Acetaminophen overdoseMucolyticAssess the efficacyLack of efficacySupportive treatmentAntioxidantsAcuteClinicalGlutathioneIntravenousTolerabilityCOPDSafetyTreatmentSubstancesTherapeuticSystemicPatientsAssessmentsMeta-AnalysisStudyEffectsTherapyReviewShownGroupArticleDevelopmentCalled N-acetylcysteine
Acetaminophen overdose6
- In September 1976, he began a protocol and was the principal investigator of the use of n-acetylcysteine for the treatment of acetaminophen overdose as part of a National Multiclinic Study which collected and published the largest series of acetaminophen cases ever collected in The New England Journal of Medicine in 1988. (wikipedia.org)
- N-acetylcysteine (NAC) is a mucolytic and nephroprotective agent and is also the antidote to acetaminophen overdose. (jcadonline.com)
- Efficacy of oral Nacetylcysteine in the treatment of acetaminophen overdose. (spine-health.com)
- Acetylcysteine, also known as N-acetylcysteine (NAC), is a modified amino acid that is used as an antidote for acetaminophen overdose to prevent hepatic injury. (vitaminhaat.com)
- Acetylcysteine is a modified amino acid that is used to reverse the toxic effects of acetaminophen overdose and prevent acute liver failure. (vitaminhaat.com)
- In multiple clinical trials, administration of acetylcysteine (also referred to as N-acetylcysteine or NAC) within 10 hours of an acetaminophen overdose effectively prevented serious liver injury. (vitaminhaat.com)
Mucolytic1
- N -acetylcysteine (NAC) is a potent mucolytic agent that reduces mucus viscosity and elasticity. (ijrc.in)
Assess the efficacy2
- The aim was to review clinical trials that assess the efficacy of N-acetylcysteine in cutaneous disorders. (jcadonline.com)
- This study was a randomized, open-label, actively controlled, prospective, single-center, two-arm, parallel to assess the efficacy, safety, and tolerability of the combination of NAC 600 + lactoferrin 50 mg against NAC 600 mg in the symptomatic treatment of patients suffering from productive cough associated with acute bronchitis. (ijrc.in)
Lack of efficacy2
- 6 Currently, there is no United States Food and Drug Administration (FDA)-approved psychoactive medication for excoriation disorder, with studies showing either mixed results or lack of efficacy. (jcadonline.com)
- However, mainly due to the lack of efficacy of the anti-inflammatory treatment approach, there was a shift to the current view that IPF is an epithelial-driven and fibroblast-activated process, in which inflammation is a secondary event [ 8 ]. (ersjournals.com)
Supportive treatment2
- We hypothesized that IV N-acetylcysteine is effective in reducing mortality rate compared to supportive treatment alone. (bvsalud.org)
- We only included randomized controlled trials that assessed the efficacy of IV N-acetylcysteine and supportive treatment versus supportive treatment alone in acute aluminum phosphide poisoning. (bvsalud.org)
Antioxidants1
- This article confers a deep understanding of the protective effects of some effective therapies, including hepatoprotective agents, attenuation of an increase in xanthine oxidase activity, and administration of antioxidants like N-acetylcysteine, superoxide dismutase (SOD), and ornithine. (bvsalud.org)
Acute6
- Role of N-Acetylcysteine Treatment in Non-Acetaminophen-Induced Acute Liver Failure: A Prospective Study. (liversupport.com)
- Efficacy and Safety of Acetylcysteine in "Non-Acetaminophen" Acute Liver Failure: A Meta-Analysis of Prospective Clinical Trials. (liversupport.com)
- Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial. (spine-health.com)
- It was observed that the combination of NAC and lactoferrin showed better primary and secondary efficacy results with respect to the treatment of acute bronchitis. (ijrc.in)
- Based on the study results/data, it can be concluded that the combination of NAC and Lactoferrin shows better efficacy results with no linked AEs with respect to the treatment of acute bronchitis compared to single treatment. (ijrc.in)
- Acetylcysteine is a hepatoprotective agent and has not been linked to significant serum enzyme elevations during therapy or to instances of clinically apparent acute liver injury. (vitaminhaat.com)
Clinical4
- This article reviews the presently available experimental and clinical data on the antioxidative effects of N ‐acetylcysteine in chronic obstructive pulmonary disease. (ersjournals.com)
- Studies that did not show clinical improvement with the administration of N-acetylcysteine, based either on objective or subjective measures, were excluded. (jcadonline.com)
- Clinical efficacy has not been proven. (medscape.com)
- Efficacy of Timolol in a Novel Intranasal Thermosensitive Gel for Hereditary Hemorrhagic Telangiectasia-Associated Epistaxis: A Randomized Clinical Trial. (cdc.gov)
Glutathione3
- The antioxidant N ‐acetylcysteine, a glutathione precursor, has been applied in these patients in order to reduce symptoms, exacerbations and the accelerated lung function decline. (ersjournals.com)
- Treatment with N-acetylcysteine (NAC) has been shown to increase levels of glutathione. (nih.gov)
- As compared with earlier otoprotectants, we hypothesized N-acetylcysteine (NAC) offers potential for stronger otoprotection through stimulation of glutathione (GSH) production. (figshare.com)
Intravenous2
- Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. (vitaminhaat.com)
- A lack of race and ethnicity data in the treatment of hereditary hemorrhagic telangiectasia: a systematic review of intravenous bevacizumab efficacy. (cdc.gov)
Tolerability1
- The efficacy and tolerability of NAC was examined across a range of conditions to evaluate the evidence supporting the use of NAC for each indication. (nih.gov)
COPD1
- At present the only antioxidant widely available for the treatment of patients with COPD is N ‐acetylcysteine (NAC). (ersjournals.com)
Safety3
- A randomised controlled trial of the safety and efficacy of N-Acetyl Cysteine (NAC) as a pharmacotherapy for methamphetamine ("ice") dependence. (turningpoint.org.au)
- This study tested the optimal dose, safety, and efficacy of NAC to prevent CIHL. (figshare.com)
- Embolization of Recurrent Pulmonary Arteriovenous Malformations by Ethylene Vinyl Alcohol Copolymer (Onyx) in Hereditary Hemorrhagic Telangiectasia: Safety and Efficacy. (cdc.gov)
Treatment1
- mentions that treatment with acetylcysteine within 16 hours of an overdose of acetaminophen can minimize hepatic injury and prevent fatalities). (vitaminhaat.com)
Substances1
- For some substances there is also a risk assessment made on the basis of concentrations measured in the environment in Sweden and efficacy studies with high quality. (janusinfo.se)
Therapeutic2
- The review of available literature suggests that N-acetylcysteine could potentially serve as a safe, tolerable, and effective therapeutic option for a variety of dermatologic conditions. (jcadonline.com)
- The therapeutic efficacy of oral N-acetylcysteine (NAC) and ambroxol as compared with the effect of placebos was studied in 36 cystic fibrosis (CF) patients with mild to moderate pulmonary disease. (nih.gov)
Systemic1
- Antibiotic sensitivity data can be used to predict the efficacy of systemic drugs, although penetration to the ear tissues is often low and high doses are needed. (vin.com)
Patients4
- The purpose of this study is to compare the effect of n-acetylcysteine (NAC) plus standard care with matched placebo plus standard of care in patients diagnosed with idiopathic pulmonary fibrosis (IPF) who have the TOLLIP rs3750920 TT genotype. (stanford.edu)
- 91 patients were distributed in N-acetylcysteine group and 86 patients in the control group. (bvsalud.org)
- It was assessed in 67 patients in N-acetylcysteine group and 60 patients in the control group. (bvsalud.org)
- Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa. (cdc.gov)
Assessments1
- To evaluate efficacy, serial age-appropriate audiology assessments were performed. (figshare.com)
Meta-Analysis1
- CONCLUSION: Our meta-analysis revealed that IV N-acetylcysteine may be effective in reducing mortality of severe aluminum phosphide poisoning cases. (bvsalud.org)
Study1
- Efficacy study in vitro: assessment of the properties of resveratrol and resveratrol + N-acetyl-cysteine on proliferation and inhibition of collagen activity]. (greenmedinfo.com)
Effects3
- activated charcoal decreases effects of acetylcysteine by Other (see comment). (medscape.com)
- acetylcysteine increases effects of nitroglycerin IV by Other (see comment). (medscape.com)
- Comment: Acetylcysteine may enhance vasodilatory effects of nitroglycerin. (medscape.com)
Therapy1
- N-acetylcysteine has been used in some studies as adjuvant therapy depending on to its antioxidant properties. (bvsalud.org)
Review1
- N-Acetylcysteine to Combat COVID-19: An Evidence Review. (liversupport.com)
Shown1
- In recent studies, N-acetylcysteine has been shown to be efficacious in several dermatologic conditions. (jcadonline.com)
Group2
- 7.) Sun L, Gu L, Wang S, Yuan J, Yang H, Zhu J, Zhang H. N-acetylcysteine protects against apoptosis through modulation of group I metabotropic glutamate receptor activity. (drmyattswellnessclub.com)
- Mortality rates in N-acetylcysteine group and in the control group were 43.95% 66.27% respectively. (bvsalud.org)
Article1
- Nous sommes désolés, mais cet article n'est pas disponible actuellement en français. (esantementale.ca)
Development1
- NAC was safe at the RP2D, with strong evidence for efficacy to prevent CIHL, warranting further development as a next-generation otoprotectant. (figshare.com)
Called N-acetylcysteine1
- A medication called N-acetylcysteine (NAC) can be used treat an overdose but is most successful if administered within eight hours of the overdose to help remove the acetaminophen from the body. (spine-health.com)