• Lovastatin, sold under the brand name Mevacor among others, is a statin medication, to treat high blood cholesterol and reduce the risk of cardiovascular disease. (wikipedia.org)
  • Mevacor ( medical name Lovastatin ) is a medicine that helps patients to lower cholesterol in their body and they need to keep a suitable diet along with it. (tabletsmanual.com)
  • The liver makes a lot of cholesterol when it is night, so you should take Mevacor during evening for a better effect. (tabletsmanual.com)
  • This is because one of the most crucial ingredients in red yeast rice extract is monacolin K. It is also referred to as lovastatin which is the active component in a prescription drug called Mevacor. (articlecity.com)
  • So, RYRE on one hand is a supplement which assists in lowering cholesterol while on the other hand, the Mevacor drug manufacturer claims that it owns the patent rights to the lovastatin ingredient. (articlecity.com)
  • LOVASTATIN (Mevacor®) is used to reduce the amount of cholesterol and it helps to blocks the body's ability to make cholesterol. (family-health-information.com)
  • If you are taking Mevacor, then discuss the side effects of Mevacor with your doctor and if you feel any change in intensity, then tell your doctor immediately. (family-health-information.com)
  • Because it may cause serious effects and only your doctor can determine if it is safe for you to continue taking Mevacor. (family-health-information.com)
  • If you are taking certain drugs with Mevacor, then it may be increased, decreased, or altered the effects of Mevacor. (family-health-information.com)
  • Diet and exercise can help to keep your low density lipoprotein (bad cholesterol) and triglycerides levels low, but not everyone is successful without help from medication such as Mevacor or generic Lovastatin. (discountdrugsfromcanada.com)
  • Until you know how your body reacts to Mevacor or Lovastatin generic, you should not drive or take part in any activities that require you to be alert. (discountdrugsfromcanada.com)
  • Some statins, like lovastatin (Mevacor), are better absorbed by the body when taken with a meal. (unh.edu)
  • As with atorvastatin, simvastatin, and other statin drugs metabolized via CYP3A4, drinking grapefruit juice during lovastatin therapy may increase the risk of side effects. (wikipedia.org)
  • The ability of lovastatin, mevastatin and simvastatin to inhibit the melanoma cell proliferation was examined using cytotoxicity and apoptosis assays. (biomedcentral.com)
  • Lovastatin, mevastatin and simvastatin inhibited the growth, cell migration and invasion of HT144, M14 and SK-MEL-28 melanoma cells. (biomedcentral.com)
  • They found that three out of the six statins (Fluvastatin, Lovastatin, and Simvastatin) interfered with mitochondria energy levels, as did the blood-pressure drug Propranolol. (genengnews.com)
  • Our results show that HMGR inhibition by simvastatin induces anxiogenic-like effects in the social interaction but not in the elevated plus-maze test, and improves memory consolidation in the inhibitory avoidance task. (nature.com)
  • Thus, atorvastatin, lovastatin and simvastatin are metabolised by isoform 3. (who.int)
  • atorvastatin will increase the level or effect of ivermectin by P-glycoprotein (MDR1) efflux transporter. (medscape.com)
  • Lovastatin and other statins have been studied for their chemopreventive and chemotherapeutic effects. (wikipedia.org)
  • More recent investigations revealed some chemopreventive and therapeutic effects, for certain types of cancer, especially in combination of statins with other anticancer drugs. (wikipedia.org)
  • It is likely that these effect are mediated by the properties of statins to reduce proteasome activity, leading to an accumulation of cyclin-dependent kinase inhibitors p21 and p27, and to subsequent G1-phase arrest, as seen in cells of different cancer lines. (wikipedia.org)
  • Lovastatin belongs to a group of drugs called HMG-CoA reductase inhibitors, also known as statins. (medicineshoppe.com)
  • Statins exert their effects through the inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase). (biomedcentral.com)
  • In addition to the cholesterol lowering effects of statins, a number of recent studies suggest that the cancer incidence rates may be lower in patients receiving statins. (biomedcentral.com)
  • These conflicting reports highlight the need for further studies on the effects of statins on cancer cells. (biomedcentral.com)
  • Common side effects include muscle cramps, joint aches, abdominal pain, nausea, headache and weakness, symptoms that occur with all of the currently available statins. (nih.gov)
  • ABSTRACT We aimed to study the prevalence of the side-effects of statins among Iranians patients admitted to a cardiac-specialized hospital and had taken statins prior to hospitalization. (who.int)
  • In all, 63.5% of the participants reported experiencing side-effects due to statins. (who.int)
  • Although, the clinical benefits outweigh the small risk of liver failure and myopathy, clinicians should be aware of the side-effects of statins. (who.int)
  • Some medications may interact with statins and affect their effectiveness or increase the risk of side effects. (nhcs.com.sg)
  • Second, the team looked at statins to analyze previous suppositions that mitochondria were involved in side effects such as muscle cramping and aches. (genengnews.com)
  • Grapefruit juice has been shown to increase the effects of statins. (unh.edu)
  • The essential role of MVA end-products in the CNS physiology is also supported by growing preclinical and clinical studies on the pleiotropic effects of statins in the brain. (nature.com)
  • After statins were introduced into clinical practice, they were shown to have effects other than lipid lowering, referred to as pleiotropic effects (7). (cdc.gov)
  • The objective of this study was to investigate the association between persistent use of statins and the risk of overall and site-specific cancer in adults, to assess dose-response relationship, and to examine the effects of varying types of statins. (cdc.gov)
  • continuing medical education (CME) for this journal article, allowing clinicians the Assess the pleiotropic effects of statins opportunity to earn CME credit. (cdc.gov)
  • If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage reduction of dihydrocodeine until stable drug effects are achieved. (pdr.net)
  • Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. (hindawi.com)
  • 1 These interactions with food might make your medicine less effective, or they might cause overdose effects. (unh.edu)
  • Your doctor may need to change the doses of your medications or monitor you carefully for side effects. (medlineplus.gov)
  • Many medications can cause side effects. (medbroadcast.com)
  • If you are allergic to lovastatin or any other medications, then tell your doctor and pharmacist. (family-health-information.com)
  • Lovastatin belongs to the family of medications known as lipid metabolism regulators . (pharmachoice.com)
  • Some foods can interact with your medications, making the risk of harmful side effects higher by changing how the medicine is absorbed, or how it works inside the body. (unh.edu)
  • Components of grapefruit juice, the flavonoid naringin, or the furanocoumarin bergamottin inhibit CYP3A4 in vitro, and may account for the in vivo effect of grapefruit juice concentrate decreasing the metabolic clearance of lovastatin, and increasing its plasma concentrations. (wikipedia.org)
  • Grapefruit and grapefruit juice may interact with lovastatin. (medicineshoppe.com)
  • Avoid taking grapefruit or grapefruit juice as they may interact with your medication and increase the risk of side effects. (nhcs.com.sg)
  • 2 In fact, grapefruit can have an effect on more than 85 different medicines! (unh.edu)
  • Lovastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate. (wikipedia.org)
  • Mevalonate is a required building block for cholesterol biosynthesis and lovastatin interferes with its production by acting as a reversible competitive inhibitor for HMG-CoA, which binds to the HMG-CoA reductase. (wikipedia.org)
  • Additionally, the mRNA and protein expression of cyclin D1, cyclin-dependent kinase 4 (CDK4) and retinoblastoma protein (pRb), was further down-regulated under exposure to lovastatin in condition of BRCA1 overexpression, but the expression of p21WAF1/CIP1, a cyclin-dependent kinase inhibitor (CDKI), was further up-regulated, both in vitro and in vivo detected with quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis. (nih.gov)
  • Hydrocodone is a CYP3A4 substrate, and coadministration with CYP3A4 inhibitors like zafirlukast can increase hydrocodone exposure resulting in increased or prolonged opioid effects including fatal respiratory depression, particularly when an inhibitor is added to a stable dose of hydrocodone. (pdr.net)
  • These effects could be more pronounced in patients also receiving a CYP2D6 inhibitor. (pdr.net)
  • Compactin and lovastatin, natural products with a powerful inhibitory effect on HMG-CoA reductase, were discovered in the 1970s, and taken into clinical development as potential drugs for lowering LDL cholesterol. (wikipedia.org)
  • Then, the inhibitory activity of lovastatin on cancer cells and tumoral xenografts, and the underlying mechanism involving in cell-cycle regulatory proteins were analyzed. (nih.gov)
  • Owing to its potential to disrupt infant lipid metabolism, lovastatin should not be taken while breastfeeding. (wikipedia.org)
  • Inhibition of HMG-CoA reductase by statin in effect prevents the synthesis of mevalonic acid, a precursor of nonsteroidal isoprenoids, lipid attachment molecules for small G proteins, such as Ras, Rho, and Rac. (cdc.gov)
  • Severe hepatic impairment could result in an increase of darunavir exposure and a worsening of side effects. (who.int)
  • atazanavir will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • chloramphenicol will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • clarithromycin will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • idelalisib will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • indinavir will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • itraconazole will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • ketoconazole will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
  • However, red yeast rice has potential side effects that include digestive disruption, heartburn, and dizziness. (healthline.com)
  • According to scientists, the other constituents of red yeast rice may lower the risk of side effects caused by monacolin K. such as muscle weakness. (articlecity.com)
  • The lovastatin ingredient in red yeast rice extract is also classified as a prescription drug by the FDA. (articlecity.com)
  • Red yeast rice extract cholesterol controlling effect results from its ability to increase HDL (good cholesterol) in the blood and decrease triglycerides and LDL (bad cholesterol). (articlecity.com)
  • A test-tube research also proved that applying red yeast rice extract powder to prostate cancer cells lowered the growth of cancer cells to a larger extent than lovastatin. (articlecity.com)
  • Avoid taking a supplement called red yeast rice as this supplement may increase the risk of side effects. (nhcs.com.sg)
  • Side effects can be mild or severe, temporary or permanent. (medbroadcast.com)
  • Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. (hindawi.com)
  • They may have been calmed down by the trial directors, according to whom side effects of statin treatment are rare and mild. (thincs.org)
  • In 1982, some small-scale clinical investigations of lovastatin, a polyketide-derived natural product isolated from Aspergillus terreus, in very high-risk patients were undertaken, in which dramatic reductions in LDL cholesterol were observed, with very few adverse effects. (wikipedia.org)
  • Although Western medicines have been the dominant treatment used by hyperlipidemic patients, their adverse effects and part of patients' intolerance to the pharmacotherapy make traditional Chinese medicine (TCM) one of their alternatives. (hindawi.com)
  • However, there is no evidence that this causes any adverse side effects in statin-treated patients. (oregonstate.edu)
  • Excessive smoking can result in shooting up of levels of LDL cholesterol, which, in turn, can cause adverse effects on the heart and other vital organs. (natural-homeremedies.com)
  • After introducing nearly 2,500 compounds to this platform many of which are FDA-approved the researchers say that they were able to discern new insights into basic mitochondrial function, which in turn revealed why some commonly used drugs have particular adverse effects. (genengnews.com)
  • However, these agents have not achieved worldwide use because of limited efficacy or unacceptable adverse effects. (keywen.com)
  • This can be life-threatening if not recognised and treated in time, so any unexplained muscle pain or weakness whilst on lovastatin should be promptly mentioned to the prescribing doctor. (wikipedia.org)
  • It can cause some side effects such as stomach upset, intestinal gas, and nausea. (webmd.com)
  • You may experience these side effects: Nausea (eat frequent small meals), headache, muscle and joint aches and pains (may lessen). (rnpedia.com)
  • The most common side effects of ITZ are nausea, abdominal pain, and rash. (ecancer.org)
  • The concentrations required to inhibit proliferation of melanoma cells (0.8-2.1 μM) have previously been achieved in a phase I clinical trial of lovastatin in patients with solid tumours, (45 mg/kg/day resulted in peak plasma concentrations of approximately 3.9 μM). (biomedcentral.com)
  • Common side effects include constipation, memory loss, confusion, and and dizziness or blurred vision. (medicineshoppe.com)
  • Lovastatin can cause dizziness or blurred vision. (medicineshoppe.com)
  • Drug dynamics describes the following properties of drugs: Therapeutic effects (such as relief of pain and reduction. (msdmanuals.com)
  • Like other calcium channel antagonists, because of its effect on vascular smooth muscle, diltiazem decreases total peripheral resistance resulting in a decrease in both systolic and diastolic blood pressure. (nih.gov)
  • These effects were similar across age, sex, baseline LDL-C, and previous vascular disease. (medscape.com)
  • Effects on vascular disease and mortality were found to be similar in men and women of equivalent CV risk. (medscape.com)
  • The evidence for these anticancer effects, in vitro , in vivo , and clinical are summarised, and the putative mechanisms of their action outlined. (ecancer.org)
  • Patients with liver disease should not take lovastatin. (wikipedia.org)
  • It has no effect on the sinus node recovery time or on the sinoatrial conduction time in patients without SA nodal dysfunction. (nih.gov)
  • In a limited number of studies of patients with compromised myocardium (severe congestive heart failure, acute myocardial infarction, hypertrophic cardiomyopathy), administration of intravenous diltiazem produced no significant effect on contractility, left ventricular end diastolic pressure, or pulmonary capillary wedge pressure. (nih.gov)
  • RÉSUMÉ Nous avions l'objectif d'étudier la prévalence des effets secondaires causés par les statines chez des patients iraniens admis dans un hôpital spécialisé en cardiologie et sous traitement par statines avant leur hospitalisation. (who.int)
  • Most of these patients were using the only effective drug then available, bromide, which had terrible side effects and limited efficacy. (keywen.com)
  • [ 1 ] The first, lovastatin , [ 2 ] was approved about 30 years ago, and since then these drugs have been prescribed to reduce cardiovascular (CV) events and mortality in patients both with and without CV disease. (medscape.com)
  • The first cases were described in 1988 in patients taking lovastatin, including several patients with a kidney transplant using concomitant cyclosporine , which is now known to be an interacting medication. (medscape.com)
  • The Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) trial to evaluate the efficacy of lovastatin for preventing coronary events, found a significantly decreased incidence of new melanomas in the lovastatin arm compared with the placebo arm. (biomedcentral.com)
  • Efficacy is the capacity to produce an effect. (keywen.com)
  • This study showed no significant differences in efficacy or side effects between amitriptyline and gabapentin. (keywen.com)
  • The mechanisms by which thyroid hormones exert their physiologic actions are not completely understood, but it is thought that their principal effects are exerted through control of DNA transcription and protein synthesis. (nih.gov)
  • The protein anabolic effects of thyroid hormones are essential to normal growth and development. (nih.gov)
  • Lovastatin therapy should be discontinued immediately if myopathy is diagnosed or suspected. (medicineshoppe.com)
  • Serious side effects may include liver problems, muscle breakdown, and kidney failure. (wikipedia.org)
  • Common side effects include headaches, low blood sugar levels, and upper respiratory infections. (rxwiki.com)
  • We examined the effects of statin drugs on in vitro proliferation, migration and invasion of melanoma cells. (biomedcentral.com)
  • These drugs have been shown to produce an alarming array of side effects,' states Uffe Ravnskov, MD, PhD, THINCS Chairman. (thincs.org)
  • By reverse engineering the drugs' toxic effects, they may be able to reconstruct normal function. (genengnews.com)
  • Additionally, based on the properties summarised previously, it is proposed that itraconazole may synergise with a range of other drugs to enhance the anti-cancer effect, and some of these possible combinations are presented in the supplementary materials accompanying this paper. (ecancer.org)
  • The drugs then interact with cells or tissues where they produce their intended effects (target sites). (msdmanuals.com)
  • Where drugs exert their effects has to do with how they interact with specific cells or substances such as enzymes. (msdmanuals.com)
  • This document does not contain all possible side effects and others may occur. (rxlist.com)
  • This is not a complete list of side effects and others may occur. (drugs.com)
  • 9.5% reported muscle-related side-effects such as myalgia. (who.int)
  • Does the Nocebo Effect Explain Statin Muscle Complaints? (medscape.com)
  • Circulating serum T 3 and T 4 levels exert a feedback effect on both TRH and TSH secretion. (nih.gov)
  • Our results suggest that BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway, which will provide an innovative experimental framework to study control of breast cancer cell proliferation. (nih.gov)
  • Similarly, there are enzyme inducers that will decrease their pharmacological effect (1-3) , such as enzalutamide. (who.int)
  • Your pharmacist may be able to advise you on managing side effects. (medbroadcast.com)
  • Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation. (theodora.com)
  • The proliferative ability of MCF-7 cells treated with lovastatin was reduced compared to normal, and further decreased in the presence of excess BRCA1, detected by methyl thiazolyl tetrazolium and flow cytometry techniques in vitro or by 5-bromodeoxyuridine incorporation in vivo. (nih.gov)
  • The Se-enriched exopolysaccharide fraction significantly enhanced cell viability when incubated with normal (human umbilical vein endothelial cells (HUVEC)) cells (but this effect was absent for malignant human cervical HeLa cells) and this fraction also protected the cells from oxidative stress conditions. (bvsalud.org)
  • In vitro studies have shown that the effect of tadalafil is more potent on PDE5 than on other phosphodiesterases. (theodora.com)
  • Obviously the Committee is unfamiliar with the scientific literature because a large number of serious side effects from statin treatment have already been published in international medical journals and/or have been reported to the American Food and Drug Administration. (thincs.org)