• Experiments were performed across multiple-scales: the whole-heart in vivo and ex vivo , and its trabeculae in vitro . (frontiersin.org)
  • In contrast, under both ex vivo and in vitro conditions, where the effect of RV pressure overload was circumvented, we found that LV was capable of developing normal systolic pressure and stress. (frontiersin.org)
  • Koulaxouzidis G, Reim G, Witzel C: Fibrin glue repair leads to enhanced axonal elongation during early peripheral nerve regeneration in an in vivo mouse model. (uniklinik-freiburg.de)
  • FSD 8, and related in vivo and in vitro experiments, the effects of nine FSDs on the respiratory, cardiovascular and immune systems, brain and blood were reported in the preceding eight tandem papers. (cdc.gov)
  • Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF in vivo on tumor nerve invasion as well as on nociceptive transmission. (hindawi.com)
  • In vivo tumorigenesis experiments, Tanezumab markedly alleviated nerve invasion of PC cells as well as relieved nociceptive conduction in animal models. (hindawi.com)
  • The AAV non-coding RNA expression vector is a highly efficient vehicle for in vitro and in vivo delivery of non-coding RNAs of interest. (vectorbuilder.kr)
  • In vitro analysis of the recombinant FeLV-B-like viruses (rFeLVs) employed in this study confirmed these viruses were replication competent prior to their use in an in vivo study without FeLV-A helper virus. (lookformedical.com)
  • It's also possible to use the same interface board for in vitro MEA experiments and tethered / wireless in vivo recordings. (multichannelsystems.com)
  • It has been reported that signaling from the nerve growth factor (NGF) pathway associated with peripheral nerves is able to contribute to perineural invasion (PNI) of pancreatic cancer (PC). (hindawi.com)
  • GM-CSF is also involved in bone cancer pain development by regulating tumor-nerve interactions, remodeling of peripheral nerves and sensitization of damage-sensing (nociceptive) nerves. (iasp-pain.org)
  • Instead, the time taken to produce 90% inhibition of nerve-mediated twitches (i.e. t90) in skeletal muscle preparations can be determined. (wikipedia.org)
  • Administration of gene therapy viruses into skeletal muscle, where distal terminals of motor and sensory neurons reside, has been shown to result in extensive transduction of cells within the spinal cord, brainstem, and sensory ganglia. (frontiersin.org)
  • 1987. The influence of skeletal muscle on the electrical excitability of dorsal root ganglion neurons in culture. (cdc.gov)
  • Its importance has been documented in a number of physiologic and pathologic conditions including neuronal and muscle development, lymphocyte activation, cardiac hypertrophy, switching of skeletal muscle fiber type, and expression of ion channels. (pancreapedia.org)
  • 1983. Correlation of metal toxicity with in vitro calmodulin inhibition. (cdc.gov)
  • Mortality (often determined by measured toxicity on mice) is a commonly used indicator to determine the danger of any given venomous snake, but important too are its efficiency of venom delivery, its venom yield and its behavior when it encounters humans. (wikipedia.org)
  • A method for producing horseshoe crab amebocytes in vitro by isolating amebocyte producing tissue from the gill flaps of horseshoe crabs, especially Limulus polyphemus. (gc.ca)
  • Once isolated, the tissue can be cultured long term in vitro on an artificial surface or as part of the gill flap leaflets, opened along one edge to allow access of the media to the developing amebocytes. (gc.ca)
  • Dr. Yang has extensive expertise in developing novel biomaterials and stem cell-based therapeutics for musculoskeletal tissue engineering, or engineering 3D in vitro cancer models for drug screening and mechanistic discovery. (stanford.edu)
  • No trial dealt with the brand new subtype with antibodies to a muscle tissue specific kinase. (niepokorny.org)
  • Significantly less than five % of patients have got car\antibodies to a?muscle tissue tyrosine kinase. (niepokorny.org)
  • This approach reduces the time required to collect DRG, thereby improving efficiency, permitting less opportunity for tissue deterioration, and, ultimately, increasing the chances of generating healthy primary DRG cultures or high quality, reproducible experiments using DRG tissue. (biomedcentral.com)
  • Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct in vitro . (open.ac.uk)
  • Engineered neural tissue for peripheral nerve repair. (open.ac.uk)
  • Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
  • There are several comprehensive reviews on Cn (4, 68), more recent brief updates (3, 37, 44), information on Cn inhibitors (42, 55), and disease- or organ/tissue-specific reviews relating to Cn in the neurosciences (29), muscle (65), islet cells (35). (pancreapedia.org)
  • Soft tissue, muscle, and skin resist pressure to differing degrees. (medscape.com)
  • A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
  • Muscles contain the synaptic connection between lower motor neurons and muscle fibers, i.e., the neuromuscular junction (NMJ), as well as specialized sensory nerve endings (e.g., muscle spindles). (frontiersin.org)
  • In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
  • Rodent DRG neurons have long been studied in the laboratory to improve understanding of sensory nerve development and function, and have been instrumental in determining mechanisms underlying pain and neurodegeneration in disorders of the peripheral nervous system. (biomedcentral.com)
  • In order to perceive diverse stimuli from the environment, functional sensory subtypes target different regions of the periphery, for instance proprioceptive neurons, which are important for sensing body position in space, innervate muscle spindles, while temperature-sensing thermoceptive cells often end in the skin [ 2 ]. (biomedcentral.com)
  • The distal ends of sensory nerves are consequently specialised, culminating in or synapsing with assorted sense organs adapted to function, for example Pacinian corpuscles for pressure perception or Golgi tendon organs for detecting muscle tension [ 3 ]. (biomedcentral.com)
  • Morphogenetic cell movements along the rostro-caudal and dorso-ventral axes (medio-lateral in fish) are responsible for the formation of the elongated tube that will connect the brain to organs and body muscles. (biologists.com)
  • Recent evidence shows that overactivation of the amygdala under stressful stimuli causes rhythmic jaw muscle activity by over activating the mesencephalic and motor trigeminal nuclei. (spandidos-publications.com)
  • Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
  • Our group routinely carries out projects on nerve conduits, aiming at replacement of autologous nerve grafts. (uniklinik-freiburg.de)
  • At the moment, our group is working on a joint interdisciplinary project with the Department Of Microsystems Engineering to use innovative 3D bioprinting technology to improve the efficacy of nerve conduits. (uniklinik-freiburg.de)
  • Indeed, we have shown previously that mutation of a tyrosine phosphorylation site in the long cytoplasmic loop of the β subunit impairs agrin-induced cytoskeletal anchoring and aggregation of mutant AChR in muscle cells ( Borges and Ferns, 2001 ). (jneurosci.org)
  • We have developed new in vitro models and further developed the functional evaluation of existing models. (uniklinik-freiburg.de)
  • C@CF/CaP could cause mitochondrial Ca2+ overload, trigger the mitochondrial apoptotic pathway, destroy the mitochondrial structure and finally have good anti-tumor efficiency. (bvsalud.org)
  • For successful transgene expression, viruses administered into muscle must undergo a series of processes, including host cell interaction and internalization, intracellular sorting, long-range retrograde axonal transport, endosomal liberation, and nuclear import. (frontiersin.org)
  • To reveal that the NGF-TrkA signaling pathway was closely associated with PC PNI, in vitro neuroinvasion model was established by using MiaPaCa-2 cells via coculturing DRG cells in Matrigel. (hindawi.com)
  • We demonstrate that transgenic AAVR overexpression greatly increases the efficiency of transduction of many diverse cell types, including muscle stem cells, which are normally refractory to AAV transduction. (nature.com)
  • If you choose 2 Lesson Overview how do you get high off wellbutrin stations Students falls out, wash binding should be greatly on the it in your vitro has been class period. (grey-panthers.it)
  • This was for two reasons: (1) mice have a thin olfactory nerve layer compared to rats and this will favor drug access to the glomerular layer, and (2) transgenic G-CaMP2 mice express the fluorescent calcium sensor protein G-CaMP2 in mitral cells. (jneurosci.org)
  • The technique works with near-perfect efficiency in mice and humans for all types of cells tested in the laboratories of USC's stem cell center. (usc.edu)
  • Ultrastructurally, the degeneration of nerve cells was characterized by abnormal proliferation of neurofilaments. (lookformedical.com)
  • Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. (wanfangdata.com.cn)
  • Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. (wanfangdata.com.cn)
  • Due to its role as a potent vasoconstrictor and essential reproductive hormone, we examined how kisspeptin is involved in nano-TiO2-induced vascular dysfunction and placental efficiency. (cdc.gov)
  • In animal studies, stress-induced muscle hyperactivity was associated with muscle dysfunction and pain ( 13 ), whereas humans who experience panic attacks more frequently exhibit tooth clenching, bruxism and nail-biting ( 14 ). (spandidos-publications.com)
  • A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury. (open.ac.uk)
  • Mobile or portable hair loss transplant has appeared in a variety of nerve ailments, such as new cerebrovascular accident, being a successful recovery-promoting strategy also in the actual post-acute cerebrovascular event period. (chk-signal.com)
  • method to introduce genetic material into select neuronal populations is by virus administration into muscle, which is the focus of this review. (frontiersin.org)
  • Rapid signaling at neuronal synapses is mediated by ligand-gated ion channels, which are concentrated in the postsynaptic membrane beneath the nerve terminal. (jneurosci.org)
  • In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
  • When injected into a muscle, viruses are close to nerve endings for longer periods and at higher concentrations than when systemically injected. (frontiersin.org)
  • Emotional stress is associated with an increase in head and muscle tonicity, as well as an increase in non-functional muscle activity ( 7 , 8 ). (spandidos-publications.com)
  • People most commonly use alpha-lipoic acid for nerve pain in people with diabetes. (medlineplus.gov)
  • The one proven medical treatment for Duchenne muscular dystrophy is corticosteroids, which are known to help to protect muscle mass and function and ameliorate some of the secondary aspects of this disease, thus improving quality of life. (medscape.com)
  • Activation of the hypothalamic‑pituitary‑adrenal axis (HPA) and subsequent release of corticosteroids lead to increased muscle activity. (spandidos-publications.com)
  • This route is minimally invasive and therefore clinically relevant for gene therapy targeting to peripheral nerve soma. (frontiersin.org)
  • Until these molecular therapies become clinically available, supportive therapies can be used to protect muscle mass and function and to help improve quality of life. (medscape.com)
  • Clinically, there was lower motor neuron disease with areflexia and muscle atrophy in all limbs. (lookformedical.com)
  • Due to ethical reasons, these studies are being superseded by in vitro studies. (wikipedia.org)
  • In vitro effects of PCBs and OH-PCBs on the basal and dexamethasone-modified thyroid hormone metabolism in chicken liver. (krakow.pl)
  • If you are certainly favors muscles men to attempt in this industry, sleep with it Go is providing the items of karma we like business with the most common side effects from wearing. (grey-panthers.it)
  • The muscle biopsy with protein analysis can be valuable in this determination. (medscape.com)
  • Also, talk to your doctor about depression or anxiety automation platforms such you have kidney widely recognized that controllers, and distributed communication between nerve and how do you get high off wellbutrin concerns emotional conditions, haloperidol of angioedema swelling many aspects of Phenergan, thiothixene Navane. (grey-panthers.it)
  • These disruptions impair the abilities to counteract the overactivity of the HPA axis and disinhibit involuntary muscle activity, while at the same time, there is activation of the amygdala. (spandidos-publications.com)
  • El-Karabaty H, Hetzel A, Galla TJ, Horch RE, Lucking CH, Glocker FX: The effect of carpal tunnel release on median nerve flattening and nerve conduction. (uniklinik-freiburg.de)
  • An antioxidant powerhouse, high in flavonoids with an adaptogenic effect that nourishes the body, improves circulation, reduces inflammation by dampening future inflammatory pathways, reducing pain response, wound healing, anxiety, treatment of osteoarthritis, and reducing muscle soreness. (positivehealth.com)
  • Reprogramming involves changing one cell into another type of cell, such as a blood cell into a muscle or nerve cell. (usc.edu)
  • The MEA2100-System is the most versatile in vitro recording system from Multi Channel Systems. (multichannelsystems.com)
  • In addition, the activation of the sympathetic system in response to stressful stimuli leads to increased muscle tone and reduced pain thresholds ( 8 , 9 ). (spandidos-publications.com)
  • Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro . (open.ac.uk)
  • The actual outcomes keep the speculation of a microstate school D reduction being an endophenotypic sign pertaining to psychosis and offer the first descriptive account of the way caffeinated drinks is affecting these types of microstate lessons within an first period psychosis taste.Mulibrey (Muscle-Liver-Brain-Eye) Nanism syndrome is certainly a exceptional innate condition along with multiorgan engagement. (acyltransferase-receptor.com)