Efficacy in bortezomib proteasome inhibitors. Medical search. Frequent questions

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Anatomy19

Cell Line, Tumor Cell Line Tumor Cells, Cultured Endoplasmic Reticulum Cells, Cultured HeLa Cells HEK293 Cells Cell Nucleus Mitochondria Jurkat Cells COS Cells HCT116 Cells Fibroblasts Plasma Cells K562 Cells Cytosol HL-60 Cells Inclusion Bodies Cell Line, Transformed

Organisms8

Mice, Nude Mice, SCID Mice, Inbred C57BL Mice, Inbred BALB C Thermoplasma Saccharomyces cerevisiae Rats, Sprague-Dawley Cercopithecus aethiops

Diseases8

Multiple Myeloma Lymphoma, Mantle-Cell Neoplasms Peripheral Nervous System Diseases Recurrence Disease Models, Animal Prostatic Neoplasms Breast Neoplasms

Chemicals and Drugs110

Proteasome Inhibitors Boronic Acids Pyrazines Proteasome Endopeptidase Complex Leupeptins Protease Inhibitors Cysteine Proteinase Inhibitors Cysteine Endopeptidases Multienzyme Complexes Antineoplastic Agents Acetylcysteine Ubiquitins Ubiquitin Oligopeptides Lactones NF-kappa B Thalidomide Ubiquitinated Proteins Thiostrepton Enzyme Inhibitors Caspases Peptide Hydrolases Polyubiquitin Chymotrypsin Proto-Oncogene Proteins c-bcl-2 Ubiquitin-Protein Ligases Dexamethasone I-kappa B Proteins RNA, Small Interfering Myeloid Cell Leukemia Sequence 1 Protein Protein Subunits Pyrroles Hydroxamic Acids TNF-Related Apoptosis-Inducing Ligand Apoptosis Regulatory Proteins RNA, Messenger Caspase 3 Clioquinol Tumor Suppressor Protein p53 Ubiquitin-Activating Enzymes Lactams, Macrocyclic Histone Deacetylase Inhibitors Cyclin-Dependent Kinase Inhibitor p27 Benzoquinones Ubiquitin-Conjugating Enzymes HSP90 Heat-Shock Proteins Neoplasm Proteins 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt Doxorubicin Proteins Activating Transcription Factor 4 DNA-Binding Proteins bcl-2-Associated X Protein Calpain Cell Cycle Proteins Protein Synthesis Inhibitors Dipeptides Butanes Endopeptidases Hydroxyquinolines X-Linked Inhibitor of Apoptosis Protein Cyclin-Dependent Kinase Inhibitor p21 Membrane Proteins Receptors, TNF-Related Apoptosis-Inducing Ligand Caspase 8 Reactive Oxygen Species Molecular Chaperones Transcription Factors Caspase Inhibitors Recombinant Proteins Sulfones bcl-2 Homologous Antagonist-Killer Protein Transcription Factor CHOP HSP70 Heat-Shock Proteins Nuclear Proteins Adenosine Triphosphatases Carrier Proteins HSP72 Heat-Shock Proteins Transcription Factor RelA Tumor Necrosis Factor-alpha Thiocarbamates Receptors, Death Domain Melphalan Proto-Oncogene Proteins c-mdm2 Intracellular Signaling Peptides and Proteins Boron Compounds Microtubule-Associated Proteins Antibiotics, Antineoplastic Inhibitor of Apoptosis Proteins Proto-Oncogene Proteins Recombinant Fusion Proteins Cycloheximide Heat-Shock Proteins Peptides Piperazines Antibodies, Monoclonal bcl-X Protein Glutathione Synthase Sulfonamides S-Phase Kinase-Associated Proteins Amino Acid Chloromethyl Ketones Protein-Serine-Threonine Kinases JNK Mitogen-Activated Protein Kinases Proto-Oncogene Proteins c-akt Cytochromes c Ligases Chloroquine Green Fluorescent Proteins CASP8 and FADD-Like Apoptosis Regulating Protein Lactate Dehydrogenases

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Treatment Outcome Antineoplastic Combined Chemotherapy Protocols Xenograft Model Antitumor Assays Blotting, Western Drug Screening Assays, Antitumor Immunoblotting Transfection Drug Administration Schedule Maximum Tolerated Dose Inhibitory Concentration 50 Reverse Transcriptase Polymerase Chain Reaction Drug Evaluation, Preclinical Models, Biological Clinical Trials as Topic Disease Models, Animal Immunoprecipitation Flow Cytometry Drug Therapy, Combination Maintenance Chemotherapy Drug Delivery Systems Immunohistochemistry Gene Knockdown Techniques Transplantation, Heterologous Survival Rate Combined Modality Therapy Double-Blind Method Microscopy, Fluorescence

Phenomena and Processes44

Apoptosis Drug Synergism Ubiquitination Drug Resistance, Neoplasm Proteolysis Dose-Response Relationship, Drug Down-Regulation Cell Survival Signal Transduction Time Factors Cell Proliferation Protein Processing, Post-Translational Cell Death Transfection Enzyme Activation Phosphorylation Unfolded Protein Response Cell Cycle Protein Binding Autophagy Maximum Tolerated Dose Inhibitory Concentration 50 Mutation Amino Acid Sequence Protein Transport Protein Stability Up-Regulation Endoplasmic Reticulum Stress RNA Interference Gene Expression Regulation Gene Expression Regulation, Neoplastic Hydrolysis Transcription, Genetic Oxidative Stress Protein Structure, Tertiary Protein Folding Endoplasmic Reticulum-Associated Degradation Cell Division Protein Biosynthesis Gene Expression Cell Growth Processes Drug Interactions G2 Phase Substrate Specificity

Disciplines and Occupations1

Immunohistochemistry

Information Science3

Molecular Sequence Data Amino Acid Sequence Survival Rate

Health Care4

Treatment Outcome Clinical Trials as Topic Survival Rate Double-Blind Method

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Information Science Health Care

Proteasome Inhibitors Boronic Acids Pyrazines Proteasome Endopeptidase Complex Leupeptins Protease Inhibitors Cysteine Proteinase Inhibitors Cysteine Endopeptidases Multienzyme Complexes Multiple Myeloma Antineoplastic Agents Acetylcysteine Apoptosis Cell Line, Tumor Ubiquitins Ubiquitin Drug Synergism Oligopeptides Lactones Ubiquitination NF-kappa B Drug Resistance, Neoplasm Proteolysis Thalidomide Dose-Response Relationship, Drug Cell Line Treatment Outcome Antineoplastic Combined Chemotherapy Protocols Xenograft Model Antitumor Assays Blotting, Western Ubiquitinated Proteins Thiostrepton Down-Regulation Enzyme Inhibitors Tumor Cells, Cultured Lymphoma, Mantle-Cell Cell Survival Caspases Peptide Hydrolases Polyubiquitin Chymotrypsin Proto-Oncogene Proteins c-bcl-2 Ubiquitin-Protein Ligases Signal Transduction Dexamethasone Endoplasmic Reticulum Time Factors Cell Proliferation I-kappa B Proteins RNA, Small Interfering Myeloid Cell Leukemia Sequence 1 Protein Drug Screening Assays, Antitumor Cells, Cultured Immunoblotting Protein Processing, Post-Translational Protein Subunits HeLa Cells Cell Death Transfection Enzyme Activation Neoplasms Pyrroles Phosphorylation Unfolded Protein Response Hydroxamic Acids Cell Cycle TNF-Related Apoptosis-Inducing Ligand Drug Administration Schedule Apoptosis Regulatory Proteins RNA, Messenger Protein Binding Caspase 3 Clioquinol Autophagy Mice, Nude Tumor Suppressor Protein p53 Ubiquitin-Activating Enzymes Mice, SCID Maximum Tolerated Dose Lactams, Macrocyclic Molecular Sequence Data Inhibitory Concentration 50 Histone Deacetylase Inhibitors Mutation Cyclin-Dependent Kinase Inhibitor p27 Benzoquinones Ubiquitin-Conjugating Enzymes Amino Acid Sequence HSP90 Heat-Shock Proteins Protein Transport Protein Stability Reverse Transcriptase Polymerase Chain Reaction Peripheral Nervous System Diseases Neoplasm Proteins Drug Evaluation, Preclinical 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt Up-Regulation Doxorubicin Models, Biological Recurrence

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