, have also undergone clinical development. (sigmaaldrich.com)
  • anti-EGFR antibody
  • 2 . The method of claim 1 wherein the anti-EGFR antibody is an antibody which recognizes an EGFR epitope which is found in tumorigenic, hyperproliferative or abnormal cells and not detectable in normal cells. (google.es)
  • 3 . The method of claim 2 wherein the anti-EGFR antibody is mAb806 or an active fragment thereof. (google.es)
  • gene
  • In support of earlier observations, fulvestrant treatment reduced ERα protein and ERmediated gene expression (progesterone receptor mRNA and cyclin D1 protein) and cell proliferation (cell number and Ki67 staining) in all four cell lines. (biomedcentral.com)
  • The gene expression signature revealed various genes previously described to be associated with breast cancer, such as the activator protein-1 complex member Fos-like antigen 2 ( Fosl2 ), early growth response 1 ( Egr1 ), gelsolin ( Gsn ), and tumor protein translationally controlled 1 ( Tpt1 ), among others. (aacrjournals.org)
  • Immunohistological examination revealed the presence of enterovirus in pancreatic islet cells and exocrine tissues and hyperexpression of pattern recognition receptors (PRRs) including melanoma differentiation-associated antigen 5 (MDA5), retinoic acid-inducible gene-I (RIG-I), Toll-like receptor (TLR)3 and TLR4, essential sensors of innate immunity, in islet cells and mononuclear cells (MNCs) infiltrating islets. (cancerindex.org)
  • metastatic
  • In particular, EGFR overexpression correlates with high metastatic rate, short survival time (3) , and poor prognosis (4) for patients with squamous cell carcinoma of the lung. (aacrjournals.org)
  • These data are consistent with the biology of the EGFR family members mediating control of cellular responses such as proliferation, differentiation, survival and apoptosis, essential for the maintenance of the transformed and metastatic phenotype. (biomedcentral.com)
  • EGFR is associated not only with the proliferation of tumor cells, but also with enhanced tumor cell survival, angiogenesis and metastatic spread. (sigmaaldrich.com)
  • Signaling
  • Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. (semanticscholar.org)
  • These results implied that the activation of AKT, p44/42 MAPK and STAT3 signaling transmitted by EGFR would be critical for the growth and survival of lung cancer cells, but specific features of mutant EGFR in lung cancer cells was not discriminated by these approaches. (naver.com)
  • Iressa
  • It is important to note that it was recently found that the response of patients suffering from non-small-cell lung carcinoma to Iressa, is limited to the 7-10% harboring mutations in the kinase domain of the receptor. (sigmaaldrich.com)
  • clinical
  • Relevance of E-cadherin expression to EGFR-TKI molecular targeted therapy sensitivity/resistance and its clinical significance. (semanticscholar.org)
  • For PDGFR-positive and/or EGFR-positive chordoma, clinical benefits were achieved with acceptable AEs. (frontiersin.org)
  • In primary breast cancer, because increased levels of EGFR (9) and c-erbB-2 (10) were first reported, several thousand cases have been studied, and the clinical significance of EGFR (11) and c-erbB-2 (12) has been extensively reviewed. (aacrjournals.org)
  • It has been noted that the co-expression of EGFR with Her-2 and Her-3 is associated with more aggressive clinical behavior. (sigmaaldrich.com)