SymptomsPsychotherapyObsessive CompulsiMajor depressionPsychiatricMoodAntidepressantsRemissionSymptomatologyNasal sprayChildren and AdolescentsAdultsPredictorsCognitiveSchizophreniaBipolar depressionSymptomUnipolar depressionPsychiatryRefractoryImminent risk of suicide2019AcuteEvaluate the EfficacyEsketamine2021OutcomesShort-term efficacySerotoninPeople with major depressiEtiologyAffective disordersDysthymiaSuicidalMeta-AnalysisMental disordersBaselinePatients with depressionAntidepressant treatmentNeurosciencePost-traumatiTranscranial magnetic stTrialsRTMSSeverePharmacologicElectroconvulsive TherapyKetamine treatmentUses and efficacyParticipantsPsychotherapeutic interventionsAdolescentsRelapseSSRIs2022Safety
Symptoms51
- The olanzapine/fluoxetine combination showed rapid, robust, and sustained improvement in depressive symptoms in patients with MDD, including patients with TRD. (psychiatrist.com)
- Treatment type and duration must be adjusted to characteristics of the patient and the depressive episode, including symptoms, number of previous episodes, comorbidities, and previous treatment response and side effects. (frontiersin.org)
- As a result, ~50-80% of treated patients are reported to have a recurring episode throughout their lives, with only 30-45% of patients reaching complete remission of symptoms after first-line antidepressant treatment ( 6 , 7 ). (frontiersin.org)
- In our study we included patients with major depressive disorder, who still had residual symptoms and functional impairment despite receiving antidepressant treatment. (news-medical.net)
- This is a very interesting study targeting remaining depressive symptoms in patients who insufficiently responded to previous treatment trials of antidepressants. (news-medical.net)
- Vortioxetine demonstrated good tolerability and a beneficial effect on cognition that appears largely independent from the effect on depressive symptoms. (psychiatrictimes.com)
- Data from the studies demonstrated that intranasally delivered esketamine, alongside an oral antidepressant, provided statistically significant, rapid, and sustained improvement of depressive symptoms. (outsourcing-pharma.com)
- In some cases, a deficiency in certain nutrients may be linked with depression symptoms, in other cases, a higher intake of certain vitamins may be associated with improved mood. (psychcentral.com)
- Several studies have noted the link between vitamin D deficiency and depression symptoms. (psychcentral.com)
- One study found that taking 500 milligrams a day for 8 weeks could improve symptoms of depression. (psychcentral.com)
- While there is older research to show that zinc can help symptoms of depression, newer research does not indicate statistically significant improvement. (psychcentral.com)
- There is not enough research to show that niacin can help improve depression symptoms alone, but some studies suggest that a combination of B-vitamins may help. (psychcentral.com)
- Subjects took an average of nearly 6 weeks to respond, and about 7 weeks to achieve remission from depressive symptoms. (uspharmacist.com)
- In 2000, Berman et al published the first double-blind, placebo-controlled, crossover trial evaluating the use a single dose of 0.5 mg/kg ketamine over 40 minutes in eight patients with recurrent unipolar major depression and one with bipolar disorder, which showed progressive decreases in depressive symptoms within 3 days of treatment. (uspharmacist.com)
- Spravato is also used to treat depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions. (drugs.com)
- CBT is more effective than no treatment at reducing depression symptoms. (edu.au)
- CBT can also be used alongside antidepressant medication, and using both of these treatments together is more effective at reducing symptoms of depression than only taking antidepressants or only learning CBT. (edu.au)
- Despite possessing serotonin reuptake inhibitory activity in addition to D 2 receptor partial agonism, WS-50030 displays activity in preclinical models predictive of antipsychotic- and antidepressant efficacy similar to aripiprazole, suggesting potential efficacy of WS-50030 versus positive and negative symptoms of schizophrenia, comorbid mood symptoms, bipolar disorder, major depressive disorder, and treatment-resistant depression. (montclair.edu)
- While many people think of depression as a primarily psychological condition, it can also manifest with physical symptoms, known as somatic symptoms. (progress.im)
- These physical symptoms can be just as distressing and debilitating as the emotional symptoms of depression, and can make it difficult for individuals to carry out daily activities. (progress.im)
- In this article, we will explore the somatic symptoms of depression, their impact on daily life, and the various treatment options available. (progress.im)
- What are Somatic Symptoms of Depression? (progress.im)
- Somatic symptoms of depression refer to physical symptoms that occur as a result of depression. (progress.im)
- They can also make it difficult for individuals to recognize that they are experiencing depression, as they may attribute their symptoms to physical illnesses rather than mental health issues. (progress.im)
- Somatic symptoms of depression can have a significant impact on daily life. (progress.im)
- Overall, somatic symptoms of depression can significantly impact quality of life and make it difficult for individuals to function on a daily basis. (progress.im)
- There are several treatment options available for somatic symptoms of depression. (progress.im)
- Depression with somatic symptoms is frequently treated with selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). (progress.im)
- The somatic symptoms of depression can be effectively treated with vortioxetine, a more recent antidepressant. (progress.im)
- The effectiveness of vortioxetine in managing somatic symptoms of depression has been examined in a number of trials. (progress.im)
- Vortioxetine was found to be more beneficial than a placebo in lowering somatic symptoms of depression, such as exhaustion, sleep difficulties, and pain, in randomized, double-blind research that lasted 10 weeks. (progress.im)
- 2014) discovered that vortioxetine was helpful in lowering both emotional and physical symptoms of depression in addition to enhancing the overall quality of life. (progress.im)
- Psychotherapy, or talk therapy, can be helpful in treating both the emotional and physical symptoms of depression. (progress.im)
- It can be particularly effective in treating somatic symptoms of depression. (progress.im)
- The " trait" hypothesis suggests that an underlying vulnerability prior to the start of depression can contribute to the development of symptoms in depression as well as contribute to treatment resistance and relapses [ 11 ]. (biomedcentral.com)
- Areas covered: The authors review novel antidepressants with rapid efficacy for diverse MDD symptoms and have fewer adverse effects (AEs). (uky.edu)
- These strategies would lead to a systematic approach to tackle treatment resistant depression (TRD) and treatment of residual symptoms in partially remitted MDD. (uky.edu)
- The results showed that psilocybin produced rapid and sustained reductions in depressive symptoms at one week and three months after treatment. (awholenewhigh.com)
- The combination treatment seemed to have benefits beyond depressive symptoms. (dr-bob.org)
- Cognitive symptoms are also present in other psychiatric disorders, are a hallmark of aging, and define several late-life disorders, including Alzheimer's disease. (nature.com)
- Together, this suggests that reduced signaling of the SST+ neuron/α5-GABA-A receptor pathway contributes to cognitive dysfunctions, and that it represents a novel therapeutic target for remediating mood and cognitive symptoms in depression, other psychiatric disorders and during aging. (nature.com)
- For example, several studies have shown that the pathophysiology of depression is partly linked to hypo-activity in the left prefrontal cortex and that "normalization" of this area's activity with TMS improves depressive symptoms. (tmsdrrachid.com)
- Depression is often a downstream effect of a bigger issue, and providers, both prescriber and therapist, could only be focusing on reducing depression symptoms. (psychologytoday.com)
- A provider could, understandably, assume that the inhibitions and lack of confidence are due to the depression, and thus pointedly work on reducing depression symptoms. (psychologytoday.com)
- The objective of this study was to verify the effectiveness of individual psychotherapeutic treatment from CBT for depressive symptoms within 6 and 12 months after the intervention. (bvsalud.org)
- CBT significantly reduces depressive symptoms by maintaining this condition up to 12 months post-intervention without significant influence of other characteristics beyond the intensity of depressive symptoms at the beginning of the therapeutic process. (bvsalud.org)
- Taking 5-HTP by mouth seems to improve symptoms of depression in some people. (medlineplus.gov)
- WASHINGTON - More intense dissociative symptoms exhibited during ketamine infusion for severe depression , particularly depersonalization, may be key predictors of treatment response. (medscape.com)
- They found a significant association between dissociative symptoms experienced during infusion and reductions in depressive symptoms, as reflected in some, but not all, dissociation subscale measures. (medscape.com)
- In one of the studies, dissociative effects, measured using the Clinician-Administered Dissociative States Scale (CADSS) at baseline and at the end of infusion, were associated with symptoms of depression, as measured with the Hamilton Depression Rating Scale (HDRS-17), at day 7 following the infusion ( P = .04). (medscape.com)
- No association was observed between amnesia symptoms during infusion and reduction in depression, as reflected in percentage change in HDRS score. (medscape.com)
Psychotherapy22
- Psychotherapy should be considered in parallel to pharmacological treatment. (frontiersin.org)
- Further work is needed to both replicate these results and compare this strategy with alternative treatment options (e.g. psychotherapy or additional pharmacotherapeutic steps). (news-medical.net)
- Some of the firm's current and past clinical trials have focused in the area of psychedelic medicine including a Phase 2 study of MDMA-assisted psychotherapy for eating disorders, a ketamine-assisted psychotherapy study for end-of-life palliative care and a ketamine study to treat suicidal ideation. (streetwisereports.com)
- Multiple types of scientific studies report psychedelics-augmented (or assisted) psychotherapy to be a promising treatment for several mental disorders. (ovid-clinics.com)
- For instance, psychedelic-assisted psychotherapy was found to be effective in phase II studies for anxiety and depression secondary to a life-threatening illness (5), treatment-resistant depression (6, 7, 8) and substance use disorders (SUDs) (9), including alcohol (10) and tobacco (11). (ovid-clinics.com)
- Cognitive-behavioral therapy (CBT) is a type of psychotherapy that focuses on changing negative thought patterns and behaviors that contribute to depression. (progress.im)
- A large study by Donse, Padberg, Sack, Rush and Arns 1), carried out in the Netherlands has investigated the effects of combining brain stimulation (rTMS) with concurrent psychotherapy in treatment resistant depression. (brainclinics.com)
- Studies show that when either rTMS or Psychotherapy are conducted as a monotherapy, an average of 30-40% of patients achieve remission, clearly less than the 56% remission achieved with the combined treatment of rTMS and psychotherapy. (brainclinics.com)
- Similarly, it is widely known that 'psychotherapy and drugs' combined show better outcomes, however this approach often requires two separate treatment programs and specialists, i.e. a Psychiatrist to deliver medications and a Psychologist to deliver Psychotherapy. (brainclinics.com)
- A combined approach of Psychotherapy at the same time as brain stimulation, can be performed by one clinician and is shown to be more efficient, and above all, a more effective treatment for treatment resistant Depression. (brainclinics.com)
- Simultaneous rTMS and psychotherapy in major depressive disorder: Clinical outcomes and predictors from a large naturalistic study. (brainclinics.com)
- While there are effective treatments for depression, such as antidepressant medications and psychotherapy, they are not without limitations. (awholenewhigh.com)
- Comparative short-term efficacy and acceptability of a combination of pharmacotherapy and psychotherapy for depressive disorder in children and adolescents: a systematic review and meta-analysis. (sld.cu)
- rTMS has also been approved in many countries like Canada, the United Kingdom, the Netherlands and Finland as a treatment for depression in patients who have not responded to pharmacotherapy and/or to psychotherapy. (tmsdrrachid.com)
- Many recent studies have particularly shown the therapeutic efficacy of rTMS in treatment-resistant depression, i.e. depression that does not respond to conventional therapeutic approaches (medications, psychotherapy). (tmsdrrachid.com)
- Some researchers have begun investigating the efficacy of psychotherapy in conjunction with pharmacology for treatment-resistant depression cases. (psychologytoday.com)
- They found that the former was more efficacious, and opined that psychotherapy should be included in treatment-resistant depression guidelines. (psychologytoday.com)
- Current evidence-supported interventions include cognitive-behavioral psychotherapy, pharmacotherapy, or a combination of both should be offered as treatment for children and adolescents with major depressive disorder (MDD). (medscape.com)
- Psychotherapy appears to be a useful initial acute treatment for mild to moderate depression. (medscape.com)
- Psychodynamic psychotherapy, interpersonal therapy, cognitive-behavioral therapy, behavior therapy, family therapy, supportive psychotherapy, and group psychotherapy have all been used for the treatment of youths with MDD. (medscape.com)
- [ 42 ] More studies that compare the complementary and differential effects of the various types of psychotherapy in children and adolescents with depression are needed. (medscape.com)
- Cognitive-behavioral therapy is one of the most frequently studied psychotherapy treatments. (medscape.com)
Obsessive Compulsi6
- The first report of DBS for a psychiatric indication, published in The Lancet in 1999, described implantation of electrodes into the bilateral anterior limbs of the internal capsule for treatment of refractory Obsessive-Compulsive Disorder (OCD) in a series of four patients. (medscape.com)
- Acute management of anxiety disorders, obsessive-compulsive disorder, and specific phobias through antidepressant use. (appi.org)
- These substances showed promising results also in the treatment of obsessive-compulsive disorder (OCD) (13), even suggesting applicability for psychosomatic disorders like functional blindness, aphonia/dysphonia, sensory changes and weakness (14). (ovid-clinics.com)
- Over the past two decades, the safety and efficacy of high and low frequency rTMS have been demonstrated in the treatment of depression and other neuropsychiatric and neurological disorders such as auditory hallucinations in people suffering from schizophrenia, and more recently, post-traumatic stress disorder, obsessive-compulsive disorder, substance dependence (addiction), depersonalization disorder and tinnitus. (tmsdrrachid.com)
- rTMS has been approved by the USA Food and Drug Administration since October 2008 for treatment-resistant major depression and since 2020 for obsessive-compulsive disorder. (tmsdrrachid.com)
- rTMS has proven its efficacy in the treatment of patients with major depression, with bipolar disorder in their depressive phase and in obsessive-compulsive disorder, as well as patients with schizophrenia suffering from auditory hallucinations, post-traumatic stress disorder, substance dependence, depersonalization and tinnitus. (tmsdrrachid.com)
Major depression6
- A randomized trial of an N -methyl- D -aspartate antagonist in treatment-resistant major depression. (nature.com)
- Noninvasive neurostimulation treatments are increasingly being used to treat major depression, which is a common cause of disability worldwide. (biomedcentral.com)
- One of the challenges, however, is that major depression is associated with reduced synaptic plasticity, and so TMS may be asking the depressed brain to adapt to stimulation in a way that it can not readily do. (dr-bob.org)
- Augmentative pharmacological strategies in treatment‐resistant major depression: A comprehensive review. (sld.cu)
- Cuijpers P, Karyotaki E, Weitz E, Andersson G, Hollon SD, van Straten A. The effects of psychotherapies for major depression in adults on remission, recovery and improvement: a meta-analysis. (jamanetwork.com)
- Determinants of poor 1-year outcome of DSM-III-R major depression in the general population: results of the Netherlands Mental Health Survey and Incidence Study (NEMESIS). (jamanetwork.com)
Psychiatric18
- Serotonin Syndrome and MAOIs: Do not use MAOIs intended to treat psychiatric disorders with fluoxetine or within 5 weeks of stopping treatment with fluoxetine. (nih.gov)
- Do not use fluoxetine within 14 days of stopping an MAOI intended to treat psychiatric disorders. (nih.gov)
- Electroconvulsive therapy (ECT) or electroshock therapy (EST) is a psychiatric treatment where a generalized seizure (without muscular convulsions) is electrically induced to manage refractory mental disorders. (wikipedia.org)
- Depressive disorders are among the most frequent psychiatric disorders, with a prevalence of 4.4% worldwide ( 1 ), and around 7-9% in Portugal, which is one of the most affected European countries ( 2 - 4 ). (frontiersin.org)
- Amongst these agents, there has been an increased interest in the use of psilocybin for the treatment of numerous psychiatric disorders (2). (researchgate.net)
- While neuromodulation techniques are currently used primarily for the management of chronic pain and movement disorders, there has been considerable interest in their use for medically refractory psychiatric disease. (medscape.com)
- There is also substantial public trepidation about the use of surgical therapies in the treatment of psychiatric disease as a direct consequence of the abuse of psychosurgery in the mid-twentieth century, specifically the heavy human toll exacted by the careless and widespreaduse of the frontal lobotomy. (medscape.com)
- The two surgical neuromodulatory therapies currently in use for the treatment of psychiatric conditions are deep brain stimulation (DBS) and vagal nerve stimulation (VNS). (medscape.com)
- Larger trials followed, followed by trials using DBS to treat other psychiatric diseases, particularly Major Depressive Disorder (MDD). (medscape.com)
- We conducted a survey of the readership of Psychiatric Times to assess the general attitudes toward the prevalence of-and the existing treatment approaches toward-TRD in adults 60 years and older. (psychiatrictimes.com)
- Therapies involving these substances are said to be a real disruption in the psychiatric field as potentially effective treatments for several mental disorders. (ovid-clinics.com)
- Attempts to treat psychiatric disorders with electromagnetism are far from new. (beppemicalleftrigona.com)
- By 1840 a 'magneto-electric device', attributed to DuBois Raymond, was being used on patients with psychiatric disorders in Europe and North America. (beppemicalleftrigona.com)
- But, within several years of its discovery, non-focal rTMS from circular coils was being delivered to patients with psychiatric disorders. (beppemicalleftrigona.com)
- A few years later, however, the treatment of psychiatric disorders with TMS had been transformed by neuroimaging studies and by improved understanding of TMS effects. (beppemicalleftrigona.com)
- While we cannot predict who will respond to ketamine, a meta-analysis by the American Psychiatric Association using data from multiple ketamine trials reported that over 70% of treatment-resistant patients responded positively after receiving the initial round of low-dose infusions. (mbodyhealthcare.com)
- Ketamine is not approved for the treatment of psychiatric conditions. (mbodyhealthcare.com)
- Therefore, its use as a psychiatric treatment is considered "off-label. (mbodyhealthcare.com)
Mood14
- Background: Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. (elsevierpure.com)
- The impact of depression is greatest for those who do not benefit from standard treatments," said -Michael E. Thase, MD, Professor of Psychiatry and Director of the Mood and Anxiety Disorders Treatment and Research Program, Perelman School of Medicine, University of Pennsylvania, and a principal investigator of esketamine. (ahdbonline.com)
- I specialize in a variety of mental health conditions including: mood disorders, schizophrenia, ADHD, PTSD, anxiety disorders and OCD. (freditveldt.com)
- He conducts clinical and translational research aimed at understanding the biological basis of mood and anxiety disorders in order to point the way towards new, more effective treatments. (va.gov)
- In addition to his research and educational activities, Dr. Murrough oversees a clinical program at Mount Sinai focused on evidence-based treatments for treatment-resistant depression and other refractory forms of mood and anxiety disorders. (va.gov)
- Martinowich K, Lu B. Interaction between BDNF and serotonin: role in mood disorders. (nature.com)
- Diehl DJ, Gershon S. The role of dopamine in mood disorders. (nature.com)
- Pizzagalli DA, Whitton AE, Webb CA. Mood disorders. (jamanetwork.com)
- Multiple studies and trials at Mt. Sinai in New York, Yale, and other prestigious universities and hospitals since 1990 have shown that ketamine is exceptionally effective in treating treatment-resistant depression, PTSD, anxiety, suicidal ideation, neuropathic pain, and other related mood disorders. (mbodyhealthcare.com)
- The term depression is often loosely used to describe the low or discouraged mood that results from disappointment (eg, serious illness) or loss (eg, death of a loved one). (msdmanuals.com)
- In 1996, Thase wrote, "The role of personality disorders in the management of chronic, treatment-refractory depressive states is one of the least studied, yet more interesting topics in the treatment of mood disorder . (psychologytoday.com)
- Prenatal marijuana or low mood disorders in anxiety. (myjuicecup.com)
- In another presentation at the ADAA conference, Samuel Wilkinson, MD, assistant director of the Depression Research Program at Yale University, New Haven, Connecticut, reported details from his institution's experience with the use of ketamine during a period of more than 30 months in patients with severe and treatment-resistant mood disorders. (medscape.com)
- Because conventional antidepressants can take weeks if not months to reach full effect and are completely ineffective in many patients, interest in ketamine, an N -methyl-d-aspartate receptor antagonist, as a rapid-acting treatment for severe mood disorders has soared in recent years, noted Niciu. (medscape.com)
Antidepressants17
- There are treatments for depression, but up to a third of people don't respond to treatment, even after trying different antidepressants. (news-medical.net)
- Now a new pilot study from Korea indicates that neurofeedback may be offer a viable treatment to patients suffering from TRD, if used with antidepressants. (news-medical.net)
- The second book in the Evidence-Based Guides series, The Evidence-Based Guide to Antidepressant Medications, provides a clear reference to the current knowledge and evidence base for the use of antidepressants among a variety of patients across a wide range of disorders. (appi.org)
- Use of selective serotonin reuptake inhibitors, MAOIs, and tricyclic antidepressants in major depressive disorder, bipolar depression, psychotic depression, and treatment-resistant depression. (appi.org)
- While there appears to be no definitive, standardized definition for treatment resistant-depression (TRD), it is generally accepted as failure to respond to at least two adequate trials of different classes of antidepressants, an adequate trial being defined as an adequate dose given for an adequate duration (i.e., 6 or 8 weeks). (uspharmacist.com)
- The authors note that the study's PDQ-9 response and remission rates indicate that clinical outcomes are comparable to those of the seven antidepressants studied in Level 2 of the large Sequenced Treatment Alternatives to Relieve Depression (STAR-D) trial. (medscape.com)
- 1 Among patients who receive treatment, approximately 30% have treatment-resistant depression (ie, an inadequate response to ≥2 different antidepressants at adequate dosing and duration during a depressive episode). (ahdbonline.com)
- Pharmacologic treatments for MDD include 1 or more antidepressants, including serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), atypical antidepressants, tricyclics, tetracyclics, and monoamine oxidase inhibitors (MAOIs), among others. (ahdbonline.com)
- Introduction: There are numerous antidepressants for the treatment of major depressive disorder (MDD) on the market. (uky.edu)
- However, inadequate treatment response, therapeutic lag between drug administration and the onset of clinical improvement, and safety/tolerability issues with the use of contemporary antidepressants have accelerated the search for newer antidepressants with novel mechanisms of action. (uky.edu)
- New generation antidepressants for depression in children and adolescents: a network meta-analysis. (sld.cu)
- Antidepressants for people with epilepsy and depression. (sld.cu)
- Second-generation antidepressants for treatment of seasonal affective disorder. (sld.cu)
- Treatment is with antidepressants, supportive and cognitive-behavioral therapy, or a combination of these modalities. (msdmanuals.com)
- The investigators wrote, "Our findings lend economic support to the American College of Physicians' conclusion that either [second-generation antidepressants] or CBT is a reasonable initial treatment for [major depressive disorder]. (psychiatryadvisor.com)
- The key finding was that from a cost-effectiveness perspective, either CBT or antidepressants would be a reasonable option for the initial treatment of depression. (psychiatryadvisor.com)
- Currently, it is used primarily in depression that is resistant to more commonly used antidepressants such as the selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs). (medscape.com)
Remission11
- These treatment parameters can pose significant differences in both adverse side effects and symptom remission in the treated patient. (wikipedia.org)
- The most relevant objectives of TRD treatment are reaching response and remission, prevention of suicide, and improvement of quality of life, functionality, and wellbeing. (frontiersin.org)
- These aspects highlight that conventional pharmacotherapy does not lead to remission in many patients and that optimization strategies are frequently necessary to achieve satisfactory treatment outcomes. (frontiersin.org)
- The researchers found that in the neurofeedback group, 8 of the 12 patients responded to treatment, and 5 of those responded well enough to be classified as being in remission. (news-medical.net)
- Neurofeedback has been trialed with psychological conditions in the past, but as far as we know this is the first time that anyone has succeeded in achieving remission and overall recovery (functional recovery)with treatment-resistant depression. (news-medical.net)
- BACKGROUND: In treatment-resistant depression, commonly defined as a lack of response to two or more consecutive treatments during the current depressive episode, the percentage of patients with remission is low and the percentage with relapse is high. (bvsalud.org)
- While the agents in current use help many patients, more than half of those treated fail to achieve remission and are resistant to treatment with a first-line antidepressant. (uspharmacist.com)
- 5,6 Achieving and sustaining complete remission early in the treatment sequence is a crucial goal for patients with MDD. (ahdbonline.com)
- 66% of the patients in this study responded positively to the combined therapy (i.e. symptom decrease of more than 50%), while 56% of the total sample achieved remission (meaning that they no longer met criteria for depression). (brainclinics.com)
- For example, Carpenter and Colleagues (please see References page), who treated 307 patients with rTMS at high frequency, showed significant improvement in depression severity at the end of treatment (six weeks) with response rate of 58% and 37.1% remission rate. (tmsdrrachid.com)
- The rates of response and remission demonstrated in both naturalistic studies were comparable to the efficacy results observed in two multicenter controlled studies (O'Reardon et al. (tmsdrrachid.com)
Symptomatology2
- Response rates with a secondary outcome, the Inventory of Depressive Symptomatology - Self-Report (IDS-SR 30 ), were 17.0% (active) and 7.3% (sham) (p = .032, LOCF). (elsevierpure.com)
- Such combined treatment increases the likelihood not only of mitigating depressive symptomatology but also of improving self-esteem, coping skills, adaptive strategies, and family and peer relationships. (medscape.com)
Nasal spray4
- Spravato (esketamine) nasal spray is an investigational prescription treatment for adults with treatment-resistant depression, with a different form of drug delivery compared to current options for major depressive disorder and treatment-resistant depression. (outsourcing-pharma.com)
- The efficacy and safety of esketamine nasal spray as compared with extended-release quetiapine augmentation therapy, both in combination with ongoing treatment with a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI), in patients with treatment-resistant depression are unknown. (bvsalud.org)
- Spravato is a nasal spray that is used together with medication taken by mouth to treat adults with depression that is resistant to to other treatments. (drugs.com)
- 7,11,12 This is the first NMDA receptor antagonist to receive FDA approval for treatment-resistant depression, with a new delivery system via a nasal spray. (ahdbonline.com)
Children and Adolescents2
- Cognitive-behavioral therapy has been shown in multiple randomized, clinical trials to be effective in the treatment of mild to moderate MDDs in children and adolescents. (medscape.com)
- A Cochrane Database of Systematic Reviews study found that both targeted and universal depression prevention programs may effectively prevent the onset of depressive disorder in children and adolescents when compared with no intervention. (medscape.com)
Adults7
- There is a lot of scientific evidence on CBT for the treatment of depression in adults and older adults. (edu.au)
- Major depressive disorder (MDD) is a serious, life-threatening mental disorder that affects approximately 17.3 million adults, or nearly 7.1% of the US adult population. (ahdbonline.com)
- Janssen Pharmaceuticals) was approved by the US Food and Drug Administration (FDA), in conjunction with an oral antidepressant, for the treatment of adults with treatment-resistant depression. (ahdbonline.com)
- Among psychotherapeutic alternatives, cognitive behavioral therapy (CBT) is regarded as being the most suitable and the most researched for the treatment of depression in adults. (bvsalud.org)
- In a meta-analysis carried out with 115 studies, which verified the effects of CBT compared to control groups, other psychotherapies, and pharmacologic intervention, it was shown that CBT is an effective treatment for depression in adults when compared to the control group (Cuijpers et al. (bvsalud.org)
- Adults with a history of epilepsy and with active epilepsy were more likely to report fair or poor health, be unem ployed or unable to work, live in households with the lowest annual incomes, and have a history of co-occurring disorders (e.g., stroke or arthritis). (cdc.gov)
- Few studies have explored factors influencing medication adherence and treatment satisfaction among adults, with little focus on adolescents. (bvsalud.org)
Predictors1
- Predictors of treatment could be the publication status epilepticus causes significant laboratory abnormalities in the most common. (myjuicecup.com)
Cognitive15
- High-dose unilateral ECT has some cognitive advantages compared to moderate-dose bilateral ECT while showing no difference in antidepressant efficacy. (wikipedia.org)
- Cognitive therapy teaches people how to overcome distorted, negative thinking patterns linked with depression. (edu.au)
- A meta-analysis of cognitive-behavioural therapy for adult depression, alone and in comparison with other treatments. (edu.au)
- Combined treatment with cognitive-behavioural therapy in adolescent depression: meta-analysis. (edu.au)
- Cognitive behavioral therapy for depression in older people: A meta-analysis and meta-regression of randomized controlled trials. (edu.au)
- The management of depression includes psychosocial, cognitive and pharmacotherapeutic approaches. (biomedcentral.com)
- Conversely, augmenting SST+ cell post-synaptic α5-GABA-A receptor activity has pro-cognitive efficacy in stress and aging models. (nature.com)
- Cognitive function following a major depressive episode: a systematic review and meta-analysis. (nature.com)
- Efficacy of hypnotherapy compared to cognitive behavioral therapy for mild to moderate depression - Results of a randomized controlled rater-blind clinical trial. (sld.cu)
- Liu W, Li G, Wang C, Wang X, Yang L. Efficacy of Sertraline Combined with Cognitive Behavioral Therapy for Adolescent Depression: A Systematic Review and Meta-Analysis. (sld.cu)
- Fournier JC, DeRubeis RJ, Shelton RC, Hollon SD, Amsterdam JD, Gallop R. Prediction of response to medication and cognitive therapy in the treatment of moderate to severe depression. (jamanetwork.com)
- Cognitive-Behavioral therapy and nicotine craving difficulty with psychotic depression. (myjuicecup.com)
- In Brazil, little is known about the maintenance of results after treatment of cognitive-behavioral therapy (CBT) for major depressive disorder (MDD). (bvsalud.org)
- Brent et al reported that individual supportive treatment was considerably less efficacious than cognitive-behavioral therapy in adolescents who were depressed. (medscape.com)
- In a subset of 14 patients who received 12 to 45 total treatments during a period of 14 to 126 weeks, there was no evidence of cognitive decline or delusions, as measured with the CogState cognitive assessment tool, Wilkinson reported. (medscape.com)
Schizophrenia2
- Convulsive therapy was introduced in 1934 by Hungarian neuropsychiatrist Ladislas J. Meduna who, believing mistakenly that schizophrenia and epilepsy were antagonistic disorders, induced seizures first with camphor and then metrazol (cardiazol). (wikipedia.org)
- It was believed early on that inducing convulsions aided in helping those with severe schizophrenia but later found to be most useful with affective disorders such as depression. (wikipedia.org)
Bipolar depression2
- 8 Ketamine has generated significant interest in the treatment of MDD, bipolar depression, and in depression with suicidal ideation after the publication of a number of studies demonstrating its rapid-acting antidepressant effect following low IV doses. (uspharmacist.com)
- In the new study, 84 of the 126 participants had major depressive disorder, and 42 had bipolar depression . (medscape.com)
Symptom5
- Meanwhile, the gold standard Montgomery Asberg Depression Rating Scale was used to measure depressive symptom severity. (dr-bob.org)
- Multimodal treatment efficacy differs in dependence of core symptom profiles in adult Attention-Deficit/Hyperactivity Disorder: An analysis of the randomized controlled COMPAS trial. (sld.cu)
- Depression is not uncommon as a symptom in Diagnostic and Statistical Manual (DSM) personality disorders, particularly borderline, histrionic, avoidant, and dependent personality disorders (DSM-5). (psychologytoday.com)
- 0.001), with no difference between the end of the treatment and the symptom assessment at 6 ( p = 0.486) and 12 months ( p = 0.098). (bvsalud.org)
- Controlled and comparative studies have been published showing the efficacy of psychological treatment in depressive symptom decrease (Cuijpers et al. (bvsalud.org)
Unipolar depression2
- This hypothesis is, in part, supported by an early rTMS study, which showed that a 2 week protocol of high-frequency rTMS in the region of the left DLPFC affects both prefrontal and paralimbic activities in patients suffering from bipolar as well as unipolar depression (Teneback, 1999). (beppemicalleftrigona.com)
- Nonpharmacological interventions for relapse prevention in unipolar depression: A network meta-analysis. (sld.cu)
Psychiatry7
- A questionnaire was conducted, followed by two advisory boards with seven Portuguese psychiatry experts, to characterize and discuss MDD and TRD epidemiology, diagnosis, patient journey, treatment options, and unmet clinical needs. (frontiersin.org)
- Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment Resistant Depression: A Decade of Clinical Follow-up The Journal of Clinical Psychiatry October 2021. (upenn.edu)
- Dr. Murrough is Associate Professor of Psychiatry and Neuroscience, Director of the Depression and Anxiety Center for Discovery and Treatment , faculty member of the Friedman Brain Institute, and a primary principal investigator of the Center of Excellence in Neuropharmacology, all at the Icahn School of Medicine at Mount Sinai. (va.gov)
- Goossens J, Morrens M, Coppens V. The Potential Use of Peripheral Blood Mononuclear Cells as Biomarkers for Treatment Response and Outcome Prediction in Psychiatry: A Systematic Review. (sld.cu)
- World Federation of Societies of Biological Psychiatry Task Force on Unipolar Depressive Disorders. (jamanetwork.com)
- World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 1: update 2013 on the acute and continuation treatment of unipolar depressive disorders. (jamanetwork.com)
- Taylor l: in gad and effects with agoraphobia are the anxiety disorder in child adolesc psychiatry cogn neurosci 2006 10: maois. (myjuicecup.com)
Refractory1
- Treatment-resistant (refractory) depression has been a fertile topic for several decades (e.g. (psychologytoday.com)
Imminent risk of suicide1
- Carla Canuso, a researcher at Janssen, explained to us the role of esketamine in the treatment of treatment-resistant depression and patients at imminent risk of suicide. (outsourcing-pharma.com)
20193
- 2019), it's surprising that the idea of treatment resistance primarily considers a pharmacological standpoint. (psychologytoday.com)
- METHODS: Data from US patients treated with BPaL between 14 October 2019 and 30 April 2022 were compiled and analyzed by the BPaL Implementation Group (BIG), including baseline examination and laboratory, electrocardiographic, and clinical monitoring throughout treatment and follow-up. (cdc.gov)
- In this cohort, effective treatment required less than half the duration recommended in 2019 US guidelines for drug-resistant tuberculosis. (cdc.gov)
Acute1
- Methods: This 10-week, acute, randomized, controlled, masked trial compared adjunctive VNS with sham treatment in 235 outpatients with nonpsychotic major depressive disorder (n = 210) or nonpsychotic, depressed phase, bipolar disorder (n = 25). (elsevierpure.com)
Evaluate the Efficacy1
- The company listed that study is commencing participant enrollment this month and is named "A Phase 2a, Randomized, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-1942 Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression. (streetwisereports.com)
Esketamine6
- The FDA has granted breakthrough therapy designations for esketamine for treatment-resistant depression, as well as for the indication of major depressive disorder with an imminent risk for suicide. (outsourcing-pharma.com)
- We previously reported on Janssen's two clinical trials for esketamine: a Phase III trial of esketamine in treatment-resistant depression, and a Phase II trial of esketamine in participants with an imminent risk for suicide. (outsourcing-pharma.com)
- According to Canuso, esketamine is an antimere of ketamine and a glutamate receptor modulator that can help restore synaptic connections in brain cells in people with major depressive disorder. (outsourcing-pharma.com)
- There is a risk for abuse and dependence with esketamine treatment. (drugs.com)
- Esketamine is available only through certified physicians' offices or clinics under a Risk Evaluation and Mitigation Strategy (REMS) program, because of the risk for serious adverse outcomes resulting from sedation and dissociation caused by esketamine treatment and the potential for abuse and misuse. (ahdbonline.com)
- At the end of the induction phase (weeks 1-4), the evidence of therapeutic benefit should be assessed to establish whether continued esketamine treatment is needed. (ahdbonline.com)
20212
- 2021) involved 24 patients with major depressive disorder who received two doses of psilocybin (20 mg/70 kg) two weeks apart. (awholenewhigh.com)
- 2021) did a meta-analysis and noted that "…patients meeting diagnostic criteria for a [personality disorder] tended to improve less than patients without a [personality disorder] after CBT for depression. (psychologytoday.com)
Outcomes5
- The Sequenced Treatment Alternatives to Relieve Depression (STAR * D) study is the most comprehensive assessment of MDD treatment outcomes, consisting of a randomized controlled trial that ran between July 2001 and September 2006, and providing a demonstration of the latter point ( 8 ). (frontiersin.org)
- However, the investigators note that there is a need to characterize and identify patient- and treatment-related clinical outcomes. (medscape.com)
- Targeting individualized Inhibitors,research,lifescience,medical treatment In addition to raising the bar for outcomes, the ways to measure and predict them have also become topics of increasing interest. (hivprotease-signal.com)
- Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. (jamanetwork.com)
- only one-third of persons start treatment, and outcomes are often inadequate. (cdc.gov)
Short-term efficacy1
- Conclusions: This study did not yield definitive evidence of short-term efficacy for adjunctive VNS in treatment-resistant depression. (elsevierpure.com)
Serotonin3
- Objective To analyze the impact of the antidepressant vortioxetine on sexual function, compared to selective serotonin reuptake inhibitors (SSRIs) and mixed selective serotonin and norepinephrine reuptake inhibitors (IRSN or Dual) in patients with depression. (bvsalud.org)
- Pharmacologic management of depression today is based largely on the monoamine hypothesis of depression and the neurotransmitters norepinephrine, serotonin, and dopamine. (uspharmacist.com)
- Despite aripiprazole's reported lack of effect on serotonin transporters, long-term treatment with aripiprazole or WS-50030 reversed olfactory bulbectomy-induced hyperactivity at doses that did not reduce activity in sham-operated rats, indicating antidepressant-like activity for both compounds. (montclair.edu)
People with major depressi1
- The antibiotic D-Cycloserine (DCS) helps magnetic stimulation (TMS) for people with major depressive disorder (MDD). (dr-bob.org)
Etiology2
- Comparisons of childhood trauma, alexithymia, and defensive styles in patients with psychogenic non-epileptic seizures vs. epilepsy: Implications for the etiology of conversion disorder. (uc.edu)
- TMS is used for therapeutic purposes because it modulates the activity of neural networks involved in the etiology and pathophysiology of neuropsychiatric and neurological disorders. (tmsdrrachid.com)
Affective disorders1
- The results were also published in the May issue of the Journal of Affective Disorders . (medscape.com)
Dysthymia1
- 2,3 The economic burden of depression, including MDD, bipolar disorder, and dysthymia, has also increased from an estimated $83.1 billion in 2000 to $210.5 billion in 2010. (uspharmacist.com)
Suicidal3
- We can engage in psychotherapies which are ultimately effective, but the treatments [for the imminently suicidal] are just safety measures that have little immediate benefit. (outsourcing-pharma.com)
- Later studies have replicated the robust antidepressant effect of ketamine and showed that ketamine significantly reduces suicidal ideation in patients with depression . (catalystcenterllc.com)
- Spravato may cause worsening of depression and suicidal thoughts and behaviors, especially during the first few months of treatment and when the dose is changed. (drugs.com)
Meta-Analysis3
- A meta-analysis, performed in 2001 on 12 studies comparing Hamilton Depression Rating score (HDRS) reduction with rTMS and sham stimulation, found rTMS to be statistically superior in the treatment of depression (Holtzheimer, 2001). (beppemicalleftrigona.com)
- Meta-analysis: Exposure to early life stress and risk for depression in childhood and adolescence. (msdmanuals.com)
- Lead study author Eric L. Ross, MD, of McLean Hospital in Belmont, Massachusetts, and colleagues conducted a decision analytic modeling evaluation of the cost-effectiveness of the 2 treatments based on data from a meta-analysis of randomized controlled trials, as well as clinical and economic data from other publications. (psychiatryadvisor.com)
Mental disorders1
- By 1801, James Lind as well as Giovanni Aldini had used galvanism to treat patients with various mental disorders. (wikipedia.org)
Baseline3
- MADRS mean total scores decreased 7 points from baseline (31.6 [N = 552]) at 1/2 week of treatment, 11 points at 1 week of treatment, and 18 points at 8 weeks of treatment. (psychiatrist.com)
- Participants completed the nine-item Patient Health Questionnaire (PHQ-9) at baseline and at least one other time following a TMS treatment. (medscape.com)
- In this cohort study of 52,641 patients with a diagnosis of head and neck cancer, the proportion with mental health disorders at baseline was 20.6% compared with the national average of 17.9%, as estimated by the National Survey on Drug Use and Health. (psychnews.org)
Patients with depression2
- Functional imaging studies using positron emission tomography (PET) and single photon emission computed tomography (SPECT) have examined resting cerebral blood flow and glucose metabolism in patients with depression. (beppemicalleftrigona.com)
- These studies suggest that psilocybin assisted therapy can have rapid and significant antidepressant effects in patients with depression that are comparable or superior to conventional treatments. (awholenewhigh.com)
Antidepressant treatment3
- Clinical experience and preliminary scientific evidence support the option of augmenting when partial symptomatic improvement is observed during the current antidepressant treatment. (psychiatrictimes.com)
- Repetitive transcranial magnetic stimulation (rTMS) provided promising results in the treatment of TRD after 2 or more antidepressant treatment trials failed. (psychiatrictimes.com)
- The sociodemographic and clinical profile of patients with major depressive disorder receiving SSRIs as first-line antidepressant treatment in European countries. (sld.cu)
Neuroscience1
- Dr. Reid Robison, chief medical officer of Novamind and principal investigator at CCR, remarked, "We're proud to partner with Merck and support its innovative neuroscience work to develop a potential new drug for treatment-resistant depression. (streetwisereports.com)
Post-traumati1
- Psilocybin has been used for centuries by indigenous cultures for spiritual and healing purposes, and more recently, by modern researchers and therapists for its potential to treat various mental health conditions, such as depression, anxiety, addiction, and post-traumatic stress disorder (PTSD). (awholenewhigh.com)
Transcranial magnetic st3
- Treatment with transcranial magnetic stimulation (TMS) has a robust effect for patients with major depressive disorder (MDD), results from a large registry study show. (medscape.com)
- Clinical Efficacy of repetitive Transcranial magnetic Stimulation in Depression Clinical Guide to the Administration of Transcranial Magnetic Stimulation. (upenn.edu)
- While electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) are both effective in treating depressive episodes, their mechanisms of action are, however, not completely understood. (biomedcentral.com)
Trials6
- Once they started trials on patients, they found that after 10-20 treatments the results were significant. (wikipedia.org)
- IntroductionPsilocybin is a psychedelic tryptamine that has shown promise in recent clinical trials for the treatment of depression and substance use disorders. (researchgate.net)
- In phase 3 clinical trials, we saw this therapy provide sustained improvement to patients with treatment-resistant depression. (ahdbonline.com)
- Wright I, Mughal F, Bowers G, Meiser-Stedman R. Dropout from randomised controlled trials of psychological treatments for depression in children and youth: a systematic review and meta-analyses. (sld.cu)
- Unfortunately, as noted by Voineskos, treatment-resistant depression is generally defined as patients having failed two antidepressant trials. (psychologytoday.com)
- Several trials demonstrate 90% efficacy using an all-oral, 6-month regimen of bedaquiline, pretomanid, and linezolid (BPaL), but significant toxicity occurred using 1200-mg linezolid. (cdc.gov)
RTMS9
- The efficacy of rTMS as a monotherapy (i.e. conducted without individual psychotherapeutic support) is recognized throughout the world as a valid treatment for Depression and is furthermore supported by FDA approval in the United States, and is recognized by NICE in the United Kingdom. (brainclinics.com)
- Since 2011, Health Insurance providers in The United States, and more recently, in The Netherlands, reimburse rTMS treatment for treatment resistant depression. (brainclinics.com)
- Before I go on to describe the uses and efficacy of rTMS, I will briefly discuss the underlying mechanism of action. (beppemicalleftrigona.com)
- It is hypothesised that rTMS increases activities at the left DLPFC and anterior cingulum, in return normalising the syregulation of the limbic-cortical system, known to underlie depression. (beppemicalleftrigona.com)
- Today, rTMS is an approved treatment for depression in Europe and the USA. (beppemicalleftrigona.com)
- More specifically, rTMS is used to manage treatment resistant depression. (beppemicalleftrigona.com)
- A vast amount of research using rTMS, for indications other than depression, is ongoing. (beppemicalleftrigona.com)
- For what disorders has rTMS shown its efficacy? (tmsdrrachid.com)
- The main advantage of rTMS is the absence of notable side effects (no weight gain, cardio-vascular complications, sexual side effects, nausea, memory problems etc.) that are caused by other treatments. (tmsdrrachid.com)
Severe6
- In daily practice, TRD can be defined as moderate to severe MDD episodes with insufficient clinical improvement after two antidepressant treatments, taken in adequate doses and duration. (frontiersin.org)
- ECT is used for the most severe cases of depression and is usually not prescribed before other options have failed. (biomedcentral.com)
- Depressive disorders are characterized by sadness or irritability that is severe or persistent enough to interfere with functioning or cause considerable distress. (msdmanuals.com)
- Depressive Disorders Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities. (msdmanuals.com)
- In mild cases, psychosocial interventions are often recommended as first-line treatments, whereas, in the more severe cases, medication in addition to psychotherapeutic intervention is often recommended. (medscape.com)
- For the prolonged relief of severe and most severe pain (such as cancer pain) that is resistant to other analgesics. (who.int)
Pharmacologic1
- In a presumably treatment-resistant population, the efficacy compared favorably with virtually all pharmacologic treatments" tested in the studies, said Sackeim. (medscape.com)
Electroconvulsive Therapy1
- Some of the other work that I had done with Dr Zivin looked at things like electroconvulsive therapy and other treatments for treatment-resistant depression, which is often managed by psychiatrists. (psychiatryadvisor.com)
Ketamine treatment4
- What are the chances of responding to ketamine treatment? (mbodyhealthcare.com)
- Unfortunately, not everyone responds to ketamine treatment. (mbodyhealthcare.com)
- How do I prepare for a ketamine treatment? (mbodyhealthcare.com)
- All were treated with the standard ketamine treatment for depression, consisting of a single subanesthetic dose (0.5 mg/kg) delivered by infusion over 40 minutes. (medscape.com)
Uses and efficacy1
- Each chapter also features useful tables pertaining to specific topics, such as summaries of uses and efficacy, and important clinical pearls of wisdom in the Key Clinical Concepts. (appi.org)
Participants2
- All participants will undergo multimodal magnetic resonance imaging (MRI) as well as neuropsychological and clinical assessments at multiple time points before, during and after treatment. (biomedcentral.com)
- We evaluated 94 participants with MDD from the Beck Depression Inventory (BDI-II). (bvsalud.org)
Psychotherapeutic interventions1
- Due to these characteristics, in the last decade, a substantial increase in the search for alternatives to the treatment of depression occurred, mainly on psychotherapeutic interventions. (bvsalud.org)
Adolescents3
- More scientific studies on CBT for the treatment of depression in adolescents are needed. (edu.au)
- Objectives: To assess medication adherence, treatment satisfaction and factors influencing adherence to ART medication among adolescents living with HIV in Lagos, Nigeria. (bvsalud.org)
- Methods: This descriptive, cross-sectional study was conducted among diagnosed and registered adolescents aged 10-19 years living with HIV and receiving treatment at eight selected antiretroviral centres in Lagos state, Nigeria. (bvsalud.org)
Relapse3
- However, you may have a relapse of depression if you stop taking your antidepressant. (rxlist.com)
- furthermore, the risk for the relapse of MDD increases in patients who cycle through 3 or more treatment stages. (ahdbonline.com)
- Vivitrol was approved by the Food and Drug Administration in 2006 to prevent the relapse in those recovering from an alcohol use disorder. (freditveldt.com)
SSRIs1
- 2)control, maintaining treatment with SSRIs or Duals. (bvsalud.org)
20221
- Se consideraron un total de 1000 artículos comprendidos de 1916-2022, de los cuales, en los cinco últimos años (2018-2022) fueron 20, con alto impacto e índice "h" relevante. (sld.cu)
Safety9
- Long-term efficacy and safety were therefore investigated in a group of patients with major depressive disorder (MDD) with and without TRD. (psychiatrist.com)
- The committee reached this conclusion after analyzing the safety and efficacy data from five Phase III studies conducted in patients with treatment-resistant depression. (outsourcing-pharma.com)
- The integrated workflow provides customers with a diverse array of predictive compound safety and efficacy insights. (clarivate.com)
- Novamind advised that the Phase 2a study is designed to evaluate the safety and efficacy of a new drug that is being developed and advanced by Merck to counter treatment-resistant depression (TRD). (streetwisereports.com)
- Safety or other concerns have been raised for the use of these treatments. (edu.au)
- It is also listed on the World Health Organization's "essential medicines" list due to its efficacy and safety record. (mbodyhealthcare.com)
- Use of individualized linezolid dosing and monitoring likely enhanced safety and treatment completion. (cdc.gov)
- In addition, new safety and efficacy data for off-label use of the drug are encouraging. (medscape.com)
- 12 years due to insufficientdata on safety and efficacy. (who.int)