• This report describes the long term safety and efficacy of intrathecal therapy using Sufentanil for the management of chronic intractable neuropathic pain in 12 chronic pain patients. (epain.org)
  • Intrathecal therapy with Sufentanil therapy offers a good treatment alternative for those cases that have failed both surgery and standard pain treatment. (epain.org)
  • The purpose of the study is to describe the long-term safety and efficacy of intrathecal therapy using Sufentanil for the management of chronic intractable neuropathic pain, including failed back surgery syndrome. (epain.org)
  • Ten male volunteers were randomly assigned to receive an intrathecal injection of either 10 microg sufentanil or saline in a double-blind fashion. (silverchair.com)
  • THE lipid-soluble opioid agents sufentanil and fentanyl are frequently given intrathecally to provide analgesia during labor. (silverchair.com)
  • Patients undergoing open abdominal partial hepatectomy, according to their willingness, accepted one of the following managements for the postoperative pain: continuous wound catheter (CWC) infiltration, patient-controlled epidural analgesia (PCEA), patient-controlled intravenous analgesia of morphine (PCIAM), and patient-controlled intravenous analgesia of sufentanil (PCIAS). (cams.cn)
  • Group SUB: Subarachnoid analgesia (administered once only immediately before the general anesthesia) using 10.5 mg ropivacaine 0.75%, 30 mcg clonidine150 mcg/mL, 2 mcg/Kg morphine 100 mcg/mL and 0.03 mcg/Kg sufentanil 5 mcg/mL with a sterile 27 G needle at the L1-L2 or L2-L3 interspace. (who.int)
  • The main objective is the comparison of intubation conditions after anesthetic induction bolus of propofol-sufentanil when compared to injection of propofol-remifentanil in patients undergoing surgery for tooth extraction. (druglib.com)
  • However, remifentanil was never compared to sufentanil in terms of intubating conditions without muscle relaxant. (druglib.com)
  • Comparison of Intubation Conditions After Induction With Propofol Associated With a Dose of Remifentanil or Sufentanil in Surgical Tooth Extraction. (druglib.com)
  • ESPB was associated with decreased use of intraoperative sufentanil and remifentanil and decreased opioid consumption within 24 to 48 hours after surgery. (clinicalpainadvisor.com)
  • Investigators will "evaluate the analgesic efficacy of Oxycodone DETERx compared with placebo in opioid-experienced and opioid-naive subjects with moderate-to-severe chronic low back pain . (hcplive.com)
  • Due to issues associated with post-surgical opioid use, researchers in China sought to determine the efficacy and safety of treating pain following lumbar spinal surgery with ESPB. (clinicalpainadvisor.com)
  • Investigators will evaluate the efficacy and safety of the Sufentanil NanoTab PCA System/15 mcg for the management of acute postoperative pain after total unilateral knee or total unilateral hip replacement surgery. (hcplive.com)
  • Sufentanil and morphine were associated with increases in the respiratory depression incidence. (elsevierpure.com)
  • [1,2] Whether the decrease in blood pressure results from a sympathectomy caused by weak local anesthetic action of sufentanil [1] or to pain relief remains controversial, although recent studies support the latter explanation. (silverchair.com)
  • To investigate the efficacy and safety of continuous local anesthetic wound infiltration following open abdominal partial hepatectomy. (cams.cn)
  • Intubation without myorelaxant with propofol and sufentanil is classic but less efficient than induction with curare on achieving perfect intubation conditions. (druglib.com)
  • The authors concluded that "ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting. (theanesthesiaconsultant.com)
  • 1. Seeberger MD, Staender S, Oertli D, Kindler CH, Marti W. Efficacy of specific aseptic precautions for preventing propofol-related infections: analysis by a quality-assurance programme using the explicit outcome method. (cdc.gov)
  • Objectives: The aim of this study was to compare the efficacy and safety of ketofol (a mixture of propofol and ketamine) versus fentafol (a mixture of propofol and fentanyl) during the ERPC. (bvsalud.org)
  • 2022. Efficacy of tricaine (MS-222) and hypothermia as anesthetic agents for blocking sensorimotor responses in larval zebrafish. (awionline.org)
  • 2021. Anesthetic efficacy of magnesium chloride and ethyl alcohol in temperate octopus and cuttlefish species. (awionline.org)
  • But underlying the debate surrounding this approval is a broader issue that must be addressed head on: why do we need an oral formulation of sufentanil - a more potent form of fentanyl that's been approved for intravenous and epidural use in the U.S. since 1984 - on the market? (healthjobsnationwide.com)
  • This study did not find efficacy of the study drug against placebo. (medscape.com)
  • This study demonstrated the drug's efficacy compared with placebo but did not demonstrate the duration of the nerve block (only the first 72 hours) or adequately report cardiac safety data. (medscape.com)
  • In this particular case, Dsuvia is a sublingual (under the tongue) formulation of sufentanil that's delivered through a disposable, pre-filled, single-dose applicator. (healthjobsnationwide.com)
  • DURECT's proprietary oral, transdermal and injectable depot delivery technologies may enable new indications and superior clinical/commercial attributes such as abuse deterrence, improved convenience, compliance, efficacy and safety for small molecule and biologic drugs. (durect.com)
  • Fecal microbiota transplantation across the lifespan: balancing efficacy, safety, and innovation. (umn.edu)
  • Efficacy and Safety of a Continuous Wound Catheter in Open Abdominal Partial Hepatectomy[J].Chinese Medical Sciences Journal, 2017, 32(3): 171-176. (cams.cn)
  • Safety and efficacy have not been established. (mayoclinic.org)
  • Although the vote was close, the committee believed the drug company did not adequately demonstrate the drug's safety and efficacy. (medscape.com)
  • I wasn't convinced of the data that was presented here at the FDA of both efficacy and safety. (medscape.com)
  • The FDA requested that the applicant demonstrate efficacy from an adequate and well-controlled trial in one or more additional clinical settings and to adequately characterize safety for femoral block with the study drug. (medscape.com)
  • Efficacy and safety of erector spinae plane block for perioperative pain management in lumbar spinal surgery: a systematic review and meta-analysis of randomized controlled trials. (clinicalpainadvisor.com)
  • However, safety and efficacy have not been established in children younger than 6 years of age. (drugs.com)
  • The DH loss caused by a certain degree of cage subsidence after surgery does not affect the clinical efficacy. (bvsalud.org)
  • Discovering and optimizing therapeutic efficacy, or elucidating toxicity, for new and existing compounds through drug metabolism and pharmacokinetic/pharmacodynamic analyses. (environmentalchemistry.com)
  • The procedure of testing the efficacy of a pharmacological agent as a reinforcer would soon become a standard assay. (wikipedia.org)
  • Adamus M, Koutná J, Gabrhelík T, Zapletalová J. [Tracheal intubation without muscle relaxant--the impact of different sufentanil doses on the quality of intubating conditions: a prospective study]. (druglib.com)
  • sufentanil, calcium/magnesium/potassium/sodium oxybates. (medscape.com)
  • This suggests that the hypotension occurring in these women after intrathecally administered sufentanil is secondary to relief of pain, rather than to a sympathectomy. (silverchair.com)
  • DURECT is a specialty pharmaceutical company developing innovative drugs for pain and other chronic diseases, with late-stage development programs including REMOXY ® , POSIDUR â"¢ , ELADUR ® , and TRANSDUR ® -Sufentanil. (durect.com)
  • Coadministration of specific drugs with itraconazole may result in changes in efficacy of itraconazole and/or the coadministered drug, life-threatening effects and/or sudden death. (druginteractionchecker.com)
  • Avoid use when taking any oral drug that is dependent on threshold concentrations for efficacy. (medscape.com)
  • REMOXY, POSIDUR, ELADUR and TRANSDUR-Sufentanil are drug candidates under development and have not been approved for commercialization by the U.S. Food and Drug Administration or other health authorities. (durect.com)
  • In this study, the authors examined whether intrathecally administered sufentanil has similar effects in pain-free individuals with low concentrations of progesterone (i.e., male volunteers). (silverchair.com)
  • In one report in which 20 [micro sign]g of intrathecally administered sufentanil (ITS) was given to men and women for lithotripsy, [5] no mention was made of hypotension, nausea was absent, and pruritus occurred in only 27% of the patients. (silverchair.com)
  • For some substances there is also a risk assessment made on the basis of concentrations measured in the environment in Sweden and efficacy studies with high quality. (janusinfo.se)