Effects polymorphism single nucleotide. Medical search. Frequent questions

What are single nucleotide polymorphisms (SNPs)? (medlineplus.gov)
Single nucleotide polymorphisms, frequently called SNPs (pronounced "snips"), are the most common type of genetic variation among people. (medlineplus.gov)
They occur almost once in every 1,000 nucleotides on average, which means there are roughly 4 to 5 million SNPs in a person's genome. (medlineplus.gov)
Most SNPs have no effect on health or development . (medlineplus.gov)
We used simulated and empirical data (from Arabidopsis lyrata) to show the effects of missing data filtering, sample size, number of single nucleotide polymorphisms (SNPs) and population structure on the accuracy and variance of DFE estimates. (iiasa.ac.at)
The current study explored the combined effect of ICAM-1 gene polymorphisms and exposure to environmental carcinogens on the susceptibility of developing oral squamous cell carcinoma (OSCC) and the clinicopathological characteristics of the tumors.Methodology and Principal Findings:Four single-nucleotide polymorphisms (SNPs) of the ICAM-1 gene from 595 patients with oral cancer and 561 non-cancer controls were analyzed by a real-time PCR. (tmu.edu.tw)
We found that the ICAM-1 rs5498 polymorphism and the TAGG or TACG haplotype of 4 ICAM-1 SNPs (rs3093030, rs5491, rs281432, and rs5498) combined were associated with oral-cancer susceptibility. (tmu.edu.tw)
Approximately 30,000 single nucleotide polymorphisms (SNPs) were included in the genome-wide association study (GWAS), using a linear mixed model for survival time, a linear mixed model and a generalized linear mixed model for repeated binomial survival (0/1). (springer.com)
Four SNPs associated with DGE were found in cross W1 * WB, with effects ranging from 16 to 35 days. (springer.com)
6 ] conducted an association study using 1022 single nucleotide polymorphisms (SNPs) and identified 81 SNPs that were associated with IGE for plumage condition in laying hens. (springer.com)
The aim of this study was to investigate comprehensively the association between single nucleotide polymorphisms (SNPs) in all three NOS genes and FENO in an adult population, and to assess whether such associations are modified by asthma or atopy. (bmj.com)
OBJECTIVE: We hypothesized that single-nucleotide polymorphisms (SNPs) in metallothionein (MT) genes may underlie interindividual differences in mercury biomarker levels. (cdc.gov)
We studied the potential modifying effects of MT SNPs on mercury exposure-biomarker relationships. (cdc.gov)
Log-transformed urine and hair levels were modeled in multivariable linear regression separately against respective exposure surrogates, and the effect modification of 13 MT SNPs on exposure was investigated. (cdc.gov)
Of the 18 associated SNPs, three polymorphisms, rs6920220, rs13207033 and rs5029937, remained significant after conditional logistic regression analysis. (whiterose.ac.uk)
That project looked at nearly 10 million single nucleotide polymorphisms (SNPs). (bigthink.com)
SNPs are a single variant responsible for a particular trait. (bigthink.com)
Single-nucleotide polymorphisms (SNPs) in the glucocorticoid receptor (GR) gene influence the sensitivity to glucocorticoids and are related to both microbial colonization and susceptibility to develop auto-immune disease. (eur.nl)
For instrumental variables, 37 single nucleotide polymorphisms that had been previously identified to be related to CRP levels were used, including 4 SNPs of conservative CRP genetic variants and 33 SNPs of liberal CRP genetic variants. (frontiersin.org)
In this study, single nucleotide polymorphisms (SNPs) related to CRP levels were used as instrumental variables. (frontiersin.org)
Single nucleotide mutations form the majority of genetic polymorphisms (single nucleotide polymorphisms, SNPs) in populations. (i-sis.org.uk)
Common genetic mutations called Single nucleotide polymorphisms, or SNPs, have been implicated in changing the placebo response in clinical trials. (mentalfloss.com)
In this study, 74 single nucleotide polymorphisms (SNPs) were identified. (nih.gov)
After assessing the effect of 115 independent single-nucleotide polymorphisms (SNPs) from the GWAS of depression, they uncovered significant evidence "that the SNPs cause depression, which in turn cause AD," said Wingo. (medscape.com)
We genotyped the two ADIPOQ SNPs in 140 unrelated T2DM patients and 66 nondiabetic controls using the polymerase chain reaction-restriction fragment length polymorphism assay. (who.int)
Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms). (bvsalud.org)
We ing practice, different workload, and the use of personal are monitoring single nucleotide polymorphisms (SNPs) protection devices. (cdc.gov)
They measured single-nucleotide polymorphisms (SNPs) in the fatty acid desaturase ( FADS ) gene cluster that modulate fatty acid levels. (medscape.com)

A recurring problem in the clinic is that many detectable changes within the BRCA1 gene produce subtle alterations to the protein that are not easily recognized as either harmful (loss-of-function) alleles or harmless and thus inconsequential polymorphisms. (jci.org)

By including data from functional genomics literature to simulate the effects of common variants of these genes, we showed that variants of voltage-gated Na + channel or hyperpolarization-activated cation channel-encoding genes cause qualitatively similar effects on layer V pyramidal cell and sinoatrial node cell excitability. (nih.gov)
By contrast, variants of Ca 2+ channel or transporter-encoding genes mostly have opposite effects on cellular excitability in the two cell types. (nih.gov)
and increases and decreases in the expression of intact genes due to, e.g. the methylation of gene promotors and various less direct effects. (wikipedia.org)
There was no evidence that polymorphisms in catecholamine genes COMT Val108Met, ADRA2A C1291G, and DRD4-rs7403703 moderated the effect on ADHD symptoms. (nih.gov)
Histamine may mediate the effects of food additives on ADHD symptoms, and variations in genes influencing the action of histamine may explain the inconsistency between previous studies. (nih.gov)
Background Polymorphisms in nitric oxide synthase genes ( NOS1 , NOS2 , and NOS3 ) have been suggested to have a major impact on fraction of exhaled nitric oxide (FENO), a biomarker of airway inflammation. (bmj.com)
Genetic variants and their putative effects on microRNAseed sites: Characterization of 3' untranslated region of genes associated with temperament. (usda.gov)
This identified approximately 140 chromosome loci where nucleotides deviated from the reference sequence GRCh37 hg19 comprising the three genes TRPV1, LTB4R and LTB4R2. (researchgate.net)
We identified imprinted genes that were specifically expressed in fetal pancreas both on a tissue and single cell level. (lu.se)

Novel single nucleotide polymorphism biomarkers to predict opioid effects for cancer pain. (cdc.gov)
Although acceptable been studied in many biomonitoring studies as putative exposure limits have been fixed for the working envi- biomarkers of individual susceptibility to cancer (and ronment, it has become clear that various factors can possibly other diseases), measured alongside markers of affect exposure, including additional skin absorption, exposure and effect. (cdc.gov)

A GWAS identified several genetic variants with age-specific effects on BMI, most of which are more important for BMI prior to age 55 than at later ages [ 7 ]. (biomedcentral.com)

Do you agree with those effects known to occur in humans as reported in the text? (cdc.gov)
Are the effects only observed in animals likely to be of concern to humans? (cdc.gov)
I agree that the effects noted in animals are likely to be of concern to exposed humans. (cdc.gov)
While mainly central nervous system excitation has been noted following acute and chronic exposure, the effects observed in animals (body weight changes, hepatic, neurological, reproductive, and developmental effects) are toxicities that can occur in humans. (cdc.gov)

For each patient and control we measured lipid parameters, CRP-us and sought the G894T polymorphism of eNOS gene by PCR-RFLP. (scirp.org)
In paper III we investigated whether genetic variants which were previously reported to be associated with lipid traits will exert different effects on obesity and blood lipid traits based on their parental origin. (lu.se)
Moreover, our results indicate possible sex-specific parental effects on some blood lipid traits. (lu.se)

The distribution of fitness effects (DFE) of new mutations has been of interest to evolutionary biologists since the concept of mutations arose. (iiasa.ac.at)
Until the current decade, synonymous mutations were assumed to be neutral, with no effect on the protein or any other functions of the organism. (i-sis.org.uk)
A single synonymous mutation was sufficient to alter the substrate specificity of a multidrug resistance phenotype in mammalian cells [8].Synonymous mutations affect the stability of mRNA secondary structure in mammals [9]. (i-sis.org.uk)
Led by Kathryn Hall of Harvard Medical School, a group of scientists reviewed previous research for evidence of a genetic variation in the placebo effect by looking for correlations between certain genetic mutations and the strength of a person's placebo response. (mentalfloss.com)

We could distinguish six different GR haplotypes of which two carried the BclI polymorphism: haplotype 1, which consists of the minor allele of BclI in combination with the common variant of TthIIII and haplotype 2, which carries the minor allele of BclI as well as the minor allele of TthIIII. (eur.nl)
Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans. (medscape.com)

In this work we proposed to study the role of genetic polymorphism of the eNOS G894T gene in the development of diabetes on the one hand and of these degenerative complications other. (scirp.org)
Conclusion: The G894T polymorphism of eNOS gene appears to be a risk factor of T2DM. (scirp.org)
The eNOS gene has several single nucleotide polymorphisms reported, one of which is G894T. (scirp.org)
All volunteers were retrospectively genotyped for the eNOS G298T polymorphism and the effect of genotype on the measurements is discussed. (cambridge.org)

and Mendelian randomization studies, which can be used to infer a causal role for a teratogenic effect of a medication. (cdc.gov)
Here, we performed a two-sample Mendelian randomization to further understand the causal effects of C-reactive protein levels on the risk of ALS. (frontiersin.org)

For example, IGE are less exposed to natural selection compared to DGE [ 5 ], and therefore we expect that some loci may have large effects for IGE. (springer.com)
This is the first study to show that the confirmed loci from the GWA studies, that confer only a modest effect size, could harbour a significantly greater effect once the effect of additional risk variants are accounted for. (whiterose.ac.uk)
A UK study indicated that physical activity may attenuate the cumulative effect of 12 of these loci, but replication studies are lacking. (lu.se)
Therefore, we tested whether the aggregate effect of these loci is diminished in adults of European ancestry reporting high levels of physical activity. (lu.se)

Furthermore, we used this assay to determine the effects of BRCA1 variants on cell cycle regulation, differentiation, and genomic stability. (jci.org)

WIDER IMPLICATIONS OF THE FINDINGS: The results are reassuring and indicate that the embryo biopsy itself has no adverse effect on the perinatal, early childhood, or maternal outcomes. (bvsalud.org)

CONCLUSION: Our findings suggest that some MT genetic polymorphisms may influence mercury biomarker concentrations at levels of exposure relevant to the general population. (cdc.gov)
Internal exposure envisaged in terms of validation and acceptable varia- and biochemical effects of groups of the general popu- bility. (cdc.gov)

In the present study, we analysed the nonsynonymous single nucleotide polymorphism of GATA4, which are involved in congenital heart disease by predicting the changes in protein structures. (uni-mysore.ac.in)
Aldrin: acute oral MRL is based on a LOAEL of 2 mg/kg/day for neurobehavioral effects (increased electroconvulsive shock threshold, the study did not identify a NOAEL) in offspring of maternal mice administered aldrin by gavage during the third trimester of pregnancy (Al-Hachim 1971). (cdc.gov)
[ 19 ] the results of which were corroborated by a linkage study with high-density, single-nucleotide polymorphisms. (medscape.com)
Commenting on the findings for Medscape Medical News , Nicholas LaRocca, PhD, vice president, health care delivery and policy research, National MS Society, said that while the study shows an association it does not establish cause and effect, so the clinical implications for MS are uncertain. (medscape.com)

A SNP associated with DGE was found in cross W1 * WA, with an allele substitution effect of 22 days. (springer.com)
However, haplotypes carrying the minor allele of the BclI polymorphism were related to the phenotype and outcome of GBS. (eur.nl)
Association between opioid and dopamine receptor gene polymorphisms OPRM1rs1799971, DAT VNTR9-10 repeat allele, DRD1 rs4532 and DRD2 rs1799732 and alcohol dependence: an ethnicity oriented meta-analysis. (cdc.gov)

Not only does the association between BMI and dementia differ depending on age at BMI measurement, but also the effect of genetic influences. (biomedcentral.com)
There was association between KCNQ1 gene and IGF2BP2 gene polymorphism in Gestational diabetes mellitus. (jptcp.com)

Genetic polymorphisms in the serotonin, dopamine and opioid pathways influence social attention in rhesus macaques (Macaca mulatta). (cdc.gov)

It can help advance our understanding of the biological pathways involved in fetal development and reveal possible gene-environment interaction effects associated with birth defects. (cdc.gov)

Sensitivity analyses showed minimal evidence for genetic confounding that could have biased the causal effect estimates. (bmj.com)

Based on the finding that alcohol alters the circulating levels of dozens of peptides shown to influence bone metabolism, we arrive at the conclusion that no single unifying mechanism adequately explains the diversity of reports or successfully predicts individuals most likely to be impacted favorably or unfavorably by alcohol consumption. (springer.com)

This was particularly striking at the Duffy/DARC locus, where we observed an epistatic interaction between the SCD genotype and the Duffy null variant (rs2814778) that led to a two-fold weaker effect on neutrophil count. (haematologica.org)

These genetic abnormalities effect the Wnt signaling pathway, regulation of the cell cycle, RNA metabolism, protein folding, and cadherin-related cell adherence to extracellular matrix. (wikipedia.org)
accidental or intentional) or to elevated blood levels or enhanced drug effects that occur during appropriate use (eg, when drug metabolism is temporarily inhibited by a disorder or another drug). (msdmanuals.com)

Investigators note the findings add new confidence that omega-3s may be behind this observed protective effect in MS. (medscape.com)
The findings provide "more confidence" that the omega-3s are providing the observed benefit vs a "substitution effect," Langer-Gould said. (medscape.com)

showed that while a genetic score comprised of 97 genetic variants for BMI was associated with BMI across all age categories, the effect declined in late-life [ 8 ]. (biomedcentral.com)
TRPV1 is the target of several novel analgesics drugs under development and therefore, TRPV1 genetic variants might represent promising candidates for pharmacogenetic modulators of drug effects. (researchgate.net)
Our results corroborated previous reports and indicated that specific genetic variants show parent-of-origin specific effects. (lu.se)
Our results indicate that the parental specific effects of cardiometabolic and anthropometric traits and associated genetic variants manifested in early life. (lu.se)

First, we scrutinized gene expression data from adult pancreas, adult pancreatic islets, fetal pancreas, and single cell expression data. (lu.se)

The single nucleotide polymorphism in GATA4 is associated with various congenital heart disease phenotypes. (uni-mysore.ac.in)
Total of 49 nonsynonymous single nucleotide polymorphisms of GATA4 was screened from congenital heart disease patients of Mysore and also globally reported nonsynonymous single nucleotide polymorphisms. (uni-mysore.ac.in)

Examining single nucleotide polymorphisms (SNP) involved in DNA damage response and tissue remodeling/repair, as a genetic approach to predict normal tissues response to ionizing radiation. (ualberta.ca)

Whenever medical researchers conduct clinical trials of a new drug, they have to account for the placebo effect -the fact that if you give people a treatment, even if it's sugar pills, some of them will feel better. (mentalfloss.com)

The power to detect SNP associations was relatively low and thus we expect that many effects on DGE and IGE remained undetected. (springer.com)

Among 727 smokers, ICAM-1 polymorphisms carriers with the betel-nut chewing habit had a 27.49-36.23-fold greater risk of having oral cancer compared to ICAM-1 wild-type (WT) carriers without the betel-nut chewing habit. (tmu.edu.tw)
Among 549 betel-nut chewers, ICAM-1 polymorphisms carriers who smoked had a 9.93-14.27-fold greater risk of having oral cancer compared to those who carried the WT but did not smoke. (tmu.edu.tw)
Transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism as a risk factor for gestational diabetes mellitus: a meta-analysis. (jptcp.com)
Numerous studies have evaluated the relationship between RNASEL gene polymorphisms (rs486907 G>A and rs627928 T>G) and the risk of cancer. (medscimonit.com)
We report the effect of rs627928 on the development of prostate cancer and confirm that rs486907 is not involved in the risk of prostate cancer in the current meta-analysis. (medscimonit.com)
We aimed to determine whether CRP has causal effects on risk of ALS. (frontiersin.org)
Its influence on many cardiovascular risk factors, combined with its proven effect in reducing the risk of cardiovascular events in primary prevention, has boosted scientific interest in this age-old nutritional model. (mdpi.com)
Two randomised controlled cross-over intervention studies investigating the effects of chronic and acute consumption of commercially-available fruit- and vegetable-puree-based drinks (FVPD) on bioavailability, antioxidant status and CVD risk factors are described. (cambridge.org)
There were no significant effects on oxidative stress, antioxidant status and other CVD risk factors. (cambridge.org)

Nucleotides are what make up DNA: A, G, C, and T. An SNP variant would be for instance a G replacing an A in a certain location on a DNA strand. (bigthink.com)

The synonymous codons were assumed to be neutral and to have no effect on the transgenic proteins, and presumed to be safe [2] ( Bt Toxins in Genetically Modified Crops: Regulation by Deceit , SiS 22). (i-sis.org.uk)

To understand the role of nonsynonymous single nucleotide polymorphisms, we mutated the sequence and translated into amino acids. (uni-mysore.ac.in)
To explore the role of RNASEL gene polymorphisms in prostate cancer, we carried out the present meta-analysis. (medscimonit.com)
[ 18 ] as well as in the kynurenine pathway, all of which are thought to play a role in the mood-stabilizing effect of lithium. (medscape.com)

The adverse effect of food additives on ADHD symptoms was moderated by histamine degradation gene polymorphisms HNMT T939C and HNMT Thr105Ile in 3- and 8/9-year-old children and by a DAT1 polymorphism (short versus long) in 8/9-year-old children only. (nih.gov)
2008. Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. . (oregonstate.edu)

Recent evidence now points to TaZIP4-B2 (the additional ZIP4 copy on 5BL) as being responsible for the effect of this locus on homoeologous recombination 20 , 21 . (nature.com)

The genetic effect of NOS polymorphisms on FENO, asthma, and atopy was estimated using multiple regression methods. (bmj.com)

In summary, in this thesis we investigate paternal and maternal effects as a function of fetal programming and parentof- origin effects to better understand their influence on type 2 diabetes and insulin secretion. (lu.se)

However, this relationship may not be valid for individual alcohol consumers, as small quantities of alcohol can have detrimental skeletal effects and not all studies report clinically relevant bone loss with long-duration alcohol abuse. (springer.com)

Because adolescents and young adults underestimate and discount the long-term risks associated with hookah and LCC use, effective messages may be those that focus on the acute/immediate health and cosmetic effects. (who.int)

Side effect is an imprecise term often used to refer to the unintended effects of a medication that occur within the therapeutic range. (msdmanuals.com)

Cannibalism is a social behavior where individual survival is affected by direct genetic effects (DGE) and indirect genetic effects (IGE). (springer.com)

The Effect of Genetic Variation on the Sensitivity to Opioid Analgesics in Patients With Postoperative Pain: An Updated Meta-analysis. (cdc.gov)
The meta-analysis yielded a statistically significant GRS × physical activity interaction effect estimate (Pinteraction = 0.015). (lu.se)

Thus, the cumulative effect of more years in education on refractive error means that a university graduate from the United Kingdom with 17 years of education would, on average, be at least −1 dioptre more myopic than someone who left school at age 16 (with 12 years of education). (bmj.com)

We propose that a more holistic approach - in which drinking pattern and intrinsic factors are accounted for - is required to better understand and respond to the end-organ effects of alcohol on the skeleton. (springer.com)
In this thesis we aim to better understand the effect of genetic and environmental factors by investigating parental effects manifesting from early life until adulthood. (lu.se)

They also work together to make their effect stronger. (bigthink.com)

Adverse drug reaction (ADR, or adverse drug effect) is a broad term referring to unwanted, uncomfortable, or dangerous effects that drugs (including medications ) may have. (msdmanuals.com)
Balancing Drug Benefits and Adverse Effects Obviously, a drug (or any medical treatment) should be used only when it will benefit a patient. (msdmanuals.com)

As a result, we explored parent-of-origin effects on cardiometabolic and anthropometric traits in a birth cohort which was followed up from delivery until 18 years. (lu.se)

Anatomy5

Organisms3

Diseases6

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Psychiatry and Psychology1

Phenomena and Processes111

Disciplines and Occupations7

Anthropology, Education, Sociology and Social Phenomena1

Information Science10

Named Groups4

Health Care18

Geographicals9

SNPs28

Alleles1

Genes9

Biomarkers2

GWAS1

Humans4

Lipid3

Mutations4

Haplotype2

ENOS4

Mendelian2

Loci4

Assay1

Outcomes1

Exposure2

Study4

Allele3

Association2

Dopamine1

Gene-environment1

Analyses1

CONCLUSION1

Genotype1

Metabolism2

Findings2

Variants4

Pancreatic1

Disease2

Predict1

Clinical1

Associations1

Risk9

Variant1

Proteins1

Role3

Versus2

Evidence1

Methods1

Type1

Studies1

Acute1

Occur1

Survival1

Analysis2

Cumulative effect1

Understand2

Stronger1

Drug2

Birth1