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  • Oncology
  • In vivo méthode d'imagerie à distinguer inflammation aiguë et chronique Jen-Chieh Tseng 1 , Andrew L. Kung 2 1 Lurie Family Imaging Center, Dana-Farber Cancer Institute, Harvard Medical School, 2 Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Medical Center Nous décrivons une méthode d'imagerie non-invasive permettant de distinguer les stades inflammatoires. (jove.com)
  • demonstrate
  • Additionally, tumor cells treated with dichloroacetate (DCA), which inhibits pyruvate dehydrogenase kinase (PDK) and increases mitochondrial metabolism of pyruvate, demonstrate reduced rates of proliferation. (cancernetwork.com)
  • Our purpose was to demonstrate the efficacy of cytokine removal by combined use of continuous veno-venous hemofiltration (CVVH) and hemoadsorption by CytoSorb® in treatment of a patient with septic shock and septic cardiomyopathy, resistant to vasopressors and inotropes. (biomedcentral.com)
  • tumor
  • Pubmed ID: 14647233 To improve the efficacy of tumor cell-based and dendritic cell (DC)-based cancer vaccines, this study explored the potential of a new cancer vaccine strategy, that is, the use of CD40 ligand-transfected tumor (CD40L-tumor) cells to simultaneously deliver both tumor-derived antigens (Ag) and maturation stimuli to DCs. (jove.com)
  • disorders
  • Mitochondrial diseases were once thought of as rare disorders, in part due to failure to recognize the diagnosis because of the wide variability among phenotypes. (dovepress.com)
  • Ophthalmic manifestations are frequent among mitochondrial disorders and can result in retinopathy, ocular motility disorders, or optic neuropathy. (dovepress.com)
  • mechanisms
  • The differences in structure and in mitochondrial function observed relative to WT may represent compensatory mechanisms for the disease-related reduction of calcium storage capacity of the SR and/or SR Ca(2+)-leakage. (jove.com)
  • study
  • In this study we aimed to clarify how the SR determines mitochondrial calcium handling using dCASQ-null mice which lack both isoforms of the major Ca(2+)-binding protein inside SR, calsequestrin. (jove.com)
  • Estaban Gomez, MD, is leading this study to investigate the relationship between iron overload and mitochondrial DNA damage in a group of well-characterized patients with beta-thalassemia major. (chori.org)
  • Safety and efficacy of pomalidomide plus low-dose dexamethasone in STRATUS (MM-010): a phase 3b study in refractory multiple myeloma. (bloodjournal.ru)
  • cells
  • We have demonstrated these compounds to induce apoptosis/autophagy by mitochondrial targeting in these cancer cells. (jove.com)
  • treatment
  • Mangafodipir, therefore, though its efficacy might be limited, may be a new option for the preservation of fertility during anticancer treatment. (biomedcentral.com)
  • Metformin (MET), a first-line antidiabetic medication for the treatment of type 2 diabetes, has been reported to inhibit the mitochondrial respiratory chain and activate AMP-activated protein kinase (AMPK). (biomedcentral.com)