Efficacy of praziquantel against schistosoma. Medical search. Frequent questions

However, the efficacy was satisfactory (ERR ≥ 90%) in females, children ˂ 5 years, and some localities and for individuals with heavy infection intensity. (biomedcentral.com)
Previous studies have shown that Sida pilosa aqueous extract (SpAE) has schistosomicidal, antioxidant, anti-inflammatory and anti-fibrotic activities in Schistosoma mansoni infection. (nih.gov)
Seven studies (37%) focused on Schistosoma mansoni , 6/19 (31.5%) on S. haematobium and another 6 on mixed infection. (biomedcentral.com)
However, findings on efficacy of repeated doses in co-infection of S. mansoni and S. haematobium were not conclusive. (biomedcentral.com)
Uncomplicated Schistosoma haematobium infection defined by: presence of microscopically-determined Schistosoma haematobium eggs in urine with absence of Katayama fever and absence of clinically significant urinary tract pathology (see exclusion criteria). (who.int)
Efficacy and safety of ascending doses of praziquantel against Schistosoma haematobium infection in preschool-aged and school-aged children : a single-blind randomised controlled trial. (unibas.ch)
Characterizing the biochemical response to Schistosoma mansoni infection and treatment with praziquantel in preschool and school aged children. (unibas.ch)
BackgroundThe prevalence of Schistosoma mansoni infection is usually assessed by the Kato-Katz diagnostic technique. (researcher.life)
The effect of the number of stool samples on the ob-served prevalence and the infection intensity with Schistosoma mansoni among a population in an area of low transmission. (ac.ir)
Infection with Schistosoma haematobium may cause Female Genital Schistosomiasis (FGS) with pathological lesions in the female genital tract, especially the cervix. (drugpatentwatch.com)
The present study was designed to investigate the potential complementary schistosomicidal and hepatoprotective activities of the methanol extract of Capparis spinosa L. (C. spinosa) with or without praziquantel (PZQ) and compare results with silymarin (Milk thistle), a known hepatoprotective and antiﬁ brotic agent, on induced liver ﬁ brosis by experimental Schistosoma mansoni (S. mansoni) infection. (cu.edu.eg)
Infection by Schistosoma mansoni during pregnancy: Effects on offspring immunity. (freebily.eu)
FGS Isa manifestation mainly o f schistosoma haematobium infection. (researchkey.net)
Studies have shown strong associations between schistosoma infection and schistosoma-induced cytokine profiles [ 6 ]. (hindawi.com)
8 ] speculated that IL-10 is important in regulating the human immune response to Schistosoma mansoni infection and that it is the main cytokine that plays part in the control of morbidity. (hindawi.com)
The main objective of this study was to assess the prevalence and risk factors associated with Schistosoma (S.) mansoni infection among PSAC from Panamasso village, western Burkina Faso. (researchsquare.com)

In Asia, vertebrate reservoirs for Schistosoma japonicum (largely ruminants, rodents, and other mammals) play a crucial role in perpetuating the transmission of this zoonotic parasite, even under strong multisectoral control pressures ( 4 , 5 ). (cdc.gov)
At least five known species infect humans, the three most common being Schistosoma haematobium , S japonicum , and S mansoni . (appliedradiology.com)
Schistosoma haematobium , S. mansoni and S. japonicum . (wikitropica.org)
Infections with Schistosoma mansoni, S. japonicum, S. mekongi, and S. intercalatum are associated with intestinal lesions and chronic hepatic fibrosis. (wikitropica.org)
This review discusses aspects of the epidemiology and transmission of Schistosoma japonicum in China and considers the pathology, clinical outcomes, diagnosis, treatment, immunobiology, and genetics of schistosomiasis japonica together with an overview of current progress in vaccine development, all of which will have an impact on future control efforts. (edu.au)
of Sj23LHDGST bivalent antigen from Schistosoma japonicum and. (moam.info)
Nov 17, 2012 - Molecular cloning and characterization of Schistosoma japonicum aldose reductase. (moam.info)
study of the hatching biology of Schistosoma japonicum. (moam.info)
Abstract Background: The endemic countries are in a diagnostic dilemma concerning Schistosoma japonicum with increasing difficulties in diagnosing the infected individuals. (moam.info)
2009) Low Sensitivity of the Formol-Ethyl Acetate Sedimentation Concentration Technique in Low-Intensity Schistosoma japonicum Infections. (moam.info)

Chemotherapy using praziquantel has been the most effective and widespread control measure used. (biomedcentral.com)
Effectively, more than 66 million received preventive chemotherapy with praziquantel (PZQ). (biomedcentral.com)
The use of synchronous praziquantel (PZQ) chemotherapy for humans and domestic animals is only temporarily effective, as schistosome reinfection occurs rapidly. (edu.au)
In 2010, only 12.2% of people at risk of schistosomiasis morbidity and 22.8% of school-age children at risk of morbidity due to soil-transmitted helminthiases benefitted from preventive chemotherapy with praziquantel and with benzimidazoles, respectively. (who.int)
the number of benefitting from preventive chemotherapy with praziquantel rose from 12 million in 2006 to 32.6 million in 2010. (who.int)
This neglected tropical disease infects an estimated 190 million people a year predominantly in sub-Saharan Africa, and efforts to treat and curtail morbidity in endemic populations is conducted through large-scale mass drug administration (MDA) of preventative chemotherapy using praziquantel. (biomedcentral.com)
These program was chiefly engaged in preventing chemotherapy campaigns administering Praziquantel to targeted groups. (researchkey.net)
New drugs for schistosomiasis would be welcome given that current treatment and control strategies rely on chemotherapy with just one drug, praziquantel. (biomedcentral.com)
Un 40% de esos trabajos han sido publicados en revistas del primer cuartil entre las que destacan New England Journal of Medicine, Lancet, Lancet Infectious Diseases, Clinical Infectious Diseases, Clinical Microbiology Reviews, Antimicrobial Agents and Chemotherapy, Journal Clinical Microbiology, Journal Antimicrobial Chemotherapy, Mayo Clinic Proceedings y Malaria Journal. (unav.edu)

Praziquantel (PZQ), sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections in mammals, birds, amphibians, reptiles, and fish. (wikipedia.org)
NT008 trade name] is indicated for elimination of schistosoma infections through mass drug administration programmes. (who.int)
The efficacy and safety of praziquantel is well established based on extensive clinical experience in the treatment of schistosoma infections. (who.int)
The search included studies published from 2008 to 2017 (August) with emphasis on the efficacy of praziquantel on S. haematobium and S. mansoni infections among preschool and school children. (biomedcentral.com)
Clearance of infections and resolution of morbidity were subsequently studied in two phases following systematic anti-STI and anti-schistosoma treatment, respectively. (drugpatentwatch.com)
Tools for diagnosis, monitoring and screening of Schistosoma infections utilizing lateral-flow based assays and upconverting phosphor labels. (freebily.eu)

Treatment with praziquantel was efficacious and safe showing reduction in prevalence as well as mean egg load in some individuals with few adverse events recorded. (biomedcentral.com)
Considering that the disease has a focal distribution, the WHO recommends that distribution of praziquantel should be done following the prevalence in the communities. (biomedcentral.com)
In the same light, in low-risk communities where parasite prevalence is ˂ 10%, all school-age children should be treated twice during primary school age while praziquantel is made available in health care institutions for treatment of suspected cases. (biomedcentral.com)
A cross-sectional study from Zimbabwe indicated that the pathologic genital lesions were unchanged two years after praziquantel treatment in adult women whereas in those who had been treated with praziquantel in childhood the prevalence of genital lesions was significantly lower. (drugpatentwatch.com)
A five-country evaluation of a point-of-care circulating cathodic antigen urine assay for the prevalence of Schistosoma mansoni. (freebily.eu)
The study aimed to detect the molecular prevalence of urine schistosomiasis and evaluate microscopic examination vs. PCR technique for detection of Schistosoma haematobium ( S. haematobium ) in urine of patients with suggestive symptoms or previous history of urine schistosomiasis coming from endemic regions. (springeropen.com)

Immunohistochemical investigations of treatment with Ro 13-3978, praziquantel, oxamniquine, and mefloquine in Schistosoma mansoni-infected mice. (unibas.ch)

The schistosoma blood flukes have a unique life cycle requiring two hosts to reproduce and survive. (appliedradiology.com)
Schistosomiasis is an acute and chronic parasitic disease caused by blood flukes (trematoda flat worms) of genus Schistosoma .FGS is mostly caused by the presence of S.haematobium eggs lodged in the female reproductive tract. (researchkey.net)

Schistosomiasis caused by trematodes of the genus Schistosoma: As of 2005, praziquantel is the primary treatment for human schistosomiasis, for which it is usually effective in a single dose. (wikipedia.org)
Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial. (freebily.eu)

The large-scale use of praziquantel might result in selection of drug-resistant parasites. (eg.net)
With a constant risk of parasites becoming resistant to many anti-parasitic drugs, it is also pertinent to quantify parasite abundance so that drug efficacy can be accurately assessed, i.e. to establish whether there had been a significant, if not complete, reduction in parasite load following a targeted treatment. (biomedcentral.com)
A recent research article published in Parasites & Vectors by Joaquin Prada and colleagues encompasses some of these issues by comparing two widely used diagnostic tests for intestinal schistosomiasis (caused by Schistosoma mansoni ) in Uganda. (biomedcentral.com)

Participants were treated with a unique dose of praziquantel of 40 mg/Kg body weight. (biomedcentral.com)
However, failure/resistant cases have been reported after the use of a single standard dose of praziquantel at 40 mg/kg body weight. (biomedcentral.com)

Despite the worldwide distribution and transmission of schistosoma, 85% of cases of schistosomiasis are linked to Africa. (appliedradiology.com)

The distribution of praziquantel in the area should be extended to other age groups and not just school-age children. (biomedcentral.com)
The proposed project aims at achieving a better understanding of how annual distribution of praziquantel to pre- and post-pubertal schoolgirls may prevent FGS. (drugpatentwatch.com)

Schistosomiasis is a parasitic disease caused by trematode worms of the genus Schistosoma and affects over 200 million people worldwide. (ox.ac.uk)
Schistosomiasis (also called bilharzia) is a vector- borne disease caused by trematoda flat worms of the genus Schistosoma. (researchkey.net)

This, and the lack of efficacy of praziquantel against juvenile worms, highlights the urgency for new antischistosomal therapies. (ox.ac.uk)
In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms. (ac.ir)
Mainstay treatment with praziquantel, active against adult worms only. (wikitropica.org)
This study aimed for assessment of antischistosomal properties of an antimalarial drug, mefloquine (MFQ), on juvenile and adult Schistosoma haematobium worms. (eg.net)
The reduction in the cytokine levels can be directly related to the influence of the drug praziquantel, modulating the cytokine response by elimination of adult worms, decline in parasitic load, and reduction of morbidity. (hindawi.com)
In the developing world, over 207 million people are infected with parasitic Schistosoma worms. (cdc.gov)

Short communication: In vitro efficacy testing of praziquantel, ivermectin, and oxfendazole against Taenia solium cysts. (ac.ir)

Another trial found that treatment with praziquantel did not increase the rates of low birthweight, fetal death, or congenital anomalies. (wikipedia.org)
A single standard dose of 40 mg/kg body weight was the most used regimen (9) followed by the repeated single standard dose assessed for efficacy at 3-4 weeks post-treatment. (biomedcentral.com)
The control and treatment of this neglected tropical disease is based on a single drug, praziquantel, which raises concerns about the development of drug resistance. (ox.ac.uk)
Guidelines recommend praziquantel (PZQ) for the treatment and control of schistosomiasis, with no real alternative. (ox.ac.uk)
This increase was due to greater access to large-scale treatment, for instance through donations of praziquantel and provision of more resources by multiple partners for the control of neglected tropical diseases. (who.int)
The purpose of this study is to determine the comparative efficacy of artesunate plus sulfamethoxypyrazine-pyrimethamine versus Praziquantel in the treatment of school children infected with S.mansoni in western Kenya. (drugpatentwatch.com)
Antigen-positive participants were retested one year after MDA to assess treatment efficacy. (cdc.gov)
Praziquantel for the treatment of schistosomiasis during human pregnancy. (freebily.eu)
This cross-sectional study was performed for detection of S. haematobium for patients attending the Outpatient Clinic of Sohag University Hospital from August 2016 to July 2018, who had suggestive symptoms, previous history of urine schistosomiasis, or history of contact with water canals, or received Schistosoma treatment and were coming from endemic regions. (springeropen.com)

Praziquantel is the only drug recommended by the World Health Organization to treat both urogenital and intestinal schistosomiasis. (biomedcentral.com)

Pharmacokinetics of praziquantel in Schistosoma mansoni and Schistosoma haematobium infected school- and preschool- aged children. (unibas.ch)

Praziquantel is effective in reducing schistosomiasis during pregnancy. (wikipedia.org)

Parasitological assessment (worm burden, tissue egg load, and oogram pattern), histopathological examination, and scanning electron microscopy were performed to evaluate MFQ efficacy. (eg.net)
Diagnosis of schistosomiasis depends mainly on stool or urine microscopy for Schistosoma egg detection as well as immunoassays. (springeropen.com)

We characterized the evolutionary relationships among multiple Schistosoma mansoni isolates collected from snails (intermediate hosts), humans (definitive hosts), and rodents (definitive hosts) in Senegal. (cdc.gov)

Sometimes referred to as bilharzias, bilharziasis, or snail fever, schistosomiasis was discovered by Theodore Bilharz, a German surgeon working in Cairo, who first identified the etiological agent Schistosoma hematobium in 1851. (medscape.com)
Egg of Schistosoma hematobium, with its typical terminal spine. (medscape.com)

The magnitude of Schistosoma zoonotic transmission, in which both domestic animals and wildlife are active participants, is yet to be determined in endemic countries across Africa. (cdc.gov)

Acting beyond 2020 : better characterization of praziquantel and promising antischistosomal leads. (unibas.ch)
Results concluded by this study elucidate promising MFQ antischistosomal efficacy on both juvenile and adult stages of S. haematobium with more evident effect on juvenile forms, which enforces the potential use of MFQ as an effective antischistosomal drug. (eg.net)

This systematic review was conducted to identify gaps and recent progress on the efficacy of different regimens of praziquantel in treating schistosomiasis among children in sub-Saharan Africa where Schistosoma mansoni and S. haematobium are endemic. (biomedcentral.com)

Schistosomiasis is due to immunologic reactions to Schistosoma eggs trapped in tissues. (medscape.com)
Schistosoma mansoni is one of the most widespread species, and its routine diag- nosis is based on microscopic detection of parasite eggs in stool samples. (cdc.gov)

Is PCR the Next Reference Standard for the Diagnosis of Schistosoma in Stool? (cdc.gov)

Evaluation of the Clinitek®, a point-of-care urinalysis system for the measurement of clinically significant urinary metabolites and detection of haematuria in Schistosoma haematobium infected children in southern Côte d'Ivoire. (unibas.ch)

The aim of this study was to assess the efficacy and safety of praziquantel against Schistosoma haematobium among infected individuals in the Ikata-Likoko area of southwest Cameroon. (biomedcentral.com)

Although, several drugs have been found to be efficacious against all five species of Schistosoma [ 3 ], praziquantel has been the most widely used. (biomedcentral.com)
A repeated standard dose of 40 mg/kg achieved satisfactory efficacy compared to a single dose against both parasite species. (biomedcentral.com)
Patients infected chronically with one of the intestinal species of schistosoma may present with intermittent abdominal pain, diarrhea, and hematochezia. (appliedradiology.com)
Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against Schistosoma mansoni and Schistosoma haematobium. (unibas.ch)
There are three main forms of schistosomias species which includes, intestinal schistosomias caused by schistosoma mansoni . (researchkey.net)
PZQ is safe, active against all species of Schistosoma and is affordable, or distributed free of charge. (biomedcentral.com)

Diseases, CHINA shortcomings that greatly affect the efficacy of current schistosomiasis control programs. (cdc.gov)

Concomitant use may enhance drug efficacy by mobilizing hepatic stores and elevating plasma concentrations, particularly in very-low-birth-weight (VLBW) neonates with bronchopulmonary dysplasia. (interactionsguide.com)

A study with multiple drug doses and longer period of evaluation could reveal more information on praziquantel efficacy in the area. (biomedcentral.com)
The review indicates that further investigations are necessary to conclusively determine efficacy of praziquantel on coinfection of S. haematobium and S. mansoni to formulate concrete guidelines on the use of repeated doses at 40 or 60 mg/kg for treating schistosomiasis. (biomedcentral.com)

This set of potential candidates will then be tested for protective efficacy in a mouse model using a phage-display delivery system, which is known to promote a strong immune response and to stabilize the vaccine antigen candidate. (fapesp.br)

The drug's mode of action is not exactly known at present, but experimental evidence indicates praziquantel increases the permeability of the membranes of schistosome cells towards calcium ions. (wikipedia.org)

The present study aimed to investigate the schistosomicidal effects of the methanolic extract of Argemone mexicana L. and its active component, berberine against Schistosoma mansoni on in-vitro experiments. (ac.ir)
Schistosoma mansoni: In vitro schistosomicidal ac-tivity of essential oil of Baccharis trimera (less) DC. (ac.ir)

Here, we screened the Pathogen Box against the post-infective larvae (schistosomula) of Schistosoma mansoni using assays particular to the three contributing institutions, namely, the University of California San Diego (UCSD) in the USA, the Swiss Tropical and Public Health Institute (Swiss TPH) in Switzerland, and the Fundação Oswaldo Cruz (FIOCRUZ) in Brazil. (biomedcentral.com)

The antibiotic rifampicin decreases plasma concentrations of praziquantel. (wikipedia.org)

Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni. (unibas.ch)

Global supplies of praziquantel are insufficient, and this lack of praziquantel is the major barrier to schistosomiasis control in many endemic countries. (who.int)
We performed a cluster-randomized community study to compare the safety and efficacy of IDA and DA in an LF-endemic area in northern Haiti. (cdc.gov)

Praziquantel is also effective against Echinococcus multilocularis. (wikipedia.org)

It is a pyrazinoquinoline derivative whose safety and efficacy have ensured its widespread usage. (biomedcentral.com)
On the basis of data submitted and public information on the use of praziquantel in neglected tropical diseases, the team of assessors advised that [NT008 trade name] is of acceptable quality, efficacy and safety to allow inclusion of [NT008 trade name] in the list of prequalified medicinal products. (who.int)
In a Cochrane systematic review assessing the efficacy and safety of drugs for treating urinary schistosomiasis, 24 randomized controlled trials (n=6315 individuals) met our inclusion criteria. (ox.ac.uk)

Our project aims at identifying new vaccine candidate targets with the use of a novel unbiased screening methodology, namely the use of a phage-display Schistosoma mansoni peptide library constructed by our group with synthetic oligonucleotides that encode the entire set of parasite proteins. (fapesp.br)
The present study determined the intermediate host proteins expressing the immunogenic properties against the parasite by determining the efficacy. (academicjournals.org)

Metrifonate was still widely used against Schistosoma haematobium in the 1990s, and then withdrawn. (ox.ac.uk)

En mayo de 2007 obtuve el Certificate of Training in Molecular Biological Techniques en el Department of Molecular Biology y desde Junio de 2008 a Junio de 2009 completé el Certificate in Clinical Research en el Center for Translational Science Activities en Mayo Clinic College of Medicine, Rochester Minnesota. (unav.edu)

Praziquantel administrated at 60 mg/kg was slightly more efficacious than the 40 mg/kg standard dose. (biomedcentral.com)

Anatomy3

Organisms24

Diseases28

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes5

Disciplines and Occupations1

Information Science1

Health Care4

Geographicals10

Infection16

Japonicum10

Chemotherapy9

Infections6

Prevalence6

Mansoni-infected mice1

Flukes2

Human schistosomiasis2

Parasites3

Dose of praziquantel2

Transmission of Schistosoma1

Distribution of praziquantel2

Genus2

Worms6

Ivermectin1

Treatment9

Intestinal schistosomiasis1

Pharmacokinetics1

Schistosomiasis during pr1

Microscopy2

Snails1

Hematobium2

Zoonotic1

Antischistosomal2

Regimens1

Eggs2

Stool1

Detection1

Assess the efficacy1

Species6

Current schistosomiasis1

Drug efficacy1

Doses2

Antigen1

Schistosome1

Vitro2

Schistosomula1

Plasma concentrations1

Assays1

Endemic2

Echinococcus1

Safety3

Parasite2

Widely1

Clinical1

Efficacious1