Effects oxidative stress. Medical search. Frequent questions

However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)
The mechanisms of the cytotoxicity, apoptosis, and oxidative stress induced by the 5-15 nm SiNPs still remain unclear. (mdpi.com)
Under oxidative stress, the effects of maltol on cell viability, apoptosis, and neurite outgrowth were assessed. (molvis.org)
To observe the effect of H2O2 induced oxidative stress on autophagy and apoptosis of human bone marrow mesenchymal stem cells (hBMSCs). (researchsquare.com)
Under oxidative stress conditions, hMSCs can promote protective autophagy and reduce cell apoptosis or the level of apoptosis caused by excessive autophagy. (researchsquare.com)
This experiment intends to activate the oxidative stress response by H2O2, regulate the autophagy level of human bone mesenchymal stem cells (hBMSCs), and observe the effect of autophagy on the proliferation and apoptosis of hMSCs under oxidative stress. (researchsquare.com)
However, more severe oxidative stress can cause cell death, and even moderate oxidation can trigger apoptosis, while more intense stresses may cause necrosis. (wikipedia.org)
Chronic ER stress promotes apoptosis, at least in part through the UPR-induced transcription factor C/EBP homologous protein (CHOP). (jci.org)
These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)
Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
Administration of POS extract reversed the ACR-induced epididymides weight loss with improved semen quality and count, ameliorated the ACR-decreased testicular lesion scoring, testicular oxidative stress, testicular degeneration, Leydig cell apoptosis and the dysregulated PCNA and Caspase-3 expression in a dose-dependent manner. (biomedcentral.com)
Moreover, p53 plays a key role in the oxidative stress-dependent apoptosis. (uky.edu)
FOXA2 overexpression alleviated LPS‑induced inflammation, oxidative stress, apoptosis and ERS in WI‑38 cells. (spandidos-publications.com)
Furthermore, the inhibitory effects of FOXA2 on inflammation, oxidative stress and apoptosis, as well as ERS in LPS‑induced WI‑38 cells were partly weakened by additional treatment with U46619. (spandidos-publications.com)
It has been demonstrated that Cd induces cancer by multiple mechanisms and the most important among them are aberrant gene expression, inhibition of DNA damage repair, induction of oxidative stress, and inhibition of apoptosis. (cdc.gov)
The available evidence indicates that, perhaps, oxidative stress plays a central role in Cd carcinogenesis because of its involvement in Cd-induced aberrant gene expression, inhibition of DNA damage repair, and apoptosis. (cdc.gov)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)

While many of these products are used as markers of oxidative stress, the products derived from linoleic acid appear far more predominant than arachidonic acid products and therefore easier to identify and quantify in, for example, atheromatous plaques. (wikipedia.org)
The effect of Capicor on the protein markers of oxidative stress development in rat brain mitochondria under modeling of Parkinson's disease. (ukrbiochemjournal.org)
We conducted an ancillary study to the CALERIE 2 randomized controlled trial to examine the effects of 12 months of 25% CR on in vivo skeletal muscle mitochondrial energetics, mitochondrial content, and markers of oxidative stress. (medscape.com)

The effect of the extract was studied on lipid peroxidation and antioxidant parameters in liver and gastrocnemius muscle of rats on attaining the rectal temperature (T(rec)) of 23 degrees C during C-H-R exposure and after recovery (T(rec)37 degrees C) from C-H-R-induced hypothermia. (nih.gov)
Basal levels of oxidative stress were assessed by measuring urinary markers of nucleic acid damage and lipid peroxidation. (nau.edu)
UNLABELLED The aim of this study was to investigate the effect of lipoic acid (LA) on lipid peroxidation , hydrogen peroxide concentration (H2O2), sulphydryl group (-SH) contents and total capacity protein a few hours after administration lipopolysaccharide (LPS) -induced oxidative stress in rats . (bvsalud.org)
The early administration of LA a significant decreased symptoms of oxidative stress - induced LPS, that shows decrease in lipid peroxidation process, H2O2 concentration and increase in -SH groups and protein contents in rat 's lung homogenates. (bvsalud.org)
To analyze the effect of homeopathic Arnica on mitochondrial oxidative stress induced by Ca 2+ plus inorganic phosphate and/or Fe 2+ -citrate-mediated lipid peroxidation through changes in oxygen consumption rates. (thieme-connect.de)
15 Castilho R.F., Meinicke A.R., Alemida A.M., Hermes-Lima M., Vercesi A.E. Oxidative damage of mitochondria induced by Fe(II)citrate is potentiated by Ca 2+ and includes lipid peroxidation and alterations in membrane proteins. (thieme-connect.de)
As OS biomarkers, lipid peroxidation, protein oxidative modification, H 2 O 2 production, the activity of MnSOD, GPx and glutathione pool indexes were measured. (ukrbiochemjournal.org)
Rotenone intoxication increased the intensity of lipid peroxidation, protein oxidative modification, and H 2 O 2 production. (ukrbiochemjournal.org)
Capicor administration increased the endogenous antioxidant defense, weakening the lipid peroxidation and oxidative modification of mitochondrial proteins. (ukrbiochemjournal.org)

Increasing evidence suggests that the etiology of AD may involve disruptions of zinc homeostasis, and oxidative stress facilitating reactive oxygen species production is an early and sustained event in AD disease progression. (springer.com)
Oxidative stress, in which production of highly reactive oxygen species (ROS) and reactive nitrogen species (RNS) overwhelms antioxidant defenses, is a feature of many neurological diseases and neurodegeneration. (unboundmedicine.com)
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. (wikipedia.org)
Further, some reactive oxidative species act as cellular messengers in redox signaling. (wikipedia.org)
Production of reactive oxygen species is a particularly destructive aspect of oxidative stress. (wikipedia.org)
High concentrations of reactive oxygen species (ROS) can lead to oxidative damage to macromolecules. (nau.edu)
They were looking specifically for downstream changes in gene expression that would produce oxidative stress in the cell, a circumstance in which highly reactive forms of oxygen can create a toxic environment. (sciencedaily.com)
There are quite a few situations mentioned in articles and studies which can cause your body to be overly stressed from the results of oxidation and all the reactive oxygen species. (stopthethyroidmadness.com)
To followup these promising preliminary findings, we tested the efficacy of two doses of supplemental calcium (1.0 or 2.0 g/day) relative to placebo on modulating circulating biomarkers of inflammation [C-reactive protein (CRP) and 10 cytokines] and oxidative stress (F2-isoprostanes) over a 4-month treatment period among 193 patients with previous sporadic, colorectal adenoma in a randomized, double-blinded, placebo-controlled clinical trial. (umn.edu)

MSC co-culture with skin fibroblasts from mitochondrial disease patients rescued aberrant mitochondrial morphology from a fission state to a more fused appearance indicating an effect of MSC co-culture on host cell mitochondrial network formation. (frontiersin.org)
Mitochondrial function or the ability to generate energy through OXPHOS (oxidative phosphorylation) is vital for cell homeostasis and its dysfunction has been linked to the pathogenesis of nearly all chronic diseases ( Pieczenik and Neustadt, 2007 ). (frontiersin.org)
In oxidative stress conditions, in the presence of Ca 2+ and inorganic phosphate, animals receiving Arnica 30cH had a significant decrease in mitochondrial O 2 consumption compared to control animals. (thieme-connect.de)
The effects of caloric restriction (CR) on in vivo muscle mitochondrial function in humans are controversial. (medscape.com)
[ 12 ] The activity of key mitochondrial enzymes of the tricarboxylic acid cycle, β-oxidation, and the electron transport system, conversely, were unchanged, [ 12 ] leaving many unanswered questions regarding the effects of CR on muscle-specific mitochondrial function in humans. (medscape.com)
To date, there have been no randomized controlled trials that have examined the effects of long-term CR on muscle mitochondrial function in humans. (medscape.com)

Results suggested that supplementation with seabuckthorn extract helps to reduce oxidative stress in liver and muscle of rats during C-H-R exposure and post-stress recovery. (nih.gov)
The purpose of the current study is to investigate the effect of aquatic Rosa damascena extract against the oxidative damage induced by aluminum chloride intoxication in Alzheimer's model of Wister rats. (scienceopen.com)
There are about 24,000 oxidative DNA adducts per cell in young rats and 66,000 adducts per cell in old rats. (wikipedia.org)
Because the toxicity is associated with oxidative stress and inflammation, the study explored antioxidant and anti-inflammatory effect of virgin coconut oil (VCO) supplementation in nephrotoxicity induced by MTX in rats. (nih.gov)
The cytoprotective action of the green tea- catechins against ethanol - or restraint plus water -immersion stress-induced acute gastric mucosal injury, and acetic acid-induced chronic gastric ulcers in rats has been reported. (rsc.org)
In this study, our aim was to study the effects of PTX on free oxygen radicals and oxidative damage in rats with ACS model. (hakanyanar.com)
The antioxidant effects of Portulaca oleracea seeds extract (POS) and its fertility-enhancing effects were inspiring to evaluate the protective potential and pinpoint the mechanisms and molecular targets of the UPLC-MS fingerprinted POS extract on ACR-induced testicular toxicity in rats. (biomedcentral.com)
Also, purslane exerted anti-fertility effect in female rats by disrupting ovulation and female fertility hormones [ 18 ], while it diminished aging alterations in female reproductive system in aged mice [ 19 ]. (biomedcentral.com)
In this study, we investigated in adult Long-Evans rats the effect of the alteration of CN production through the ACN metabolism on the promotion of NIHL by ACN. (cdc.gov)
This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
Our findings evidenced the cardioprotective effect of trans- resveratrol in rats exposed to cigarette smoke. (bvsalud.org)

Regarding NF-κB, the active form of phosphorylated NF-κB (pNF-κB) increased the oxidative stress level but the maltol treatment again reduced it to an unstressful level. (molvis.org)

Overall, our results provide no evidence that calcium supplementation favorably modulates concentrations of circulating biomarkers of inflammation or oxidative stress over 4 months among patients with a previous colorectal adenoma. (umn.edu)
It is concluded that weight loss improves the n-3 LCPUFA status of obese patients in association with significant amelioration in the biomarkers of oxidative stress, membrane FA insaturation, and n-3 LCPUFA biosynthesis capacity, thus representing a central therapeutic issue in the improvement of obesity-related metabolic alterations involved in the mechanism of hepatic steatosis. (arasysperfector.com)
Arsenic metabolism efficiency did not have a clear effect on the concentrations of either of these biomarkers. (lu.se)

Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. (vendys2.com)
Inflammation and oxidative stress play important roles in colorectal carcinogenesis. (umn.edu)

This review focuses on the differential responses of cell types to ATZ toxicity, testicular effects of ATZ in both in vitro and in vivo models and chemopreventive strategies, so as to highlight the current state of the art on the toxicological outcomes of ATZ exposure in several experimental model systems. (frontiersin.org)
The question as to what causes the destruction of the dopamine-producing cells has puzzled researchers for years but a consensus is now emerging that Parkinson's disease is caused by oxidative stress and metal toxicity. (diagnose-me.com)
There is strong evidence that calcium reduces risk for colorectal neoplasms, possibly through its ability to bind bile acids and prevent their colonic toxicity (which occurs via an oxidative mechanism and results in an inflammatory response). (umn.edu)
Very little is known about the general toxicity of these compounds, especially about their possible neurotoxic effects at the cell level. (imi.hr)
Carbon Tetrachloride Toxicity: What Are the Toxicological Effects of Carbon Tetrachloride Exposure? (cdc.gov)

H2O2 can induce hMSCs to produce oxidative stress response. (researchsquare.com)

The patho-physiological characteristic of AD is abnormal deposition of fibrillar amyloid β protein, intracellular neurofibrillary tangles, oxidative damage and neuronal death in the brain. (springer.com)
Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)
Among the most interesting of his findings was that switching off the gene for a protein called prosaposin, which normally assists with the cell's recycling of waste products, greatly increased the levels of oxidative stress. (sciencedaily.com)
The focus of these studies was to measure the oxidation and nitration status of this important proapoptotic protein, consistent with the hypothesis that oxidative modification of p53 could be involved in the neuronal loss observed in neurodegenerative conditions. (uky.edu)
Additionally, continual oxidative stress from CCl 3 causes DNA damage, protein malfunction, and disrupted calcium homeostasis. (cdc.gov)
Western blotting was performed to examine the protein expression levels of endoplasmic reticulum stress (ERS)‑associated factors. (spandidos-publications.com)

In conclusion, these data suggest that the benefits of feeding a SCFP during transport stress may be mitigated through suppression of innate immune cell activation rather than through suppressing oxidative damage to lipids. (asas.org)

Moreover, oxidative stress also activates mechanisms that result in a glia-mediated inflammation that also causes secondary neuronal damage. (unboundmedicine.com)
A clearer appreciation of the potential therapeutic utility of antioxidants would emerge only when the complexity of their effects on mechanisms that interact to determine the extent of oxidative damage in vivo are more fully defined and understood. (unboundmedicine.com)
Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. (nature.com)
Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. (wikipedia.org)
Biochemical and genetic mechanisms of oxidative stress (OS) developing in rat heart mitochondria were studied in a rotenone model of Parkinson's disease (PD), and the effect of Capicor (combination of meldonium dihydrate and gamma-butyrobetain dihydrate) on these mechanisms was evaluated. (ukrbiochemjournal.org)
In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)
Mechanisms of oxidative stress in the potentiation of noise -induced hearing loss by acrylonitrile. (cdc.gov)
establish mechanisms of action by studying the effects of the same chemicals in experimental animals and on human cells in vitro, allowing for a better prediction of human carcinogenicity and assessment of carcinogenic mechanisms. (who.int)

To be sure, this will lead to oxidative stress. (h-h-c.com)

Inflammatory cytokines were evaluated using ELISA kits and oxidative stress markers were assessed using a malondialdehyde assay kit, superoxide dismutase assay kit and CATalase assay kit. (spandidos-publications.com)

Oxidative stress from oxidative metabolism causes base damage, as well as strand breaks in DNA. (wikipedia.org)
For this purpose, two different drugs were used: (1) Sodium thiosulfate (STS), a CN antidote commonly used in humans in case of CN poisoning and (2) 4-methylpyrazole (4MP) which blocks ACN metabolism through the oxidative pathway, preventing CN formation. (cdc.gov)

Our results illustrate that administration of R. damascene extract has a protective effect against the oxidative damage induced by AlCl 3 intoxication in Alzheimer's model. (scienceopen.com)
Increased free radical activity ( oxidative stress ) appears to fuel Alzheimer's pathology - acting simultaneously as a mediator, product, and trigger for this "clogging" process and its related neural damage. (diagnose-me.com)
Many studies reported that oxidative and nitrosative stress might be important for the pathogenesis of Alzheimer's disease (AD) beginning with arguably the earliest stage of AD, i.e., as mild cognitive impairment (MCI). (uky.edu)

Using a randomized crossover study design, 16 adult pointer dogs were used to compare changes in fecal characteristics, oxidative stress marker concentrations, and gene expression when fed a SCFP-supplemented diet or control diet. (asas.org)
This study tested the hypothesis that physically fit older adults would have less oxidative stress than unfit age-matched controls, due to greater circulating concentrations of non-enzymatic antioxidants and greater capacity to upregulate antioxidant enzymes. (nau.edu)
The lower levels of oxidative stress in the fit individuals were not mediated by known effects of exercise training such as adiposity, HDL concentrations, or small molecular weight antioxidants. (nau.edu)
The administration of LA after to LPS -induced oxidative stress caused a significant decrease in TBARS and H2O2 concentrations (appropriate 3.65 +/- 0.2 microM and 0.014 +/- 0.008 microM) compared with the group treated with LPS (appropriate 6.030 +/- 0.16 microM and 0.189 +/- 0.03 microM). (bvsalud.org)
After cell viability was established, cells treated with concentrations that reduced their viability up to 30 % were further subjected to the alkaline comet assay and biochemical assays that enable estimation of oxidative stress-related effects. (imi.hr)
This study was conducted to evaluate the effects of a diesel particulate filter (DPF) regeneration process on the concentrations and size distributions of aerosols in an underground mine. (cdc.gov)

Neurons are most susceptible to direct oxidative injury by ROS and RNS. (unboundmedicine.com)

Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. (wikipedia.org)
Oxidative stress is an imbalance between free radicals and antioxidants in your body. (h-h-c.com)
‌Because free radicals deplete your cell tissue, oxidative stress may have enduring repercussions. (h-h-c.com)

ROS and RNS can also indirectly contribute to tissue damage by activating a number of cellular pathways resulting in the expression of stress-sensitive genes and proteins to cause oxidative injury. (unboundmedicine.com)
Oxidative stress is an important activator of PKD1 in cellular models, but its capacity to activate this kinase in vivo is largely unknown. (nature.com)
Of note, DAPK can activate PKD in HeLa cells under oxidative stress conditions 11 , thus suggesting that PKD activation may contribute to cellular death. (nature.com)
Activation of this receptor leads to increased oxidative stress that may result in cellular damage. (diagnose-me.com)

Oxidative stress associated with NAFLD in obese patients represents a nutritional type of phenomenon, resulting from prolonged excess oxidative load (carbohydrates, lipids) and inadequate nutrient supply (dietary antioxidants) favoring pro-oxidant reactions (Sies et al. (arasysperfector.com)

Mechanism of oxidative stress in neurodegeneration. (ukrbiochemjournal.org)

Co-exposure to carbon black and Fe2O3 particles causes a synergistic oxidative effect that is significantly greater than the additive effects of exposures to either particle type alone. (rti.org)
Oxidative burst in the whole blood showed a maximum at 4d or 7d of noise exposure. (vendys2.com)
ROS formation gradually increases with ongoing exposure without significant adaptation or tolerance in mice in response to chronic noise stress at moderate levels. (vendys2.com)
These data further illustrate health side effects of long-term noise exposure and further strengthen a consequent implementation of the WHO noise guidelines in order to prevent the development of noise-related future cardiovascular disease. (vendys2.com)
The aim of this study was to address these gaps by assessing the toxic effects of 24-hour exposure to LSD and PCP in the concentration range of 0.39-100 µmol/L in the human neuroblastoma SH-SY5Y cell line. (imi.hr)
Describe the toxicological effects associated with carbon tetrachloride (CCl 4 ) exposure. (cdc.gov)
The immediate effect of acute CCl 4 exposure by all routes is CNS depression [Laine and Riihimaki 1986]. (cdc.gov)
The intensity of the effects is proportional to exposure dose. (cdc.gov)
The CNS effects of chronic exposure are open to question. (cdc.gov)
Sensorimotor neuropathy and abnormalities of vision have been reported, but epidemiological data are insufficient to support an association between CCl 4 exposure and these effects [O'Donoghue 2000]. (cdc.gov)
Acute hepatic injury usually manifests after CNS effects have subsided, typically 1 to 4 days after acute exposure. (cdc.gov)
During particle exposure, ROS and RNS are mainly generated from the oxidative burst of pulmonary inflammatory cells, i.e. neutrophils and AMs. (ecetoc.org)
However, the exposure of these cells to excessive levels of oxidative stress by too high levels of ROS or too low levels of antioxidative protection will render these cells dysfunctional thereby failing the fertilization process and causing couples to be infertile. (hindawi.com)
ABSTRACT Currently no reports are available from Egypt regarding occupational exposure to nickel and its effects on the liver. (who.int)

Chemically, oxidative stress is associated with increased production of oxidizing species or a significant decrease in the effectiveness of antioxidant defenses, such as glutathione. (wikipedia.org)

The aim of the study was to evaluate the anti-cancer effect and mechanism of action of SiNPs in breast cancer cell lines. (mdpi.com)
The present study aimed to explore the functional effects and regulatory mechanism of FOXA2 in pneumonia. (spandidos-publications.com)
The mechanism by which ACN renders the cochlea more vulnerable to noise damage is still unknown, but we hypothesize that the decrease of GSH and/or the inhibition of SOD reduce the cochlear intrinsic anti-oxidant defenses and ultimately create oxidative stress. (cdc.gov)

To evaluate the neuroprotective and neurite outgrowth effects of maltol, a natural aroma compound, on retinal ganglion cells (RGCs) under oxidative stress in vitro. (molvis.org)
This oxidative stress significantly increased the number of TUNEL-positive RGCs, but the maltol drastically reduced the proportion of those apoptotic cells. (molvis.org)
However, after it was discovered that oxidative stress injury to retinal ganglion cells (RGCs) is a leading pathophysiology of glaucoma [ 2 ], researchers' attention has turned to how to directly rescue the damaged RGCs from fatal oxidative stress. (molvis.org)
Our findings suggest that LSD has a greater DNA damaging potential and stronger oxidative activity than PCP in SH-SY5Y cells. (imi.hr)
The influx and subsequent activation of such inflammatory cells into the lung therefore may lead to an oxidative burst which overwhelms the pulmonary antioxidative defences, resulting in oxidative DNA damage. (ecetoc.org)

VCO supplementation prior to MTX injection attenuated MTX-induced oxidative nephrotoxicity via prominent increases in GSH and antioxidant enzyme activities in a dose-dependent manner. (nih.gov)
VCO supplementation demonstrates nephroprotective activity by attenuating MTX oxidative nephrotoxicity via antioxidant and anti-inflammatory activities in kidney. (nih.gov)
The supplementation with POS extract may provide a potential protective effect for ACR-induced testicular dysfunction which is mediated by its antioxidant, antiapoptotic and steroidogenic modulatory effects. (biomedcentral.com)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)

Protective effects of Mangifera indica L extract (Vimang), and its major component mangiferin, on iron-induced oxidative damage to rat serum and liver. (udea.edu.co)

Autophagy is the process of maintaining cell homeostasis under oxidative stress conditions. (researchsquare.com)

Mango (Mangifera indica L.) is one of the world's most consumed fruit, and it is also a rich source of antioxidants that may prevent oxidative stress. (udea.edu.co)
Since this mutagenic response was inhibited in the presence of catalase as antioxidant, the authors concluded that oxidative stress in form of the generation and release of ROS and/or depletion of antioxidants may significantly contribute to this response. (ecetoc.org)

In contrast, expression of an active dephosphorylation-resistant PKD1 mutant potentiates the IKK/NF-κB/SOD2 oxidative stress detoxification pathway and confers neuroprotection from in vitro and in vivo excitotoxicity. (nature.com)
Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo. (ukrbiochemjournal.org)

Natural News) Chinese researchers investigated the effects of Moringa oleifera stem extract (MOSE) on cataract formation induced by oxidative stress in cultured mouse lenses. (naturalnews.com)

With this in mind, the present study investigates whether maltol attenuates oxidative stress injury in primary RGCs in vitro. (molvis.org)

These findings suggested that CA is an effective treatment approach for preventing atherosclerotic lesion progression attributed to protection against oxidative stress and various enzymatic activities in the Ath model. (hindawi.com)

Inflammation in the body is also caused by several lifestyle factors such as excessive drinking, chronic stress, excessive smoking etc. (h-h-c.com)

Oxidative stress pathways are caused by the imbalance of oxidation and antioxidation in body. (springer.com)

The levels of peroxisome proliferator‑activated receptor gamma coactivator (PGC)‑1α/nuclear factor erythroid‑2‑related factor 2 (Nrf2) signalling, oxidative stress and pyroptosis‑related proteins were detected by western blotting. (spandidos-publications.com)
Inhibition of miR‑132 activated PGC‑1α/Nrf2 signalling and inhibited oxidative stress and the expression of the pyroptosis‑related proteins NLRP3, caspase‑1 and IL‑1β, which were all reversed by inhibiting SIRT1 with EX527. (spandidos-publications.com)

The intracellular redox reaction between carbon black and Fe3+ is likely responsible for the synergistic oxidative effect. (rti.org)
Oxidative stress pathways regulate redox balance by Nrf2 and other ways. (springer.com)

According to the latest scientific evidence, most so-called "lifestyle" disorders are connected to chronic inflammation and the consequent oxidative stress. (h-h-c.com)
The sugars lactose and galactose that are found in milk can increase oxidative stress and chronic inflammation in the body - both of which are major causes of serious and chronic diseases. (diagnose-me.com)

Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)
Targeted transcriptional profiling showed no effects on pathways involved inmitochondrial biogenesis, function, or oxidative stress. (medscape.com)

Biological effects of single-base damage by radiation or oxidation, such as 8-oxoguanine and thymine glycol, have been extensively studied. (wikipedia.org)
Anthropometric measurements noted between both groups as regards scribe the effect of oxidation in which an included weight, height and body mass weight, height and BMI. (who.int)

The purpose of this review is to summarize the current evidence in support of this critical role played by oxidative stress of neuronal and glial origin in neurodegenerative diseases. (unboundmedicine.com)
Oxidative stress and its significant roles in neurodegenerative diseases and cancer. (udea.edu.co)

DNA damage induced by ionizing radiation is similar to oxidative stress, and these lesions have been implicated in aging and cancer. (wikipedia.org)

Amongst various factors, hypercholesterolemia is directly linked with obesity and is the primary trigger of underlying inflammation, insulin resistance, and oxidative stress [ 5 ]. (hindawi.com)
These hepatic alterations are related to insulin resistance and oxidative stress as crucial pathogenic factors (Videla et al. (arasysperfector.com)

The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)

However, clinical practice and experiments have shown that ischemia, hypoxia, and inflammatory cell infiltration at the injured site will produce a large amount of ROS, forming an oxidative stress microenvironment. (researchsquare.com)

there is no definitive study which has shown that maltol effectively protects them from the devastating effects of oxidative stress. (molvis.org)
In this study, SCFP was investigated for its impacts on fecal characteristics and oxidative stress of dogs undergoing transport stress. (asas.org)
Blood samples were collected at the end of the study to measure serum lipid profile, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and tissue oxidative stress level. (hindawi.com)
In a new study appearing May 24 in Nature Neuroscience , UCSF researchers have successfully catalogued this effect in the human neuron by separately toggling each of the 20,000 genes in the human genome. (sciencedaily.com)
2 Conforti A., Bellavite P., Bertani S., Chiaroti F., Menniti-Ippolito F., Raschetti R. Rat models of acute inflammation: a randomized controlled study on the effects of homeopathic remedies. (thieme-connect.de)
Effect of homeopathy on analgesic intake following knee ligament reconstruction: a phase III monocentre randomized placebo controlled study. (thieme-connect.de)
The effect of the homeopathic remedies Arnica montana and Bellis perennis on mild postpartum bleeding - a randomized, double-blind, placebo-controlled study - preliminary results. (thieme-connect.de)
With a recent Italian study hypothesizing a significant correlation between T4-only levothyroxine use and lung cancer because of " oxidative stress " (possibly due to the serum peak of T4), or the same oxidative stress simply from the hypothyroidism itself, it spurs curiosity as to what oxidative stress is about and what we, as thyroid patients, can learn from this biological phenomena! (stopthethyroidmadness.com)
Therefore, this study was conducted to investigate the effects of LJP on exercise endurance and oxidative stress in a forced swimming mouse model. (biomedcentral.com)
Our aim was to study the influence of weight loss on the fatty acid (FA) composition of liver and erythrocyte phospholipids and oxidative stress status in obese, non-alcoholic, fatty liver disease (NAFLD) patients. (arasysperfector.com)
The purpose of this study was to assess the effects of hyperbaric oxygen (HBO) and near-infrared light therapy on wound healing. (researchgate.net)
A study to compare the effects of particles generated by engine fueled with neat biodiesel and neat petroleum-based diesel. (cdc.gov)

Furthermore, pro-oxidant activity can induce either beneficial or harmful effects in biologic systems. (diagnose-me.com)

However, under the severe levels of oxidative stress that cause necrosis, the damage causes ATP depletion, preventing controlled apoptotic death and causing the cell to simply fall apart. (wikipedia.org)
Current research was proposed to detect the correlation between pregnancy status and oxidative stress (OS) levels among gingivitis pregnant women and to elucidate the role of pregnancy status in the pathogenicity of gingivitis. (jmchemsci.com)
The pregnancy status had an effect on the OS level which lead to a higher level of OS in both serum and saliva and the correlation between the pregnancy status and serum and/or saliva OS levels was positive which indicated the possible utility of its present lead to gingivitis development. (jmchemsci.com)
In addition, we found that isolated islets from Chop -/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. (jci.org)
ing high levels of oxidative stress [1]. (who.int)

Meanwhile, Zn may play paradoxical roles in initiating and inhibiting oxidative stress and neurotoxicity. (springer.com)

Estimation of the effect of lipoic acid in the rat's lung during lipopolysaccharide-induced oxidative stress]. (bvsalud.org)

Anatomy21

Organisms5

Diseases10

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes39

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science1

Health Care3

Apoptosis17

Markers of oxidative stress3

Lipid Peroxidation9

Reactive9

Mitochondrial6

Rats11

Increased the oxidative stress level1

BIOMARKERS3

Inflammation and oxidative stress2

Toxicity5

Produce oxidative stress1

Protein6

Suppressing oxidative damage1

Mechanisms9

Lead to oxidative1

Superoxide Dismutase1

Metabolism2

Alzheimer's3

Concentrations6

Neurons1

Free radicals3

Cellular4

Lipids1

Neurodegeneration1

Exposure14

Glutathione1

Mechanism3

Cells5

Supplementation4

Protective1

Homeostasis1

Antioxidants2

Vivo2

Extract1

Vitro1

Lesion1

Excessive1

Imbalance1

Proteins2

Redox2

Chronic inflammation2

Pathways3

Oxidation2

Neurodegenerative diseases2

Damage induced1

Insulin2

Inhibition1

Inflammatory1

Study12

Induce1

Levels5

Roles1

Lipopolysaccharide1