Effects of oxidative. Medical search. Frequent questions

Meanwhile, Zn may play paradoxical roles in initiating and inhibiting oxidative stress and neurotoxicity. (springer.com)
Yan B, Ma Z, Shi S, Hu Y, Ma T, Rong G and Yang J: Sulforaphane prevents bleomycin-induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2-related factor-2 activation. (spandidos-publications.com)

Increasing evidence suggests that the etiology of AD may involve disruptions of zinc homeostasis, and oxidative stress facilitating reactive oxygen species production is an early and sustained event in AD disease progression. (springer.com)
Oxidative stress, in which production of highly reactive oxygen species (ROS) and reactive nitrogen species (RNS) overwhelms antioxidant defenses, is a feature of many neurological diseases and neurodegeneration. (unboundmedicine.com)
The effects of EGCG on glucose oxidase (GO)-induced reactive oxygen species (ROS) production was determined using the ROS probe CM-H 2 DCFDA. (molvis.org)
In work presented at the 2013 meeting of the Society of Biological Psychiatry, Anna Andreason showed that over-activity of neurons increases oxidative stress through the production of reactive oxygen species (ROS). (bipolarnews.org)
Oxidative stress may occur when the production of reactive oxygen and nitrogen species (RONS) overwhelms endogenous and exogenous antioxidant defenses, with the potential outcome being oxidation of large and small molecules within a variety of susceptible tissues [ 1 ]. (biomedcentral.com)
The ability of different organic and inorganic oxidative and sulfhydryl reactive agents to unmask or inhibit 125I-Sar1Ile8 angiotensin II (SI-Ang II) binding to this site was presently examined. (nova.edu)
The aim of this study was to examine 900-MHz mobile phone-induced oxidative stress that promotes production of reactive oxygen species (ROS) on renal tubular damage and the role of melatonin on kidney tissue against possible oxidative damage in rats. (greenmedinfo.com)
Treatment with NU7026 did not alter the production of reactive oxygen species and oxidative stress by hydroquinone but repressed the protein level of DNA-PKcs and blocked the induction of the kinase mRNA and protein expression by hydroquinone. (cdc.gov)
Increased oxidative stress due to high production of reactive oxygen species (ROS) is proposed to be involved in pathogenesis of SS 5 . (bvsalud.org)

Effects of EGCG on mitogen-activated protein kinase (MAPK) phosphorylation were determined by cell-based enzyme-linked immunosorbent assay (ELISA) and western blotting. (molvis.org)
Mitochondrial function or the ability to generate energy through OXPHOS (oxidative phosphorylation) is vital for cell homeostasis and its dysfunction has been linked to the pathogenesis of nearly all chronic diseases ( Pieczenik and Neustadt, 2007 ). (frontiersin.org)
reduced oxidative phosphorylation. (cdc.gov)
Thirteen of these genes provide instructions for making enzymes involved in oxidative phosphorylation. (medlineplus.gov)
Oxidative phosphorylation is a process that uses oxygen and simple sugars to create adenosine triphosphate (ATP), the cell's main energy source. (medlineplus.gov)
Cytochrome c oxidase is responsible for the last step in oxidative phosphorylation before the generation of ATP. (medlineplus.gov)
A lack of functional cytochrome c oxidase disrupts oxidative phosphorylation, causing a decrease in ATP production. (medlineplus.gov)
Researchers believe that impaired oxidative phosphorylation can lead to cell death in tissues that require large amounts of energy, such as the brain, muscles, and heart. (medlineplus.gov)

Regarding NF-κB, the active form of phosphorylated NF-κB (pNF-κB) increased the oxidative stress level but the maltol treatment again reduced it to an unstressful level. (molvis.org)

However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)
To explore the protective function and molecular mechanism of tribuloside in hydrogen peroxide-induced apoptosis and oxidative damage of human lens epithelial cells. (ijpsonline.com)
Tribuloside could attenuate apoptosis and oxidative damage in hydrogen peroxide-induced cataract model, which was related to microRNA-335-3p/Kriippel-like factor 6 axis. (ijpsonline.com)
The mechanisms of the cytotoxicity, apoptosis, and oxidative stress induced by the 5-15 nm SiNPs still remain unclear. (mdpi.com)
Under oxidative stress, the effects of maltol on cell viability, apoptosis, and neurite outgrowth were assessed. (molvis.org)
To observe the effect of H2O2 induced oxidative stress on autophagy and apoptosis of human bone marrow mesenchymal stem cells (hBMSCs). (researchsquare.com)
Under oxidative stress conditions, hMSCs can promote protective autophagy and reduce cell apoptosis or the level of apoptosis caused by excessive autophagy. (researchsquare.com)
This experiment intends to activate the oxidative stress response by H2O2, regulate the autophagy level of human bone mesenchymal stem cells (hBMSCs), and observe the effect of autophagy on the proliferation and apoptosis of hMSCs under oxidative stress. (researchsquare.com)
Protective effects in L02 cells were determined by CCK‑8, cell apoptosis and lactate dehydrogenase leakage assays. (spandidos-publications.com)
A growing body of evidence suggests that hyperglycemia-induced oxidative stress plays an important role in pancreatic β-cells dysfunction and apoptosis, as well as in the development and progression of diabetic complications. (currentmedicinalchemistry.com)
Lastly, hydroquinone and NU7026 exhibited synergistic effects on promoting apoptosis by increasing the protein levels of pro-apoptotic proteins Bax and caspase-3 but decreasing the protein expression of anti-apoptotic protein Bcl-2. (cdc.gov)

However, no statistically detected difference is observed in resting or exercise-induced oxidative stress biomarkers, in quality of life, or in GXT time to exhaustion. (biomedcentral.com)
Arsenic metabolism efficiency did not have a clear effect on the concentrations of either of these biomarkers. (lu.se)

The purpose of this review is to summarize the current evidence in support of this critical role played by oxidative stress of neuronal and glial origin in neurodegenerative diseases. (unboundmedicine.com)

However, after it was discovered that oxidative stress injury to retinal ganglion cells (RGCs) is a leading pathophysiology of glaucoma [ 2 ], researchers' attention has turned to how to directly rescue the damaged RGCs from fatal oxidative stress. (molvis.org)

It can be concluded that RFW causes oxidative stress in the eyes and vitamin C improves the antioxidant enzymes activity and decreases MDA. (nih.gov)
What Causes Oxidative Stress? (h-h-c.com)

The present study aimed to investigate the potential hepatoprotective effects of diosmetin on hydrogen peroxide (H2O2)‑induced oxidative damage in L02 cells and attempted to evaluate the role of the nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response element pathway in this process. (spandidos-publications.com)
Conversely, diosmetin (20‑40 µM) significantly reversed the damaging effects of H2O2, which indicated that diosmetin may exhibit potent hepatoprotective potential against H2O2‑induced oxidative damage. (spandidos-publications.com)
Protective effects of Mangifera indica L extract (Vimang), and its major component mangiferin, on iron-induced oxidative damage to rat serum and liver. (udea.edu.co)

2002). The aetiology and pathogenesis of neurodegenerative disorders is not fully understood, but it is known that inflammation and oxidative damage are a key component. (unimib.it)

These findings suggested that CA is an effective treatment approach for preventing atherosclerotic lesion progression attributed to protection against oxidative stress and various enzymatic activities in the Ath model. (hindawi.com)

H2O2 can induce hMSCs to produce oxidative stress response. (researchsquare.com)
UNLABELLED The aim of this study was to investigate the effect of lipoic acid (LA) on lipid peroxidation , hydrogen peroxide concentration (H2O2), sulphydryl group (-SH) contents and total capacity protein a few hours after administration lipopolysaccharide (LPS) -induced oxidative stress in rats . (bvsalud.org)
The administration of LA after to LPS -induced oxidative stress caused a significant decrease in TBARS and H2O2 concentrations (appropriate 3.65 +/- 0.2 microM and 0.014 +/- 0.008 microM) compared with the group treated with LPS (appropriate 6.030 +/- 0.16 microM and 0.189 +/- 0.03 microM). (bvsalud.org)
The early administration of LA a significant decreased symptoms of oxidative stress - induced LPS, that shows decrease in lipid peroxidation process, H2O2 concentration and increase in -SH groups and protein contents in rat 's lung homogenates. (bvsalud.org)

Mango (Mangifera indica L.) is one of the world's most consumed fruit, and it is also a rich source of antioxidants that may prevent oxidative stress. (udea.edu.co)
In order to prevent oxidative damage, the antioxidant system presents a group of cellular enzymes (SOD, catalase and glutathione system) responsible for the control of free radicals. (bvsalud.org)

Distraction of these elements in central nervous system (CNS) have been demonstrated in many neurological disorders, which are vital in generating free radicals, causing oxidative stress, and contributing to neuronal maladies. (fluoridealert.org)
Oxidative stress refers to the stress on our bodies from the normal effects of free radicals combined with environmental stressors like tobacco smoke or radiation. (bipolarnews.org)
These are a type of free radicals that can damage cells in two ways: nitrosylation of proteins (adding nitric oxide to a thiol molecule), and oxidation, which results in more lasting effects on synaptic structures. (bipolarnews.org)
Oxidative stress is an imbalance between free radicals and antioxidants in your body. (h-h-c.com)
‌Because free radicals deplete your cell tissue, oxidative stress may have enduring repercussions. (h-h-c.com)

CEE had no overall effect on CYP2C19, CYP2E1, CYP-mediated dapsone metabolism, and N-acetyltransferase 2. (nih.gov)
CEE significantly influenced CYP1A2, CYP2D6, and CYP-mediated dapsone oxidative metabolism but not CYP2C19, CYP2E1, or N-acetyltransferase 2 metabolism in postmenopausal women. (nih.gov)

No effect of Ca2+ on control lipid peroxidation, hemolysis and thiol contents of erythrocytes was observed. (scirp.org)
Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
Toxic effect of heavy metal salts and hydrogen peroxide lipid per oxidation inducers was studied on the culture of Paramecium caudatum cells. (taylorfrancis.com)
Purpose: The effect of exercise training on lipid peroxidation and endogenous estrogens is not well understood in premenopausal women. (psu.edu)
The purpose of the study is to determine the effect of 15 weeks of aerobic exercise on lipid peroxidation, endogenous estrogens, and body composition in young, healthy eumenorrheic women. (psu.edu)
Blood samples were collected at the end of the study to measure serum lipid profile, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and tissue oxidative stress level. (hindawi.com)
CA treatment ameliorated lipid profile and significantly reduced the oxidative stress level. (hindawi.com)
Concerning in vivo studies, several natural extracts have shown beneficial effects in the setting of diabetes by decreasing blood glucose and lipid levels, increasing insulin sensitivity, and by up-regulating intrinsic antioxidant enzyme activity. (currentmedicinalchemistry.com)
Suwimol S, Pimpanit L, Aporn M, Pichita S, Ratiyaporn S, Wiroj J. Impact of Fruit and Vegetables on Oxidative Status and Lipid Profiles in Healthy Individuals. (udea.edu.co)
Malondialdehyde (MDA), an index of lipid peroxidation), and urine N-acetyl-beta-d-glucosaminidase (NAG), a marker of renal tubular damage were used as markers of oxidative stress-induced renal impairment. (greenmedinfo.com)

Neurons are most susceptible to direct oxidative injury by ROS and RNS. (unboundmedicine.com)

Orange juice vs vitamin C: effect on hydrogen peroxide-induced. (cambridge.org)

ROS and RNS can also indirectly contribute to tissue damage by activating a number of cellular pathways resulting in the expression of stress-sensitive genes and proteins to cause oxidative injury. (unboundmedicine.com)
Espinosa-Diez C, Miguel V, Mennerich D, Kietzmann T, Sánchez-Pérez P, Cadenas S and Lamas S: Antioxidant responses and cellular adjustments to oxidative stress. (spandidos-publications.com)
Oxidative stress is an important activator of PKD1 in cellular models, but its capacity to activate this kinase in vivo is largely unknown. (nature.com)
Of note, DAPK can activate PKD in HeLa cells under oxidative stress conditions 11 , thus suggesting that PKD activation may contribute to cellular death. (nature.com)

The patho-physiological characteristic of AD is abnormal deposition of fibrillar amyloid β protein, intracellular neurofibrillary tangles, oxidative damage and neuronal death in the brain. (springer.com)
The results suggest that oxidative damage of erythrocyte caused by phenyl hydrazine could be prevented by calcium channel antagonist, diltiazem, which may act as antioxidant also. (scirp.org)
Halder, J. and Bhaduri, A.N. (1998) Protective role of bla- ck tea against oxidative damage of human red blood cells. (scirp.org)
Moreover, oxidative stress also activates mechanisms that result in a glia-mediated inflammation that also causes secondary neuronal damage. (unboundmedicine.com)
A clearer appreciation of the potential therapeutic utility of antioxidants would emerge only when the complexity of their effects on mechanisms that interact to determine the extent of oxidative damage in vivo are more fully defined and understood. (unboundmedicine.com)
The results confirm that the fluoride provoked oxidative stress and biometal deformations are synergistic that successively governs the neuronal damage and developing CNS no longer prevents exacerbations of fluoride. (fluoridealert.org)
Hu Y, Wang S, Wang A, Lin L, Chen M and Wang Y: Antioxidant and hepatoprotective effect of Penthorum chinense Pursh extract against t-BHP-induced liver damage in L02 cells. (spandidos-publications.com)
In conclusion, these data suggest that the benefits of feeding a SCFP during transport stress may be mitigated through suppression of innate immune cell activation rather than through suppressing oxidative damage to lipids. (asas.org)
The purpose of the current study is to investigate the effect of aquatic Rosa damascena extract against the oxidative damage induced by aluminum chloride intoxication in Alzheimer's model of Wister rats. (scienceopen.com)
Our results illustrate that administration of R. damascene extract has a protective effect against the oxidative damage induced by AlCl 3 intoxication in Alzheimer's model. (scienceopen.com)
Considering the vulnerability of pancreatic β-cells to oxidative damage, the induction of endogenous antioxidant enzymes or exogenous antioxidant administration has been proposed to protect pancreatic β-cells from damage. (currentmedicinalchemistry.com)
The aim of the present investigation was to study the effect of the intake of a single portion of blood orange juice (BOJ, 300 ml, providing 150 mg vitamin C) on mononuclear blood cell (MNBC) DNA damage, compared with a drink supplemented with the same amount of vitamin C (C-drink) or sugars (S-drink). (cambridge.org)
Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin. (greenmedinfo.com)
Cells that have high energy demands, such as those in the inner ear that are critical for hearing, are particularly sensitive to the effects of mitochondrial DNA damage. (medlineplus.gov)

The aim of the study was to evaluate the anti-cancer effect and mechanism of action of SiNPs in breast cancer cell lines. (mdpi.com)
This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects via an HO-1-independent mechanism. (uni-rostock.de)
The concerted mechanism produces a cis dihydride, while the stereochemistry of the other oxidative addition pathways do not usually produce cis adducts. (wikipedia.org)
The ionic mechanism of oxidative addition is similar to the SN2 type in that it involves the stepwise addition of two distinct ligand fragments. (wikipedia.org)
In this study, the increase in MDA levels of renal tissue and in urine NAG and also the decrease in renal SOD, CAT, GSH-Px activities demonstrated the role of oxidative mechanism induced by 900-MHz mobile phone exposure, and melatonin, via its free radical scavenging and antioxidant properties, ameliorated oxidative tissue injury in rat kidney. (greenmedinfo.com)

Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. (nature.com)

To investigate the effect of caffeine on the levels of malondialdehyde (MDA), nitric oxide (NO), and advanced oxidation protein products (AOPP) in the liver and heart tissues of rats. (tubitak.gov.tr)
With that in mind, a group of researchers conducted a study on whether an aqueous extract can be used to treat oxidative stress in the submandibular glands of diabetic rats. (naturalnews.com)
The effect of the L. divaricata aqueous extract on the pro-oxidant and antioxidant homeostasis in the salivary glands of healthy rats has also been studied. (naturalnews.com)
Based on the results of their experiment, the researchers concluded that the aqueous extract of L. divaricata is capable of reversing oxidative stress induced by the administration of STZ in the submandibular glands of rats. (naturalnews.com)
CONCLUSIONS: These results show that melatonin may exhibit a protective effect on mobile phone-induced renal impairment in rats. (greenmedinfo.com)
This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
Our findings evidenced the cardioprotective effect of trans- resveratrol in rats exposed to cigarette smoke. (bvsalud.org)

Many natural extracts have been tested in vitro in pancreatic β-cell lines in terms of their antioxidant and diabetes mellitus ameliorating effects, and the majority of them have shown a dose-dependent protective role. (currentmedicinalchemistry.com)
Aim To examine those claims, i.e the effects of oxygenated water on hypertension and Diabetes Mellitus (DM).Methods In this clinical trial, 108 subjects of Diabetes Mellitus were recruited. (researchgate.net)
Aim T o examine those claims, i.e the effects of oxygenated water on hypertension and Diabetes Mellitus (DM). (researchgate.net)

A significant protective effect of substances with antioxidant effect (ascorbic acid, piracetam) in the experimental model of induced oxidative stress in unicellular infusoria is established. (taylorfrancis.com)
however, the protective effect of BOJ was not explained by vitamin C alone, thus other phytochemicals could be involved. (cambridge.org)

The present study is the first, to the best of our knowledge, to demonstrate that activation of the Nrf2/NQO1‑HO‑1 signaling pathway maybe involved in the cytoprotective effects of diosmetin against oxidative stress. (spandidos-publications.com)
Nguyen T, Nioi P and Pickett CB: The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. (spandidos-publications.com)

Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
ALI was induced by tracheal infusion of warm saline (30 mL/kg, 38 degrees C) and lung oxidative stress was assessed by total antioxidant performance (TAP) assay. (fapesp.br)

This review focuses on the differential responses of cell types to ATZ toxicity, testicular effects of ATZ in both in vitro and in vivo models and chemopreventive strategies, so as to highlight the current state of the art on the toxicological outcomes of ATZ exposure in several experimental model systems. (frontiersin.org)
To evaluate the neuroprotective and neurite outgrowth effects of maltol, a natural aroma compound, on retinal ganglion cells (RGCs) under oxidative stress in vitro. (molvis.org)
With this in mind, the present study investigates whether maltol attenuates oxidative stress injury in primary RGCs in vitro. (molvis.org)
In contrast, expression of an active dephosphorylation-resistant PKD1 mutant potentiates the IKK/NF-κB/SOD2 oxidative stress detoxification pathway and confers neuroprotection from in vitro and in vivo excitotoxicity. (nature.com)
Objectives: The present review aims to provide evidence of the effect of oxidative stress and antioxidant therapies on pancreatic β-cell function, based on in vitro and in vivo studies. (currentmedicinalchemistry.com)
On the other hand, there is relatively limited evidence regarding the in vitro antioxidant effects of antidiabetic drugs on pancreatic β -cells. (currentmedicinalchemistry.com)
establish mechanisms of action by studying the effects of the same chemicals in experimental animals and on human cells in vitro, allowing for a better prediction of human carcinogenicity and assessment of carcinogenic mechanisms. (who.int)

Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)

Autophagy is the process of maintaining cell homeostasis under oxidative stress conditions. (researchsquare.com)
But researchers from Argentina's Universidad de Buenos Aires and the Instituto de Investigaciones Biomédicas UCA-CONICET noted that the effect of the L. divaricata aqueous extract on the homeostasis in submandibular glands subjected to the effects of an oxidative stressor has not yet been studied. (naturalnews.com)

Nash, G.B., Boghossian, S., Parmar, J., Dormandy, J.A. and Bevan, D. (1989) Alteration of the mechanical properties of sickle cells by repetitive deoxygenation: role of calcium and the effects of calcium blockers. (scirp.org)
This oxidative stress significantly increased the number of TUNEL-positive RGCs, but the maltol drastically reduced the proportion of those apoptotic cells. (molvis.org)
To determine the anti-inflammatory and anti-oxidant effects of epigallocatechin gallate (EGCG), the major polyphenol component of green tea, in human corneal epithelial cells (HCEpiC). (molvis.org)
Viscum album agglutinin-induced aggregation of blood cells and the lectin effects on neutrophil function. (harvard.edu)
Zhang B, Dong JL, Chen YL, Liu Y, Huang SS, Zhong XL, Cheng YH and Wang ZG: Nrf2 mediates the protective effects of homocysteine by increasing the levels of GSH content in HepG2 cells. (spandidos-publications.com)
Inhibition of DNA-PKcs by NU7026 markedly potentiated the apoptotic and growth inhibitory effects of hydroquinone in proerythroid leukemic K562 cells in a dose-dependent manner. (cdc.gov)

Effects of Inhaled Nitric Oxide on Oxidative Stres. (fapesp.br)

The effects of caloric restriction (CR) on in vivo muscle mitochondrial function in humans are controversial. (medscape.com)
[ 12 ] The activity of key mitochondrial enzymes of the tricarboxylic acid cycle, β-oxidation, and the electron transport system, conversely, were unchanged, [ 12 ] leaving many unanswered questions regarding the effects of CR on muscle-specific mitochondrial function in humans. (medscape.com)
To date, there have been no randomized controlled trials that have examined the effects of long-term CR on muscle mitochondrial function in humans. (medscape.com)

Maltol has potential as a new neuroprotective therapeutic agent for oxidative stress-related ocular diseases, including glaucoma. (molvis.org)
Oxidative stress is considered a crucial mediator in the pathogenesis of various liver diseases. (spandidos-publications.com)
Therefore, diosmetin may be considered a promising therapeutic agent for the treatment of various liver diseases associated with oxidative stress. (spandidos-publications.com)
As such, they concluded that the aqueous extract could be used as a local or systemic preventive agent against oral diseases caused by oxidative stress in diabetic subjects. (naturalnews.com)
Oxidative Stress has been related to the development of several diseases, including cancer, heart failure, and diabetes. (h-h-c.com)
Background: Oxidative stress is a hallmark of many diseases. (currentmedicinalchemistry.com)
Oxidative stress and its significant roles in neurodegenerative diseases and cancer. (udea.edu.co)

On 21st postnatal day, the concentration of fluoride, biometals, and oxidative stress markers were determined in discrete regions of CNS. (fluoridealert.org)
The correlation coefficient values among oxidative stress markers and biometals were either positive or negative and showed less significance during correlation. (fluoridealert.org)
Lithium increases cell survival factors BDNF and Bcl-2, increases markers of neuronal integrity such as N-Acetylaspartic acid (NAA), increases the volume of the hippocampus and cortex, and now helps protect mitochondria from oxidative stress. (bipolarnews.org)
We conducted an ancillary study to the CALERIE 2 randomized controlled trial to examine the effects of 12 months of 25% CR on in vivo skeletal muscle mitochondrial energetics, mitochondrial content, and markers of oxidative stress. (medscape.com)

The purpose of this investigation was to determine the effects of a dietary supplement (Ambrotose AO ® ) on resting and exercise-induced blood antioxidant capacity and oxidative stress in exercise-trained and untrained men and women. (biomedcentral.com)

however, the hepatoprotective effects of diosmetin against oxidative stress, and the underlying molecular mechanisms, remain unknown. (spandidos-publications.com)

OBJECTIVE: To analyze the early effects of low INO dose on oxygenation, oxidative stress, inflammatory, and histopathological lung injury in a rabbit model of acute lung injury (ALI). (fapesp.br)

Co-exposure to carbon black and Fe2O3 particles causes a synergistic oxidative effect that is significantly greater than the additive effects of exposures to either particle type alone. (rti.org)
MDA and AOPP levels in the heart tissue also decreased, but this effect was not significantly affected by the dose. (tubitak.gov.tr)

Using a randomized crossover study design, 16 adult pointer dogs were used to compare changes in fecal characteristics, oxidative stress marker concentrations, and gene expression when fed a SCFP-supplemented diet or control diet. (asas.org)

This study was conducted to evaluate the effect of radiofrequency wave (RFW)-induced oxidative stress in the eye and the prophylactic effect of vitamin C on this organ by measuring the antioxidant enzymes activity including: glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), and malondialdehyde (MDA). (nih.gov)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)
either do not elicit or actively suppress the oxidative step, whereas other organisms produce enzymes (eg, catalase, glutathione reductase, superoxide dismutase) that mitigate the oxidative products. (msdmanuals.com)

and to determine a possible cause for such synergistic effect if one was found. (rti.org)
The intracellular redox reaction between carbon black and Fe3+ is likely responsible for the synergistic oxidative effect. (rti.org)

The chemical compound rotenone damages mitochondria by producing ROS, and Andreason found that lithium was able to reverse this production and reverse the adverse effects of oxidative stress. (bipolarnews.org)
Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)
Given the sensitivity of -omic analyses, low- dose adverse effects could also be observed and distinguished from high dose phenomena, and if exposures were accurately assessed, dose-response data could be incorporated into risk assessments. (who.int)

Effect of maternal exposure of fluoride on biometals and oxidative stress parameters in developing CNS of rat. (fluoridealert.org)
This study aimed to investigate if gestational and lactational exposure to human-relevant doses of PAR could alter behavioural and brain oxidative stress parameters in the rat`s offspring. (physiciansweekly.com)
Here, the predominant exposure of c-surface was controlled, and its influences in methane oxidation reactions (combustion and oxidative coupling over HAP and lead-substituted HAP (Pb-HAP), respectively) were studied. (osti.gov)
The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest- observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)
3. HEALTH EFFECTS considered to be important because it helps the users of the profiles to identify levels of exposure at which major health effects start to appear. (cdc.gov)
MRLs are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration within a given route of exposure. (cdc.gov)
As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)

What are possible effects of electron transport inhibitors? (quizlet.com)

Conclusions: The effect of exercise training on oxidative stress may be relevant to risk for hormonally related cancers. (psu.edu)

STZ has been shown to generate an imbalance between oxidative and antioxidant systems by decreasing the secretion of peroxidase in submandibular glands. (naturalnews.com)

1999). In particular, several epidemiological studies have revealed that polyphenol-rich diets can provide beneficial effects in humans and coffee has been described as probably the most relevant source of dietary antioxidant compounds (Martini et al. (unimib.it)

These include modes that are predominately genotoxic (i.e., chromosomal abnormalities, oxidative stress, and gene amplification) vs. more nongenotoxic (i.e., altered growth factors, enhanced cell proliferation and promotion of carcinogenesis, and altered DNA repair). (cdc.gov)

Aim: To evaluate the effect of astaxanthin, fish oil and association of them on enzymatic antioxidant system and functional parameters of salivary glands. (bvsalud.org)

Oxidative additions proceed via many pathways that depend on the metal center and the substrates. (wikipedia.org)
Oxidative additions of nonpolar substrates such as hydrogen and hydrocarbons appear to proceed via concerted pathways. (wikipedia.org)
Targeted transcriptional profiling showed no effects on pathways involved inmitochondrial biogenesis, function, or oxidative stress. (medscape.com)

Webb C and Twedt D: Oxidative stress and liver disease. (spandidos-publications.com)
The effect of caffeine on oxidative stress in liver and heart tissues " by HATİCE PAŞAOĞLU, FATMA EBRU OFLUOĞLU DEMİR et al. (tubitak.gov.tr)
Conclusion: These results show that the short-term consumption of 2 different doses of caffeine may potentially protect against oxidative stress in the liver. (tubitak.gov.tr)
This effect is related to the dose of caffeine in the liver tissue. (tubitak.gov.tr)
This HgCl2 inhibition was independent of any interaction of HgCl2 with angiotensin II (Ang II) based on the lack of effect of HgCl2 on the dipsogenic effects of intracerebroventricularly administered Ang II and 125I-SI Ang II binding to AT1 receptors in the liver. (nova.edu)

Chemicals and Drugs4

Phenomena and Processes2

Information Science1

Inhibiting oxidative stress2

Reactive9

Phosphorylation8

Increased the oxidative stress level1

Apoptosis11

Biomarkers2

Played by oxidative stress1

Discovered that oxidative stress1

Causes oxidative stress2

Induced oxidative damage3

Inflammation and oxidative1

Protection against oxidative1

H2O24

Prevent oxidative2

Free radicals5

Metabolism2

Lipid10

Neurons1

Hydrogen peroxide1

Cellular4

Damage14

Mechanism5

Neuronal death1

Rats7

Diabetes mellitus3

Protective Effect2

Signaling pathway2

Assay2

Vitro7

Protein1

Homeostasis2

Cells6

Nitric oxide1

Mitochondrial Function3

Diseases7

Markers4

Antioxidant capacity1

Mechanisms1

Histopathological1

Significantly2

Concentrations1

Catalase3

Synergistic2

Adverse effects4

Exposure7

Inhibitors1

Conclusions1

Imbalance1

19991

Genotoxic1

Enzymatic1

Pathways3

Liver5